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The map label for this gene is panC

Identifier: 119356389

GI number: 119356389

Start: 617598

End: 618449

Strand: Reverse

Name: panC

Synonym: Cpha266_0553

Alternate gene names: 119356389

Gene position: 618449-617598 (Counterclockwise)

Preceding gene: 119356390

Following gene: 119356388

Centisome position: 19.73

GC content: 51.17

Gene sequence:

>852_bases
ATGCAGATCATTACTGACCCCATACAGATGCAGGCTATTGCTGAAAAACTCCGACTCAACCGTCAGCTTATCGGCGTTGT
CATGACCATGGGAGCCCTGCATGAAGGGCATCTGAGTCTGATTAAAGAGGCCCGCAAAATCGCCGGCACCATTATTCTCA
CCATATTTGTCAATCCGAGACAATTCGCTCCCCACGAAGATTTCCACCGCTATCCGAGGCCTTTTGAACAGGATGCCGCA
CACGCAAAGGCAGCAGAAGTGGACTACGTTTTTGCTCCGCCGGTTGATGCAATGTATACAGGAAACTTTCAGACAACGGT
TCATCCCGGCCCTCTTGGCGAACAGTTCGAAGGAAAACAGCGACCCGGACACTTCAGCGGCGTAGCAACCATCGTCACCA
AGCTTCTGCAGATAACCAGACCGCATATCGCCGTTTTCGGAGAAAAAGATGCCCAGCAGCTCGCTGTTATCAAGCAGCTT
GTCAAAGATCTTAACATCGATGTCCGGATAATCGAGGCGCCTATCATACGGGATGAAAACGGACTGGCCGTAAGTTCAAG
AAACATCTATCTCTCCGCAAAAGAACGGGATGCCGCCACCGTTCTATACAAAGGGCTCTGCCATGCTGAGCGGCGGATTG
CCGAACCGTGCCTCGACCTGGACGCGATCGTTCCGGAGGTTGAAAACATCATCAAATCGGCGCTCTCCTGCCACCCGGAA
TACATCTGTTTTGTTGATGACGAAACTTTTCTGCCTGCATCAAAAGCGGAAAAGGGAAAAACCTACCGTCTGCTGCTTGC
AGTTCAGGCCGGTACGGTCAGGCTCATCGATAACAGGAAGTTCATGGTATAA

Upstream 100 bases:

>100_bases
GACGCTCTTCGGGAACGGCTCGAACATGAAACAATACGGGGAGAATTTGTCGTTGTCGTTAATCCGGCATGCAAAAAAAA
CAAAAAAACCGAACAGGACA

Downstream 100 bases:

>100_bases
GCGACACGGAGATGACCGTTATCGGAAAACACTTTTTTGTATTATATTTAAGAACCAGTTGTTTTTCTGTTTAACCGTCA
GAACGGTCATAATGCAACAC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MQIITDPIQMQAIAEKLRLNRQLIGVVMTMGALHEGHLSLIKEARKIAGTIILTIFVNPRQFAPHEDFHRYPRPFEQDAA
HAKAAEVDYVFAPPVDAMYTGNFQTTVHPGPLGEQFEGKQRPGHFSGVATIVTKLLQITRPHIAVFGEKDAQQLAVIKQL
VKDLNIDVRIIEAPIIRDENGLAVSSRNIYLSAKERDAATVLYKGLCHAERRIAEPCLDLDAIVPEVENIIKSALSCHPE
YICFVDDETFLPASKAEKGKTYRLLLAVQAGTVRLIDNRKFMV

Sequences:

>Translated_283_residues
MQIITDPIQMQAIAEKLRLNRQLIGVVMTMGALHEGHLSLIKEARKIAGTIILTIFVNPRQFAPHEDFHRYPRPFEQDAA
HAKAAEVDYVFAPPVDAMYTGNFQTTVHPGPLGEQFEGKQRPGHFSGVATIVTKLLQITRPHIAVFGEKDAQQLAVIKQL
VKDLNIDVRIIEAPIIRDENGLAVSSRNIYLSAKERDAATVLYKGLCHAERRIAEPCLDLDAIVPEVENIIKSALSCHPE
YICFVDDETFLPASKAEKGKTYRLLLAVQAGTVRLIDNRKFMV
>Mature_283_residues
MQIITDPIQMQAIAEKLRLNRQLIGVVMTMGALHEGHLSLIKEARKIAGTIILTIFVNPRQFAPHEDFHRYPRPFEQDAA
HAKAAEVDYVFAPPVDAMYTGNFQTTVHPGPLGEQFEGKQRPGHFSGVATIVTKLLQITRPHIAVFGEKDAQQLAVIKQL
VKDLNIDVRIIEAPIIRDENGLAVSSRNIYLSAKERDAATVLYKGLCHAERRIAEPCLDLDAIVPEVENIIKSALSCHPE
YICFVDDETFLPASKAEKGKTYRLLLAVQAGTVRLIDNRKFMV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=280, Percent_Identity=40.7142857142857, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322046, Length=283, Percent_Identity=37.4558303886926, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CHLPD (A1BDY2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911033.1
- ProteinModelPortal:   A1BDY2
- SMR:   A1BDY2
- STRING:   A1BDY2
- GeneID:   4569420
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0553
- NMPDR:   fig|290317.7.peg.579
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31597; Mature: 31597

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIITDPIQMQAIAEKLRLNRQLIGVVMTMGALHEGHLSLIKEARKIAGTIILTIFVNPR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCEEEEEEEECCC
QFAPHEDFHRYPRPFEQDAAHAKAAEVDYVFAPPVDAMYTGNFQTTVHPGPLGEQFEGKQ
CCCCCHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCCEEECCEEEEECCCCCCCCCCCCC
RPGHFSGVATIVTKLLQITRPHIAVFGEKDAQQLAVIKQLVKDLNIDVRIIEAPIIRDEN
CCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCEEECCC
GLAVSSRNIYLSAKERDAATVLYKGLCHAERRIAEPCLDLDAIVPEVENIIKSALSCHPE
CCEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YICFVDDETFLPASKAEKGKTYRLLLAVQAGTVRLIDNRKFMV
EEEEECCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCCCCC
>Mature Secondary Structure
MQIITDPIQMQAIAEKLRLNRQLIGVVMTMGALHEGHLSLIKEARKIAGTIILTIFVNPR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCEEEEEEEECCC
QFAPHEDFHRYPRPFEQDAAHAKAAEVDYVFAPPVDAMYTGNFQTTVHPGPLGEQFEGKQ
CCCCCHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCCEEECCEEEEECCCCCCCCCCCCC
RPGHFSGVATIVTKLLQITRPHIAVFGEKDAQQLAVIKQLVKDLNIDVRIIEAPIIRDEN
CCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCEEECCC
GLAVSSRNIYLSAKERDAATVLYKGLCHAERRIAEPCLDLDAIVPEVENIIKSALSCHPE
CCEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YICFVDDETFLPASKAEKGKTYRLLLAVQAGTVRLIDNRKFMV
EEEEECCCCCCCCCCCCCCCEEEEEEEEECCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA