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The map label for this gene is trpE [H]

Identifier: 119357652

GI number: 119357652

Start: 2150471

End: 2152009

Strand: Reverse

Name: trpE [H]

Synonym: Cpha266_1856

Alternate gene names: 119357652

Gene position: 2152009-2150471 (Counterclockwise)

Preceding gene: 119357654

Following gene: 119357651

Centisome position: 68.67

GC content: 48.15

Gene sequence:

>1539_bases
ATGTCGGGGAAAAAATTAATGACAGGTGTCCTACAGCATTACTGTACTATGGCTTTTAATACACGGCATACTCGCTACGT
TCTCAAACCGCTTGTCAAGGAAGTTTATGCCGATACCGAAACGCCTGTTTCCGTATACCTCAAACTTCAGCGTGACTACT
CCTGCCTGCTTGAATCGGTCGAAGGCGAAGAGATGCTCGCCCGGTTTTCCTATATCGCGTTTGATCCGGTCGCACTTCTC
CGTGGTTCGGTCAATGGAGAGATCTCGCTTGCTATTCTTGATCAGAAGTTCAATTCCCTGTCAGCCATAACGGAGCAGGA
AACCAATTTGCGAACGATCATCGATCACTGCCTTGAGGCGTTTGATACCGAAGAGATTCCGAGGAAAAAAAACGGGTCAC
CGCAGATGATTACCTCCGGGGTGTTCGGTTATTTCGGTTATGATGCCATGCATCTTGTTGAACGGATTCCCGAACCCGAA
TCTCCTGATCCGGCCGGCATGCCCGATGTTTTTTTGCTTTTTTGCGATACCCTTGTGGTTTTTGACAATATCATGCGCAA
GGCCTTTATTATTGTCAACTACCTTGATGACGATGATAAGCCTGCTGCTTCAGAAAAGATAGAACGCATCGCCGAACAGA
TGTTCCGTCCGCTCTCGGCGGAGGAGATTTCGCTGCAGACGGAAAAACCGGAACCGGTAGTTTCCAATACCATGAAAGAG
GACTATTTACAGAAGGTACTTCAAGCCAAGGAGTATATTCTTGACGGTGATATATTTCAGGTACAGGTATCCCAGCGTCT
CAGAAGGAGGCTCAATACTCGCCCTTTTGATGTGTATCGAATGCTTCGAACCATAAACCCTTCGCCTTATCTCTATTATT
TCGATTTGAAGGAGTTCAGGATTATCGGTTCTTCCCCGGAACTTCTCGTCAAGGTTGAGCGAGACAGTAGCGGTCGCAGG
ATGGTTGATACCAGGCCGATAGCCGGAACGCGGCATCGGGGATTGAGCTTTGAAGAGGATGAAGCAATAGCTCACGAGCT
GCTGGCCGATGAGAAAGAGTGTGCGGAACATCTCATGCTTATTGATCTGAGCCGGAACGACATAGGAAGAATAGCCAAAA
TCGGGACAGTCGAGACCAACGAGATGATGGTTATTGAAAAATATTCACATGTCATGCATATTGTCAGCAATGTGCGCGGG
GAGTTGAGAGACGATCTTGGAACCATGGACGCCTTCTGGTCATGCTTCCCTGCCGGCACACTTACCGGAGCCCCGAAAGT
TCGTGCCATGGAGATAATATATGAGCTCGAAAAAGAAAAGCGGGGTCTGTATGGCGGCGCTGTAGGTTTTCTTGACTTCA
AAGGCAATCTGACGACTGCAATTGCAATTCGAACGATGGTTGTTGAAGGGGGAACCATCTATTTTCAGGCTGCGGGGGGT
ATTGTAGCCGACTCGAAACCGGTTGCCGAATATGACGAAACGATGAATAAGATGAGAGCCGGATTGACGGCGCTTGAACG
TATGGAAACTTTGCAGTAA

Upstream 100 bases:

>100_bases
ATGGCCAAAGCGGGTCAATGTTCTCTTTTTCATTGATATGATAGAAATTTTTTTTCTTTATTAAGCGGAAACAATTTCTG
AAACAGGGCACTCTCCCGAT

Downstream 100 bases:

>100_bases
CGACTAACCAATCATTCGGATTCCTATGAAAAAGAAAAAAAGCATGTTGAAATACCTGCTGCTTGTCTTTGCGGGTATTC
TTGTTGGCGGCCTTGTTTTT

Product: anthranilate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSGKKLMTGVLQHYCTMAFNTRHTRYVLKPLVKEVYADTETPVSVYLKLQRDYSCLLESVEGEEMLARFSYIAFDPVALL
RGSVNGEISLAILDQKFNSLSAITEQETNLRTIIDHCLEAFDTEEIPRKKNGSPQMITSGVFGYFGYDAMHLVERIPEPE
SPDPAGMPDVFLLFCDTLVVFDNIMRKAFIIVNYLDDDDKPAASEKIERIAEQMFRPLSAEEISLQTEKPEPVVSNTMKE
DYLQKVLQAKEYILDGDIFQVQVSQRLRRRLNTRPFDVYRMLRTINPSPYLYYFDLKEFRIIGSSPELLVKVERDSSGRR
MVDTRPIAGTRHRGLSFEEDEAIAHELLADEKECAEHLMLIDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRG
ELRDDLGTMDAFWSCFPAGTLTGAPKVRAMEIIYELEKEKRGLYGGAVGFLDFKGNLTTAIAIRTMVVEGGTIYFQAAGG
IVADSKPVAEYDETMNKMRAGLTALERMETLQ

Sequences:

>Translated_512_residues
MSGKKLMTGVLQHYCTMAFNTRHTRYVLKPLVKEVYADTETPVSVYLKLQRDYSCLLESVEGEEMLARFSYIAFDPVALL
RGSVNGEISLAILDQKFNSLSAITEQETNLRTIIDHCLEAFDTEEIPRKKNGSPQMITSGVFGYFGYDAMHLVERIPEPE
SPDPAGMPDVFLLFCDTLVVFDNIMRKAFIIVNYLDDDDKPAASEKIERIAEQMFRPLSAEEISLQTEKPEPVVSNTMKE
DYLQKVLQAKEYILDGDIFQVQVSQRLRRRLNTRPFDVYRMLRTINPSPYLYYFDLKEFRIIGSSPELLVKVERDSSGRR
MVDTRPIAGTRHRGLSFEEDEAIAHELLADEKECAEHLMLIDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRG
ELRDDLGTMDAFWSCFPAGTLTGAPKVRAMEIIYELEKEKRGLYGGAVGFLDFKGNLTTAIAIRTMVVEGGTIYFQAAGG
IVADSKPVAEYDETMNKMRAGLTALERMETLQ
>Mature_511_residues
SGKKLMTGVLQHYCTMAFNTRHTRYVLKPLVKEVYADTETPVSVYLKLQRDYSCLLESVEGEEMLARFSYIAFDPVALLR
GSVNGEISLAILDQKFNSLSAITEQETNLRTIIDHCLEAFDTEEIPRKKNGSPQMITSGVFGYFGYDAMHLVERIPEPES
PDPAGMPDVFLLFCDTLVVFDNIMRKAFIIVNYLDDDDKPAASEKIERIAEQMFRPLSAEEISLQTEKPEPVVSNTMKED
YLQKVLQAKEYILDGDIFQVQVSQRLRRRLNTRPFDVYRMLRTINPSPYLYYFDLKEFRIIGSSPELLVKVERDSSGRRM
VDTRPIAGTRHRGLSFEEDEAIAHELLADEKECAEHLMLIDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGE
LRDDLGTMDAFWSCFPAGTLTGAPKVRAMEIIYELEKEKRGLYGGAVGFLDFKGNLTTAIAIRTMVVEGGTIYFQAAGGI
VADSKPVAEYDETMNKMRAGLTALERMETLQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=379, Percent_Identity=36.6754617414248, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1788114, Length=458, Percent_Identity=31.8777292576419, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786809, Length=214, Percent_Identity=26.6355140186916, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=490, Percent_Identity=39.5918367346939, Blast_Score=306, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6324361, Length=400, Percent_Identity=24.75, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 58071; Mature: 57940

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKKLMTGVLQHYCTMAFNTRHTRYVLKPLVKEVYADTETPVSVYLKLQRDYSCLLESV
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHC
EGEEMLARFSYIAFDPVALLRGSVNGEISLAILDQKFNSLSAITEQETNLRTIIDHCLEA
CHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHH
FDTEEIPRKKNGSPQMITSGVFGYFGYDAMHLVERIPEPESPDPAGMPDVFLLFCDTLVV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
FDNIMRKAFIIVNYLDDDDKPAASEKIERIAEQMFRPLSAEEISLQTEKPEPVVSNTMKE
HHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCHHHHHHHH
DYLQKVLQAKEYILDGDIFQVQVSQRLRRRLNTRPFDVYRMLRTINPSPYLYYFDLKEFR
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEEEE
IIGSSPELLVKVERDSSGRRMVDTRPIAGTRHRGLSFEEDEAIAHELLADEKECAEHLML
EECCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHEEE
IDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGELRDDLGTMDAFWSCFPAGT
EECCCCCCCHHHEECEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTGAPKVRAMEIIYELEKEKRGLYGGAVGFLDFKGNLTTAIAIRTMVVEGGTIYFQAAGG
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHEEEEEEEECCEEEEEECCC
IVADSKPVAEYDETMNKMRAGLTALERMETLQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGKKLMTGVLQHYCTMAFNTRHTRYVLKPLVKEVYADTETPVSVYLKLQRDYSCLLESV
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHC
EGEEMLARFSYIAFDPVALLRGSVNGEISLAILDQKFNSLSAITEQETNLRTIIDHCLEA
CHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHH
FDTEEIPRKKNGSPQMITSGVFGYFGYDAMHLVERIPEPESPDPAGMPDVFLLFCDTLVV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
FDNIMRKAFIIVNYLDDDDKPAASEKIERIAEQMFRPLSAEEISLQTEKPEPVVSNTMKE
HHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCHHHHHHHH
DYLQKVLQAKEYILDGDIFQVQVSQRLRRRLNTRPFDVYRMLRTINPSPYLYYFDLKEFR
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEEEEE
IIGSSPELLVKVERDSSGRRMVDTRPIAGTRHRGLSFEEDEAIAHELLADEKECAEHLML
EECCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHEEE
IDLSRNDIGRIAKIGTVETNEMMVIEKYSHVMHIVSNVRGELRDDLGTMDAFWSCFPAGT
EECCCCCCCHHHEECEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTGAPKVRAMEIIYELEKEKRGLYGGAVGFLDFKGNLTTAIAIRTMVVEGGTIYFQAAGG
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHEEEEEEEECCEEEEEECCC
IVADSKPVAEYDETMNKMRAGLTALERMETLQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]