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The map label for this gene is comEB [H]

Identifier: 119356771

GI number: 119356771

Start: 1085469

End: 1085990

Strand: Direct

Name: comEB [H]

Synonym: Cpha266_0943

Alternate gene names: 119356771

Gene position: 1085469-1085990 (Clockwise)

Preceding gene: 119356768

Following gene: 119356772

Centisome position: 34.64

GC content: 50.57

Gene sequence:

>522_bases
ATGCAGGAAGATTGTGCTGCGGGAGGGTGCTCCTGCTCCGGGAGCGATCAACCATCCGGTTCTCTCAAACGACTTGGATG
GCAGGAGTATTTTATGAGTGTCGCCCACCTGATTTCCAGAAGGGCGACCTGTACGCGTGCTCATATCGGTGCAGTGATCG
TTCGAGACAACAATATCCTCTCAACAGGATATAACGGTGCGCCCTCAGGCCTTCCTCATTGTGACGAAACAAACTGCCGG
ATCTACAGGAGCACTCATCCTGACGGAACGGTTGAAGAGAACTGTGTCAATACCATTCATGCGGAAATCAACGCCATTGC
ACAGGCCGCAAAACACGGCGTTTCCATCAAGGATGCCGATATCTATATCACGGCAAGTCCCTGTATTCACTGTCTCAAGG
TGCTGATCAACGTGGGGATCAAAACCATCTATTACGACAAGCCCTATAAACTCGAACATATCGATGAGCTGGTGAGGCTT
TCAGGTATAAGGCTGGTGCAGGTGCATGGCGATGAACAGTAA

Upstream 100 bases:

>100_bases
AATATCTATTGATTTCTTGCTCGATTTGACGCTCTCTTTTGCGTTCCGCTGAAGCAATGAAAGCTGTTCATCAGGTGGAA
TTTAACCAATAACATTGATT

Downstream 100 bases:

>100_bases
CGCGTAAGGCCATGCATCACGAAAGTCATGAATGGTATATGAACCGCTGCTTTGAGCTTGCTTTGCAGGGCTCTGGTATG
GTGAGCCCCAATCCTATGGT

Product: CMP/dCMP deaminase, zinc-binding

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MQEDCAAGGCSCSGSDQPSGSLKRLGWQEYFMSVAHLISRRATCTRAHIGAVIVRDNNILSTGYNGAPSGLPHCDETNCR
IYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKLEHIDELVRL
SGIRLVQVHGDEQ

Sequences:

>Translated_173_residues
MQEDCAAGGCSCSGSDQPSGSLKRLGWQEYFMSVAHLISRRATCTRAHIGAVIVRDNNILSTGYNGAPSGLPHCDETNCR
IYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKLEHIDELVRL
SGIRLVQVHGDEQ
>Mature_173_residues
MQEDCAAGGCSCSGSDQPSGSLKRLGWQEYFMSVAHLISRRATCTRAHIGAVIVRDNNILSTGYNGAPSGLPHCDETNCR
IYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKLEHIDELVRL
SGIRLVQVHGDEQ

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742821, Length=122, Percent_Identity=34.4262295081967, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI61742819, Length=127, Percent_Identity=34.6456692913386, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17557019, Length=150, Percent_Identity=31.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321938, Length=160, Percent_Identity=30, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667298, Length=131, Percent_Identity=31.2977099236641, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667302, Length=131, Percent_Identity=31.2977099236641, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 18894; Mature: 18894

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEDCAAGGCSCSGSDQPSGSLKRLGWQEYFMSVAHLISRRATCTRAHIGAVIVRDNNIL
CCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCEEEEECCCEE
STGYNGAPSGLPHCDETNCRIYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDAD
ECCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCE
IYITASPCIHCLKVLINVGIKTIYYDKPYKLEHIDELVRLSGIRLVQVHGDEQ
EEEECHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCC
>Mature Secondary Structure
MQEDCAAGGCSCSGSDQPSGSLKRLGWQEYFMSVAHLISRRATCTRAHIGAVIVRDNNIL
CCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHHCEEEEECCCEE
STGYNGAPSGLPHCDETNCRIYRSTHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDAD
ECCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCE
IYITASPCIHCLKVLINVGIKTIYYDKPYKLEHIDELVRLSGIRLVQVHGDEQ
EEEECHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]