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The map label for this gene is purC

Identifier: 119356846

GI number: 119356846

Start: 1158853

End: 1159563

Strand: Reverse

Name: purC

Synonym: Cpha266_1019

Alternate gene names: 119356846

Gene position: 1159563-1158853 (Counterclockwise)

Preceding gene: 119356847

Following gene: 119356845

Centisome position: 37.0

GC content: 47.12

Gene sequence:

>711_bases
ATGACAAAGACAACTCTTCTTCATGAAGGCAAGGCAAAAAAGGTTTTTTTAACCGATCAGAGCGACCTGGTGATACAGGA
GTTCAAAGACGACGCAACCGCCTTCAATAACAAGAAAAAAGGAACAATAGCCGACAAAGGCGTCGTAAACAACGCTATTT
CGTGCAGGCTTTTCACTCTGCTTGAAGAGCATGGCATCCGCACTCATCTGGTTGAAAAGCTTTCGGATCGTGATATGCTC
TGCAAGCGCCTTGATATCATCAAGGTTGAAGTTGTCGTTCGCAATATCGCTGCCGGTTCACTTGTAAAGCGTTATGGATT
CAAAGAGGGCTTCGTGCTTCAAGAGCCGCTTGTTGAGTTTTATCTGAAAGACGACGATCTTGATGACCCGCTGATGAACG
ACTTCCATGCCGTTGCGCTTGGTGTAGCCACCTCTGAAGAACTGGCGATACTCAGAAGCCGTGCAGAGGCAATCAACCTC
GTGCTCAGGCAATTTTTCGCTGATCGAAAACTGAAACTTGTTGACTTCAAGCTCGAGTTCGGACGTCACAAGAACGAGAT
TCTGCTTGGTGATGAAATAAGCCCTGATACCTGCAGATTCTGGGACCTTGATACCAACGAAAAAATGGACAAGGATCGGT
TCCGGTTCGATATGGGCGGAGTAGAAAACGCATACAGCGAGGTACAGAAACGAGTGCTCGAACTCGACTGA

Upstream 100 bases:

>100_bases
CTTTAGTGCCGAACAGACCGTATCGGCAATAAATAAATGATACTTTGCATAAGCGACCGCCGGATGCCGGAGTTAAAACA
AAAAACAGGATCATCATATC

Downstream 100 bases:

>100_bases
GTGCATGAGCACTGCTCATATTCTATTTTTTCCATCGTTCCAATGATGGAATGTGCGGCACACGCGTTGCTTTTGTATCC
CGACGAACAAGTCGGGATAC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTKTTLLHEGKAKKVFLTDQSDLVIQEFKDDATAFNNKKKGTIADKGVVNNAISCRLFTLLEEHGIRTHLVEKLSDRDML
CKRLDIIKVEVVVRNIAAGSLVKRYGFKEGFVLQEPLVEFYLKDDDLDDPLMNDFHAVALGVATSEELAILRSRAEAINL
VLRQFFADRKLKLVDFKLEFGRHKNEILLGDEISPDTCRFWDLDTNEKMDKDRFRFDMGGVENAYSEVQKRVLELD

Sequences:

>Translated_236_residues
MTKTTLLHEGKAKKVFLTDQSDLVIQEFKDDATAFNNKKKGTIADKGVVNNAISCRLFTLLEEHGIRTHLVEKLSDRDML
CKRLDIIKVEVVVRNIAAGSLVKRYGFKEGFVLQEPLVEFYLKDDDLDDPLMNDFHAVALGVATSEELAILRSRAEAINL
VLRQFFADRKLKLVDFKLEFGRHKNEILLGDEISPDTCRFWDLDTNEKMDKDRFRFDMGGVENAYSEVQKRVLELD
>Mature_235_residues
TKTTLLHEGKAKKVFLTDQSDLVIQEFKDDATAFNNKKKGTIADKGVVNNAISCRLFTLLEEHGIRTHLVEKLSDRDMLC
KRLDIIKVEVVVRNIAAGSLVKRYGFKEGFVLQEPLVEFYLKDDDLDDPLMNDFHAVALGVATSEELAILRSRAEAINLV
LRQFFADRKLKLVDFKLEFGRHKNEILLGDEISPDTCRFWDLDTNEKMDKDRFRFDMGGVENAYSEVQKRVLELD

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=220, Percent_Identity=33.6363636363636, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI5453539, Length=220, Percent_Identity=33.6363636363636, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI119220559, Length=227, Percent_Identity=32.15859030837, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=45.2586206896552, Blast_Score=200, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=31.8181818181818, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24583917, Length=205, Percent_Identity=32.1951219512195, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18860083, Length=217, Percent_Identity=30.8755760368664, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_CHLPD (A1BF89)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911490.1
- ProteinModelPortal:   A1BF89
- SMR:   A1BF89
- STRING:   A1BF89
- GeneID:   4570174
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1019
- NMPDR:   fig|290317.7.peg.1083
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27086; Mature: 26955

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTTLLHEGKAKKVFLTDQSDLVIQEFKDDATAFNNKKKGTIADKGVVNNAISCRLFTL
CCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHH
LEEHGIRTHLVEKLSDRDMLCKRLDIIKVEVVVRNIAAGSLVKRYGFKEGFVLQEPLVEF
HHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
YLKDDDLDDPLMNDFHAVALGVATSEELAILRSRAEAINLVLRQFFADRKLKLVDFKLEF
EECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GRHKNEILLGDEISPDTCRFWDLDTNEKMDKDRFRFDMGGVENAYSEVQKRVLELD
CCCCCCEEECCCCCCCCEEEEECCCCCCCCHHHHEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKTTLLHEGKAKKVFLTDQSDLVIQEFKDDATAFNNKKKGTIADKGVVNNAISCRLFTL
CCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHH
LEEHGIRTHLVEKLSDRDMLCKRLDIIKVEVVVRNIAAGSLVKRYGFKEGFVLQEPLVEF
HHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
YLKDDDLDDPLMNDFHAVALGVATSEELAILRSRAEAINLVLRQFFADRKLKLVDFKLEF
EECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
GRHKNEILLGDEISPDTCRFWDLDTNEKMDKDRFRFDMGGVENAYSEVQKRVLELD
CCCCCCEEECCCCCCCCEEEEECCCCCCCCHHHHEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA