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The map label for this gene is phoR [H]

Identifier: 119356709

GI number: 119356709

Start: 1005105

End: 1006877

Strand: Direct

Name: phoR [H]

Synonym: Cpha266_0881

Alternate gene names: 119356709

Gene position: 1005105-1006877 (Clockwise)

Preceding gene: 119356708

Following gene: 119356710

Centisome position: 32.07

GC content: 50.37

Gene sequence:

>1773_bases
ATGAATGCTAAAGTATCCGTTCGACTGGGCATTGTTTTCGGCCTGATTGTCTTTCTCTCCATTGCCCTGAGTTATCTCCT
TCAGGGCAAGCTGATCAATGAACTTCTGCTTAAGAATATCCGTCAGGAGCTCTACAAAGAGCTTCGTTTGAGCCGCCAGG
TGATCGACAGCCGTTCACCGATCTGGCTTGTTTCTGAAGAACCCGACCATTGGACCGACAACGTCGGGCGGGTTCTTGAT
GTTCGTGTCACCCTGATCGGAAAGGATGGCAGGGTGGCCGGTGATTCATACCTCTCCTTATCAGCACTTGCAAAAGTCCG
CAATCATCTTCATCGGCCGGAAGTTAAAGAGGCCCTTTCAACAGGTTACGGTGAAGATATCCGTTACAGCGAAACCGTCA
GGGAGCAGATGCTCTATATGGCTGTACCGGTCGGCGGCGAGGCACCTTATGCGGTACTGCGCTTTGCCAAACCTCTGTAC
GATATCGGCGAACTTGAATCCGAAGCAAGAAAGGGACTTGAAGGAGGTCTTCTCTGGGCACTACTGTTTTCTTTATTAAT
CGGAGGCTTGACGGCGTTATTGCTTGCCCGTCCTCTGCGTCGTATTGTGGACGCCGCAGAAAAATGCGTGCATGGAGACT
ATTCGGGTACCATTGCTGTGAACCGTGACGATGAAATCGGTAAAATGGCAAGAGCATTCAATTTCATGTCTGCAGAAATA
AACACCATGCAGCGCAAGGAGGAGTGGTATCGCGCAGTACTTTCAGGCATTCGTGAGGCAATTATTGTTACCAATGCCGA
TGGCGAGATAATTCTTGTCAATCCCGCAGCCTCAAGAATGTTCCGTATCGACGGGGCTATGCTCAAATCACATCCGGTCA
AGCAACTGGCCGATCAGAAACTCAGGGAGCTGTTCAGCGACGTCCATACAAAAAGGACAACACTGCAAAAAGAAGAGGTG
TCGCTGGTTACCGTAAAAGGGAAGCGGACGATGCAGATCAGCTCCATGCCGGTAAAGAGGGATGGCCAGTTCGACGGCAC
GGTTTTTGTTCTCAACGACATCACCAAGCTTCGCAATCTCGAAAGAATCCGCAGGGATTTTGTATCAAGTGTTTCCCATG
AACTGCGCACCCCGCTCACCAGCATCAAGGGTTATACGGAAACCCTGCTTGACGGAGCCATGCATGATCCGGAGCACGCA
GCAGCCTTTCTCAGGATCATCCTTCAGGAGAGCGAACAGCTTACCGCACTGGTTAACGATGTTCTTGACCTGTCGCGAAT
AGAGTCGGGTAAAATTGATTACCGTTTCGCTCCGACAGATCTTCGCTCCATTCTTCAAAAAAGCTCCGAGCTGGTACTGC
CGGCCATTGAAAAAAAGAAGATCAAGCTCGACATGCAGTTTCAGGAAGAACTGCCTCTGGTCTATGCCGATGCAGCCTAT
CTTGAAATAGCCGTTCGCAATCTCCTTGACAATGCCGTCAAATATGTTGAGGATACCGTTGGTCGGATCAGGGTGACGGC
ATACAAAAGTGAGAGCAACGTGATCCTTGAGGTGCACGATAACGGTCTCGGTATTCATCCCTCCGATCTTGACCGGATTT
TTGAGCGTTTCTACCGAGCCGACAAAGCCCGGTCGCGCCAGTCAGGAGGAACAGGACTCGGGCTTGCCATCGTCAAACAT
ATCGTCCTTGCCCATAAAGGCACCATTGAGGTTCACTCGCGGCTTAATCAGGGATCGGTTTTCAGAATGAGTTTGCCCGT
ATCGACAGTATAA

Upstream 100 bases:

>100_bases
CACATCACCAGACTTCGGGAAAAACTCGGTGTAACCGGAAGTATGATCAAAACCGTCCGCGGTCTTGGCTACAAGTTCGA
GGAAGCAACGGAAAGCAGCA

Downstream 100 bases:

>100_bases
AACTTCCCGAAAACAGTAGCTTCATGAAGCAATCAATCATCAGGTATCTTGAACATTTTCCTGCAATAACGGCGGATCAG
GCGATTCTGATCTATACGAT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MNAKVSVRLGIVFGLIVFLSIALSYLLQGKLINELLLKNIRQELYKELRLSRQVIDSRSPIWLVSEEPDHWTDNVGRVLD
VRVTLIGKDGRVAGDSYLSLSALAKVRNHLHRPEVKEALSTGYGEDIRYSETVREQMLYMAVPVGGEAPYAVLRFAKPLY
DIGELESEARKGLEGGLLWALLFSLLIGGLTALLLARPLRRIVDAAEKCVHGDYSGTIAVNRDDEIGKMARAFNFMSAEI
NTMQRKEEWYRAVLSGIREAIIVTNADGEIILVNPAASRMFRIDGAMLKSHPVKQLADQKLRELFSDVHTKRTTLQKEEV
SLVTVKGKRTMQISSMPVKRDGQFDGTVFVLNDITKLRNLERIRRDFVSSVSHELRTPLTSIKGYTETLLDGAMHDPEHA
AAFLRIILQESEQLTALVNDVLDLSRIESGKIDYRFAPTDLRSILQKSSELVLPAIEKKKIKLDMQFQEELPLVYADAAY
LEIAVRNLLDNAVKYVEDTVGRIRVTAYKSESNVILEVHDNGLGIHPSDLDRIFERFYRADKARSRQSGGTGLGLAIVKH
IVLAHKGTIEVHSRLNQGSVFRMSLPVSTV

Sequences:

>Translated_590_residues
MNAKVSVRLGIVFGLIVFLSIALSYLLQGKLINELLLKNIRQELYKELRLSRQVIDSRSPIWLVSEEPDHWTDNVGRVLD
VRVTLIGKDGRVAGDSYLSLSALAKVRNHLHRPEVKEALSTGYGEDIRYSETVREQMLYMAVPVGGEAPYAVLRFAKPLY
DIGELESEARKGLEGGLLWALLFSLLIGGLTALLLARPLRRIVDAAEKCVHGDYSGTIAVNRDDEIGKMARAFNFMSAEI
NTMQRKEEWYRAVLSGIREAIIVTNADGEIILVNPAASRMFRIDGAMLKSHPVKQLADQKLRELFSDVHTKRTTLQKEEV
SLVTVKGKRTMQISSMPVKRDGQFDGTVFVLNDITKLRNLERIRRDFVSSVSHELRTPLTSIKGYTETLLDGAMHDPEHA
AAFLRIILQESEQLTALVNDVLDLSRIESGKIDYRFAPTDLRSILQKSSELVLPAIEKKKIKLDMQFQEELPLVYADAAY
LEIAVRNLLDNAVKYVEDTVGRIRVTAYKSESNVILEVHDNGLGIHPSDLDRIFERFYRADKARSRQSGGTGLGLAIVKH
IVLAHKGTIEVHSRLNQGSVFRMSLPVSTV
>Mature_590_residues
MNAKVSVRLGIVFGLIVFLSIALSYLLQGKLINELLLKNIRQELYKELRLSRQVIDSRSPIWLVSEEPDHWTDNVGRVLD
VRVTLIGKDGRVAGDSYLSLSALAKVRNHLHRPEVKEALSTGYGEDIRYSETVREQMLYMAVPVGGEAPYAVLRFAKPLY
DIGELESEARKGLEGGLLWALLFSLLIGGLTALLLARPLRRIVDAAEKCVHGDYSGTIAVNRDDEIGKMARAFNFMSAEI
NTMQRKEEWYRAVLSGIREAIIVTNADGEIILVNPAASRMFRIDGAMLKSHPVKQLADQKLRELFSDVHTKRTTLQKEEV
SLVTVKGKRTMQISSMPVKRDGQFDGTVFVLNDITKLRNLERIRRDFVSSVSHELRTPLTSIKGYTETLLDGAMHDPEHA
AAFLRIILQESEQLTALVNDVLDLSRIESGKIDYRFAPTDLRSILQKSSELVLPAIEKKKIKLDMQFQEELPLVYADAAY
LEIAVRNLLDNAVKYVEDTVGRIRVTAYKSESNVILEVHDNGLGIHPSDLDRIFERFYRADKARSRQSGGTGLGLAIVKH
IVLAHKGTIEVHSRLNQGSVFRMSLPVSTV

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=348, Percent_Identity=30.1724137931034, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=35.8649789029536, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=34.468085106383, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=35.3448275862069, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788549, Length=381, Percent_Identity=25.1968503937008, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI48994928, Length=274, Percent_Identity=30.2919708029197, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=32.4324324324324, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI87081816, Length=224, Percent_Identity=30.3571428571429, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790861, Length=348, Percent_Identity=28.1609195402299, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788713, Length=374, Percent_Identity=25.668449197861, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=30.6666666666667, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=32.2869955156951, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=30.5309734513274, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788279, Length=230, Percent_Identity=26.9565217391304, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1789808, Length=224, Percent_Identity=29.4642857142857, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789403, Length=206, Percent_Identity=33.9805825242718, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=28.0334728033473, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790551, Length=241, Percent_Identity=27.8008298755187, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=25.7510729613734, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66223; Mature: 66223

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAKVSVRLGIVFGLIVFLSIALSYLLQGKLINELLLKNIRQELYKELRLSRQVIDSRSP
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IWLVSEEPDHWTDNVGRVLDVRVTLIGKDGRVAGDSYLSLSALAKVRNHLHRPEVKEALS
EEEEECCCCCCHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
TGYGEDIRYSETVREQMLYMAVPVGGEAPYAVLRFAKPLYDIGELESEARKGLEGGLLWA
CCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLFSLLIGGLTALLLARPLRRIVDAAEKCVHGDYSGTIAVNRDDEIGKMARAFNFMSAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
NTMQRKEEWYRAVLSGIREAIIVTNADGEIILVNPAASRMFRIDGAMLKSHPVKQLADQK
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHEECCCHHHHCCCHHHHHHHH
LRELFSDVHTKRTTLQKEEVSLVTVKGKRTMQISSMPVKRDGQFDGTVFVLNDITKLRNL
HHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHH
ERIRRDFVSSVSHELRTPLTSIKGYTETLLDGAMHDPEHAAAFLRIILQESEQLTALVND
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLDLSRIESGKIDYRFAPTDLRSILQKSSELVLPAIEKKKIKLDMQFQEELPLVYADAAY
HHHHHHCCCCCCEEEECCHHHHHHHHCCCCEECCCCCCCEEEEEEEHHHCCCEEEECHHH
LEIAVRNLLDNAVKYVEDTVGRIRVTAYKSESNVILEVHDNGLGIHPSDLDRIFERFYRA
HHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
DKARSRQSGGTGLGLAIVKHIVLAHKGTIEVHSRLNQGSVFRMSLPVSTV
HHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MNAKVSVRLGIVFGLIVFLSIALSYLLQGKLINELLLKNIRQELYKELRLSRQVIDSRSP
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IWLVSEEPDHWTDNVGRVLDVRVTLIGKDGRVAGDSYLSLSALAKVRNHLHRPEVKEALS
EEEEECCCCCCHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
TGYGEDIRYSETVREQMLYMAVPVGGEAPYAVLRFAKPLYDIGELESEARKGLEGGLLWA
CCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLFSLLIGGLTALLLARPLRRIVDAAEKCVHGDYSGTIAVNRDDEIGKMARAFNFMSAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
NTMQRKEEWYRAVLSGIREAIIVTNADGEIILVNPAASRMFRIDGAMLKSHPVKQLADQK
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHEECCCHHHHCCCHHHHHHHH
LRELFSDVHTKRTTLQKEEVSLVTVKGKRTMQISSMPVKRDGQFDGTVFVLNDITKLRNL
HHHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHH
ERIRRDFVSSVSHELRTPLTSIKGYTETLLDGAMHDPEHAAAFLRIILQESEQLTALVND
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLDLSRIESGKIDYRFAPTDLRSILQKSSELVLPAIEKKKIKLDMQFQEELPLVYADAAY
HHHHHHCCCCCCEEEECCHHHHHHHHCCCCEECCCCCCCEEEEEEEHHHCCCEEEECHHH
LEIAVRNLLDNAVKYVEDTVGRIRVTAYKSESNVILEVHDNGLGIHPSDLDRIFERFYRA
HHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
DKARSRQSGGTGLGLAIVKHIVLAHKGTIEVHSRLNQGSVFRMSLPVSTV
HHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]