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The map label for this gene is mscM [H]

Identifier: 119356710

GI number: 119356710

Start: 1006901

End: 1008163

Strand: Direct

Name: mscM [H]

Synonym: Cpha266_0882

Alternate gene names: 119356710

Gene position: 1006901-1008163 (Clockwise)

Preceding gene: 119356709

Following gene: 119356712

Centisome position: 32.13

GC content: 49.33

Gene sequence:

>1263_bases
ATGAAGCAATCAATCATCAGGTATCTTGAACATTTTCCTGCAATAACGGCGGATCAGGCGATTCTGATCTATACGATTTT
CGCCTCAACACTCTCATTGCTCATCATTGTTCTGGTATCCGGCATTATCCGCCGCGCGATGCTGCGAGTTCTGAAACGTT
TTGCCGATTCGAGCACCACAATACTCGATGATCTTATGGTGCGCCATAAAGTATTCAAGGGGCTCTCCAATCTCCTTGCA
CCTGTGCTTGTACATCTCTTTGCGGCACCGGTTCTCGAATACTACCCGGGTCTCATTCCTCTGGTGCGAAATGGGGCGAC
GCTCTATCTGACGGTTGTTATTATTCTTGTTACCCTTTCAGCCATTGACGCCTTCTTCGAATATTTCCAGGAGCACCGAA
ATCTTGCCCGTCTGCCGCTGAAGAGCTTTATACAGGTCATCAAGACCGTCATCGTGTTTCTTGGCGCCATTACTGTTCTC
TCAAAACTTATCGGCGAATCCCCGATTGTTTTCATCAGCGGTCTGGGTGCATTTACCGCCCTGCTTCTTCTGATTTTCAA
GGATTCAATCCTCGGTCTTGTTGCCGGTATACAGCTTTCAACCAATGACCTTGTAAGGCTGGGCGACTGGATTGAGCTTC
CAAAATACGGCGCGGATGGAGACGTTATCGATATATCGCTGGTTACCGTTTCGGTGCGGAACGCAGACAGAAGCATCAGT
ACGATACCGGCATACGCGCTTATTTCAGAAGGCTTTAAAAACTGGAGAGGAATGAGCGAATCCGAAGGTCGCAGAATCAA
GCGCTCGCTCAACATTGACATGACCAGCGTCGCCTTTTGCGATGAAGCGATGTTTGAAAGGCTTTTTCACATCGAGCTGC
TTCAGCGTTATCTTCTTGAAAAAAAAGAGGAGCTCAACGCCTATAACAAGGAGAACTTCCTGAACCCCGAGGTTCCGGTA
AACGGGAGGCGGCTAACCAATCTGGGTACCTTTCGGGCCTATCTTCTTGCCTATCTGCGACGACTTCCGGTAGTCAACGC
CGAAATGACGCTCATGGTGAGGTACCTGCAGTCAACAGAGCACGGTCTTCCTCTCGAAATCTATCTCTTCAGCAAAGAAA
AAGACATCGTGGCTTATGAAGCCGTTCAGGCTGACGTCATGGACCATCTGCTTGCCGTTCTGCCCTTTTTCGGGCTTCGC
GTCTACCAGTCCCCAACAGGGTACGTTCCTGTGCAAGCTGTTTCCGAATCAGCCGGTTCATAA

Upstream 100 bases:

>100_bases
AAGGCACCATTGAGGTTCACTCGCGGCTTAATCAGGGATCGGTTTTCAGAATGAGTTTGCCCGTATCGACAGTATAAAAC
TTCCCGAAAACAGTAGCTTC

Downstream 100 bases:

>100_bases
AGAGTCTGCATCGCTGATAATTCTGTTATGAAGCGGAATTCTGATGGGAGGCATCAACTCTCTCGGGTAGAACCCCGCAT
CAAACAGTTCGTGATTGAGT

Product: MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MKQSIIRYLEHFPAITADQAILIYTIFASTLSLLIIVLVSGIIRRAMLRVLKRFADSSTTILDDLMVRHKVFKGLSNLLA
PVLVHLFAAPVLEYYPGLIPLVRNGATLYLTVVIILVTLSAIDAFFEYFQEHRNLARLPLKSFIQVIKTVIVFLGAITVL
SKLIGESPIVFISGLGAFTALLLLIFKDSILGLVAGIQLSTNDLVRLGDWIELPKYGADGDVIDISLVTVSVRNADRSIS
TIPAYALISEGFKNWRGMSESEGRRIKRSLNIDMTSVAFCDEAMFERLFHIELLQRYLLEKKEELNAYNKENFLNPEVPV
NGRRLTNLGTFRAYLLAYLRRLPVVNAEMTLMVRYLQSTEHGLPLEIYLFSKEKDIVAYEAVQADVMDHLLAVLPFFGLR
VYQSPTGYVPVQAVSESAGS

Sequences:

>Translated_420_residues
MKQSIIRYLEHFPAITADQAILIYTIFASTLSLLIIVLVSGIIRRAMLRVLKRFADSSTTILDDLMVRHKVFKGLSNLLA
PVLVHLFAAPVLEYYPGLIPLVRNGATLYLTVVIILVTLSAIDAFFEYFQEHRNLARLPLKSFIQVIKTVIVFLGAITVL
SKLIGESPIVFISGLGAFTALLLLIFKDSILGLVAGIQLSTNDLVRLGDWIELPKYGADGDVIDISLVTVSVRNADRSIS
TIPAYALISEGFKNWRGMSESEGRRIKRSLNIDMTSVAFCDEAMFERLFHIELLQRYLLEKKEELNAYNKENFLNPEVPV
NGRRLTNLGTFRAYLLAYLRRLPVVNAEMTLMVRYLQSTEHGLPLEIYLFSKEKDIVAYEAVQADVMDHLLAVLPFFGLR
VYQSPTGYVPVQAVSESAGS
>Mature_420_residues
MKQSIIRYLEHFPAITADQAILIYTIFASTLSLLIIVLVSGIIRRAMLRVLKRFADSSTTILDDLMVRHKVFKGLSNLLA
PVLVHLFAAPVLEYYPGLIPLVRNGATLYLTVVIILVTLSAIDAFFEYFQEHRNLARLPLKSFIQVIKTVIVFLGAITVL
SKLIGESPIVFISGLGAFTALLLLIFKDSILGLVAGIQLSTNDLVRLGDWIELPKYGADGDVIDISLVTVSVRNADRSIS
TIPAYALISEGFKNWRGMSESEGRRIKRSLNIDMTSVAFCDEAMFERLFHIELLQRYLLEKKEELNAYNKENFLNPEVPV
NGRRLTNLGTFRAYLLAYLRRLPVVNAEMTLMVRYLQSTEHGLPLEIYLFSKEKDIVAYEAVQADVMDHLLAVLPFFGLR
VYQSPTGYVPVQAVSESAGS

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=405, Percent_Identity=43.7037037037037, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 47093; Mature: 47093

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSIIRYLEHFPAITADQAILIYTIFASTLSLLIIVLVSGIIRRAMLRVLKRFADSSTT
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ILDDLMVRHKVFKGLSNLLAPVLVHLFAAPVLEYYPGLIPLVRNGATLYLTVVIILVTLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHH
AIDAFFEYFQEHRNLARLPLKSFIQVIKTVIVFLGAITVLSKLIGESPIVFISGLGAFTA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHH
LLLLIFKDSILGLVAGIQLSTNDLVRLGDWIELPKYGADGDVIDISLVTVSVRNADRSIS
HHHHHHHHHHHHHHHCCEECCCHHHHHCCHHHCCCCCCCCCEEEEEEEEEEECCCCCCHH
TIPAYALISEGFKNWRGMSESEGRRIKRSLNIDMTSVAFCDEAMFERLFHIELLQRYLLE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEELNAYNKENFLNPEVPVNGRRLTNLGTFRAYLLAYLRRLPVVNAEMTLMVRYLQSTE
HHHHHCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HGLPLEIYLFSKEKDIVAYEAVQADVMDHLLAVLPFFGLRVYQSPTGYVPVQAVSESAGS
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MKQSIIRYLEHFPAITADQAILIYTIFASTLSLLIIVLVSGIIRRAMLRVLKRFADSSTT
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ILDDLMVRHKVFKGLSNLLAPVLVHLFAAPVLEYYPGLIPLVRNGATLYLTVVIILVTLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHH
AIDAFFEYFQEHRNLARLPLKSFIQVIKTVIVFLGAITVLSKLIGESPIVFISGLGAFTA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHH
LLLLIFKDSILGLVAGIQLSTNDLVRLGDWIELPKYGADGDVIDISLVTVSVRNADRSIS
HHHHHHHHHHHHHHHCCEECCCHHHHHCCHHHCCCCCCCCCEEEEEEEEEEECCCCCCHH
TIPAYALISEGFKNWRGMSESEGRRIKRSLNIDMTSVAFCDEAMFERLFHIELLQRYLLE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEELNAYNKENFLNPEVPVNGRRLTNLGTFRAYLLAYLRRLPVVNAEMTLMVRYLQSTE
HHHHHCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HGLPLEIYLFSKEKDIVAYEAVQADVMDHLLAVLPFFGLRVYQSPTGYVPVQAVSESAGS
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]