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The map label for this gene is mutY [H]

Identifier: 119357322

GI number: 119357322

Start: 1729391

End: 1730287

Strand: Reverse

Name: mutY [H]

Synonym: Cpha266_1520

Alternate gene names: 119357322

Gene position: 1730287-1729391 (Counterclockwise)

Preceding gene: 119357323

Following gene: 119357320

Centisome position: 55.21

GC content: 50.72

Gene sequence:

>897_bases
ATGAAAAAGGCGATAACTCCGAATGTGGTTTCATCCGCTGAACTCGAATACTATCGACGTCCTGTTGTACAGAAGGACGT
CGATATCGAGTTGTTCCATCAGAAAATCCTTGGATTCCATAAAGACAATCGTCGATCTTTTCCCTGGAGGGAAACAACAG
ACCGTTATGCCATCATGGTCAGCGAGATCATGCTTCAGCAGACACAGGCTGATCGTGTTACCGAAAAATATCAGGCCTGG
ATGAGGCGGTTTCCTGATATCAGAACACTTGCAGATGCTTCGCTCAGGGATGTGCTTGCTCTCTGGAGCGGACTTGGCTA
TAACTCCCGCGGACAGCGGTTACAGAACTGCGCAAGGGAGATCGAAGATCGTTTTAACGGGGTAGTGCCTTCACTTCCGA
CAGAGCTTAAAACTCTTCCTGGTATTGGCGATTACACCTGCCGATCCATTCCTGTATTTGCCGATAACCTCGATGTTGCC
GCAGTCGATACCAATATCCGAAGAATCATCATTCACGAGTTCGCCCTTCCGGAAGATATTTCCAAATCGCAGATTCAGGC
GGTTGCGGAGCAGCTTCTGCCGATAGGCCGCAGCAGACTGTGGCATAACGCTCTCATGGACTACGGTGCACTCTTTCTCA
CCAGTCGGAACACCGGCATTCGCCCCTTGACGAAGCAGTCGAAATTCGAGGGGTCAAAACGCTGGTATCGCGGCAGGCTG
CTCAAAGAGCTTGTCGCCAGGGATTGTGTCTTTGTTGAAGAGATTCATGAAAAATATGGCTCCTGCCCATGGGGTTTGCA
GGAGATCCTCGATGATCTCCTGCGCGAAGGTCTTGTCGAAGAGGCCGACTGGTCGAATCGGCAAGGAGGAAGAGTGTTGC
GCATAAGAGCTCGATGA

Upstream 100 bases:

>100_bases
CATTCAGTTATCTGAAGGCCGGATAGATACACTTTCGTGCAGAATCAATCTGTTATGAGGCCATGCCTTCAGTATTATCA
GGCAGCAATGCTTCGATGCC

Downstream 100 bases:

>100_bases
ATGAACGATTTCGGTTTCAATAAAACATGCGGGGGAGACTTCGCGACTGCTTGATTTTATTTCCGTAAAGAGAAGAATGG
CTGAAAGAATATCTCGGGCT

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKKAITPNVVSSAELEYYRRPVVQKDVDIELFHQKILGFHKDNRRSFPWRETTDRYAIMVSEIMLQQTQADRVTEKYQAW
MRRFPDIRTLADASLRDVLALWSGLGYNSRGQRLQNCAREIEDRFNGVVPSLPTELKTLPGIGDYTCRSIPVFADNLDVA
AVDTNIRRIIIHEFALPEDISKSQIQAVAEQLLPIGRSRLWHNALMDYGALFLTSRNTGIRPLTKQSKFEGSKRWYRGRL
LKELVARDCVFVEEIHEKYGSCPWGLQEILDDLLREGLVEEADWSNRQGGRVLRIRAR

Sequences:

>Translated_298_residues
MKKAITPNVVSSAELEYYRRPVVQKDVDIELFHQKILGFHKDNRRSFPWRETTDRYAIMVSEIMLQQTQADRVTEKYQAW
MRRFPDIRTLADASLRDVLALWSGLGYNSRGQRLQNCAREIEDRFNGVVPSLPTELKTLPGIGDYTCRSIPVFADNLDVA
AVDTNIRRIIIHEFALPEDISKSQIQAVAEQLLPIGRSRLWHNALMDYGALFLTSRNTGIRPLTKQSKFEGSKRWYRGRL
LKELVARDCVFVEEIHEKYGSCPWGLQEILDDLLREGLVEEADWSNRQGGRVLRIRAR
>Mature_298_residues
MKKAITPNVVSSAELEYYRRPVVQKDVDIELFHQKILGFHKDNRRSFPWRETTDRYAIMVSEIMLQQTQADRVTEKYQAW
MRRFPDIRTLADASLRDVLALWSGLGYNSRGQRLQNCAREIEDRFNGVVPSLPTELKTLPGIGDYTCRSIPVFADNLDVA
AVDTNIRRIIIHEFALPEDISKSQIQAVAEQLLPIGRSRLWHNALMDYGALFLTSRNTGIRPLTKQSKFEGSKRWYRGRL
LKELVARDCVFVEEIHEKYGSCPWGLQEILDDLLREGLVEEADWSNRQGGRVLRIRAR

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=254, Percent_Identity=33.8582677165354, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI6912520, Length=253, Percent_Identity=32.8063241106719, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI115298654, Length=253, Percent_Identity=32.8063241106719, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI115298652, Length=253, Percent_Identity=32.8063241106719, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI115298650, Length=253, Percent_Identity=32.8063241106719, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI115298648, Length=253, Percent_Identity=32.8063241106719, Blast_Score=128, Evalue=8e-30,
Organism=Escherichia coli, GI1789331, Length=236, Percent_Identity=29.2372881355932, Blast_Score=108, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 34520; Mature: 34520

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAITPNVVSSAELEYYRRPVVQKDVDIELFHQKILGFHKDNRRSFPWRETTDRYAIMV
CCCCCCCCHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
SEIMLQQTQADRVTEKYQAWMRRFPDIRTLADASLRDVLALWSGLGYNSRGQRLQNCARE
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IEDRFNGVVPSLPTELKTLPGIGDYTCRSIPVFADNLDVAAVDTNIRRIIIHEFALPEDI
HHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHCCCCCC
SKSQIQAVAEQLLPIGRSRLWHNALMDYGALFLTSRNTGIRPLTKQSKFEGSKRWYRGRL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHCCCHHHHHHHHH
LKELVARDCVFVEEIHEKYGSCPWGLQEILDDLLREGLVEEADWSNRQGGRVLRIRAR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKKAITPNVVSSAELEYYRRPVVQKDVDIELFHQKILGFHKDNRRSFPWRETTDRYAIMV
CCCCCCCCHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
SEIMLQQTQADRVTEKYQAWMRRFPDIRTLADASLRDVLALWSGLGYNSRGQRLQNCARE
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IEDRFNGVVPSLPTELKTLPGIGDYTCRSIPVFADNLDVAAVDTNIRRIIIHEFALPEDI
HHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHCCCCCC
SKSQIQAVAEQLLPIGRSRLWHNALMDYGALFLTSRNTGIRPLTKQSKFEGSKRWYRGRL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHCCCHHHHHHHHH
LKELVARDCVFVEEIHEKYGSCPWGLQEILDDLLREGLVEEADWSNRQGGRVLRIRAR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]