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The map label for this gene is ribD [H]

Identifier: 119356772

GI number: 119356772

Start: 1086002

End: 1087102

Strand: Direct

Name: ribD [H]

Synonym: Cpha266_0944

Alternate gene names: 119356772

Gene position: 1086002-1087102 (Clockwise)

Preceding gene: 119356771

Following gene: 119356773

Centisome position: 34.65

GC content: 51.95

Gene sequence:

>1101_bases
ATGCATCACGAAAGTCATGAATGGTATATGAACCGCTGCTTTGAGCTTGCTTTGCAGGGCTCTGGTATGGTGAGCCCCAA
TCCTATGGTTGGCTCTGTTATTGTCCATAATGGAGAGATTGTCGGCGAAGGGTATCATGAGCGGTTTGGCGGGCCTCATG
CCGAGGTCCATGCAATTGCATCGGTTGGCAATGCCGAGGTGCTGCAGAATTCCACGCTTTACGTCAATCTTGAACCTTGC
TCTCATTTTGGAAAAACGCCTCCCTGCGCGGATCTTATTCTTGCAAAACGGATACCCCGCGTCGTGATCGGTTGCCGTGA
TCCTCATGAAAAAGTGGCGGGAAAAGGTATTGAAAGGCTCACGGCCGCAGGGGTTCAGGTTACCGAGGGCGTGCTTATGC
CCGAAGCTCTTAAACTCAATGAGGCTTTTATTAAAAGCTGTACCGTCGGATTGCCTTTTGTGACGCTCAAGCTTGCCCAG
ACTCTTGACGGTAAAATTGCTACTGCCGGGGGAGCTTCACGATGGATTACCGGCGAGGAGTCGAGAACACAGGTGCATCG
CCTGAGATGCAACTGTGATGCGGTAGTTGTCGGAGAGGCGACCGTACAGGCTGACGATTCGGAGCTCACCGTCAGGCATT
GTGCCGGGCGAAATCCTCTTCGTGTTTTACTTGACCGCAGGCTCTCTCTTTTCGCCGACGCCAGGATTTTCAGTACTGAA
GCCGCGACGCTCGTTTTTACAACAAGAGCATCCTCCTGTTCAGTAAAAGCGGAGCAGCTTCGAAAGAGAGGGGTGGAGGT
GATTGGTGTTGACGAAGATGCGACAGGTCTTGATTTGAAACGAATTCTTCAGGAACTGCACAGGCGTGGAATTATCTCCC
TTCTTGTTGAAGGAGGAAGCCGTCTGTCGGCATCGTTTCTTGGTGCGGCCCTTGTCGATAAACTTCTTGTGTTTATTGCT
CCCAGGCTTTTCGGTGGTGACGGGTTGAGCGCTTTTGCTCCGCTTGGCGTGGAACTTCCGGATCAAGCTGTTCAACTGCG
TTTTCAGCCGCCGGTTTTTTTTGGCCGGGATCTTCTGCTTGAGGCCTATGTTGTATCGTGA

Upstream 100 bases:

>100_bases
ACGACAAGCCCTATAAACTCGAACATATCGATGAGCTGGTGAGGCTTTCAGGTATAAGGCTGGTGCAGGTGCATGGCGAT
GAACAGTAACGCGTAAGGCC

Downstream 100 bases:

>100_bases
CGGCCTTGAGTCCTGCTGAAACAGTGCGGCCCGGATGAGCGGTTTTTTTGAATGCATGACAGGGAATTCATCGCTTTGTA
ACCATATGACGGGTCTTATC

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MHHESHEWYMNRCFELALQGSGMVSPNPMVGSVIVHNGEIVGEGYHERFGGPHAEVHAIASVGNAEVLQNSTLYVNLEPC
SHFGKTPPCADLILAKRIPRVVIGCRDPHEKVAGKGIERLTAAGVQVTEGVLMPEALKLNEAFIKSCTVGLPFVTLKLAQ
TLDGKIATAGGASRWITGEESRTQVHRLRCNCDAVVVGEATVQADDSELTVRHCAGRNPLRVLLDRRLSLFADARIFSTE
AATLVFTTRASSCSVKAEQLRKRGVEVIGVDEDATGLDLKRILQELHRRGIISLLVEGGSRLSASFLGAALVDKLLVFIA
PRLFGGDGLSAFAPLGVELPDQAVQLRFQPPVFFGRDLLLEAYVVS

Sequences:

>Translated_366_residues
MHHESHEWYMNRCFELALQGSGMVSPNPMVGSVIVHNGEIVGEGYHERFGGPHAEVHAIASVGNAEVLQNSTLYVNLEPC
SHFGKTPPCADLILAKRIPRVVIGCRDPHEKVAGKGIERLTAAGVQVTEGVLMPEALKLNEAFIKSCTVGLPFVTLKLAQ
TLDGKIATAGGASRWITGEESRTQVHRLRCNCDAVVVGEATVQADDSELTVRHCAGRNPLRVLLDRRLSLFADARIFSTE
AATLVFTTRASSCSVKAEQLRKRGVEVIGVDEDATGLDLKRILQELHRRGIISLLVEGGSRLSASFLGAALVDKLLVFIA
PRLFGGDGLSAFAPLGVELPDQAVQLRFQPPVFFGRDLLLEAYVVS
>Mature_366_residues
MHHESHEWYMNRCFELALQGSGMVSPNPMVGSVIVHNGEIVGEGYHERFGGPHAEVHAIASVGNAEVLQNSTLYVNLEPC
SHFGKTPPCADLILAKRIPRVVIGCRDPHEKVAGKGIERLTAAGVQVTEGVLMPEALKLNEAFIKSCTVGLPFVTLKLAQ
TLDGKIATAGGASRWITGEESRTQVHRLRCNCDAVVVGEATVQADDSELTVRHCAGRNPLRVLLDRRLSLFADARIFSTE
AATLVFTTRASSCSVKAEQLRKRGVEVIGVDEDATGLDLKRILQELHRRGIISLLVEGGSRLSASFLGAALVDKLLVFIA
PRLFGGDGLSAFAPLGVELPDQAVQLRFQPPVFFGRDLLLEAYVVS

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=367, Percent_Identity=39.5095367847411, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI145693172, Length=154, Percent_Identity=35.0649350649351, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319629, Length=202, Percent_Identity=24.7524752475248, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 39560; Mature: 39560

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHESHEWYMNRCFELALQGSGMVSPNPMVGSVIVHNGEIVGEGYHERFGGPHAEVHAIA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEEEECCHHHHCCCCCHHHHHHH
SVGNAEVLQNSTLYVNLEPCSHFGKTPPCADLILAKRIPRVVIGCRDPHEKVAGKGIERL
HCCCHHHEECCEEEEEECCHHHCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHCCHHHH
TAAGVQVTEGVLMPEALKLNEAFIKSCTVGLPFVTLKLAQTLDGKIATAGGASRWITGEE
HHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCH
SRTQVHRLRCNCDAVVVGEATVQADDSELTVRHCAGRNPLRVLLDRRLSLFADARIFSTE
HHHHHHHHCCCCCEEEEECEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCEEEECC
AATLVFTTRASSCSVKAEQLRKRGVEVIGVDEDATGLDLKRILQELHRRGIISLLVEGGS
CEEEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCC
RLSASFLGAALVDKLLVFIAPRLFGGDGLSAFAPLGVELPDQAVQLRFQPPVFFGRDLLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCEEEEECCCCHHCHHHHH
EAYVVS
EEEECC
>Mature Secondary Structure
MHHESHEWYMNRCFELALQGSGMVSPNPMVGSVIVHNGEIVGEGYHERFGGPHAEVHAIA
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEEEECCHHHHCCCCCHHHHHHH
SVGNAEVLQNSTLYVNLEPCSHFGKTPPCADLILAKRIPRVVIGCRDPHEKVAGKGIERL
HCCCHHHEECCEEEEEECCHHHCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHCCHHHH
TAAGVQVTEGVLMPEALKLNEAFIKSCTVGLPFVTLKLAQTLDGKIATAGGASRWITGEE
HHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCH
SRTQVHRLRCNCDAVVVGEATVQADDSELTVRHCAGRNPLRVLLDRRLSLFADARIFSTE
HHHHHHHHCCCCCEEEEECEEEECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCEEEECC
AATLVFTTRASSCSVKAEQLRKRGVEVIGVDEDATGLDLKRILQELHRRGIISLLVEGGS
CEEEEEEECCCCCCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCC
RLSASFLGAALVDKLLVFIAPRLFGGDGLSAFAPLGVELPDQAVQLRFQPPVFFGRDLLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCEEEEECCCCHHCHHHHH
EAYVVS
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]