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The map label for this gene is metC [H]

Identifier: 119356731

GI number: 119356731

Start: 1033722

End: 1034330

Strand: Direct

Name: metC [H]

Synonym: Cpha266_0903

Alternate gene names: 119356731

Gene position: 1033722-1034330 (Clockwise)

Preceding gene: 119356730

Following gene: 119356732

Centisome position: 32.99

GC content: 51.23

Gene sequence:

>609_bases
ATGGTTAAGGCAAAAAAAGGGTTATTTACACATAACTCTCATTTTTTTATTGATTTGTGGCGACGATGGTTACATTTTCT
CCGGGAATTCAGGGTACTGACGAATAGCGGAGAGCTTGATGAAAGGGTGAAGTTTCTCGTCAATGCGCTCGGTCTCTGTG
CACAGCCGTTCGATTGCTGGCTGGTGCTCCGCGGTATCAAAACGCTTGTGGTGAGAATGAGGGAGCATGAACGCAACGCT
CTTCTTGTGGCCGGGTTTCTCGCTCAGCATCCGGGGGTGAAACGGGTTTTTTATCCCGGTCTGGAAACCCATCCGCAGCA
TGAACTGGCAAAAAAACAGCAGAGGAGTTTTGGCGGCATGGTCTCTTTCGAGCTTGAGGGCGGTATTGAGGATGTCAATC
GGGTTCTGGGAGGAACCAGGCTTTTTGCTCTTGCTGAAAGCCTTGGCGGCGTTGAATCGCTCATCGAACATCCGGCAACC
ATGAGCCACGCCTCAATGGAGAGTGAGCAGCGAGCTTCTGCCGGAATTACCGATACGGTTATCAGGCTCTCCGTTGGAAT
AGAGGATGGCGAGGATTTGATTGCCGATTTGCGCCAGGCGCTTTGCTGA

Upstream 100 bases:

>100_bases
TCCCGCTTCTCTTCTGTTCTTTCCCCCAACTCGACACGCAGTACTCAATACTCAGAAAAAGCCATGGGTGCCTTCTTTTG
TTATCGTTACTCCTGTGACT

Downstream 100 bases:

>100_bases
AAAAGGCCGGGTTCGGTACATTACGGGCATCAACACTCTTGATGAAGCGCGTTGGTGCCCTTTTGTCGGTACCCGAGCGC
CGGTTTTACTCCAGCAATCA

Product: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MVKAKKGLFTHNSHFFIDLWRRWLHFLREFRVLTNSGELDERVKFLVNALGLCAQPFDCWLVLRGIKTLVVRMREHERNA
LLVAGFLAQHPGVKRVFYPGLETHPQHELAKKQQRSFGGMVSFELEGGIEDVNRVLGGTRLFALAESLGGVESLIEHPAT
MSHASMESEQRASAGITDTVIRLSVGIEDGEDLIADLRQALC

Sequences:

>Translated_202_residues
MVKAKKGLFTHNSHFFIDLWRRWLHFLREFRVLTNSGELDERVKFLVNALGLCAQPFDCWLVLRGIKTLVVRMREHERNA
LLVAGFLAQHPGVKRVFYPGLETHPQHELAKKQQRSFGGMVSFELEGGIEDVNRVLGGTRLFALAESLGGVESLIEHPAT
MSHASMESEQRASAGITDTVIRLSVGIEDGEDLIADLRQALC
>Mature_202_residues
MVKAKKGLFTHNSHFFIDLWRRWLHFLREFRVLTNSGELDERVKFLVNALGLCAQPFDCWLVLRGIKTLVVRMREHERNA
LLVAGFLAQHPGVKRVFYPGLETHPQHELAKKQQRSFGGMVSFELEGGIEDVNRVLGGTRLFALAESLGGVESLIEHPAT
MSHASMESEQRASAGITDTVIRLSVGIEDGEDLIADLRQALC

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI299473759, Length=170, Percent_Identity=51.7647058823529, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI21361334, Length=170, Percent_Identity=51.7647058823529, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI25453487, Length=170, Percent_Identity=51.7647058823529, Blast_Score=154, Evalue=4e-38,
Organism=Escherichia coli, GI1790375, Length=168, Percent_Identity=48.8095238095238, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI1789383, Length=146, Percent_Identity=37.6712328767123, Blast_Score=85, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17538055, Length=170, Percent_Identity=49.4117647058824, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=169, Percent_Identity=50.887573964497, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71980708, Length=151, Percent_Identity=43.7086092715232, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319307, Length=171, Percent_Identity=48.5380116959064, Blast_Score=164, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6321254, Length=180, Percent_Identity=32.7777777777778, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=171, Percent_Identity=34.5029239766082, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19922554, Length=170, Percent_Identity=48.2352941176471, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 22706; Mature: 22706

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKAKKGLFTHNSHFFIDLWRRWLHFLREFRVLTNSGELDERVKFLVNALGLCAQPFDCW
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHH
LVLRGIKTLVVRMREHERNALLVAGFLAQHPGVKRVFYPGLETHPQHELAKKQQRSFGGM
HHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHCCE
VSFELEGGIEDVNRVLGGTRLFALAESLGGVESLIEHPATMSHASMESEQRASAGITDTV
EEEEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHH
IRLSVGIEDGEDLIADLRQALC
HEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVKAKKGLFTHNSHFFIDLWRRWLHFLREFRVLTNSGELDERVKFLVNALGLCAQPFDCW
CCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHH
LVLRGIKTLVVRMREHERNALLVAGFLAQHPGVKRVFYPGLETHPQHELAKKQQRSFGGM
HHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHCCE
VSFELEGGIEDVNRVLGGTRLFALAESLGGVESLIEHPATMSHASMESEQRASAGITDTV
EEEEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHH
IRLSVGIEDGEDLIADLRQALC
HEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]