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The map label for this gene is pkn1 [H]

Identifier: 119357294

GI number: 119357294

Start: 1688873

End: 1691101

Strand: Reverse

Name: pkn1 [H]

Synonym: Cpha266_1490

Alternate gene names: 119357294

Gene position: 1691101-1688873 (Counterclockwise)

Preceding gene: 119357295

Following gene: 119357292

Centisome position: 53.96

GC content: 42.31

Gene sequence:

>2229_bases
ATGGAAAAAATAATTGAAGCTGTTCTGGCATTGATTCCGTTTGGTAAGTGGTTAGAGTTGATCGGATTAAACAAAGAAAC
AAGTGCCATTTTATCACTTATTGTAACGGCCACTCTGGGTTATGTTGTTGTAAAAGGATTGAAGAGTTTTCAGAAATGGC
GGGATGTTGTTAAAGCAGCAAAAGACTTGAAACCTGAATTTGATTATTTCTCTATAAAAGATTTAAGCAGGATATTTATT
CAAACAAAAGCGACAAGAGTATCTCCAAACAGGTTTGATAATCCTGATGAGGCCTATAAGCATGGATGGAATCCTTATGC
TCTTATTGACTATATGTTGAAAACCTCGTTTAACGAAAAAGTTGAAAGTGAAAAATTTTATCTTGTCCTTGCTGATTCAG
GAATGGGAAAGACTGCTTTTATGGTGAATCTTTATTTAAAAAACTATTCTATATATAATTTTTTCTCCCGAAATAAATAT
GCGATGACGCTGCTGCGTTTTCAGAGTCCAGATAAAAATAAGCCGGTTGATATCCTGGAAAGATTGAAAAGTATAAAACA
GGAGGATATAAAAAACACAATTCTTTTGCTGGATGGATTGGATGAAGATCCCTTTATAATTTCAAGGGATAGCGCTGTTT
CTGACGAAGAGGCATTTAATAAACGGATAGATCAGATCGTATCGGCCACACGAATTTACAAGGATGTGGTTATTACCTGT
CGTACACAGTATTTTCCACAGCAGGAAACAGATGCCTATGAGTTGCATGTCAGAAAGCCAGATGGGAAGGGCATGTATAA
ACTTCAGAAATACTATATATTTCCCTTTTCAGACAGTGATATTCAGAAATATCTTGACCGAAAATATGGTGTGTTCAGAT
TCTGGAACACAGAGAAAAAGAAGAGTGCTCAATTAATAGCAAAAGATAACAAGAGTCTTCTGGCGCGACCAATGCTGATG
AACTATATCGATTATCTTGTTGAGGAAAATAATATTTATACGTGTACCTCTCAAGTATATCATGTGCTTATCGAGAAGTG
GCTGAAACGAGAGGCTGATAAATGGAAGTCGGAAGCTGAGAAAAAGGCATTCATCGATAATTTAAGAAAGTTATCAATGA
GTGTCGCGCTTGAAATTTATCATAACTGGAGGAGTGATGGCAAGCTTTCCATCCCAAAAAATCGCGCAAAAGAGATTGCG
GACGAGTATAATATTACGCTCTCCGCTGATGAGGTGCATGGAAAATCATTATTGACCTGTGATGCCTATTTGAACTGGAA
GTTCGCCCATAAATCGATACTCGAATATTTCATAGCCAAACAGGCTGCTGAAGATACAGGTTTTGCTGTGAAGTTGCAGT
TTGCGGGTATGAATATGACGAGGAAGTTCTGTTCAGAGTTTGGCTTGAGTTCACTGATCGAGTCAAATTATGTTCTGATT
CGAGGTGACGAGTTTACCATGGGGAGCCCGAAACACGAAGTTGACAGGTCAGATAATGAAACGGAACATCAGGTAAAACT
CTCTGATTATTATCTCTGTAAATATGCCGTTACGGTAGCGGATTTTAAACGGTTTGCCGAAGAGATCGGGTACACTACGG
ATGCCGAAACCGCTGGCAGCAGTTCTGTTTTTGATGGCAAAGCGTGGAATAAAAAAGTGGGTATAAACTGGCGGCATGGA
GTTTCCGAAAGTTTACGCAGTGCCGGAGAGTACAATCATCCTGTGTTGCATGTCAGTTGGAACGATGCCGTTGCCTATGC
CGGGTGGCTCTCCTTGCAAACCGGAAAATCGTTCAGGCTGCCAACAGAGGCAGAGTGGGAGTATGCGTGCCGGGCAGGAA
AGGGAGAGCCGTTCAGTACCGGCGAGAACCTCACGACCGACCAGGCAAATTATGACGGAAACTATCCCTATAATGGCAAC
AGAAAGGGAGTGTTCAGGGGAACCACGATAGCGTGTGATGCGCTTGAACCAAATGCATTGGGTTTGTACAATATGCACGG
TAATGTTTGGGAGTGGTGCAGCGACAGGTATGGGGATAAATATTATGATGAATGCAAAGCCAAAGGTATTGTTGAAAATC
CGGTTGGCCCTGAAACCGGTTCGCTCCGTGTGCTTCGTGGAGGTAGCTGGTTCAACTATGCGAGGATCTGTCGGTCGGCT
TATCGCGACGGCGACTCCCCCGACTACCGCAGCGACGACGCCGGCTTCCGCCTGGCCTTCGTCCCGTAG

Upstream 100 bases:

>100_bases
TTTCGGGAGATTCTGGGTGTGCTGAACAATGGAAAGTGAAATGCAGCTAAACAACGTGAGAAAATAAATCAGGTTCCCTC
AATAACATCCCTGTTGTTTT

Downstream 100 bases:

>100_bases
TCAGTTGGCAGCTCATTCCGACTTTACTTTGAGCAAGAGGGCTGTTACAAAAAATTGGTGAGCGGCAGCAAGGGACGCAG
CGCCGCACGCCAATTTTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 742; Mature: 742

Protein sequence:

>742_residues
MEKIIEAVLALIPFGKWLELIGLNKETSAILSLIVTATLGYVVVKGLKSFQKWRDVVKAAKDLKPEFDYFSIKDLSRIFI
QTKATRVSPNRFDNPDEAYKHGWNPYALIDYMLKTSFNEKVESEKFYLVLADSGMGKTAFMVNLYLKNYSIYNFFSRNKY
AMTLLRFQSPDKNKPVDILERLKSIKQEDIKNTILLLDGLDEDPFIISRDSAVSDEEAFNKRIDQIVSATRIYKDVVITC
RTQYFPQQETDAYELHVRKPDGKGMYKLQKYYIFPFSDSDIQKYLDRKYGVFRFWNTEKKKSAQLIAKDNKSLLARPMLM
NYIDYLVEENNIYTCTSQVYHVLIEKWLKREADKWKSEAEKKAFIDNLRKLSMSVALEIYHNWRSDGKLSIPKNRAKEIA
DEYNITLSADEVHGKSLLTCDAYLNWKFAHKSILEYFIAKQAAEDTGFAVKLQFAGMNMTRKFCSEFGLSSLIESNYVLI
RGDEFTMGSPKHEVDRSDNETEHQVKLSDYYLCKYAVTVADFKRFAEEIGYTTDAETAGSSSVFDGKAWNKKVGINWRHG
VSESLRSAGEYNHPVLHVSWNDAVAYAGWLSLQTGKSFRLPTEAEWEYACRAGKGEPFSTGENLTTDQANYDGNYPYNGN
RKGVFRGTTIACDALEPNALGLYNMHGNVWEWCSDRYGDKYYDECKAKGIVENPVGPETGSLRVLRGGSWFNYARICRSA
YRDGDSPDYRSDDAGFRLAFVP

Sequences:

>Translated_742_residues
MEKIIEAVLALIPFGKWLELIGLNKETSAILSLIVTATLGYVVVKGLKSFQKWRDVVKAAKDLKPEFDYFSIKDLSRIFI
QTKATRVSPNRFDNPDEAYKHGWNPYALIDYMLKTSFNEKVESEKFYLVLADSGMGKTAFMVNLYLKNYSIYNFFSRNKY
AMTLLRFQSPDKNKPVDILERLKSIKQEDIKNTILLLDGLDEDPFIISRDSAVSDEEAFNKRIDQIVSATRIYKDVVITC
RTQYFPQQETDAYELHVRKPDGKGMYKLQKYYIFPFSDSDIQKYLDRKYGVFRFWNTEKKKSAQLIAKDNKSLLARPMLM
NYIDYLVEENNIYTCTSQVYHVLIEKWLKREADKWKSEAEKKAFIDNLRKLSMSVALEIYHNWRSDGKLSIPKNRAKEIA
DEYNITLSADEVHGKSLLTCDAYLNWKFAHKSILEYFIAKQAAEDTGFAVKLQFAGMNMTRKFCSEFGLSSLIESNYVLI
RGDEFTMGSPKHEVDRSDNETEHQVKLSDYYLCKYAVTVADFKRFAEEIGYTTDAETAGSSSVFDGKAWNKKVGINWRHG
VSESLRSAGEYNHPVLHVSWNDAVAYAGWLSLQTGKSFRLPTEAEWEYACRAGKGEPFSTGENLTTDQANYDGNYPYNGN
RKGVFRGTTIACDALEPNALGLYNMHGNVWEWCSDRYGDKYYDECKAKGIVENPVGPETGSLRVLRGGSWFNYARICRSA
YRDGDSPDYRSDDAGFRLAFVP
>Mature_742_residues
MEKIIEAVLALIPFGKWLELIGLNKETSAILSLIVTATLGYVVVKGLKSFQKWRDVVKAAKDLKPEFDYFSIKDLSRIFI
QTKATRVSPNRFDNPDEAYKHGWNPYALIDYMLKTSFNEKVESEKFYLVLADSGMGKTAFMVNLYLKNYSIYNFFSRNKY
AMTLLRFQSPDKNKPVDILERLKSIKQEDIKNTILLLDGLDEDPFIISRDSAVSDEEAFNKRIDQIVSATRIYKDVVITC
RTQYFPQQETDAYELHVRKPDGKGMYKLQKYYIFPFSDSDIQKYLDRKYGVFRFWNTEKKKSAQLIAKDNKSLLARPMLM
NYIDYLVEENNIYTCTSQVYHVLIEKWLKREADKWKSEAEKKAFIDNLRKLSMSVALEIYHNWRSDGKLSIPKNRAKEIA
DEYNITLSADEVHGKSLLTCDAYLNWKFAHKSILEYFIAKQAAEDTGFAVKLQFAGMNMTRKFCSEFGLSSLIESNYVLI
RGDEFTMGSPKHEVDRSDNETEHQVKLSDYYLCKYAVTVADFKRFAEEIGYTTDAETAGSSSVFDGKAWNKKVGINWRHG
VSESLRSAGEYNHPVLHVSWNDAVAYAGWLSLQTGKSFRLPTEAEWEYACRAGKGEPFSTGENLTTDQANYDGNYPYNGN
RKGVFRGTTIACDALEPNALGLYNMHGNVWEWCSDRYGDKYYDECKAKGIVENPVGPETGSLRVLRGGSWFNYARICRSA
YRDGDSPDYRSDDAGFRLAFVP

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=297, Percent_Identity=35.6902356902357, Blast_Score=153, Evalue=7e-37,
Organism=Homo sapiens, GI257470975, Length=280, Percent_Identity=35.7142857142857, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI257470977, Length=294, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI194248087, Length=286, Percent_Identity=31.8181818181818, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI194248088, Length=296, Percent_Identity=31.4189189189189, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI226437577, Length=192, Percent_Identity=35.9375, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI194248090, Length=195, Percent_Identity=31.2820512820513, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130397, Length=289, Percent_Identity=34.2560553633218, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 85291; Mature: 85291

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIIEAVLALIPFGKWLELIGLNKETSAILSLIVTATLGYVVVKGLKSFQKWRDVVKAA
CHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLKPEFDYFSIKDLSRIFIQTKATRVSPNRFDNPDEAYKHGWNPYALIDYMLKTSFNEK
HHCCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCHHHH
VESEKFYLVLADSGMGKTAFMVNLYLKNYSIYNFFSRNKYAMTLLRFQSPDKNKPVDILE
CCCCEEEEEEECCCCCCEEEEEEEEEECCEEEEHHCCCCEEEEEEEECCCCCCCCHHHHH
RLKSIKQEDIKNTILLLDGLDEDPFIISRDSAVSDEEAFNKRIDQIVSATRIYKDVVITC
HHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
RTQYFPQQETDAYELHVRKPDGKGMYKLQKYYIFPFSDSDIQKYLDRKYGVFRFWNTEKK
ECCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHCCCEEEEECCCCH
KSAQLIAKDNKSLLARPMLMNYIDYLVEENNIYTCTSQVYHVLIEKWLKREADKWKSEAE
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KKAFIDNLRKLSMSVALEIYHNWRSDGKLSIPKNRAKEIADEYNITLSADEVHGKSLLTC
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCEEEEECCCCCCEEEEE
DAYLNWKFAHKSILEYFIAKQAAEDTGFAVKLQFAGMNMTRKFCSEFGLSSLIESNYVLI
EHHEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCHHHHHHCCEEEE
RGDEFTMGSPKHEVDRSDNETEHQVKLSDYYLCKYAVTVADFKRFAEEIGYTTDAETAGS
ECCCCCCCCCCHHCCCCCCCCHHEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCC
SSVFDGKAWNKKVGINWRHGVSESLRSAGEYNHPVLHVSWNDAVAYAGWLSLQTGKSFRL
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCC
PTEAEWEYACRAGKGEPFSTGENLTTDQANYDGNYPYNGNRKGVFRGTTIACDALEPNAL
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCE
GLYNMHGNVWEWCSDRYGDKYYDECKAKGIVENPVGPETGSLRVLRGGSWFNYARICRSA
EEEECCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
YRDGDSPDYRSDDAGFRLAFVP
HCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MEKIIEAVLALIPFGKWLELIGLNKETSAILSLIVTATLGYVVVKGLKSFQKWRDVVKAA
CHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLKPEFDYFSIKDLSRIFIQTKATRVSPNRFDNPDEAYKHGWNPYALIDYMLKTSFNEK
HHCCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCHHHH
VESEKFYLVLADSGMGKTAFMVNLYLKNYSIYNFFSRNKYAMTLLRFQSPDKNKPVDILE
CCCCEEEEEEECCCCCCEEEEEEEEEECCEEEEHHCCCCEEEEEEEECCCCCCCCHHHHH
RLKSIKQEDIKNTILLLDGLDEDPFIISRDSAVSDEEAFNKRIDQIVSATRIYKDVVITC
HHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
RTQYFPQQETDAYELHVRKPDGKGMYKLQKYYIFPFSDSDIQKYLDRKYGVFRFWNTEKK
ECCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHCCCEEEEECCCCH
KSAQLIAKDNKSLLARPMLMNYIDYLVEENNIYTCTSQVYHVLIEKWLKREADKWKSEAE
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
KKAFIDNLRKLSMSVALEIYHNWRSDGKLSIPKNRAKEIADEYNITLSADEVHGKSLLTC
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCEEEEECCCCCCEEEEE
DAYLNWKFAHKSILEYFIAKQAAEDTGFAVKLQFAGMNMTRKFCSEFGLSSLIESNYVLI
EHHEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCHHHHHHCCEEEE
RGDEFTMGSPKHEVDRSDNETEHQVKLSDYYLCKYAVTVADFKRFAEEIGYTTDAETAGS
ECCCCCCCCCCHHCCCCCCCCHHEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCC
SSVFDGKAWNKKVGINWRHGVSESLRSAGEYNHPVLHVSWNDAVAYAGWLSLQTGKSFRL
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCC
PTEAEWEYACRAGKGEPFSTGENLTTDQANYDGNYPYNGNRKGVFRGTTIACDALEPNAL
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCE
GLYNMHGNVWEWCSDRYGDKYYDECKAKGIVENPVGPETGSLRVLRGGSWFNYARICRSA
EEEECCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHH
YRDGDSPDYRSDDAGFRLAFVP
HCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]