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The map label for this gene is umuC [H]

Identifier: 119356858

GI number: 119356858

Start: 1168804

End: 1170084

Strand: Reverse

Name: umuC [H]

Synonym: Cpha266_1031

Alternate gene names: 119356858

Gene position: 1170084-1168804 (Counterclockwise)

Preceding gene: 119356859

Following gene: 119356857

Centisome position: 37.34

GC content: 52.54

Gene sequence:

>1281_bases
ATGTTTGCTCTGGTGGACTGCAATAACTTCTATGTCTCATGCGAGCGGGTCTTTAATCCCGGATTGCAAAACCGCCCGGT
TGTGGTACTCTCCAACAACGACGGCTGTTTTATTGCCCGTTCGGAAGAGGCAAAGGCAATAGGCCTTGCAATGGGAGACC
CTGCATATAAAAACCGTGAACTGCTCAGGCAGCACAACGTAGCTGTCTATTCCGCCAACTTCCCGCTTTATGGCGACATG
TCGGCAAGAGTCATGAAAACCCTCGAAACGCTTGCGCCTGATCTTGAGATCTACTCCATTGATGAATGTTTTCTTGATCT
CGGCGGCTTCGGAAAGTTCAACCTTGCCGACTACGCAGCAGCAACAAGAAAAACAGTACACCGAAACACCGGCATTCCGG
TCAGCATAGGCATCGGAGCAACAAAAACCATTGCCAAGGCGGCAAACCGCATGGCAAAAAAAAACCTCTCCCTCGGAGGC
GTCTGCATTCTTTCCACCGCAGCGGCAACAAGGGAGGCTCTCGGCGCCATGGCGGTTGAACACATCTGGGGCATCGGCAG
CCAGTACGCCGCACTGCTGCACAAGCAGCACATCCATACTGCTCTCGACTTTGCCGACGCACCGACGCACTGGGTACAGA
AACACCTCCACATCACCGGCGCAAGAGTGCAGCAGGAGCTGAACGGACACTCCTGTTTGCCTCTTGAGCTGGTTCGGTCG
AGAAAGCAGAGCATCTGCACCTCCCGTTCTTTCGGCTCACTGGTAAGCTCATACGAAGAAATCGGCTATGCCATAGCTCA
CTTTACCTCAACATGCGCATTCAAGCTCCGTCGAGAAGGTTCCCGGGCATCGCTGCTCACTGTTTTTCTGTATACCAGCC
CATTTATCGAAAAAGAAAACCGCTACCGGGGAACAAGAACCTTTGCGCTCCCCTTCCCTTCAAACAACACCCTTGAGCTC
CAGAAAGCTGCTCAACTGCTGCTTGCCTCGATCTACCGATCCGGATACGGCTACAAAAAAGCCGGCGTGCTGGTTTCCGG
TATTACCGATGAAAAAGGAGCCGCAATGACAACACTCTCCCTGTTTGACAACGATCCGTTACCCCGGAACCAGAAGCGGG
ACATGAAACTTATGGAAACGCTTGACGCGATAAACTCACGATTTGGTCAGGGCACACTCCGCACAGCATCCGACACCAAC
TCCGGCTGGAAACAACGACAGGAAAAGCTTTCACCGCACTATACCACACGATGGAACGACATTATCGAAATACACGCATG
A

Upstream 100 bases:

>100_bases
TGCGTTCAAGCCTATCCGGATCACCGAAGAGAATGACTTTCTTGTATGGGGTATTGTGACCTATATCATCCACAAGGCGA
GATAAACCTAAAAAAGCATC

Downstream 100 bases:

>100_bases
AGGAAAATCGACAAGAGCGGCGGCAAAGTCCGGCGCATGGTTTTACACTGCCGTAACGGTAGAAATCTTTCAAAATCGCT
ATACTGAGAACAAAGCCGAA

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MFALVDCNNFYVSCERVFNPGLQNRPVVVLSNNDGCFIARSEEAKAIGLAMGDPAYKNRELLRQHNVAVYSANFPLYGDM
SARVMKTLETLAPDLEIYSIDECFLDLGGFGKFNLADYAAATRKTVHRNTGIPVSIGIGATKTIAKAANRMAKKNLSLGG
VCILSTAAATREALGAMAVEHIWGIGSQYAALLHKQHIHTALDFADAPTHWVQKHLHITGARVQQELNGHSCLPLELVRS
RKQSICTSRSFGSLVSSYEEIGYAIAHFTSTCAFKLRREGSRASLLTVFLYTSPFIEKENRYRGTRTFALPFPSNNTLEL
QKAAQLLLASIYRSGYGYKKAGVLVSGITDEKGAAMTTLSLFDNDPLPRNQKRDMKLMETLDAINSRFGQGTLRTASDTN
SGWKQRQEKLSPHYTTRWNDIIEIHA

Sequences:

>Translated_426_residues
MFALVDCNNFYVSCERVFNPGLQNRPVVVLSNNDGCFIARSEEAKAIGLAMGDPAYKNRELLRQHNVAVYSANFPLYGDM
SARVMKTLETLAPDLEIYSIDECFLDLGGFGKFNLADYAAATRKTVHRNTGIPVSIGIGATKTIAKAANRMAKKNLSLGG
VCILSTAAATREALGAMAVEHIWGIGSQYAALLHKQHIHTALDFADAPTHWVQKHLHITGARVQQELNGHSCLPLELVRS
RKQSICTSRSFGSLVSSYEEIGYAIAHFTSTCAFKLRREGSRASLLTVFLYTSPFIEKENRYRGTRTFALPFPSNNTLEL
QKAAQLLLASIYRSGYGYKKAGVLVSGITDEKGAAMTTLSLFDNDPLPRNQKRDMKLMETLDAINSRFGQGTLRTASDTN
SGWKQRQEKLSPHYTTRWNDIIEIHA
>Mature_426_residues
MFALVDCNNFYVSCERVFNPGLQNRPVVVLSNNDGCFIARSEEAKAIGLAMGDPAYKNRELLRQHNVAVYSANFPLYGDM
SARVMKTLETLAPDLEIYSIDECFLDLGGFGKFNLADYAAATRKTVHRNTGIPVSIGIGATKTIAKAANRMAKKNLSLGG
VCILSTAAATREALGAMAVEHIWGIGSQYAALLHKQHIHTALDFADAPTHWVQKHLHITGARVQQELNGHSCLPLELVRS
RKQSICTSRSFGSLVSSYEEIGYAIAHFTSTCAFKLRREGSRASLLTVFLYTSPFIEKENRYRGTRTFALPFPSNNTLEL
QKAAQLLLASIYRSGYGYKKAGVLVSGITDEKGAAMTTLSLFDNDPLPRNQKRDMKLMETLDAINSRFGQGTLRTASDTN
SGWKQRQEKLSPHYTTRWNDIIEIHA

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=428, Percent_Identity=41.3551401869159, Blast_Score=320, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47123; Mature: 47123

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALVDCNNFYVSCERVFNPGLQNRPVVVLSNNDGCFIARSEEAKAIGLAMGDPAYKNRE
CEEEEECCCEEEEEHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEEECCCCCCCHH
LLRQHNVAVYSANFPLYGDMSARVMKTLETLAPDLEIYSIDECFLDLGGFGKFNLADYAA
HHHHCCEEEEECCCCEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCHHHHHH
ATRKTVHRNTGIPVSIGIGATKTIAKAANRMAKKNLSLGGVCILSTAAATREALGAMAVE
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHH
HIWGIGSQYAALLHKQHIHTALDFADAPTHWVQKHLHITGARVQQELNGHSCLPLELVRS
HHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RKQSICTSRSFGSLVSSYEEIGYAIAHFTSTCAFKLRREGSRASLLTVFLYTSPFIEKEN
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCC
RYRGTRTFALPFPSNNTLELQKAAQLLLASIYRSGYGYKKAGVLVSGITDEKGAAMTTLS
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEE
LFDNDPLPRNQKRDMKLMETLDAINSRFGQGTLRTASDTNSGWKQRQEKLSPHYTTRWND
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCC
IIEIHA
EEEEEC
>Mature Secondary Structure
MFALVDCNNFYVSCERVFNPGLQNRPVVVLSNNDGCFIARSEEAKAIGLAMGDPAYKNRE
CEEEEECCCEEEEEHHHHCCCCCCCCEEEEECCCCEEEEECCCCCEEEEEECCCCCCCHH
LLRQHNVAVYSANFPLYGDMSARVMKTLETLAPDLEIYSIDECFLDLGGFGKFNLADYAA
HHHHCCEEEEECCCCEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCHHHHHH
ATRKTVHRNTGIPVSIGIGATKTIAKAANRMAKKNLSLGGVCILSTAAATREALGAMAVE
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHH
HIWGIGSQYAALLHKQHIHTALDFADAPTHWVQKHLHITGARVQQELNGHSCLPLELVRS
HHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RKQSICTSRSFGSLVSSYEEIGYAIAHFTSTCAFKLRREGSRASLLTVFLYTSPFIEKEN
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCC
RYRGTRTFALPFPSNNTLELQKAAQLLLASIYRSGYGYKKAGVLVSGITDEKGAAMTTLS
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEE
LFDNDPLPRNQKRDMKLMETLDAINSRFGQGTLRTASDTNSGWKQRQEKLSPHYTTRWND
ECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCCCCCCC
IIEIHA
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]