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The map label for this gene is ffh [H]

Identifier: 119357327

GI number: 119357327

Start: 1732576

End: 1733925

Strand: Reverse

Name: ffh [H]

Synonym: Cpha266_1525

Alternate gene names: 119357327

Gene position: 1733925-1732576 (Counterclockwise)

Preceding gene: 119357329

Following gene: 119357326

Centisome position: 55.33

GC content: 47.78

Gene sequence:

>1350_bases
ATGTTTGATAATTTAAGTGATAAATTAGAGGCCACCTTTAAGAAACTTGCAGGGCAGGCGACGATCAATGAGATCAATAT
TGGTATTGCGATGCGCGATATCAAGCGCGCTCTGCTCAATGCTGACGTGAATTACAAGGTAGCAAAGAAGCTGGTTGACG
ATATCAGGGAAAAATCACTTGGCGAGCAGGTACTCAAGAGCGTTTCTCCTGCCCAGATGATTGTCAAGATTGTCAATGAC
GAGTTGACCGATCTTATGGGAGGCGAACATCAGCCGTTGAACCTCTCCCCCAAAAAGTTGCCCGCCATTATCATGGTTGC
GGGTTTACAGGGTTCCGGAAAAACGACGTTCTGCGCAAAGCTGGCCAAGCGTCTCAAAAAGAACGGGAAAAACCCCATGC
TGGTAGCTGCCGACGTCTATCGTCCAGCCGCTGTCGACCAGCTCAGGACTCTCGGCGAACAGGTTGATGTACCCGTTTTT
TCCATAGATGAGCAGGATGCGATGAAGGCCGCCGTGAAGGGTCTTGAAGCAGCCCGTCTTGCGGCAAAGGATGTCGTTAT
CATCGATACGGCAGGCCGTTTGCAGATAGATGAGAAAATGATGGCGGAGGCAGAGGCATTGAAACATGCGCTCAAGCCCG
ATGAGCTGTTGTTTGTCGTTGATTCCATGATGGGTCAGGAAGCTGTCAATACGGCCAAAGCTTTTAACGACAGGCTCGAT
TTTGACGGCGTTGTGCTAACCAAACTCGACGGAGATGCACGAGGCGGTGCGGCGCTTTCCATACGCCAGGTTGTCGAAAA
GCCGATAAAATTCATCAGTGTTGGTGAAAAGGTCGATGATCTCGATCTCTTTTATCCCGACCGTATGGCCCAGAGAATTC
TCGGTATGGGTGATATTGTCAGTTTTGTTGAAAAAGCGCAGGAAACGCTGGATCTTGAGAAGACCCTCGAGATGCAGAAG
AAACTGATGAAAAACGAGTTTGATCTCAACGACTTTTTCGATCAGCTCCAGCAGCTTAAAAAGATGGGCTCGATTCAGGG
ACTCATTTCCATGGTGCCGGGATTGAATAAAATGGTTCCGAAACAGGAAATTGAAAATCTTGATTTCAAGCCGATTGAGG
CGATGATCAACTCCATGACAAAACAGGAAAAAACAAATCCTGAAATAATCAATGGCAGTCGGAGGCAGAGAATTGCAAAG
GGAAGCGGTACCAGGGTTCAGGAAGTGAACATGCTGCTCAAGCAGTTCGGGGAGATGAAAAAGATGATGCGTTCGGTAAC
GAAGCTTTCGCAATCAGGCAGAAAAATCACCTCACAGAATCTTGCGCTCGACAAGTTTCTAAAACGTTAA

Upstream 100 bases:

>100_bases
ATATGCACTCAGATCACAAGACTCCGGTTTTATTTTTCCCTATTTTTTATTATAATTAAAGCTAATCATTTTTAAGCTTT
ATCTTGAAAAGCAAAAAGCA

Downstream 100 bases:

>100_bases
ATTACTGTTATTGTTAACAACCACTAAACTATTGCAGCATTGGTCAAGATCAGATTGAAAAGAACAGGAAGAAAAAAATT
ACCCATTTATCAGATTGTTG

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFDNLSDKLEATFKKLAGQATINEINIGIAMRDIKRALLNADVNYKVAKKLVDDIREKSLGEQVLKSVSPAQMIVKIVND
ELTDLMGGEHQPLNLSPKKLPAIIMVAGLQGSGKTTFCAKLAKRLKKNGKNPMLVAADVYRPAAVDQLRTLGEQVDVPVF
SIDEQDAMKAAVKGLEAARLAAKDVVIIDTAGRLQIDEKMMAEAEALKHALKPDELLFVVDSMMGQEAVNTAKAFNDRLD
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFISVGEKVDDLDLFYPDRMAQRILGMGDIVSFVEKAQETLDLEKTLEMQK
KLMKNEFDLNDFFDQLQQLKKMGSIQGLISMVPGLNKMVPKQEIENLDFKPIEAMINSMTKQEKTNPEIINGSRRQRIAK
GSGTRVQEVNMLLKQFGEMKKMMRSVTKLSQSGRKITSQNLALDKFLKR

Sequences:

>Translated_449_residues
MFDNLSDKLEATFKKLAGQATINEINIGIAMRDIKRALLNADVNYKVAKKLVDDIREKSLGEQVLKSVSPAQMIVKIVND
ELTDLMGGEHQPLNLSPKKLPAIIMVAGLQGSGKTTFCAKLAKRLKKNGKNPMLVAADVYRPAAVDQLRTLGEQVDVPVF
SIDEQDAMKAAVKGLEAARLAAKDVVIIDTAGRLQIDEKMMAEAEALKHALKPDELLFVVDSMMGQEAVNTAKAFNDRLD
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFISVGEKVDDLDLFYPDRMAQRILGMGDIVSFVEKAQETLDLEKTLEMQK
KLMKNEFDLNDFFDQLQQLKKMGSIQGLISMVPGLNKMVPKQEIENLDFKPIEAMINSMTKQEKTNPEIINGSRRQRIAK
GSGTRVQEVNMLLKQFGEMKKMMRSVTKLSQSGRKITSQNLALDKFLKR
>Mature_449_residues
MFDNLSDKLEATFKKLAGQATINEINIGIAMRDIKRALLNADVNYKVAKKLVDDIREKSLGEQVLKSVSPAQMIVKIVND
ELTDLMGGEHQPLNLSPKKLPAIIMVAGLQGSGKTTFCAKLAKRLKKNGKNPMLVAADVYRPAAVDQLRTLGEQVDVPVF
SIDEQDAMKAAVKGLEAARLAAKDVVIIDTAGRLQIDEKMMAEAEALKHALKPDELLFVVDSMMGQEAVNTAKAFNDRLD
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFISVGEKVDDLDLFYPDRMAQRILGMGDIVSFVEKAQETLDLEKTLEMQK
KLMKNEFDLNDFFDQLQQLKKMGSIQGLISMVPGLNKMVPKQEIENLDFKPIEAMINSMTKQEKTNPEIINGSRRQRIAK
GSGTRVQEVNMLLKQFGEMKKMMRSVTKLSQSGRKITSQNLALDKFLKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=32.579185520362, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI226371618, Length=343, Percent_Identity=34.9854227405248, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI89061728, Length=150, Percent_Identity=36, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI23308697, Length=275, Percent_Identity=30.1818181818182, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI295424842, Length=275, Percent_Identity=30.1818181818182, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=48.4777517564403, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=32.4528301886792, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=30.8045977011494, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=294, Percent_Identity=29.9319727891156, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=415, Percent_Identity=35.9036144578313, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI17647949, Length=356, Percent_Identity=34.2696629213483, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24641198, Length=304, Percent_Identity=29.2763157894737, Blast_Score=111, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49880; Mature: 49880

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLSDKLEATFKKLAGQATINEINIGIAMRDIKRALLNADVNYKVAKKLVDDIREKSL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GEQVLKSVSPAQMIVKIVNDELTDLMGGEHQPLNLSPKKLPAIIMVAGLQGSGKTTFCAK
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCCCHHHHHH
LAKRLKKNGKNPMLVAADVYRPAAVDQLRTLGEQVDVPVFSIDEQDAMKAAVKGLEAARL
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHH
AAKDVVIIDTAGRLQIDEKMMAEAEALKHALKPDELLFVVDSMMGQEAVNTAKAFNDRLD
HHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFISVGEKVDDLDLFYPDRMAQRILGMGDIV
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHH
SFVEKAQETLDLEKTLEMQKKLMKNEFDLNDFFDQLQQLKKMGSIQGLISMVPGLNKMVP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
KQEIENLDFKPIEAMINSMTKQEKTNPEIINGSRRQRIAKGSGTRVQEVNMLLKQFGEMK
HHHHHCCCCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KMMRSVTKLSQSGRKITSQNLALDKFLKR
HHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFDNLSDKLEATFKKLAGQATINEINIGIAMRDIKRALLNADVNYKVAKKLVDDIREKSL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GEQVLKSVSPAQMIVKIVNDELTDLMGGEHQPLNLSPKKLPAIIMVAGLQGSGKTTFCAK
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCEEEEEECCCCCCCHHHHHH
LAKRLKKNGKNPMLVAADVYRPAAVDQLRTLGEQVDVPVFSIDEQDAMKAAVKGLEAARL
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHH
AAKDVVIIDTAGRLQIDEKMMAEAEALKHALKPDELLFVVDSMMGQEAVNTAKAFNDRLD
HHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
FDGVVLTKLDGDARGGAALSIRQVVEKPIKFISVGEKVDDLDLFYPDRMAQRILGMGDIV
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHH
SFVEKAQETLDLEKTLEMQKKLMKNEFDLNDFFDQLQQLKKMGSIQGLISMVPGLNKMVP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
KQEIENLDFKPIEAMINSMTKQEKTNPEIINGSRRQRIAKGSGTRVQEVNMLLKQFGEMK
HHHHHCCCCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KMMRSVTKLSQSGRKITSQNLALDKFLKR
HHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]