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The map label for this gene is trpC

Identifier: 119356368

GI number: 119356368

Start: 584409

End: 585185

Strand: Direct

Name: trpC

Synonym: Cpha266_0531

Alternate gene names: 119356368

Gene position: 584409-585185 (Clockwise)

Preceding gene: 119356367

Following gene: 119356375

Centisome position: 18.65

GC content: 49.68

Gene sequence:

>777_bases
ATGACCTATCTGTCAAGGATTCTCGAAGAGAAGCGCCAGGCTGTGCTTGCGTTGAAGCAACAGCGGCCGCTTCAGCACTA
TCTTGAACAGGAAACAGAGCTTTCGCCGTGCAGGGATTTTCAGGGCTGCCTGAAACGTTCTGTTGACAGGATAAAGCTGA
TAGCCGAAATAAAAAAAGCCTCACCATCACGCGGTCTTATTGTAAGCGATTTTAAGCCGCTGGAAATGGCCCGGCGTTAT
ATGGATCTTGGCGCATCAGCTTTTTCCGTACTGACCGAAGAGGTGTTTTTTCAGGGCTCTCCGGATTATCTTAAAGAGGT
ACGTCGAGCTTTTTCCCTGCCTGTATTGCGCAAGGATTTTATCCTGGATGAATGTCAGATATTCGAATCGCGCCTGATGG
GTGCCGATGCCATATTGCTTATCGTTGCAGCGCTTGATCCACACCAGTTACAGGATTATCTCGATCTTGCTCGTCAAACA
GGGCTGCACGTGCTTGTTGAAGTTCATGATCACAGGGAGCTCGATATCGCACTTAATGCAGGATCCATGATCATCGGCAT
CAACAACAGGGATCTTAGGGACTTCAGCGTTAATCTCCACACCTCGATCAAGCTGCGGCCGTACATCCCGGAGGGGATTG
TTTCTGTTTCGGAAAGCGGCGTCAAAACTGCCGCCGACGCAGCTCTTCTCGACAATGCATCGTTTGATGCTGTACTTATC
GGTGAAGGGCTGCATGTGAGCGAAGACCTTAAGCGGGTTATCTGGACTGAGACTTGA

Upstream 100 bases:

>100_bases
ATCAGGCTACAGGCATTGATCCATGGTTTCTTGATAATATCCGTCAGATCGTGGAGTTTGAATCAGGGCTCAGGGAACTG
GCCGCTCAGGATTGAGCGAT

Downstream 100 bases:

>100_bases
GTTTTCTTGCAGCTTCAGCAGGATCAGCAGCCTTGAAAAACGCAGTGCCGGCAATCAGCGCATCAGCTCCGGCATCAACC
ACCACTCCCGCATTATCCTC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTYLSRILEEKRQAVLALKQQRPLQHYLEQETELSPCRDFQGCLKRSVDRIKLIAEIKKASPSRGLIVSDFKPLEMARRY
MDLGASAFSVLTEEVFFQGSPDYLKEVRRAFSLPVLRKDFILDECQIFESRLMGADAILLIVAALDPHQLQDYLDLARQT
GLHVLVEVHDHRELDIALNAGSMIIGINNRDLRDFSVNLHTSIKLRPYIPEGIVSVSESGVKTAADAALLDNASFDAVLI
GEGLHVSEDLKRVIWTET

Sequences:

>Translated_258_residues
MTYLSRILEEKRQAVLALKQQRPLQHYLEQETELSPCRDFQGCLKRSVDRIKLIAEIKKASPSRGLIVSDFKPLEMARRY
MDLGASAFSVLTEEVFFQGSPDYLKEVRRAFSLPVLRKDFILDECQIFESRLMGADAILLIVAALDPHQLQDYLDLARQT
GLHVLVEVHDHRELDIALNAGSMIIGINNRDLRDFSVNLHTSIKLRPYIPEGIVSVSESGVKTAADAALLDNASFDAVLI
GEGLHVSEDLKRVIWTET
>Mature_257_residues
TYLSRILEEKRQAVLALKQQRPLQHYLEQETELSPCRDFQGCLKRSVDRIKLIAEIKKASPSRGLIVSDFKPLEMARRYM
DLGASAFSVLTEEVFFQGSPDYLKEVRRAFSLPVLRKDFILDECQIFESRLMGADAILLIVAALDPHQLQDYLDLARQTG
LHVLVEVHDHRELDIALNAGSMIIGINNRDLRDFSVNLHTSIKLRPYIPEGIVSVSESGVKTAADAALLDNASFDAVLIG
EGLHVSEDLKRVIWTET

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=262, Percent_Identity=38.5496183206107, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=227, Percent_Identity=39.2070484581498, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_CHLPD (A1BDW1)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911012.1
- ProteinModelPortal:   A1BDW1
- SMR:   A1BDW1
- STRING:   A1BDW1
- GeneID:   4569068
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0531
- NMPDR:   fig|290317.7.peg.554
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29116; Mature: 28985

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLSRILEEKRQAVLALKQQRPLQHYLEQETELSPCRDFQGCLKRSVDRIKLIAEIKKA
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
SPSRGLIVSDFKPLEMARRYMDLGASAFSVLTEEVFFQGSPDYLKEVRRAFSLPVLRKDF
CCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
ILDECQIFESRLMGADAILLIVAALDPHQLQDYLDLARQTGLHVLVEVHDHRELDIALNA
HHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEC
GSMIIGINNRDLRDFSVNLHTSIKLRPYIPEGIVSVSESGVKTAADAALLDNASFDAVLI
CEEEEECCCCCCEEEEEEEEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHCCCCCCEEEE
GEGLHVSEDLKRVIWTET
ECCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TYLSRILEEKRQAVLALKQQRPLQHYLEQETELSPCRDFQGCLKRSVDRIKLIAEIKKA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
SPSRGLIVSDFKPLEMARRYMDLGASAFSVLTEEVFFQGSPDYLKEVRRAFSLPVLRKDF
CCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
ILDECQIFESRLMGADAILLIVAALDPHQLQDYLDLARQTGLHVLVEVHDHRELDIALNA
HHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEC
GSMIIGINNRDLRDFSVNLHTSIKLRPYIPEGIVSVSESGVKTAADAALLDNASFDAVLI
CEEEEECCCCCCEEEEEEEEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHCCCCCCEEEE
GEGLHVSEDLKRVIWTET
ECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA