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The map label for this gene is lpxC/fabZ [H]

Identifier: 119356378

GI number: 119356378

Start: 595389

End: 596792

Strand: Reverse

Name: lpxC/fabZ [H]

Synonym: Cpha266_0541

Alternate gene names: 119356378

Gene position: 596792-595389 (Counterclockwise)

Preceding gene: 119356379

Following gene: 119356374

Centisome position: 19.04

GC content: 48.93

Gene sequence:

>1404_bases
ATGCTCATTCATCAGCGTACACTTCAAAAAGAGGTCTCTCTGCGGGGTACCGGCCTGCATACCGGAAAGGAATGCAGAAT
CACCTTTAAACCTGCTCCGGTAAACTACGGGTACCGCTTTATCCGTTCCGATATTGAAAACAGTCCGGAAATACCCGCAC
TTATCGACAATGTAGTCGACGTGCTTCGTGGAACAACCATCGGTATCAACGGCGTCAATGTCCACACCACCGAACATGTG
CTCGCAGCGCTCTACGGCCTTCAGATTGATAACTGCTCGATCGAAATGAGCGGCCCCGAACCCCCCGTAATGGATGGCAG
CTCCCTGCCGTTTGCCGAAGCTCTGCTCAGTGCAGGCATTGCAAAACAGGATGAGCCGAAAAATTATCTTGTCATTGATG
AAACCGTCGAGTTCCATGACACAGTCAACACCGTTGATATCGTTGCCCTCCCGCTCGACAGCTTCAGGGTCACCGTGATG
GTGGATTACAAAAACCCGGCGCTCGGATCACAGCACTCGGGGCTGTTTGACCTTGAAAAAGAGTTTCTCAAAGATTTTGC
GCCATCAAGAACATTCTGTTTTCTGAGTGAAGTCGAAACCCTTGCAAACCAGGGCATTATCAAAGGAGGCGATATCGATA
ACGCCGTTGTCATTGTCGATAAATCCATGAACAACGAGGAACTGCAAAGCCTTGCAGGAAAACTCGATCTTGAGCATGAT
CATCTTGCCATAGGTGAAAACGGCATTCTCAACAACAGAGCGTTACGGTTCCAGAACGAACCTGCCCGTCATAAACTTCT
TGACCTGCTCGGCGATATCGCCCTGCTCGGCATGCCTTTAAGAGCGCAGGTTCTTGCCGCGCGTCCCGGTCACGCATCAA
ATGTTGAATTTGTCAAGCAACTGAAAAAATACGCAGACCGCAACAAACTTGCCCGGCAATACCAGCACGAAAAAAAGGCA
GGCGTCATTTTTGACATCAACGCCATTCAGAACATTCTGCCTCATCGTTATCCATTTCTCCTGATCGACAAGATTGTTGA
GTTCAAGCTTGATGAGAAAATCGTCTCCATCAAGAACGTGACCATGAACGAACCATTCTTTCAGGGCCACTTTCCAGGAA
ATCCCGTTATGCCCGGCGTGCTGATCATCGAAGCCATGGCTCAGACCGGAGGCATCATGATGCTTAACGGAACCGAAAAT
ATTCAGGAAATGCTTGTGTATTTCATGGGCATTGACAAAGCCCGATTCCGCAAACCGGTTTTACCGGGAGATACGCTCGT
TATCGAAGCGGTAATGACCAACAAGCGAAGAAGCGTATGTCAGTTCGACGCAAAAGCATATGTCCGCGGTGAACTTGTTT
GTGAAGCGTCACTTATGGCAACGGTAATGCCGAAAACAAAGTAA

Upstream 100 bases:

>100_bases
AAGCCATTCTTTATTATCTTTAAAGTCTATAATTTTCTGCTCTTGCAGTTTGCTTTCATTTCCTGTCTAACATTTCAAGA
TCAGGAACAACAATCCCACT

Downstream 100 bases:

>100_bases
ACGGCAGCGCTGCCCTGCTGCTGAAAGGCAGGGCAGCGCATACTTGTTTATAAAAACATGCCCGTCCACATCTCACAACC
CCCGCTGCGAACCGGTTTTT

Product: bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Products: NA

Alternate protein names: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MLIHQRTLQKEVSLRGTGLHTGKECRITFKPAPVNYGYRFIRSDIENSPEIPALIDNVVDVLRGTTIGINGVNVHTTEHV
LAALYGLQIDNCSIEMSGPEPPVMDGSSLPFAEALLSAGIAKQDEPKNYLVIDETVEFHDTVNTVDIVALPLDSFRVTVM
VDYKNPALGSQHSGLFDLEKEFLKDFAPSRTFCFLSEVETLANQGIIKGGDIDNAVVIVDKSMNNEELQSLAGKLDLEHD
HLAIGENGILNNRALRFQNEPARHKLLDLLGDIALLGMPLRAQVLAARPGHASNVEFVKQLKKYADRNKLARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEPFFQGHFPGNPVMPGVLIIEAMAQTGGIMMLNGTEN
IQEMLVYFMGIDKARFRKPVLPGDTLVIEAVMTNKRRSVCQFDAKAYVRGELVCEASLMATVMPKTK

Sequences:

>Translated_467_residues
MLIHQRTLQKEVSLRGTGLHTGKECRITFKPAPVNYGYRFIRSDIENSPEIPALIDNVVDVLRGTTIGINGVNVHTTEHV
LAALYGLQIDNCSIEMSGPEPPVMDGSSLPFAEALLSAGIAKQDEPKNYLVIDETVEFHDTVNTVDIVALPLDSFRVTVM
VDYKNPALGSQHSGLFDLEKEFLKDFAPSRTFCFLSEVETLANQGIIKGGDIDNAVVIVDKSMNNEELQSLAGKLDLEHD
HLAIGENGILNNRALRFQNEPARHKLLDLLGDIALLGMPLRAQVLAARPGHASNVEFVKQLKKYADRNKLARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEPFFQGHFPGNPVMPGVLIIEAMAQTGGIMMLNGTEN
IQEMLVYFMGIDKARFRKPVLPGDTLVIEAVMTNKRRSVCQFDAKAYVRGELVCEASLMATVMPKTK
>Mature_467_residues
MLIHQRTLQKEVSLRGTGLHTGKECRITFKPAPVNYGYRFIRSDIENSPEIPALIDNVVDVLRGTTIGINGVNVHTTEHV
LAALYGLQIDNCSIEMSGPEPPVMDGSSLPFAEALLSAGIAKQDEPKNYLVIDETVEFHDTVNTVDIVALPLDSFRVTVM
VDYKNPALGSQHSGLFDLEKEFLKDFAPSRTFCFLSEVETLANQGIIKGGDIDNAVVIVDKSMNNEELQSLAGKLDLEHD
HLAIGENGILNNRALRFQNEPARHKLLDLLGDIALLGMPLRAQVLAARPGHASNVEFVKQLKKYADRNKLARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEPFFQGHFPGNPVMPGVLIIEAMAQTGGIMMLNGTEN
IQEMLVYFMGIDKARFRKPVLPGDTLVIEAVMTNKRRSVCQFDAKAYVRGELVCEASLMATVMPKTK

Specific function: Involved in saturated fatty acids biosynthesis [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thioester dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=303, Percent_Identity=33.003300330033, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1786377, Length=137, Percent_Identity=47.4452554744526, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013114
- InterPro:   IPR010084
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF07977 FabA; PF03331 LpxC [H]

EC number: 3.5.1.-; 4.2.1.-

Molecular weight: Translated: 51887; Mature: 51887

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIHQRTLQKEVSLRGTGLHTGKECRITFKPAPVNYGYRFIRSDIENSPEIPALIDNVVD
CCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
VLRGTTIGINGVNVHTTEHVLAALYGLQIDNCSIEMSGPEPPVMDGSSLPFAEALLSAGI
HHCCCEEECCCCEECHHHHHHHHHHCCEECCEEEECCCCCCCCCCCCCCCHHHHHHHCCC
AKQDEPKNYLVIDETVEFHDTVNTVDIVALPLDSFRVTVMVDYKNPALGSQHSGLFDLEK
CCCCCCCCEEEEECCEECCCCCCEEEEEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHH
EFLKDFAPSRTFCFLSEVETLANQGIIKGGDIDNAVVIVDKSMNNEELQSLAGKLDLEHD
HHHHHCCCCCEEEHHHHHHHHHHCCCEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCC
HLAIGENGILNNRALRFQNEPARHKLLDLLGDIALLGMPLRAQVLAARPGHASNVEFVKQ
EEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCHHHHHH
LKKYADRNKLARQYQHEKKAGVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNV
HHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCHHEEEECC
TMNEPFFQGHFPGNPVMPGVLIIEAMAQTGGIMMLNGTENIQEMLVYFMGIDKARFRKPV
CCCCCCEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCHHHHCCCC
LPGDTLVIEAVMTNKRRSVCQFDAKAYVRGELVCEASLMATVMPKTK
CCCCCEEEEEECCCCCHHHHHHCCHHEEEEEEEEEHHHHHHHCCCCC
>Mature Secondary Structure
MLIHQRTLQKEVSLRGTGLHTGKECRITFKPAPVNYGYRFIRSDIENSPEIPALIDNVVD
CCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
VLRGTTIGINGVNVHTTEHVLAALYGLQIDNCSIEMSGPEPPVMDGSSLPFAEALLSAGI
HHCCCEEECCCCEECHHHHHHHHHHCCEECCEEEECCCCCCCCCCCCCCCHHHHHHHCCC
AKQDEPKNYLVIDETVEFHDTVNTVDIVALPLDSFRVTVMVDYKNPALGSQHSGLFDLEK
CCCCCCCCEEEEECCEECCCCCCEEEEEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHH
EFLKDFAPSRTFCFLSEVETLANQGIIKGGDIDNAVVIVDKSMNNEELQSLAGKLDLEHD
HHHHHCCCCCEEEHHHHHHHHHHCCCEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCC
HLAIGENGILNNRALRFQNEPARHKLLDLLGDIALLGMPLRAQVLAARPGHASNVEFVKQ
EEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCHHHHHH
LKKYADRNKLARQYQHEKKAGVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNV
HHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCHHEEEECC
TMNEPFFQGHFPGNPVMPGVLIIEAMAQTGGIMMLNGTENIQEMLVYFMGIDKARFRKPV
CCCCCCEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCHHHHCCCC
LPGDTLVIEAVMTNKRRSVCQFDAKAYVRGELVCEASLMATVMPKTK
CCCCCEEEEEECCCCCHHHHHHCCHHEEEEEEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]