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The map label for this gene is gcvPA

Identifier: 119356410

GI number: 119356410

Start: 644897

End: 646231

Strand: Direct

Name: gcvPA

Synonym: Cpha266_0574

Alternate gene names: 119356410

Gene position: 644897-646231 (Clockwise)

Preceding gene: 119356409

Following gene: 119356415

Centisome position: 20.58

GC content: 49.81

Gene sequence:

>1335_bases
ATGCCATTCATTGTCAATACCGATCAGGATACCAGAGAGATGCTTTCAGTTTTGGGTGCAGCTTCGTTTGACGAGCTCAT
TCCTGACATTCCTGAAGAGATCCGACTGAAAAAAGCCCTGGATCTCTTTCCCGCAATGAGCGAACAGGAGGTGAAGCGGC
TGCTTGAAGGCCTTGCTTCTTCCAACACCAGTACCTCAGACTATGTGAGCTATCTCGGCGGTGGCGCTTACGATCATTTT
ATTCCATCGGCAATCAAGACCATCGTTTCCCGAAGTGAATTCTATACGGCATACACCCCTTATCAGGCGGAGGTTTCTCA
GGGTACGCTTCAGGCGATTTATGAGTATCAGAGTCTGATGTGTCGCCTGTACGACATGGATGTGGCCAATGCGTCGATGT
ATGATGGAGCCACAGCGCTTGCCGAGGCGGTACTGATGGCAATAAGTGTTACCGGACGTCAGGAGGTAATCGTAGCCGGC
AAACTGCATCCTCACTATTGCGAAGTATTGAAAACCTATCTGGAGGCAGGCGGGCACAGCGCTGTCGTTCAGAATACGCT
GGAAAATGGCGTTGGAACTCTTGACGGGCTTGGTGCGCTCTTGACAGACCGATGTGCAGCAGTCATTGTTCAGCAGCCAA
ATTTTTACGGCTCTCTGGAGGATGTTGAGGCTATAGGGGAACTTGCGCACAGCAAGGGCGCTCTTTTTGTCGTTTCAGCA
GACCCGGTTTCCCTTGGACTTCTTGCGGCTCCGGGTAGTTATGGTGCCGATATAGCTGTCGGTGAAGGTCAACCACTTGG
AAATGCCCAGAGTTTCGGCGGCCCCTACCTTGGGATTTTTACCGTTAAACAGGATCTTGTCCGCAAGATTCCCGGACGTC
TGGTTGGAATGACTAAAGACCGGAATGGAGACGATGGTTTTATTCTGACACTGCAAACTCGCGAACAGCATATAAGAAGG
GAAAAAGCCACCTCGAACATCTGTACCAATCAGGCGCTTAACGCGCTGCACGCGGCAATCTATCTCTCTTTGCTCGGCAA
ACAGGGAATTATTGACGTTGCAGAGCAATCTGCTCTGAAATCGCACTACCTTGCTGAACAAATTGCCGATATTCCAGGTT
TTTCGCTTAAATACAGCGCACCTTTTTTCCGTGAATTTGTCGTTGAAACGCCGATGGCGGCCAGAGAGGTAATCAGCAAT
CTTCTCGAAAAGAAAATATTTGCCGGTTGCGATCTTTCCGTGTACGATGAAGCCGGTCTGCTTGTTGCCGTTACGGAAAA
ACGTACCAAAGCGGAGCTTGACGCTTTTGTGGAATACCTCGGGGCTCTTAAATAA

Upstream 100 bases:

>100_bases
ATGATGCAAAAGCGGTAGAAGAGCTGCTTGATGCCGCCTCTTACCGCCAACTGATTGGCGCGTGACACTTTTTTAAACCT
CTGTTTTTCATTACATAGCA

Downstream 100 bases:

>100_bases
GCCCGAGGAACTCCATCTCTTTTTTCAGGACAGCCTTGTTTTCATCGGATAACGGGACAAGCGGCAGTCGGTAGTTCTCC
TCAATCATTCCCATCAGGGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPFIVNTDQDTREMLSVLGAASFDELIPDIPEEIRLKKALDLFPAMSEQEVKRLLEGLASSNTSTSDYVSYLGGGAYDHF
IPSAIKTIVSRSEFYTAYTPYQAEVSQGTLQAIYEYQSLMCRLYDMDVANASMYDGATALAEAVLMAISVTGRQEVIVAG
KLHPHYCEVLKTYLEAGGHSAVVQNTLENGVGTLDGLGALLTDRCAAVIVQQPNFYGSLEDVEAIGELAHSKGALFVVSA
DPVSLGLLAAPGSYGADIAVGEGQPLGNAQSFGGPYLGIFTVKQDLVRKIPGRLVGMTKDRNGDDGFILTLQTREQHIRR
EKATSNICTNQALNALHAAIYLSLLGKQGIIDVAEQSALKSHYLAEQIADIPGFSLKYSAPFFREFVVETPMAAREVISN
LLEKKIFAGCDLSVYDEAGLLVAVTEKRTKAELDAFVEYLGALK

Sequences:

>Translated_444_residues
MPFIVNTDQDTREMLSVLGAASFDELIPDIPEEIRLKKALDLFPAMSEQEVKRLLEGLASSNTSTSDYVSYLGGGAYDHF
IPSAIKTIVSRSEFYTAYTPYQAEVSQGTLQAIYEYQSLMCRLYDMDVANASMYDGATALAEAVLMAISVTGRQEVIVAG
KLHPHYCEVLKTYLEAGGHSAVVQNTLENGVGTLDGLGALLTDRCAAVIVQQPNFYGSLEDVEAIGELAHSKGALFVVSA
DPVSLGLLAAPGSYGADIAVGEGQPLGNAQSFGGPYLGIFTVKQDLVRKIPGRLVGMTKDRNGDDGFILTLQTREQHIRR
EKATSNICTNQALNALHAAIYLSLLGKQGIIDVAEQSALKSHYLAEQIADIPGFSLKYSAPFFREFVVETPMAAREVISN
LLEKKIFAGCDLSVYDEAGLLVAVTEKRTKAELDAFVEYLGALK
>Mature_443_residues
PFIVNTDQDTREMLSVLGAASFDELIPDIPEEIRLKKALDLFPAMSEQEVKRLLEGLASSNTSTSDYVSYLGGGAYDHFI
PSAIKTIVSRSEFYTAYTPYQAEVSQGTLQAIYEYQSLMCRLYDMDVANASMYDGATALAEAVLMAISVTGRQEVIVAGK
LHPHYCEVLKTYLEAGGHSAVVQNTLENGVGTLDGLGALLTDRCAAVIVQQPNFYGSLEDVEAIGELAHSKGALFVVSAD
PVSLGLLAAPGSYGADIAVGEGQPLGNAQSFGGPYLGIFTVKQDLVRKIPGRLVGMTKDRNGDDGFILTLQTREQHIRRE
KATSNICTNQALNALHAAIYLSLLGKQGIIDVAEQSALKSHYLAEQIADIPGFSLKYSAPFFREFVVETPMAAREVISNL
LEKKIFAGCDLSVYDEAGLLVAVTEKRTKAELDAFVEYLGALK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=437, Percent_Identity=34.324942791762, Blast_Score=250, Evalue=2e-66,
Organism=Escherichia coli, GI1789269, Length=383, Percent_Identity=34.9869451697128, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=368, Percent_Identity=37.5, Blast_Score=224, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6323843, Length=357, Percent_Identity=34.453781512605, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24645648, Length=349, Percent_Identity=40.4011461318052, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_CHLPD (A1BE03)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911054.1
- ProteinModelPortal:   A1BE03
- SMR:   A1BE03
- STRING:   A1BE03
- GeneID:   4569169
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0574
- NMPDR:   fig|290317.7.peg.602
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 47961; Mature: 47830

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFIVNTDQDTREMLSVLGAASFDELIPDIPEEIRLKKALDLFPAMSEQEVKRLLEGLAS
CCEEECCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
SNTSTSDYVSYLGGGAYDHFIPSAIKTIVSRSEFYTAYTPYQAEVSQGTLQAIYEYQSLM
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHH
CRLYDMDVANASMYDGATALAEAVLMAISVTGRQEVIVAGKLHPHYCEVLKTYLEAGGHS
HHHHHCCCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCH
AVVQNTLENGVGTLDGLGALLTDRCAAVIVQQPNFYGSLEDVEAIGELAHSKGALFVVSA
HHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEC
DPVSLGLLAAPGSYGADIAVGEGQPLGNAQSFGGPYLGIFTVKQDLVRKIPGRLVGMTKD
CCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEECCCC
RNGDDGFILTLQTREQHIRREKATSNICTNQALNALHAAIYLSLLGKQGIIDVAEQSALK
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SHYLAEQIADIPGFSLKYSAPFFREFVVETPMAAREVISNLLEKKIFAGCDLSVYDEAGL
HHHHHHHHHCCCCCCEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCE
LVAVTEKRTKAELDAFVEYLGALK
EEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PFIVNTDQDTREMLSVLGAASFDELIPDIPEEIRLKKALDLFPAMSEQEVKRLLEGLAS
CEEECCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
SNTSTSDYVSYLGGGAYDHFIPSAIKTIVSRSEFYTAYTPYQAEVSQGTLQAIYEYQSLM
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHH
CRLYDMDVANASMYDGATALAEAVLMAISVTGRQEVIVAGKLHPHYCEVLKTYLEAGGHS
HHHHHCCCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCH
AVVQNTLENGVGTLDGLGALLTDRCAAVIVQQPNFYGSLEDVEAIGELAHSKGALFVVSA
HHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEC
DPVSLGLLAAPGSYGADIAVGEGQPLGNAQSFGGPYLGIFTVKQDLVRKIPGRLVGMTKD
CCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEECCCC
RNGDDGFILTLQTREQHIRREKATSNICTNQALNALHAAIYLSLLGKQGIIDVAEQSALK
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SHYLAEQIADIPGFSLKYSAPFFREFVVETPMAAREVISNLLEKKIFAGCDLSVYDEAGL
HHHHHHHHHCCCCCCEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCE
LVAVTEKRTKAELDAFVEYLGALK
EEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA