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The map label for this gene is purE [H]

Identifier: 119356449

GI number: 119356449

Start: 684476

End: 685003

Strand: Reverse

Name: purE [H]

Synonym: Cpha266_0613

Alternate gene names: 119356449

Gene position: 685003-684476 (Counterclockwise)

Preceding gene: 119356454

Following gene: 119356448

Centisome position: 21.86

GC content: 50.95

Gene sequence:

>528_bases
ATGACACAAACAATCTCTGATCAATTCAAGCCTGTTGTAGGTATCCTCATGGGCTCCGATTCCGACTTCGACATTATGAA
AGCAGCCACAACGGTTCTCGACGATTTCGCAGTCCCGTATGAAGTATCGGTTATTTCAGCGCACCGAACCCCGCACGACC
TTGAAACCTATGCCACATCGGCCCAGGAACGCGGTCTTAAAATCATCATAGCCGGAGCTGGCGGAGCAGCACATCTGCCA
GGCGTTACGGCAGCCTTGACTCTTCTTCCGGTTATCGGTGTTCCGGTTTTCAGCAAAAAGCTGAGCGGCCTGGACTCCCT
CTACTCGATCGTGCAGATGCCTGCAGGTATTCCCGTAGCGACCGTAGGTATTGATAATGCCCGAAATGCGGCGCTCCTTG
CCCTGCAGATGCTCGCGCTTTCCGATGAAGTTCTGATGCAGGCAATCAAAGCATTCCGTCTTGGGCTTGCAGAGGAATCA
AGGCTGAAAAACGAAAATATAAAACATAAACTACGTGCAAAAAGCTGA

Upstream 100 bases:

>100_bases
TGTCTGATACTGTGGAAAATACATAAAACTCGACAATTTCATAAATTCATCCCATCTTACAAACAGACCGCCTTTATATG
CCGTCAGCTCATTTATTTTT

Downstream 100 bases:

>100_bases
GTTCTGGATAACGCACCTGGCGTTGCAGCAACATCCTGAAGGAGGCTTCTACCGGGAAACATACCGAAATAGAGGGGGCT
ATGATTTCACAGGAAGCACT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MTQTISDQFKPVVGILMGSDSDFDIMKAATTVLDDFAVPYEVSVISAHRTPHDLETYATSAQERGLKIIIAGAGGAAHLP
GVTAALTLLPVIGVPVFSKKLSGLDSLYSIVQMPAGIPVATVGIDNARNAALLALQMLALSDEVLMQAIKAFRLGLAEES
RLKNENIKHKLRAKS

Sequences:

>Translated_175_residues
MTQTISDQFKPVVGILMGSDSDFDIMKAATTVLDDFAVPYEVSVISAHRTPHDLETYATSAQERGLKIIIAGAGGAAHLP
GVTAALTLLPVIGVPVFSKKLSGLDSLYSIVQMPAGIPVATVGIDNARNAALLALQMLALSDEVLMQAIKAFRLGLAEES
RLKNENIKHKLRAKS
>Mature_174_residues
TQTISDQFKPVVGILMGSDSDFDIMKAATTVLDDFAVPYEVSVISAHRTPHDLETYATSAQERGLKIIIAGAGGAAHLPG
VTAALTLLPVIGVPVFSKKLSGLDSLYSIVQMPAGIPVATVGIDNARNAALLALQMLALSDEVLMQAIKAFRLGLAEESR
LKNENIKHKLRAKS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=60.9090909090909, Blast_Score=136, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6324702, Length=159, Percent_Identity=57.8616352201258, Blast_Score=188, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18553; Mature: 18422

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTISDQFKPVVGILMGSDSDFDIMKAATTVLDDFAVPYEVSVISAHRTPHDLETYATS
CCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
AQERGLKIIIAGAGGAAHLPGVTAALTLLPVIGVPVFSKKLSGLDSLYSIVQMPAGIPVA
HHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEE
TVGIDNARNAALLALQMLALSDEVLMQAIKAFRLGLAEESRLKNENIKHKLRAKS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCC
>Mature Secondary Structure 
TQTISDQFKPVVGILMGSDSDFDIMKAATTVLDDFAVPYEVSVISAHRTPHDLETYATS
CCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
AQERGLKIIIAGAGGAAHLPGVTAALTLLPVIGVPVFSKKLSGLDSLYSIVQMPAGIPVA
HHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEE
TVGIDNARNAALLALQMLALSDEVLMQAIKAFRLGLAEESRLKNENIKHKLRAKS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]