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The map label for this gene is lysA [H]

Identifier: 119357521

GI number: 119357521

Start: 1952042

End: 1953349

Strand: Reverse

Name: lysA [H]

Synonym: Cpha266_1724

Alternate gene names: 119357521

Gene position: 1953349-1952042 (Counterclockwise)

Preceding gene: 119357524

Following gene: 119357519

Centisome position: 62.33

GC content: 50.0

Gene sequence:

>1308_bases
ATGAAGAAACACTATTATTATAGCTTTAAGAACACTTTAAATGAATGCCAAGCAGTGAGTGAACGTACTATTTTTCATTA
CAGCAAGAACACGCTCTGCTGTGATGGTCAGCGGCTTGATGATCTTGCCGATACTTTCGGAACCCCTCTTTTTGTAACCT
CGAAAAAAAATCTCATAACCCGGTACAACGAGTTTGAAGAGGCTTTCTCCGGGCTCCCGCATTTTACCTGTTATTCTGTC
AAGGCCAATTTCAATCTCAGCGTCATCAAAACGTTCGGGGAGTTGGGTTGCGGGTGCGATGTCAATTCCGGAGGAGAGCT
TTACAGGGCGCTGCAGGCAGGAGTTTCCCCTGAAAAGATTATTTTTGCCGGTGTCGGCAAAAAGGCCGAAGAGATAGCCT
ACGCGCTTCGAAGCGGCGTGCTCATGCTCAAGGCTGAGTCGTTGTCTGAACTCGCAGTGATTGATCGAATTGCCGCAGAG
TCAGGCAACGTCGCACTTGTAGCCATTCGTATCAATCCCAACGTTACAGCTGAAACCCATCCCTATATAACCACAGGAGA
CAGCAAGGAGAAATTCGGAATTGATGAAGGAGAACTTGACGCGGTGCTCATGTTGCTCTCTGAACTCAAACATGTCCGGC
TTGCAGGGCTTGACATGCATATCGGATCCCAGATTTTCGATCCGGAATACTATGTTGCGGCAACAATAAAATTGCTTGCG
ATTTTAGAGCGAGTCAAGGCTCAGGGATTCGCTATTGAGTATTTCGATATCGGCGGCGGGTTTCCCGTTACTTACGATCC
GGCTAAGCAGGCAACGCCGATCGCTCAATTCGCCGAAAAACTGATTCCGCTGCTTCGACCTGCCGGCGTGAAGGTGATCT
TTGAGCCCGGCAGGTTTCTTGTAGCCAATGCCTCGGTGCTGTTGACGCGAATTCTCTATCGCAAACAGAACCATACGGGC
AAACAGTTTTTTATCGTCGATGCGGGAATGACTGAGCTTATCCGTCCGGCACTCTATCAGTCGCATCATGAAGTACTCGC
CGTTACCCGTCACAAGGAGAGCGTTGAAGCGGATGTTGTTGGTCCGGTTTGTGAATCGAGCGACTTTTTTGCCCGGCACC
GAACCATAGACGACGCAGCGGAGGGTGAGTTGCTTGCCGTCATGTCTTCAGGCGCCTATGCGGCCGTTATGAGCAGCAAT
TATAATGGACGGCTTCGTCCTGCCGAAGTTCTTGTTGATGGCCAGGATGTTCGGCTTGTGCGCACCCGCGAAACCTACGA
GCAGCTTATCCAGAACGAACTGCTCTGA

Upstream 100 bases:

>100_bases
TCCTTTAGCCATCTGTTCTTTGGTGATAATTGTAAAGAGCTCCAAATATATGACTTCCGAGATGATTTTGCAAGTTTCGG
ATTTTGTGTTTCTCAGATAA

Downstream 100 bases:

>100_bases
ACGGATTACGGATAGGCGTGTTTATTGTCTGATGTTCCTGAAGATTTTCAGTGTGGCGTCGGCGAGGTTCAGGGTGTAGA
AGTGGATGCCTTTGCACTGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKKHYYYSFKNTLNECQAVSERTIFHYSKNTLCCDGQRLDDLADTFGTPLFVTSKKNLITRYNEFEEAFSGLPHFTCYSV
KANFNLSVIKTFGELGCGCDVNSGGELYRALQAGVSPEKIIFAGVGKKAEEIAYALRSGVLMLKAESLSELAVIDRIAAE
SGNVALVAIRINPNVTAETHPYITTGDSKEKFGIDEGELDAVLMLLSELKHVRLAGLDMHIGSQIFDPEYYVAATIKLLA
ILERVKAQGFAIEYFDIGGGFPVTYDPAKQATPIAQFAEKLIPLLRPAGVKVIFEPGRFLVANASVLLTRILYRKQNHTG
KQFFIVDAGMTELIRPALYQSHHEVLAVTRHKESVEADVVGPVCESSDFFARHRTIDDAAEGELLAVMSSGAYAAVMSSN
YNGRLRPAEVLVDGQDVRLVRTRETYEQLIQNELL

Sequences:

>Translated_435_residues
MKKHYYYSFKNTLNECQAVSERTIFHYSKNTLCCDGQRLDDLADTFGTPLFVTSKKNLITRYNEFEEAFSGLPHFTCYSV
KANFNLSVIKTFGELGCGCDVNSGGELYRALQAGVSPEKIIFAGVGKKAEEIAYALRSGVLMLKAESLSELAVIDRIAAE
SGNVALVAIRINPNVTAETHPYITTGDSKEKFGIDEGELDAVLMLLSELKHVRLAGLDMHIGSQIFDPEYYVAATIKLLA
ILERVKAQGFAIEYFDIGGGFPVTYDPAKQATPIAQFAEKLIPLLRPAGVKVIFEPGRFLVANASVLLTRILYRKQNHTG
KQFFIVDAGMTELIRPALYQSHHEVLAVTRHKESVEADVVGPVCESSDFFARHRTIDDAAEGELLAVMSSGAYAAVMSSN
YNGRLRPAEVLVDGQDVRLVRTRETYEQLIQNELL
>Mature_435_residues
MKKHYYYSFKNTLNECQAVSERTIFHYSKNTLCCDGQRLDDLADTFGTPLFVTSKKNLITRYNEFEEAFSGLPHFTCYSV
KANFNLSVIKTFGELGCGCDVNSGGELYRALQAGVSPEKIIFAGVGKKAEEIAYALRSGVLMLKAESLSELAVIDRIAAE
SGNVALVAIRINPNVTAETHPYITTGDSKEKFGIDEGELDAVLMLLSELKHVRLAGLDMHIGSQIFDPEYYVAATIKLLA
ILERVKAQGFAIEYFDIGGGFPVTYDPAKQATPIAQFAEKLIPLLRPAGVKVIFEPGRFLVANASVLLTRILYRKQNHTG
KQFFIVDAGMTELIRPALYQSHHEVLAVTRHKESVEADVVGPVCESSDFFARHRTIDDAAEGELLAVMSSGAYAAVMSSN
YNGRLRPAEVLVDGQDVRLVRTRETYEQLIQNELL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=365, Percent_Identity=28.2191780821918, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI16506287, Length=348, Percent_Identity=24.7126436781609, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI22538418, Length=379, Percent_Identity=24.2744063324538, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI21361583, Length=379, Percent_Identity=24.2744063324538, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=30.8788598574822, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562780, Length=400, Percent_Identity=24.5, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322664, Length=362, Percent_Identity=24.0331491712707, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24586472, Length=386, Percent_Identity=26.6839378238342, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24586474, Length=347, Percent_Identity=28.8184438040346, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48099; Mature: 48099

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHYYYSFKNTLNECQAVSERTIFHYSKNTLCCDGQRLDDLADTFGTPLFVTSKKNLIT
CCCEEEEHHHHHHHHHHHHHHCEEEEECCCEEEECCCHHHHHHHHHCCCEEEECCHHHHH
RYNEFEEAFSGLPHFTCYSVKANFNLSVIKTFGELGCGCDVNSGGELYRALQAGVSPEKI
HHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEE
IFAGVGKKAEEIAYALRSGVLMLKAESLSELAVIDRIAAESGNVALVAIRINPNVTAETH
EEEECCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC
PYITTGDSKEKFGIDEGELDAVLMLLSELKHVRLAGLDMHIGSQIFDPEYYVAATIKLLA
CEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHH
ILERVKAQGFAIEYFDIGGGFPVTYDPAKQATPIAQFAEKLIPLLRPAGVKVIFEPGRFL
HHHHHHHCCEEEEEEECCCCCCEEECCCHHCCHHHHHHHHHHHHHCCCCCEEEEECCCEE
VANASVLLTRILYRKQNHTGKQFFIVDAGMTELIRPALYQSHHEVLAVTRHKESVEADVV
EEHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCHHCC
GPVCESSDFFARHRTIDDAAEGELLAVMSSGAYAAVMSSNYNGRLRPAEVLVDGQDVRLV
CCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCHHHEEECCCCEEEE
RTRETYEQLIQNELL
ECHHHHHHHHHHCCC
>Mature Secondary Structure
MKKHYYYSFKNTLNECQAVSERTIFHYSKNTLCCDGQRLDDLADTFGTPLFVTSKKNLIT
CCCEEEEHHHHHHHHHHHHHHCEEEEECCCEEEECCCHHHHHHHHHCCCEEEECCHHHHH
RYNEFEEAFSGLPHFTCYSVKANFNLSVIKTFGELGCGCDVNSGGELYRALQAGVSPEKI
HHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEE
IFAGVGKKAEEIAYALRSGVLMLKAESLSELAVIDRIAAESGNVALVAIRINPNVTAETH
EEEECCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC
PYITTGDSKEKFGIDEGELDAVLMLLSELKHVRLAGLDMHIGSQIFDPEYYVAATIKLLA
CEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHH
ILERVKAQGFAIEYFDIGGGFPVTYDPAKQATPIAQFAEKLIPLLRPAGVKVIFEPGRFL
HHHHHHHCCEEEEEEECCCCCCEEECCCHHCCHHHHHHHHHHHHHCCCCCEEEEECCCEE
VANASVLLTRILYRKQNHTGKQFFIVDAGMTELIRPALYQSHHEVLAVTRHKESVEADVV
EEHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCHHCC
GPVCESSDFFARHRTIDDAAEGELLAVMSSGAYAAVMSSNYNGRLRPAEVLVDGQDVRLV
CCCCCCCCHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCHHHEEECCCCEEEE
RTRETYEQLIQNELL
ECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]