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The map label for this gene is lspA

Identifier: 119356542

GI number: 119356542

Start: 806714

End: 807220

Strand: Reverse

Name: lspA

Synonym: Cpha266_0707

Alternate gene names: 119356542

Gene position: 807220-806714 (Counterclockwise)

Preceding gene: 119356543

Following gene: 119356541

Centisome position: 25.76

GC content: 44.38

Gene sequence:

>507_bases
ATGAATTGGTTTTTTACACTTGCCTCGATTGTTATTGTTCTCGACCAGCTCACAAAAAAAATTGCGGTTATGATTCTCAA
AGAAAAAGAGAGCGTCACCCTCATTCCCGACTGGCTGAAGTTCACCTACGCAGAGAACAATGGAATCGCTTTCGGAATGG
AATTTGCTCCCAAAGAGGTGATGATCCTTCTTGTCGGAACCATCTCCCTGCTGATTGCGCTCTATGTCTTCAGATCAAAA
AACCGTACTACCCGGTTCATCCTCCCGTTCGCCCTGGTTTTCGGAGGTGGTGTCGGCAATATGATTGACCGGATAACGGG
AGGAAAAGTGATCGACTTTATTCATATCGACCTTTATAACGGAATGATCATGGGAACTTGGGTTTCGCTGTGGCCGATCT
TCAACATTGCGGATTCAGCAATCACTATTGGTGCCTGTTTACTGATTCTTTTTCACAGCACCATTTTTCCTGACCAGTCA
GTTCAAAAAAACACCGATGTTCATTGA

Upstream 100 bases:

>100_bases
AGCAAGTCAGAGCTGTTCTGATAAATAATCTGCTCTCCTCTCCATAATAATTCTATATACTGCAACAAGAGAATCATACA
AACACCATAATTTTTTTTCC

Downstream 100 bases:

>100_bases
TGCCCACTGTCATCTTTCGTTTCCGGAATTTGACCAGGATCGTTCCGAGGTGATCGAACGTCTCAATGCAGGGGGAATTT
CTCTGCTGATCGACCCGGGA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MNWFFTLASIVIVLDQLTKKIAVMILKEKESVTLIPDWLKFTYAENNGIAFGMEFAPKEVMILLVGTISLLIALYVFRSK
NRTTRFILPFALVFGGGVGNMIDRITGGKVIDFIHIDLYNGMIMGTWVSLWPIFNIADSAITIGACLLILFHSTIFPDQS
VQKNTDVH

Sequences:

>Translated_168_residues
MNWFFTLASIVIVLDQLTKKIAVMILKEKESVTLIPDWLKFTYAENNGIAFGMEFAPKEVMILLVGTISLLIALYVFRSK
NRTTRFILPFALVFGGGVGNMIDRITGGKVIDFIHIDLYNGMIMGTWVSLWPIFNIADSAITIGACLLILFHSTIFPDQS
VQKNTDVH
>Mature_168_residues
MNWFFTLASIVIVLDQLTKKIAVMILKEKESVTLIPDWLKFTYAENNGIAFGMEFAPKEVMILLVGTISLLIALYVFRSK
NRTTRFILPFALVFGGGVGNMIDRITGGKVIDFIHIDLYNGMIMGTWVSLWPIFNIADSAITIGACLLILFHSTIFPDQS
VQKNTDVH

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=148, Percent_Identity=31.7567567567568, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_CHLPD (A1BED5)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911186.1
- STRING:   A1BED5
- MEROPS:   A08.001
- GeneID:   4569881
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0707
- NMPDR:   fig|290317.7.peg.742
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   NFELRES
- ProtClustDB:   PRK14787
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18847; Mature: 18847

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 103-103 ACT_SITE 138-138

Signals:

None

Transmembrane regions:

HASH(0xfac454c)-; HASH(0xfe9de18)-; HASH(0xfe04dc0)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWFFTLASIVIVLDQLTKKIAVMILKEKESVTLIPDWLKFTYAENNGIAFGMEFAPKEV
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEHHHEEEEECCCCEEEEECCCCHHH
MILLVGTISLLIALYVFRSKNRTTRFILPFALVFGGGVGNMIDRITGGKVIDFIHIDLYN
HHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEEHHC
GMIMGTWVSLWPIFNIADSAITIGACLLILFHSTIFPDQSVQKNTDVH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure
MNWFFTLASIVIVLDQLTKKIAVMILKEKESVTLIPDWLKFTYAENNGIAFGMEFAPKEV
CCHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEHHHEEEEECCCCEEEEECCCCHHH
MILLVGTISLLIALYVFRSKNRTTRFILPFALVFGGGVGNMIDRITGGKVIDFIHIDLYN
HHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEEEHHC
GMIMGTWVSLWPIFNIADSAITIGACLLILFHSTIFPDQSVQKNTDVH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA