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The map label for this gene is umuD [H]

Identifier: 119356859

GI number: 119356859

Start: 1170100

End: 1170552

Strand: Reverse

Name: umuD [H]

Synonym: Cpha266_1032

Alternate gene names: 119356859

Gene position: 1170552-1170100 (Counterclockwise)

Preceding gene: 119356879

Following gene: 119356858

Centisome position: 37.35

GC content: 50.11

Gene sequence:

>453_bases
ATGAAACTCACCAGAATATATCGTAACGAAATCTTTGACTTTTACTCGCCGGACGTTTCCAGCGAGCTCCTGCTCCCCTA
TGCGGAAACCGGTGTTGTTGCAGGCTTTCCCTCCCCTGCCGATGACGCCATGGAGCTTGGACTCGATCTCAACAAGGCTC
TGATACGGCACCCGGAAGCCACCTTCTACGCCAGGGTAAAAGGCTCTTCGATGGTTGAAGCAAACCTGCGGGAAGGGGAT
ATTCTCGTGATCGACAAATCCCTTCATCCCAAAAACGGTGACATCGCCATCTGTTTTCTTGATGGAGAGTTCACCGTCAA
GCGCATTTCTCAGGATAAATCAGGTCTCTCGCTCATGCCGGCAAATGATGCGTTCAAGCCTATCCGGATCACCGAAGAGA
ATGACTTTCTTGTATGGGGTATTGTGACCTATATCATCCACAAGGCGAGATAA

Upstream 100 bases:

>100_bases
ATGGTTAAAAAAACAAAACCTTTGTTGCGATATGATGAAGCGCATGCAACGATTCCGTAAAATCTTTTTCAAAACAAGAG
AACTGAAGTCTGTCTGAAGC

Downstream 100 bases:

>100_bases
ACCTAAAAAAGCATCATGTTTGCTCTGGTGGACTGCAATAACTTCTATGTCTCATGCGAGCGGGTCTTTAATCCCGGATT
GCAAAACCGCCCGGTTGTGG

Product: SOS mutagenesis protein UmuD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MKLTRIYRNEIFDFYSPDVSSELLLPYAETGVVAGFPSPADDAMELGLDLNKALIRHPEATFYARVKGSSMVEANLREGD
ILVIDKSLHPKNGDIAICFLDGEFTVKRISQDKSGLSLMPANDAFKPIRITEENDFLVWGIVTYIIHKAR

Sequences:

>Translated_150_residues
MKLTRIYRNEIFDFYSPDVSSELLLPYAETGVVAGFPSPADDAMELGLDLNKALIRHPEATFYARVKGSSMVEANLREGD
ILVIDKSLHPKNGDIAICFLDGEFTVKRISQDKSGLSLMPANDAFKPIRITEENDFLVWGIVTYIIHKAR
>Mature_150_residues
MKLTRIYRNEIFDFYSPDVSSELLLPYAETGVVAGFPSPADDAMELGLDLNKALIRHPEATFYARVKGSSMVEANLREGD
ILVIDKSLHPKNGDIAICFLDGEFTVKRISQDKSGLSLMPANDAFKPIRITEENDFLVWGIVTYIIHKAR

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=138, Percent_Identity=38.4057971014493, Blast_Score=111, Evalue=2e-26,
Organism=Escherichia coli, GI1790476, Length=151, Percent_Identity=29.1390728476821, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 16806; Mature: 16806

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTRIYRNEIFDFYSPDVSSELLLPYAETGVVAGFPSPADDAMELGLDLNKALIRHPEA
CCCHHHHHHHHHHHCCCCCCCEEECEECCCCEEECCCCCCCHHHHHCCCCCHHHHCCCCC
TFYARVKGSSMVEANLREGDILVIDKSLHPKNGDIAICFLDGEFTVKRISQDKSGLSLMP
EEEEEECCCEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEE
ANDAFKPIRITEENDFLVWGIVTYIIHKAR
CCCCCCCEEEECCCCEEEHHHHHHHHHCCC
>Mature Secondary Structure
MKLTRIYRNEIFDFYSPDVSSELLLPYAETGVVAGFPSPADDAMELGLDLNKALIRHPEA
CCCHHHHHHHHHHHCCCCCCCEEECEECCCCEEECCCCCCCHHHHHCCCCCHHHHCCCCC
TFYARVKGSSMVEANLREGDILVIDKSLHPKNGDIAICFLDGEFTVKRISQDKSGLSLMP
EEEEEECCCEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCCCEEEE
ANDAFKPIRITEENDFLVWGIVTYIIHKAR
CCCCCCCEEEECCCCEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609; 1910151 [H]