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The map label for this gene is macA [H]

Identifier: 119357309

GI number: 119357309

Start: 1709292

End: 1710473

Strand: Reverse

Name: macA [H]

Synonym: Cpha266_1507

Alternate gene names: 119357309

Gene position: 1710473-1709292 (Counterclockwise)

Preceding gene: 119357310

Following gene: 119357308

Centisome position: 54.58

GC content: 56.51

Gene sequence:

>1182_bases
ATGCCGAACCGCTTTTTTGACAGATTTTCCAGAACGCAGCGCCTTGCTGCTGTTTCAGCAGTTGTTGTCGCCATCACTCT
TGTTATCGTTTTTCGGCCTGCTGCAATTCCGGTGGACGTTGCAGTGGTCGTTTCCGGACCACTCAGGGTCACCCTCGAAG
CCGAAGGGGTAACGCGGGTGAACGATCGCTTCACTCTTGCCGCTCCGGTAACGGGTAACCTGCAGCGGATCTCGCTCGAT
GAGGGCGACAGTGTCAAGCAGGGAGCCGGGGTTGCCTTTATTCTGCCACCAGATCTCGGGTCGCGAGAGTACCGGGAAGC
GGAAGCGAGGGTGGGATCGGCGCGAGCCTCGATGCAGGAAGCCCTTGCGCGACAGCGGCAGGTTGCAGTCAATCTCGGTC
AGGCCGGACTCCGGTTCAGCCGCTACCAACGGCTCTATGAGGAAGGCGCCGTATCGAAGGAGAGCTTCGAACTCGCCCGG
AACGAAGCCGAGGTGCTGAAAAAAGAAAAACAGGCAGCAGCCTCGCTGCTTGAAGCGGCCAGATACAACCTTTCCGCCGT
TCAGACCTTTGTTGATCAGACAATTTCGGGAAAACCCTATCCGGTTATCGCTCCGGTTAACGGCCGGGTGCTTCGAATCC
ATGAAAAAAACGAACGCCTTGTACAGGCGGGATCACCCCTTCTTGATATCGGAGATCCTGCGAAATTTGAGATTGTTCTC
GATGTACTCTCCTCCGATGCCGTCAGGGTCCGACCGGGCAATCCGGTGCTGATTGAGGAGTGGGGAGGCGATAAAGTGTT
GCCGGGGGTGGTTAAAACTATCGAGCCAGCCGCATTCACCAAACTTTCAGCGCTTGGCATTGAAGAAAAGAGGGTAAACA
TTATCGCCCTCCTCAACGACTACGAACCGCGCCTTGGCGACAACTTCCGTGTGCAGGGCTCCATTGTGCTCCGCGAAGCG
GCGAGTGTTCTCAAGGTTCCGGTAAGCGCTCTTTTCAGGAGCAGGGAAGGGTGGAACGTCTTTGTCATCAAGGGCGACAG
GGCAACGCAGAAAGCGGTTACTATCGGGTTGCGCGGTACCTATGAAGCCGAGGTTCTCAAAGGACTCAGCAAGGGCGACA
GGGTGATTGTACACCCTGCCAACGAACTGCACGAAGGGGCTCGTATCAAGGCAGCAGAGTAG

Upstream 100 bases:

>100_bases
TTTTGCGTTATTACAGGAGTTGCGCTTGTTTCAGCGCTGCTCATTCACCGGCGACTCGTCAAGCTTGACCTGATTGCCGT
TCTTAAAACAAGGGAGTAGC

Downstream 100 bases:

>100_bases
CAGGGCAGTGAATTCGGCGGCGTAAAATCGCGATTGTCGATACCTGTAAACCTAACACATCCTGCTGTCCGGTTCCATTA
TCGAAACGGATGAACGGAGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MPNRFFDRFSRTQRLAAVSAVVVAITLVIVFRPAAIPVDVAVVVSGPLRVTLEAEGVTRVNDRFTLAAPVTGNLQRISLD
EGDSVKQGAGVAFILPPDLGSREYREAEARVGSARASMQEALARQRQVAVNLGQAGLRFSRYQRLYEEGAVSKESFELAR
NEAEVLKKEKQAAASLLEAARYNLSAVQTFVDQTISGKPYPVIAPVNGRVLRIHEKNERLVQAGSPLLDIGDPAKFEIVL
DVLSSDAVRVRPGNPVLIEEWGGDKVLPGVVKTIEPAAFTKLSALGIEEKRVNIIALLNDYEPRLGDNFRVQGSIVLREA
ASVLKVPVSALFRSREGWNVFVIKGDRATQKAVTIGLRGTYEAEVLKGLSKGDRVIVHPANELHEGARIKAAE

Sequences:

>Translated_393_residues
MPNRFFDRFSRTQRLAAVSAVVVAITLVIVFRPAAIPVDVAVVVSGPLRVTLEAEGVTRVNDRFTLAAPVTGNLQRISLD
EGDSVKQGAGVAFILPPDLGSREYREAEARVGSARASMQEALARQRQVAVNLGQAGLRFSRYQRLYEEGAVSKESFELAR
NEAEVLKKEKQAAASLLEAARYNLSAVQTFVDQTISGKPYPVIAPVNGRVLRIHEKNERLVQAGSPLLDIGDPAKFEIVL
DVLSSDAVRVRPGNPVLIEEWGGDKVLPGVVKTIEPAAFTKLSALGIEEKRVNIIALLNDYEPRLGDNFRVQGSIVLREA
ASVLKVPVSALFRSREGWNVFVIKGDRATQKAVTIGLRGTYEAEVLKGLSKGDRVIVHPANELHEGARIKAAE
>Mature_392_residues
PNRFFDRFSRTQRLAAVSAVVVAITLVIVFRPAAIPVDVAVVVSGPLRVTLEAEGVTRVNDRFTLAAPVTGNLQRISLDE
GDSVKQGAGVAFILPPDLGSREYREAEARVGSARASMQEALARQRQVAVNLGQAGLRFSRYQRLYEEGAVSKESFELARN
EAEVLKKEKQAAASLLEAARYNLSAVQTFVDQTISGKPYPVIAPVNGRVLRIHEKNERLVQAGSPLLDIGDPAKFEIVLD
VLSSDAVRVRPGNPVLIEEWGGDKVLPGVVKTIEPAAFTKLSALGIEEKRVNIIALLNDYEPRLGDNFRVQGSIVLREAA
SVLKVPVSALFRSREGWNVFVIKGDRATQKAVTIGLRGTYEAEVLKGLSKGDRVIVHPANELHEGARIKAAE

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=377, Percent_Identity=24.1379310344828, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42756; Mature: 42624

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNRFFDRFSRTQRLAAVSAVVVAITLVIVFRPAAIPVDVAVVVSGPLRVTLEAEGVTRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCEEE
NDRFTLAAPVTGNLQRISLDEGDSVKQGAGVAFILPPDLGSREYREAEARVGSARASMQE
CCCEEEEECCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ALARQRQVAVNLGQAGLRFSRYQRLYEEGAVSKESFELARNEAEVLKKEKQAAASLLEAA
HHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYNLSAVQTFVDQTISGKPYPVIAPVNGRVLRIHEKNERLVQAGSPLLDIGDPAKFEIVL
HCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCHHHHCCCCEEECCCCCEEEEEE
DVLSSDAVRVRPGNPVLIEEWGGDKVLPGVVKTIEPAAFTKLSALGIEEKRVNIIALLND
EECCCCCEEEECCCCEEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEEEEC
YEPRLGDNFRVQGSIVLREAASVLKVPVSALFRSREGWNVFVIKGDRATQKAVTIGLRGT
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCC
YEAEVLKGLSKGDRVIVHPANELHEGARIKAAE
HHHHHHHCCCCCCEEEEECCHHHCCCCEEEECC
>Mature Secondary Structure 
PNRFFDRFSRTQRLAAVSAVVVAITLVIVFRPAAIPVDVAVVVSGPLRVTLEAEGVTRV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCEEE
NDRFTLAAPVTGNLQRISLDEGDSVKQGAGVAFILPPDLGSREYREAEARVGSARASMQE
CCCEEEEECCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ALARQRQVAVNLGQAGLRFSRYQRLYEEGAVSKESFELARNEAEVLKKEKQAAASLLEAA
HHHHHHHHHEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYNLSAVQTFVDQTISGKPYPVIAPVNGRVLRIHEKNERLVQAGSPLLDIGDPAKFEIVL
HCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCHHHHCCCCEEECCCCCEEEEEE
DVLSSDAVRVRPGNPVLIEEWGGDKVLPGVVKTIEPAAFTKLSALGIEEKRVNIIALLND
EECCCCCEEEECCCCEEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEEEEC
YEPRLGDNFRVQGSIVLREAASVLKVPVSALFRSREGWNVFVIKGDRATQKAVTIGLRGT
CCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCC
YEAEVLKGLSKGDRVIVHPANELHEGARIKAAE
HHHHHHHCCCCCCEEEEECCHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]