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The map label for this gene is ilvD

Identifier: 119356685

GI number: 119356685

Start: 977433

End: 979130

Strand: Reverse

Name: ilvD

Synonym: Cpha266_0854

Alternate gene names: 119356685

Gene position: 979130-977433 (Counterclockwise)

Preceding gene: 119356694

Following gene: 119356684

Centisome position: 31.24

GC content: 53.3

Gene sequence:

>1698_bases
ATGAGATCCGATACCATAAAAAAAGGGTTTGATAAAGCCCCCCATCGCAGCCTTCTTAAAGCCACCGGAGTCATAACGTC
GTCCGATGACTATCAAAAGCCGTTTATCGGCATCTGCAACTCATTCAACGAACTGATTCCCGGGCATGCCCACTTGCAGG
AACTGGGAAGAATCGCAAAGAATGAGGTGCGCAAAGCCGGTGGAATTCCCTTTGAATTCAATACTATCGGGGTCTGCGAC
GGCATCGCCATGGGCCATATCGGCATGCGCTACTCGCTTGCAAGCCGTGAACTCATTGCCGACAGCGTTGAAACCGTCGT
TGAGGCGCACCGGCTCGACGGAATCGTCTGTATACCGAACTGCGACAAGATCACGCCAGGCATGATGATGGCGGCACTCC
GCGTCAACATTCCGGTCATCTTTGTTTCCGGCGGACCGATGAAAGCCGGTCATACTCCGGATGGAAAAACTGTAGATCTC
ATTTCAGTCTTCGAAGCCGTTGGAAGGCACAGCACAGCCGAAATCACCGACGGCGAACTCCAGACGATCGAAGAGAACGC
CTGTCCCGGTTGCGGATCATGCTCAGGAATGTTTACAGCCAACTCGATGAACTGCCTTAGCGAAGCGCTCGGTCTGGCGC
TGCCCGGAAACGGAACCATCCTTGCCTCCGACCCAAGGCGCAACGAGCTGGTAAAAGAAGCTTCGCGAAAAATCATCGAC
CTTGTCAGGAGCAACACGAGGCCACGCGACATTCTTTCAAGAAAAGCGCTGCTCAATGCCTTTGCCCTCGATTTTGCCAT
GGGAGGCAGCACCAATACCATTCTGCACACCCTGGCCATAGCAAATGAAGCCGAACTTGACTTCGATTTCTCGGAGCTCA
ACGCCCTCTCTGCAAAAACACCTTATATCTGCAAGGTAAGCCCGGCAACCATGGCTGTACATATTGAAGACGTCGATCGG
GCAGGTGGAGTTTCAGCAATTCTCCTGGAGCTCAGCAAGATAGATGGACTTCTCGATCTGTCGGCACCGACAGTAAGCGG
GAAAACCCTCGGCGAAAACATTGCCGGCGCAGAGATCAAGGACGAAAAGGTCATTCGTACCATCGACAACCCTTACTCTG
CCACAGGCGGTCTTGCCGTTCTTTACGGAAACCTCGCACCCCAGGGAGCTGTGGTCAAAACCGGCGCGGTAAGCCCATCG
ATGATGCGGCATACCGGACCGGCAAAGGTCTTCGACTGCCAGGATGACGCCATCAAAGGCATCATGGAAGACATCATCAA
ACCGGGAGATGTTGTTGTGATCCGTTACGAAGGCCCAAAGGGCGGCCCCGGCATGCCGGAAATGCTCTCGCCGACAAGCG
CAATCATGGGTCGGGGTCTTGGTGACTCGGTTGCTCTTATCACCGACGGACGATTCTCCGGGGGGTCAAGAGGAGCCTGT
ATCGGCCACGTTTCTCCTGAAGCAGCCGAAAACGGCCCGATCGCCGCACTGAAAAACGGCGACATGATCACCATTGACAT
TCCCGCAAGAACCATTTCGGTCGATCTCTCAACAGAAGCAATAAATGAAAGAATTGCTCTTCTGCCGGTTTTTGAGCCGA
AAATCAAAAAAGGGTATCTGGCAAGATATGCGCAACTTGTCACGTCAGCCTGCACCGGCGCTATACTGAAAACATCTCCT
TACTGTGAACCAAAATAA

Upstream 100 bases:

>100_bases
CGACCCCAAGTCCATTTTATCTTCCAGACAGTATCATCTCAGTGGCTTCGGGAACGGCAGTCCCGGAATTGTTTTTTCTA
ATTTTATTTTTTTCAAAGCA

Downstream 100 bases:

>100_bases
ACCGAACATGAATGTACCAGGTCAAACACTGAACGGTTCAGAAATATTTTTTGAATGTCTGAGAAGAGAAAACGTTGAAT
ATATCTTCGGGTATCCCGGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MRSDTIKKGFDKAPHRSLLKATGVITSSDDYQKPFIGICNSFNELIPGHAHLQELGRIAKNEVRKAGGIPFEFNTIGVCD
GIAMGHIGMRYSLASRELIADSVETVVEAHRLDGIVCIPNCDKITPGMMMAALRVNIPVIFVSGGPMKAGHTPDGKTVDL
ISVFEAVGRHSTAEITDGELQTIEENACPGCGSCSGMFTANSMNCLSEALGLALPGNGTILASDPRRNELVKEASRKIID
LVRSNTRPRDILSRKALLNAFALDFAMGGSTNTILHTLAIANEAELDFDFSELNALSAKTPYICKVSPATMAVHIEDVDR
AGGVSAILLELSKIDGLLDLSAPTVSGKTLGENIAGAEIKDEKVIRTIDNPYSATGGLAVLYGNLAPQGAVVKTGAVSPS
MMRHTGPAKVFDCQDDAIKGIMEDIIKPGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
IGHVSPEAAENGPIAALKNGDMITIDIPARTISVDLSTEAINERIALLPVFEPKIKKGYLARYAQLVTSACTGAILKTSP
YCEPK

Sequences:

>Translated_565_residues
MRSDTIKKGFDKAPHRSLLKATGVITSSDDYQKPFIGICNSFNELIPGHAHLQELGRIAKNEVRKAGGIPFEFNTIGVCD
GIAMGHIGMRYSLASRELIADSVETVVEAHRLDGIVCIPNCDKITPGMMMAALRVNIPVIFVSGGPMKAGHTPDGKTVDL
ISVFEAVGRHSTAEITDGELQTIEENACPGCGSCSGMFTANSMNCLSEALGLALPGNGTILASDPRRNELVKEASRKIID
LVRSNTRPRDILSRKALLNAFALDFAMGGSTNTILHTLAIANEAELDFDFSELNALSAKTPYICKVSPATMAVHIEDVDR
AGGVSAILLELSKIDGLLDLSAPTVSGKTLGENIAGAEIKDEKVIRTIDNPYSATGGLAVLYGNLAPQGAVVKTGAVSPS
MMRHTGPAKVFDCQDDAIKGIMEDIIKPGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
IGHVSPEAAENGPIAALKNGDMITIDIPARTISVDLSTEAINERIALLPVFEPKIKKGYLARYAQLVTSACTGAILKTSP
YCEPK
>Mature_565_residues
MRSDTIKKGFDKAPHRSLLKATGVITSSDDYQKPFIGICNSFNELIPGHAHLQELGRIAKNEVRKAGGIPFEFNTIGVCD
GIAMGHIGMRYSLASRELIADSVETVVEAHRLDGIVCIPNCDKITPGMMMAALRVNIPVIFVSGGPMKAGHTPDGKTVDL
ISVFEAVGRHSTAEITDGELQTIEENACPGCGSCSGMFTANSMNCLSEALGLALPGNGTILASDPRRNELVKEASRKIID
LVRSNTRPRDILSRKALLNAFALDFAMGGSTNTILHTLAIANEAELDFDFSELNALSAKTPYICKVSPATMAVHIEDVDR
AGGVSAILLELSKIDGLLDLSAPTVSGKTLGENIAGAEIKDEKVIRTIDNPYSATGGLAVLYGNLAPQGAVVKTGAVSPS
MMRHTGPAKVFDCQDDAIKGIMEDIIKPGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
IGHVSPEAAENGPIAALKNGDMITIDIPARTISVDLSTEAINERIALLPVFEPKIKKGYLARYAQLVTSACTGAILKTSP
YCEPK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=47.4631751227496, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1786464, Length=502, Percent_Identity=33.6653386454183, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI2367371, Length=507, Percent_Identity=33.1360946745562, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1788157, Length=525, Percent_Identity=31.047619047619, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6322476, Length=550, Percent_Identity=39.6363636363636, Blast_Score=376, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_CHLPD (A1BES8)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911329.1
- ProteinModelPortal:   A1BES8
- SMR:   A1BES8
- STRING:   A1BES8
- GeneID:   4570448
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0854
- NMPDR:   fig|290317.7.peg.909
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK00911
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59598; Mature: 59598

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDTIKKGFDKAPHRSLLKATGVITSSDDYQKPFIGICNSFNELIPGHAHLQELGRIAK
CCCCCHHHCCCCCCHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
NEVRKAGGIPFEFNTIGVCDGIAMGHIGMRYSLASRELIADSVETVVEAHRLDGIVCIPN
HHHHHHCCCCEEECEEECCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEECCC
CDKITPGMMMAALRVNIPVIFVSGGPMKAGHTPDGKTVDLISVFEAVGRHSTAEITDGEL
CCCCCHHHHHHHHEECCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHH
QTIEENACPGCGSCSGMFTANSMNCLSEALGLALPGNGTILASDPRRNELVKEASRKIID
HHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCEEEECCCCHHHHHHHHHHHHHH
LVRSNTRPRDILSRKALLNAFALDFAMGGSTNTILHTLAIANEAELDFDFSELNALSAKT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEHHCCCCCCCCCHHHHHHHCCCC
PYICKVSPATMAVHIEDVDRAGGVSAILLELSKIDGLLDLSAPTVSGKTLGENIAGAEIK
CEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCHHCCCCCCCCCC
DEKVIRTIDNPYSATGGLAVLYGNLAPQGAVVKTGAVSPSMMRHTGPAKVFDCQDDAIKG
CCHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHCCCCCEEEECCHHHHHH
IMEDIIKPGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
HHHHHCCCCCEEEEEECCCCCCCCCCHHCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEE
IGHVSPEAAENGPIAALKNGDMITIDIPARTISVDLSTEAINERIALLPVFEPKIKKGYL
EECCCCCCCCCCCEEEEECCCEEEEEECCEEEEEECCHHHHCCCEEEEECCCCHHHHHHH
ARYAQLVTSACTGAILKTSPYCEPK
HHHHHHHHHHHCCCEEECCCCCCCC
>Mature Secondary Structure
MRSDTIKKGFDKAPHRSLLKATGVITSSDDYQKPFIGICNSFNELIPGHAHLQELGRIAK
CCCCCHHHCCCCCCHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
NEVRKAGGIPFEFNTIGVCDGIAMGHIGMRYSLASRELIADSVETVVEAHRLDGIVCIPN
HHHHHHCCCCEEECEEECCCCHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEECCC
CDKITPGMMMAALRVNIPVIFVSGGPMKAGHTPDGKTVDLISVFEAVGRHSTAEITDGEL
CCCCCHHHHHHHHEECCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHH
QTIEENACPGCGSCSGMFTANSMNCLSEALGLALPGNGTILASDPRRNELVKEASRKIID
HHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCEEEECCCCHHHHHHHHHHHHHH
LVRSNTRPRDILSRKALLNAFALDFAMGGSTNTILHTLAIANEAELDFDFSELNALSAKT
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEHHCCCCCCCCCHHHHHHHCCCC
PYICKVSPATMAVHIEDVDRAGGVSAILLELSKIDGLLDLSAPTVSGKTLGENIAGAEIK
CEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCHHCCCCCCCCCC
DEKVIRTIDNPYSATGGLAVLYGNLAPQGAVVKTGAVSPSMMRHTGPAKVFDCQDDAIKG
CCHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHCCCCCEEEECCHHHHHH
IMEDIIKPGDVVVIRYEGPKGGPGMPEMLSPTSAIMGRGLGDSVALITDGRFSGGSRGAC
HHHHHCCCCCEEEEEECCCCCCCCCCHHCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEE
IGHVSPEAAENGPIAALKNGDMITIDIPARTISVDLSTEAINERIALLPVFEPKIKKGYL
EECCCCCCCCCCCEEEEECCCEEEEEECCEEEEEECCHHHHCCCEEEEECCCCHHHHHHH
ARYAQLVTSACTGAILKTSPYCEPK
HHHHHHHHHHHCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA