Click here to switch to the map view.

The map label for this gene is acrE [H]

Identifier: 119357366

GI number: 119357366

Start: 1778450

End: 1779559

Strand: Reverse

Name: acrE [H]

Synonym: Cpha266_1564

Alternate gene names: 119357366

Gene position: 1779559-1778450 (Counterclockwise)

Preceding gene: 119357367

Following gene: 119357365

Centisome position: 56.78

GC content: 48.38

Gene sequence:

>1110_bases
ATGGTCGCTATCTGTATGGCAGCGATGGTGTCGGGTTGCGGCGGTAACAATGGAAACGAAAAGGCCGGAGGGGCGCAGCC
ATTACCGGCGATGAAGCTTGCATATGTATCGGCTAAAGTATATAGCGAATATCCTGCAATGATCGAAGGACGGGTCAATG
TTGAGATACGTCCACAGGTTGATGGCACTCTGGAGAAGATTTTAGTGAATGAGGGCGCTTTTGTTAATGCCGGACAGCCT
TTATTTCAAATTAAGGGAGGAGTATACCGGGAGCAGTATAATCAGGCAATTGCAAATCAGCATGCAGCGGAAGCCGCTCT
GGTCAATGCAAGGCTTGATGTCGACAAGATTACTCCTCTTGTGCAGAACAAGGTTGTTTCTGATGTTCAGCTCAAAGCCG
CAAAAGCGTCATATCAAGCTGCAAAAGCAAATGTTGAACAGGCAAAGGCTGCTGCCCAGTCAGCAGGAATCAGTTTGGGG
TATACGACATTGCGCGCTCCTGTAAGCGGTTATATCGGGAAAATTCCTTATCGCCTCGGCAGTCTTGTAACCAAAAATCA
GAATGAGTCTCTGACTGTTTTATCGGATGTTCAGGAGGTGAATGCCTATTTCAGCATGAGCGAAACGGACTTTATTCGTT
TCAGGGGGCAGTATGCCGGAGCTACTATCGAGGAGAAGATCCGGAACGTCCCTCCGGTGACTCTCATTCTTGCTGATGCG
AGCGAGCACTCTGAAAAGGGTGTGCTTCAAATGGCTGGAGGGCAATTTGATAATGCTACCGGAGCGATCAGCATGAAGGC
GGTTTTTGCGAATCCTCAGGGACTTCTGAGAACGGGGAGTACCGGAAAGGTAAGGATCGAGGTTTTATACAACAATGTGC
TGCTTGTACCTCAGGCTGCAACGACCGAGTTGCAGGACAAGGTTTTTGTTTTCCGACTGGCTGAGGGAAATAAAGCCGTG
AAAATCCCCATAACTGTTTCCGGAAAAAGCGGCAACAGCTATATCGTTACGACAGGGCTTAAACCTGGCGATGTTATTGT
CACAGCCGGATTGTTGAAATTGAAAGAAGGCGCAGTTGTCAAGCCGCAATTTGATGCTCCGCAAATCTGA

Upstream 100 bases:

>100_bases
TTTGTTTTTATTGAGCTTTAAAAGATTACGGGTAATGGTTATTAATAAAACAAACCGCATTGTCATGTTACGCAAACACA
GGTTTTTTCGGGTTCCGGTG

Downstream 100 bases:

>100_bases
AGCCGACAGAGGAGGCTAATCCACAGGTTTACCGAATCAGTGACAGGTTTATCAAACTTGCAGAGAGAAAAAGGTTTCAT
GGTAACAGCTATTTAAAAAA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MVAICMAAMVSGCGGNNGNEKAGGAQPLPAMKLAYVSAKVYSEYPAMIEGRVNVEIRPQVDGTLEKILVNEGAFVNAGQP
LFQIKGGVYREQYNQAIANQHAAEAALVNARLDVDKITPLVQNKVVSDVQLKAAKASYQAAKANVEQAKAAAQSAGISLG
YTTLRAPVSGYIGKIPYRLGSLVTKNQNESLTVLSDVQEVNAYFSMSETDFIRFRGQYAGATIEEKIRNVPPVTLILADA
SEHSEKGVLQMAGGQFDNATGAISMKAVFANPQGLLRTGSTGKVRIEVLYNNVLLVPQAATTELQDKVFVFRLAEGNKAV
KIPITVSGKSGNSYIVTTGLKPGDVIVTAGLLKLKEGAVVKPQFDAPQI

Sequences:

>Translated_369_residues
MVAICMAAMVSGCGGNNGNEKAGGAQPLPAMKLAYVSAKVYSEYPAMIEGRVNVEIRPQVDGTLEKILVNEGAFVNAGQP
LFQIKGGVYREQYNQAIANQHAAEAALVNARLDVDKITPLVQNKVVSDVQLKAAKASYQAAKANVEQAKAAAQSAGISLG
YTTLRAPVSGYIGKIPYRLGSLVTKNQNESLTVLSDVQEVNAYFSMSETDFIRFRGQYAGATIEEKIRNVPPVTLILADA
SEHSEKGVLQMAGGQFDNATGAISMKAVFANPQGLLRTGSTGKVRIEVLYNNVLLVPQAATTELQDKVFVFRLAEGNKAV
KIPITVSGKSGNSYIVTTGLKPGDVIVTAGLLKLKEGAVVKPQFDAPQI
>Mature_369_residues
MVAICMAAMVSGCGGNNGNEKAGGAQPLPAMKLAYVSAKVYSEYPAMIEGRVNVEIRPQVDGTLEKILVNEGAFVNAGQP
LFQIKGGVYREQYNQAIANQHAAEAALVNARLDVDKITPLVQNKVVSDVQLKAAKASYQAAKANVEQAKAAAQSAGISLG
YTTLRAPVSGYIGKIPYRLGSLVTKNQNESLTVLSDVQEVNAYFSMSETDFIRFRGQYAGATIEEKIRNVPPVTLILADA
SEHSEKGVLQMAGGQFDNATGAISMKAVFANPQGLLRTGSTGKVRIEVLYNNVLLVPQAATTELQDKVFVFRLAEGNKAV
KIPITVSGKSGNSYIVTTGLKPGDVIVTAGLLKLKEGAVVKPQFDAPQI

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=367, Percent_Identity=31.0626702997275, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789929, Length=362, Percent_Identity=29.8342541436464, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786668, Length=362, Percent_Identity=32.0441988950276, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI87082036, Length=311, Percent_Identity=26.3665594855305, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39146; Mature: 39146

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAICMAAMVSGCGGNNGNEKAGGAQPLPAMKLAYVSAKVYSEYPAMIEGRVNVEIRPQV
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECEEEEEEECCC
DGTLEKILVNEGAFVNAGQPLFQIKGGVYREQYNQAIANQHAAEAALVNARLDVDKITPL
CCHHHHHHCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHH
VQNKVVSDVQLKAAKASYQAAKANVEQAKAAAQSAGISLGYTTLRAPVSGYIGKIPYRLG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEECHHHHHCCHHHHHHCCCHHHH
SLVTKNQNESLTVLSDVQEVNAYFSMSETDFIRFRGQYAGATIEEKIRNVPPVTLILADA
HHEECCCCCCEEEEHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEEEECC
SEHSEKGVLQMAGGQFDNATGAISMKAVFANPQGLLRTGSTGKVRIEVLYNNVLLVPQAA
CCCCCCCEEEECCCCCCCCCCEEEEEEEEECCCHHEEECCCCEEEEEEEECCEEEECCCC
TTELQDKVFVFRLAEGNKAVKIPITVSGKSGNSYIVTTGLKPGDVIVTAGLLKLKEGAVV
CCCCCCEEEEEEEECCCEEEEEEEEEECCCCCEEEEECCCCCCCEEEEECCEEECCCCEE
KPQFDAPQI
CCCCCCCCC
>Mature Secondary Structure
MVAICMAAMVSGCGGNNGNEKAGGAQPLPAMKLAYVSAKVYSEYPAMIEGRVNVEIRPQV
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECEEEEEEECCC
DGTLEKILVNEGAFVNAGQPLFQIKGGVYREQYNQAIANQHAAEAALVNARLDVDKITPL
CCHHHHHHCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHH
VQNKVVSDVQLKAAKASYQAAKANVEQAKAAAQSAGISLGYTTLRAPVSGYIGKIPYRLG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEECHHHHHCCHHHHHHCCCHHHH
SLVTKNQNESLTVLSDVQEVNAYFSMSETDFIRFRGQYAGATIEEKIRNVPPVTLILADA
HHEECCCCCCEEEEHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEEEECC
SEHSEKGVLQMAGGQFDNATGAISMKAVFANPQGLLRTGSTGKVRIEVLYNNVLLVPQAA
CCCCCCCEEEECCCCCCCCCCEEEEEEEEECCCHHEEECCCCEEEEEEEECCEEEECCCC
TTELQDKVFVFRLAEGNKAVKIPITVSGKSGNSYIVTTGLKPGDVIVTAGLLKLKEGAVV
CCCCCCEEEEEEEECCCEEEEEEEEEECCCCCEEEEECCCCCCCEEEEECCEEECCCCEE
KPQFDAPQI
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]