Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 119357651

GI number: 119357651

Start: 2148931

End: 2150445

Strand: Reverse

Name: degP [H]

Synonym: Cpha266_1855

Alternate gene names: 119357651

Gene position: 2150445-2148931 (Counterclockwise)

Preceding gene: 119357652

Following gene: 119357650

Centisome position: 68.62

GC content: 50.3

Gene sequence:

>1515_bases
ATGAAAAAGAAAAAAAGCATGTTGAAATACCTGCTGCTTGTCTTTGCGGGTATTCTTGTTGGCGGCCTTGTTTTTGCCAA
TGTCGAATTCAGCATTCCGGGCCAGGGGAAAGTTGCGATAGTAAAAAATAATCCCAACTATGCCAACGCGAAAAACAATT
TCGAGAACTATCCCATACACTCGCTCAGGGATTTCAACGAAGCCTTTGTCCAGATCGCCGAATCAGCGACGCCCTCTGTT
GTTACCGTGTTTACCGAAAAAACCGTGAGCCGCAGGCTCATCAGCCCCTTTGACTTCTTCGGAAGATCATTCGACGATTT
TTTCGGAACGCCAGGAGGCGCGCGATCCCCGAATGAGCGAAAAGAGGTGCGTCACGGTCTCGGTTCGGGGGTAATCGTGA
CGGACGACGGTTATATTCTTACCAATAACCATGTTATCGAGAATGCCGATGCGATTTATATCCGCACAAGCGATAACAAG
AAAATAGATGCCACAATTATCGGCAAGGATCCCAAGACTGATCTTGCTGTGATCAAGGTCAATGCTCGCGGCCTGAAACC
CATCATGATCGGCAACAGCGACAACCTGAGGGTTGGTGAATGGGTGATTGCCATAGGCAGTCCGCTCGGCGAAAATCTTG
CGCGAACGGTTACCCAGGGAATCGTAAGCGCAATAGGCCGCGCAAATGTAGGCCTTGCCGACTATGAGGATTTCATTCAG
ACCGATGCGGCCATCAATCCGGGCAATTCAGGTGGTCCGCTTGTCAACATCAATGGAGAGCTTGTTGGTATTAACACAGC
TATTGCAAGCCGCACAGGGGGTTTTGAAGGCATAGGTTTTGCGGTACCCTCCAATATGGCTCAACAGGTTCTGACCGCTC
TTATTACAAAAGGAAAGGTGAGCAGGGGATATCTTGGCATCAGTATCCAGGATATCGATGAAAATATTGCCAAAGGTCTT
CAGCTCCCTAAAGCTGAAGGAGTTATTGTTGGAACGGTGGTCGCCGGAAGTCCGGCTGCACGAAGCGGAATGAAAACCGG
TGACATCATTACGGAGTTCAACGACAAAAAAGTCACGGGCAGCGCAGAGCTTCGCAATACTATTGCAGCAATGCAGCCCG
GTTCGACGGCCCGTCTTCGCATTCTTCGCGATGGTCAGATCAGGATGTATGCAGTCAAGCTTGAAGAGCAGCCGTTACAA
GAGGTTGCTTCCAGAGAGGTCGCTCGTTCCAGCGAAGTCCTTGGATTCAGGTCCCAGGAGCTTACGCCCGAACTTGCCCG
GCAGTATCAGTTAAAAGAGGCATCAGGGAAGATGATCGTCACCGGCGTCGACCAGTCCAGCAACGCATTCCGTGCAGGGC
TTCGCGCAGGCGATGTGATCGTATCTGTCAATAAACAGCCGATAACCACCTCAGCGCAGTACAGCGAGATACTGAGCAAG
GTTAAAAGCGGCGATCTGCTTTTTCTTCTGGTTGAGCGGGGTGGCAACAAACTTTATCTGGCCTTTAATGTTTAG

Upstream 100 bases:

>100_bases
GCCGAATATGACGAAACGATGAATAAGATGAGAGCCGGATTGACGGCGCTTGAACGTATGGAAACTTTGCAGTAACGACT
AACCAATCATTCGGATTCCT

Downstream 100 bases:

>100_bases
GAGCTTCCCGGCTCTGTATATTATTCGTGAGGATCGATCGGTCCTGGAAATGCAAAACAAATACCATGAGGGGTTCAAAA
AGTTTTTTGGCCTGAAGCAA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKKKKSMLKYLLLVFAGILVGGLVFANVEFSIPGQGKVAIVKNNPNYANAKNNFENYPIHSLRDFNEAFVQIAESATPSV
VTVFTEKTVSRRLISPFDFFGRSFDDFFGTPGGARSPNERKEVRHGLGSGVIVTDDGYILTNNHVIENADAIYIRTSDNK
KIDATIIGKDPKTDLAVIKVNARGLKPIMIGNSDNLRVGEWVIAIGSPLGENLARTVTQGIVSAIGRANVGLADYEDFIQ
TDAAINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAQQVLTALITKGKVSRGYLGISIQDIDENIAKGL
QLPKAEGVIVGTVVAGSPAARSGMKTGDIITEFNDKKVTGSAELRNTIAAMQPGSTARLRILRDGQIRMYAVKLEEQPLQ
EVASREVARSSEVLGFRSQELTPELARQYQLKEASGKMIVTGVDQSSNAFRAGLRAGDVIVSVNKQPITTSAQYSEILSK
VKSGDLLFLLVERGGNKLYLAFNV

Sequences:

>Translated_504_residues
MKKKKSMLKYLLLVFAGILVGGLVFANVEFSIPGQGKVAIVKNNPNYANAKNNFENYPIHSLRDFNEAFVQIAESATPSV
VTVFTEKTVSRRLISPFDFFGRSFDDFFGTPGGARSPNERKEVRHGLGSGVIVTDDGYILTNNHVIENADAIYIRTSDNK
KIDATIIGKDPKTDLAVIKVNARGLKPIMIGNSDNLRVGEWVIAIGSPLGENLARTVTQGIVSAIGRANVGLADYEDFIQ
TDAAINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAQQVLTALITKGKVSRGYLGISIQDIDENIAKGL
QLPKAEGVIVGTVVAGSPAARSGMKTGDIITEFNDKKVTGSAELRNTIAAMQPGSTARLRILRDGQIRMYAVKLEEQPLQ
EVASREVARSSEVLGFRSQELTPELARQYQLKEASGKMIVTGVDQSSNAFRAGLRAGDVIVSVNKQPITTSAQYSEILSK
VKSGDLLFLLVERGGNKLYLAFNV
>Mature_504_residues
MKKKKSMLKYLLLVFAGILVGGLVFANVEFSIPGQGKVAIVKNNPNYANAKNNFENYPIHSLRDFNEAFVQIAESATPSV
VTVFTEKTVSRRLISPFDFFGRSFDDFFGTPGGARSPNERKEVRHGLGSGVIVTDDGYILTNNHVIENADAIYIRTSDNK
KIDATIIGKDPKTDLAVIKVNARGLKPIMIGNSDNLRVGEWVIAIGSPLGENLARTVTQGIVSAIGRANVGLADYEDFIQ
TDAAINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAQQVLTALITKGKVSRGYLGISIQDIDENIAKGL
QLPKAEGVIVGTVVAGSPAARSGMKTGDIITEFNDKKVTGSAELRNTIAAMQPGSTARLRILRDGQIRMYAVKLEEQPLQ
EVASREVARSSEVLGFRSQELTPELARQYQLKEASGKMIVTGVDQSSNAFRAGLRAGDVIVSVNKQPITTSAQYSEILSK
VKSGDLLFLLVERGGNKLYLAFNV

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=267, Percent_Identity=37.8277153558052, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI22129776, Length=277, Percent_Identity=37.1841155234657, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI24308541, Length=252, Percent_Identity=36.9047619047619, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI7019477, Length=270, Percent_Identity=34.0740740740741, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1786356, Length=376, Percent_Identity=42.2872340425532, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1789629, Length=433, Percent_Identity=39.2609699769053, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789630, Length=285, Percent_Identity=39.6491228070175, Blast_Score=192, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24646839, Length=318, Percent_Identity=34.5911949685535, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 54077; Mature: 54077

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKKSMLKYLLLVFAGILVGGLVFANVEFSIPGQGKVAIVKNNPNYANAKNNFENYPIH
CCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCH
SLRDFNEAFVQIAESATPSVVTVFTEKTVSRRLISPFDFFGRSFDDFFGTPGGARSPNER
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCHHHHCCCHHHHCCCCCCCCCCCHH
KEVRHGLGSGVIVTDDGYILTNNHVIENADAIYIRTSDNKKIDATIIGKDPKTDLAVIKV
HHHHHCCCCCEEEECCCEEEECCEEEECCCEEEEEECCCCEEEEEEECCCCCCCEEEEEE
NARGLKPIMIGNSDNLRVGEWVIAIGSPLGENLARTVTQGIVSAIGRANVGLADYEDFIQ
ECCCCCEEEECCCCCCEECEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TDAAINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAQQVLTALITKGKV
CCCCCCCCCCCCCEEEECCEEEEEEHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCCC
SRGYLGISIQDIDENIAKGLQLPKAEGVIVGTVVAGSPAARSGMKTGDIITEFNDKKVTG
CCCEEEEEEEHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHCCCCCCCEEEECCCCEECC
SAELRNTIAAMQPGSTARLRILRDGQIRMYAVKLEEQPLQEVASREVARSSEVLGFRSQE
CHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCC
LTPELARQYQLKEASGKMIVTGVDQSSNAFRAGLRAGDVIVSVNKQPITTSAQYSEILSK
CCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHH
VKSGDLLFLLVERGGNKLYLAFNV
HCCCCEEEEEEECCCCEEEEEEEC
>Mature Secondary Structure
MKKKKSMLKYLLLVFAGILVGGLVFANVEFSIPGQGKVAIVKNNPNYANAKNNFENYPIH
CCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCH
SLRDFNEAFVQIAESATPSVVTVFTEKTVSRRLISPFDFFGRSFDDFFGTPGGARSPNER
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCHHHHCCCHHHHCCCCCCCCCCCHH
KEVRHGLGSGVIVTDDGYILTNNHVIENADAIYIRTSDNKKIDATIIGKDPKTDLAVIKV
HHHHHCCCCCEEEECCCEEEECCEEEECCCEEEEEECCCCEEEEEEECCCCCCCEEEEEE
NARGLKPIMIGNSDNLRVGEWVIAIGSPLGENLARTVTQGIVSAIGRANVGLADYEDFIQ
ECCCCCEEEECCCCCCEECEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TDAAINPGNSGGPLVNINGELVGINTAIASRTGGFEGIGFAVPSNMAQQVLTALITKGKV
CCCCCCCCCCCCCEEEECCEEEEEEHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCCC
SRGYLGISIQDIDENIAKGLQLPKAEGVIVGTVVAGSPAARSGMKTGDIITEFNDKKVTG
CCCEEEEEEEHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHCCCCCCCEEEECCCCEECC
SAELRNTIAAMQPGSTARLRILRDGQIRMYAVKLEEQPLQEVASREVARSSEVLGFRSQE
CHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCC
LTPELARQYQLKEASGKMIVTGVDQSSNAFRAGLRAGDVIVSVNKQPITTSAQYSEILSK
CCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHH
VKSGDLLFLLVERGGNKLYLAFNV
HCCCCEEEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]