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The map label for this gene is comEC [H]

Identifier: 119357519

GI number: 119357519

Start: 1948838

End: 1951039

Strand: Reverse

Name: comEC [H]

Synonym: Cpha266_1722

Alternate gene names: 119357519

Gene position: 1951039-1948838 (Counterclockwise)

Preceding gene: 119357521

Following gene: 119357518

Centisome position: 62.26

GC content: 52.27

Gene sequence:

>2202_bases
ATGTCGGCAATTTTCGCTCCATATCCTGCACTCAGGCTTCTGTTACAGGTTATAGCAGGTATTCTTTGCGGAACGCTGCT
TCTTGTGCCGCTTGAGGCGTGGCTTGCTTGCTCACTTTTCTTTTTTATTCTGCTTTCCTGCGCTCTTTTTTACGAGTTTA
TTGGACGTAAAGGTTCGTTTCCACTATCGTTGACGGCGATCGGGTATTTTTTTTTCGTGGTTGTTGCTTTTGCGGCCTAT
AGCGACTATCTGGTACACTATCAGTCCAAAGCCGGACTTTTACGTTACAGCGGAAAAGAGGTGATTCTCTACGGGCGGGT
TGCCGACAGGCCGGAACGTACCGAAAAGGGAGTCAAGTGGACGATGGAGGCAGAAGAGCTGTTTTTTGAAGGCCGGACAA
TCACACTTCATGAGCGGCTCAAGGTGTTTATGAGGGCACCGGCGGGCGAAAAGATCCGAATGGCTTATGGCGACAGGATT
CGCGTGAAGGGACAGATTGCCGCGATTCCCGGTGCTGCAAACCGTGGAGAATTCGATCCCCGATACTATGCGATGCTTCA
GCAGGTCAGGGTGCAGCTATACTGTCACGGTCCATGGATGGTGTTGCATGATGGCCGGAACACTCTGAGTGTGTTTGAAC
GCTTTGTGGTGCAGCCGGTTTATGCCTATGTTGTCCGGAGCGTTGAAACGCTGATTCCGCCGGGCGAAGAGCGCAAGCTT
GTCAGGGGCGTGCTGCTCGGAGAAAAGGAGGTGCTGACCGAAGAGGTTTTCGACGCCTTCAAACGAACCGGCACAGCGCA
TGTGCTTGCTGTTTCGGGCTTCAACGTCGCGCTTCTCGCACTCGGCATTCACGTCTGTCTGCAGCGCGTCAAGGTGACAG
CTCAGGGCCGATGGATCTCTTTTCTTCTGATTGCCTTTATTCTGCTCGTTTTCAGCTATGTCACCGGCAATTCCGCATCG
GTAAAACGTGCGGCCATCATGTCGGTCGTGCTCCTCGGTGGCGAGACGCTCGGGAGAAAAGCCTTTGCGGTCAACTCACT
TGCCGCATCCGATGTGATTATTCTGTTTATTGACCCGCTTGACCTGTTCAATCCCGGTTTTCTGATGACCAACGCCGCGG
TTCTTGCCATTCTGCTGGTCTATCCGCTTTTTTACGGATCGGATAAGGAGGAAGAGGGCGTATGGCGCAGGATATGGAGA
TTTCTGCTCAGCAGTTTTTTTGTCAGTCTTGCCGCCATCATCGGGGTTTCTCCCGTTATAGCCTATTACTTCGGTACCTT
TTCACTTGTCAGTCTTGTCGCCAATCTGCCGGTCGTTCTCTTTTCAACGCTCCTGATGTATGCCCTGATGCCGATGCTGC
TTGTAAACCTCGTTTCAGGGTATCTCGCCTCATATTTTGCCATGAGCGGCTATCTTTTTGCCTGGTTGACTCTCCAGTCT
GCTCTTTTTTTCAGCAAGCTCCCGTTTGCCTCGATAGAACTTAAACCCGATATGATCGAAGTGGCGATCTACTATACTGT
ACTGACGGTTGCAGCATGGTATCTGTACAAAAAAACATGGGGCAGGCTTGCCATTACCCTGCTTCTTGGTCTCAATCTGT
TTTTCTGGTACTCTTTTCTCTCCGCCGGGGAACAGGGCAGGGGAGTGGTGACGGTGAATCTTGGAAAAAATCTTGCCGTT
CTCTTTTCGACGCATGGCGAGACGGTGGTGATCGATACCGGAACCCGATCACGCGACGTTGAACGAGTGATGCGCCAGGT
CAGTGAGTACAGGTTGGCCGAGCCTGTGGCAGCGGTACAGTTTTTTTCGCCGGATTCACTTGTCGGGATGGTGCCGGTAA
AGCGCCATCTTCGGCAGCAGGAGAACTCCCTTGCGCTTGCCTCCATGGTGATCGTGCGTCCGGAGGAGAAGGTGCTGAAA
CTCTGGAGCAGAGAGCGCTCGCTGCTTCTGATCTCCGGCACCAGCCGATTGAAAGAGGAGGAACTCTACAAAGCCGATGT
GGTGCTGCTCTGGGTTTACCGGTTTGCCGAAAAACAGCGGCGGGAAATTTCTTCATGGCTGAACTATGCTCGTCCAATAA
AGTGCATCATCGTTCCAGGCTCGTTTCTCACCCTTCGACAGAAAGAGGATCTCATCCGTTTTGCCGCAGCTCATCCCGAA
CTCGAAATCCGTTCCAAAGCCCGACAGATCGTGATTCGCTGA

Upstream 100 bases:

>100_bases
TTTTTTTGCGTTACTTTTTTTAAGATAAGAATATATGAAAACAATGATTTCGTTACGGTAAAGAAATTTATCTGCGCTCT
ACCATAACCACACTGCGTTC

Downstream 100 bases:

>100_bases
GGTTTTCTTTGTCTCTGACGATGCTGCCCCGGGTTTTCTGTTCCGTTTTTTTGACAGGGCATTTTCGTTGTTTAAATTAC
GTCGAAAATATTTGTTGCGA

Product: ComEC/Rec2-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 733; Mature: 732

Protein sequence:

>733_residues
MSAIFAPYPALRLLLQVIAGILCGTLLLVPLEAWLACSLFFFILLSCALFYEFIGRKGSFPLSLTAIGYFFFVVVAFAAY
SDYLVHYQSKAGLLRYSGKEVILYGRVADRPERTEKGVKWTMEAEELFFEGRTITLHERLKVFMRAPAGEKIRMAYGDRI
RVKGQIAAIPGAANRGEFDPRYYAMLQQVRVQLYCHGPWMVLHDGRNTLSVFERFVVQPVYAYVVRSVETLIPPGEERKL
VRGVLLGEKEVLTEEVFDAFKRTGTAHVLAVSGFNVALLALGIHVCLQRVKVTAQGRWISFLLIAFILLVFSYVTGNSAS
VKRAAIMSVVLLGGETLGRKAFAVNSLAASDVIILFIDPLDLFNPGFLMTNAAVLAILLVYPLFYGSDKEEEGVWRRIWR
FLLSSFFVSLAAIIGVSPVIAYYFGTFSLVSLVANLPVVLFSTLLMYALMPMLLVNLVSGYLASYFAMSGYLFAWLTLQS
ALFFSKLPFASIELKPDMIEVAIYYTVLTVAAWYLYKKTWGRLAITLLLGLNLFFWYSFLSAGEQGRGVVTVNLGKNLAV
LFSTHGETVVIDTGTRSRDVERVMRQVSEYRLAEPVAAVQFFSPDSLVGMVPVKRHLRQQENSLALASMVIVRPEEKVLK
LWSRERSLLLISGTSRLKEEELYKADVVLLWVYRFAEKQRREISSWLNYARPIKCIIVPGSFLTLRQKEDLIRFAAAHPE
LEIRSKARQIVIR

Sequences:

>Translated_733_residues
MSAIFAPYPALRLLLQVIAGILCGTLLLVPLEAWLACSLFFFILLSCALFYEFIGRKGSFPLSLTAIGYFFFVVVAFAAY
SDYLVHYQSKAGLLRYSGKEVILYGRVADRPERTEKGVKWTMEAEELFFEGRTITLHERLKVFMRAPAGEKIRMAYGDRI
RVKGQIAAIPGAANRGEFDPRYYAMLQQVRVQLYCHGPWMVLHDGRNTLSVFERFVVQPVYAYVVRSVETLIPPGEERKL
VRGVLLGEKEVLTEEVFDAFKRTGTAHVLAVSGFNVALLALGIHVCLQRVKVTAQGRWISFLLIAFILLVFSYVTGNSAS
VKRAAIMSVVLLGGETLGRKAFAVNSLAASDVIILFIDPLDLFNPGFLMTNAAVLAILLVYPLFYGSDKEEEGVWRRIWR
FLLSSFFVSLAAIIGVSPVIAYYFGTFSLVSLVANLPVVLFSTLLMYALMPMLLVNLVSGYLASYFAMSGYLFAWLTLQS
ALFFSKLPFASIELKPDMIEVAIYYTVLTVAAWYLYKKTWGRLAITLLLGLNLFFWYSFLSAGEQGRGVVTVNLGKNLAV
LFSTHGETVVIDTGTRSRDVERVMRQVSEYRLAEPVAAVQFFSPDSLVGMVPVKRHLRQQENSLALASMVIVRPEEKVLK
LWSRERSLLLISGTSRLKEEELYKADVVLLWVYRFAEKQRREISSWLNYARPIKCIIVPGSFLTLRQKEDLIRFAAAHPE
LEIRSKARQIVIR
>Mature_732_residues
SAIFAPYPALRLLLQVIAGILCGTLLLVPLEAWLACSLFFFILLSCALFYEFIGRKGSFPLSLTAIGYFFFVVVAFAAYS
DYLVHYQSKAGLLRYSGKEVILYGRVADRPERTEKGVKWTMEAEELFFEGRTITLHERLKVFMRAPAGEKIRMAYGDRIR
VKGQIAAIPGAANRGEFDPRYYAMLQQVRVQLYCHGPWMVLHDGRNTLSVFERFVVQPVYAYVVRSVETLIPPGEERKLV
RGVLLGEKEVLTEEVFDAFKRTGTAHVLAVSGFNVALLALGIHVCLQRVKVTAQGRWISFLLIAFILLVFSYVTGNSASV
KRAAIMSVVLLGGETLGRKAFAVNSLAASDVIILFIDPLDLFNPGFLMTNAAVLAILLVYPLFYGSDKEEEGVWRRIWRF
LLSSFFVSLAAIIGVSPVIAYYFGTFSLVSLVANLPVVLFSTLLMYALMPMLLVNLVSGYLASYFAMSGYLFAWLTLQSA
LFFSKLPFASIELKPDMIEVAIYYTVLTVAAWYLYKKTWGRLAITLLLGLNLFFWYSFLSAGEQGRGVVTVNLGKNLAVL
FSTHGETVVIDTGTRSRDVERVMRQVSEYRLAEPVAAVQFFSPDSLVGMVPVKRHLRQQENSLALASMVIVRPEEKVLKL
WSRERSLLLISGTSRLKEEELYKADVVLLWVYRFAEKQRREISSWLNYARPIKCIIVPGSFLTLRQKEDLIRFAAAHPEL
EIRSKARQIVIR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=437, Percent_Identity=24.7139588100687, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 82624; Mature: 82492

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIFAPYPALRLLLQVIAGILCGTLLLVPLEAWLACSLFFFILLSCALFYEFIGRKGSF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLSLTAIGYFFFVVVAFAAYSDYLVHYQSKAGLLRYSGKEVILYGRVADRPERTEKGVKW
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCEEEEEECCCCCCCHHCCCCEE
TMEAEELFFEGRTITLHERLKVFMRAPAGEKIRMAYGDRIRVKGQIAAIPGAANRGEFDP
EEEHHHHHHCCCEEEHHHHHHHHHCCCCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCH
RYYAMLQQVRVQLYCHGPWMVLHDGRNTLSVFERFVVQPVYAYVVRSVETLIPPGEERKL
HHHHHHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VRGVLLGEKEVLTEEVFDAFKRTGTAHVLAVSGFNVALLALGIHVCLQRVKVTAQGRWIS
HHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHH
FLLIAFILLVFSYVTGNSASVKRAAIMSVVLLGGETLGRKAFAVNSLAASDVIILFIDPL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCCCEEEEEECCH
DLFNPGFLMTNAAVLAILLVYPLFYGSDKEEEGVWRRIWRFLLSSFFVSLAAIIGVSPVI
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYYFGTFSLVSLVANLPVVLFSTLLMYALMPMLLVNLVSGYLASYFAMSGYLFAWLTLQS
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFFSKLPFASIELKPDMIEVAIYYTVLTVAAWYLYKKTWGRLAITLLLGLNLFFWYSFL
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAGEQGRGVVTVNLGKNLAVLFSTHGETVVIDTGTRSRDVERVMRQVSEYRLAEPVAAVQ
HCCCCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHE
FFSPDSLVGMVPVKRHLRQQENSLALASMVIVRPEEKVLKLWSRERSLLLISGTSRLKEE
ECCCCCCEEHHHHHHHHHHHHCCHHHHHHEEECCHHHHHHHHCCCCCEEEEECCCHHHHH
ELYKADVVLLWVYRFAEKQRREISSWLNYARPIKCIIVPGSFLTLRQKEDLIRFAAAHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHHHCCCC
LEIRSKARQIVIR
HHHHHHHHHHCCC
>Mature Secondary Structure 
SAIFAPYPALRLLLQVIAGILCGTLLLVPLEAWLACSLFFFILLSCALFYEFIGRKGSF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PLSLTAIGYFFFVVVAFAAYSDYLVHYQSKAGLLRYSGKEVILYGRVADRPERTEKGVKW
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCEEEEEECCCCCCCHHCCCCEE
TMEAEELFFEGRTITLHERLKVFMRAPAGEKIRMAYGDRIRVKGQIAAIPGAANRGEFDP
EEEHHHHHHCCCEEEHHHHHHHHHCCCCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCH
RYYAMLQQVRVQLYCHGPWMVLHDGRNTLSVFERFVVQPVYAYVVRSVETLIPPGEERKL
HHHHHHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VRGVLLGEKEVLTEEVFDAFKRTGTAHVLAVSGFNVALLALGIHVCLQRVKVTAQGRWIS
HHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHH
FLLIAFILLVFSYVTGNSASVKRAAIMSVVLLGGETLGRKAFAVNSLAASDVIILFIDPL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCCCEEEEEECCH
DLFNPGFLMTNAAVLAILLVYPLFYGSDKEEEGVWRRIWRFLLSSFFVSLAAIIGVSPVI
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYYFGTFSLVSLVANLPVVLFSTLLMYALMPMLLVNLVSGYLASYFAMSGYLFAWLTLQS
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFFSKLPFASIELKPDMIEVAIYYTVLTVAAWYLYKKTWGRLAITLLLGLNLFFWYSFL
HHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAGEQGRGVVTVNLGKNLAVLFSTHGETVVIDTGTRSRDVERVMRQVSEYRLAEPVAAVQ
HCCCCCCEEEEEECCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHE
FFSPDSLVGMVPVKRHLRQQENSLALASMVIVRPEEKVLKLWSRERSLLLISGTSRLKEE
ECCCCCCEEHHHHHHHHHHHHCCHHHHHHEEECCHHHHHHHHCCCCCEEEEECCCHHHHH
ELYKADVVLLWVYRFAEKQRREISSWLNYARPIKCIIVPGSFLTLRQKEDLIRFAAAHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHHHCCCC
LEIRSKARQIVIR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]