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The map label for this gene is accD [C]

Identifier: 119357394

GI number: 119357394

Start: 1805718

End: 1807262

Strand: Reverse

Name: accD [C]

Synonym: Cpha266_1593

Alternate gene names: 119357394

Gene position: 1807262-1805718 (Counterclockwise)

Preceding gene: 119357395

Following gene: 119357393

Centisome position: 57.67

GC content: 53.27

Gene sequence:

>1545_bases
ATGAATATTGACCAGAAAATACAGGAGCTGAACCAGCGTAAAGATGAAATACAGCTCGGTGGGGGAGTGGCGCGGATTGA
GAAGCAGCACGAAGGTGGCAGTCTGACCGCCCGCGAGCGTCTCAATGTTCTTCTCGATCAGGACAGCTTTCAGGAAACAG
GACTTTTCGCCCGTCATCGCGGAACACTTTTCGGTATGGCCGAAAAAGAGATGCATGCGGACGGGGTAGTCACCGGAGCA
GGCAGCGTCAACAGTCGACTTGTGCATATTGCCTGTCAGGACTTTACGGTTGGCGGTGGCTCTGTAGGTGAGATCCATTC
CGCAAAGATCGTCCAGATGATGCAGTCCTCTCTGAAAACCGGTTCGCCATTCATCATGATCAACGATTCCGGTGGAGCCC
GTATACAGGAGGGAATCGACAGCCTTTCCGGTTACGGCAAGGTTTTCTACAACAACGTCATGCTTTCCGGCGTGGTACCG
CAGATTTCGCTTATCTGTGGCCCCTGTGCCGGCGGGGCGGCTTACAGCCCCGCCCTGACCGACTTTATCATCCAGACGAA
GTCAGCCCGCATTTTTATCACCGGACCTTCGGTTATCAAGGCCGTAACCGGTGAAGAGGTCAGTTCGGAAGATCTTGGTG
GTCCGGCAGCCCAGATGAACATCTCCGGCGTGGTTCATTTCATTGCTGAGGATGATATGGATGCCATTGCCATCTGCAAG
CGCCTGCTTTCGTTCCTTCCTTCCAACAATCTGGAGGATCCGCCACGCAAGGAAGCAGAAGAGACTATCCTTCCTGACAA
ACAGCTTAACGAGATTGTTCCCGTTGACCCTAAACAGAGCTACGATGTTCGCGACGTGATCGGCCATGTTGTGGATCACG
CTGATTTCATGGAGGTGCAGGCCTTTTTTGCCTCCAACATCGTCATCGGCTTCGCCAGACTTCAAGGCCGTTCGGTAGGA
ATTGTGGCAAATCAGCCGTGTGTCATGGCCGGGGTGCTTGATATCAACGCATCGGACAAGGCGGCCCGTTTCATTCGCTT
CTGCAATGCCTTCAATATACCGCTTCTTACTTTTGTTGATGTCCCGGGCTTTCTTCCAGGTGTCGAGCAGGAGTATGGTG
GTATCATCCGCCACGGCGCTAAAATGCTTTTTGCCTACTCTGCGGCCACGGTGCCGAAAATTACCGTTATCATGCGTAAG
GCATATGGCGGAGCCTATCTGGCCATGTGTTGCAAGGATCTGGATGCCGACAGGGTCATTTCCTGGCCGACAGCGGAAAT
TGCGGTCATGGGAGCGGAAGGCGCCGTTGATGTGATTTTCCGCAACGAGATCAAGAAAGCGGAAGATCCGGTATTACGCC
GTCAGGAGTTGATTACAGAGTACAGGGATACATTTTCCACCCCGTACGTTTCAGCTTCACGCCTCCATGTTGACGATATT
ATCGAGCCGGCCGACACCCGGCGATATCTGGCCCTGGCTCTCGACATTCTTCATTCCAAACGGGAGTTCAGGCCTCAGAA
AAAGCATGGCCTGATTCCCCTGTAA

Upstream 100 bases:

>100_bases
CAGGGCATCATAACCGGCCCCATCACCTACTCAGTGACCATGAGTGGTCGGCAGCATAAGGTGACGGTAGCGCCATACCA
GTAAACACAGGCGAACAAAC

Downstream 100 bases:

>100_bases
CCATAATGAACAGAGTAACCATGAACGAACAGGAACTACCTGAGAAGGAGCCGGAAATAACACCGGAACTCCTGATCATC
ATGTCGGCCTCCATAGCGGC

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MNIDQKIQELNQRKDEIQLGGGVARIEKQHEGGSLTARERLNVLLDQDSFQETGLFARHRGTLFGMAEKEMHADGVVTGA
GSVNSRLVHIACQDFTVGGGSVGEIHSAKIVQMMQSSLKTGSPFIMINDSGGARIQEGIDSLSGYGKVFYNNVMLSGVVP
QISLICGPCAGGAAYSPALTDFIIQTKSARIFITGPSVIKAVTGEEVSSEDLGGPAAQMNISGVVHFIAEDDMDAIAICK
RLLSFLPSNNLEDPPRKEAEETILPDKQLNEIVPVDPKQSYDVRDVIGHVVDHADFMEVQAFFASNIVIGFARLQGRSVG
IVANQPCVMAGVLDINASDKAARFIRFCNAFNIPLLTFVDVPGFLPGVEQEYGGIIRHGAKMLFAYSAATVPKITVIMRK
AYGGAYLAMCCKDLDADRVISWPTAEIAVMGAEGAVDVIFRNEIKKAEDPVLRRQELITEYRDTFSTPYVSASRLHVDDI
IEPADTRRYLALALDILHSKREFRPQKKHGLIPL

Sequences:

>Translated_514_residues
MNIDQKIQELNQRKDEIQLGGGVARIEKQHEGGSLTARERLNVLLDQDSFQETGLFARHRGTLFGMAEKEMHADGVVTGA
GSVNSRLVHIACQDFTVGGGSVGEIHSAKIVQMMQSSLKTGSPFIMINDSGGARIQEGIDSLSGYGKVFYNNVMLSGVVP
QISLICGPCAGGAAYSPALTDFIIQTKSARIFITGPSVIKAVTGEEVSSEDLGGPAAQMNISGVVHFIAEDDMDAIAICK
RLLSFLPSNNLEDPPRKEAEETILPDKQLNEIVPVDPKQSYDVRDVIGHVVDHADFMEVQAFFASNIVIGFARLQGRSVG
IVANQPCVMAGVLDINASDKAARFIRFCNAFNIPLLTFVDVPGFLPGVEQEYGGIIRHGAKMLFAYSAATVPKITVIMRK
AYGGAYLAMCCKDLDADRVISWPTAEIAVMGAEGAVDVIFRNEIKKAEDPVLRRQELITEYRDTFSTPYVSASRLHVDDI
IEPADTRRYLALALDILHSKREFRPQKKHGLIPL
>Mature_514_residues
MNIDQKIQELNQRKDEIQLGGGVARIEKQHEGGSLTARERLNVLLDQDSFQETGLFARHRGTLFGMAEKEMHADGVVTGA
GSVNSRLVHIACQDFTVGGGSVGEIHSAKIVQMMQSSLKTGSPFIMINDSGGARIQEGIDSLSGYGKVFYNNVMLSGVVP
QISLICGPCAGGAAYSPALTDFIIQTKSARIFITGPSVIKAVTGEEVSSEDLGGPAAQMNISGVVHFIAEDDMDAIAICK
RLLSFLPSNNLEDPPRKEAEETILPDKQLNEIVPVDPKQSYDVRDVIGHVVDHADFMEVQAFFASNIVIGFARLQGRSVG
IVANQPCVMAGVLDINASDKAARFIRFCNAFNIPLLTFVDVPGFLPGVEQEYGGIIRHGAKMLFAYSAATVPKITVIMRK
AYGGAYLAMCCKDLDADRVISWPTAEIAVMGAEGAVDVIFRNEIKKAEDPVLRRQELITEYRDTFSTPYVSASRLHVDDI
IEPADTRRYLALALDILHSKREFRPQKKHGLIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=519, Percent_Identity=51.0597302504817, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI295821216, Length=539, Percent_Identity=49.165120593692, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI11545863, Length=504, Percent_Identity=35.1190476190476, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI134142062, Length=492, Percent_Identity=25, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI38679977, Length=354, Percent_Identity=24.5762711864407, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679967, Length=354, Percent_Identity=24.5762711864407, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679960, Length=354, Percent_Identity=23.728813559322, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679971, Length=354, Percent_Identity=23.728813559322, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679974, Length=354, Percent_Identity=24.5762711864407, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788655, Length=187, Percent_Identity=31.5508021390374, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=511, Percent_Identity=50.880626223092, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI25147359, Length=511, Percent_Identity=50.880626223092, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17552936, Length=502, Percent_Identity=33.4661354581673, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71997163, Length=390, Percent_Identity=25.8974358974359, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324343, Length=391, Percent_Identity=23.5294117647059, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586065, Length=518, Percent_Identity=35.1351351351351, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 55938; Mature: 55938

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDQKIQELNQRKDEIQLGGGVARIEKQHEGGSLTARERLNVLLDQDSFQETGLFARHR
CCHHHHHHHHHCCHHHEEECCCHHHHHHHCCCCCEEHHHHHHEEECCCCHHHCCCHHHCC
GTLFGMAEKEMHADGVVTGAGSVNSRLVHIACQDFTVGGGSVGEIHSAKIVQMMQSSLKT
CCEEECHHHHHCCCCEEECCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCC
GSPFIMINDSGGARIQEGIDSLSGYGKVFYNNVMLSGVVPQISLICGPCAGGAAYSPALT
CCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCHHHCCCCEEEEEECCCCCCCCCCHHHH
DFIIQTKSARIFITGPSVIKAVTGEEVSSEDLGGPAAQMNISGVVHFIAEDDMDAIAICK
HHHEEECCCEEEEECHHHHHHHCCCCCCCCCCCCCHHEEEHHHEEEEEECCCCHHHHHHH
RLLSFLPSNNLEDPPRKEAEETILPDKQLNEIVPVDPKQSYDVRDVIGHVVDHADFMEVQ
HHHHHCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
AFFASNIVIGFARLQGRSVGIVANQPCVMAGVLDINASDKAARFIRFCNAFNIPLLTFVD
HHHHHHHEEEEEEECCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGVEQEYGGIIRHGAKMLFAYSAATVPKITVIMRKAYGGAYLAMCCKDLDADRVI
CCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCEEEEHHHHCCCHHHHHHHHCCCCCCEE
SWPTAEIAVMGAEGAVDVIFRNEIKKAEDPVLRRQELITEYRDTFSTPYVSASRLHVDDI
ECCCCEEEEECCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHH
IEPADTRRYLALALDILHSKREFRPQKKHGLIPL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure
MNIDQKIQELNQRKDEIQLGGGVARIEKQHEGGSLTARERLNVLLDQDSFQETGLFARHR
CCHHHHHHHHHCCHHHEEECCCHHHHHHHCCCCCEEHHHHHHEEECCCCHHHCCCHHHCC
GTLFGMAEKEMHADGVVTGAGSVNSRLVHIACQDFTVGGGSVGEIHSAKIVQMMQSSLKT
CCEEECHHHHHCCCCEEECCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCC
GSPFIMINDSGGARIQEGIDSLSGYGKVFYNNVMLSGVVPQISLICGPCAGGAAYSPALT
CCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCHHHCCCCEEEEEECCCCCCCCCCHHHH
DFIIQTKSARIFITGPSVIKAVTGEEVSSEDLGGPAAQMNISGVVHFIAEDDMDAIAICK
HHHEEECCCEEEEECHHHHHHHCCCCCCCCCCCCCHHEEEHHHEEEEEECCCCHHHHHHH
RLLSFLPSNNLEDPPRKEAEETILPDKQLNEIVPVDPKQSYDVRDVIGHVVDHADFMEVQ
HHHHHCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
AFFASNIVIGFARLQGRSVGIVANQPCVMAGVLDINASDKAARFIRFCNAFNIPLLTFVD
HHHHHHHEEEEEEECCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEC
VPGFLPGVEQEYGGIIRHGAKMLFAYSAATVPKITVIMRKAYGGAYLAMCCKDLDADRVI
CCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCEEEEHHHHCCCHHHHHHHHCCCCCCEE
SWPTAEIAVMGAEGAVDVIFRNEIKKAEDPVLRRQELITEYRDTFSTPYVSASRLHVDDI
ECCCCEEEEECCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHH
IEPADTRRYLALALDILHSKREFRPQKKHGLIPL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]