Click here to switch to the map view.

The map label for this gene is folP [H]

Identifier: 119356342

GI number: 119356342

Start: 555596

End: 556507

Strand: Reverse

Name: folP [H]

Synonym: Cpha266_0505

Alternate gene names: 119356342

Gene position: 556507-555596 (Counterclockwise)

Preceding gene: 119356343

Following gene: 119356341

Centisome position: 17.76

GC content: 52.85

Gene sequence:

>912_bases
ATGAAAAGTGTAACCGACAAGCCGGATCAATACCTGATCAACTGCTCAGGCGTCACGCTTGATCTCCGTAAAGCGCCTGT
TGTCATGGGCATCGTCAACGTTACACCCGACTCCTTTTATGACGGCGGCATGTTTGTACAAAAAAAGGATAAGCCAGACT
ATGACCGGGCGCTCAATCACGCCCTGCAGTTGATACGCTCCGGAGCCACGATTATCGATATCGGCGGAGAATCAAGCCGA
CCTGGAGCAGAGCCCATTCCGACAGAAGAAGAGATCCGGAGAACGGTCCCCCTTATCGGGATGCTCAGAAAAAAAACCGA
TGCGCTTATTTCAATCGATACCTGGAAATCCGAAGTAGCAGAAGCGGCAATTCGTGCCGGTGCGCAGTTGGTGAATGATA
TTTCAGGGTTTACCTTTGACGCTGATCTTCCCGAAATATGCCGAAAATACCAGGCCGCCGTGATCCTGATGCACACCCCG
ACAAAACCCCAATCCATGCAGTGGAGCACCGGCACCAGCTCCACAAGCAACGATATCATAACAACCGTCACGGCATATCT
GCAACGGTCAATCCTGACGGCACGTCATCACGGCATCAACGATATCATTATCGATCCGGGATTCGGTTTCGGTAAAACCG
TTGAGGAAAACTACCGTCTTCTGGGCGCTATGAACAAGCTGCAAAAACTCCAGCGCCCGCTGCTTGCCGGAGTTTCAAGA
AAATCGTTTCTCGGCCATGTCATAGCAGAACCCCGCCAACCAACTCCTCCTCCATCGGAACGGCTTTCCGCGACTCTTGC
CGCGGAAACCATTGCGCTGCTTAATGGAGCATCCATTATAAGGGCGCACGACGTAAAGGCCGCCATGCAGACGATCGCTG
TCGTCATGGCCTCCCGGGCTGCATCGGCATAG

Upstream 100 bases:

>100_bases
CCAGTCATGATTGCTCCCTTTCAGCTTCACGCCGGGCAATCGGCTGGGTTGCTATCGTCATTTTTATCATAACGTTCGTA
CCGGTACCATTCGGCGTACA

Downstream 100 bases:

>100_bases
AACGAAAATATTCGCGTATTCAACCCTGAAACCAGTTTTTTTATTAACTTTATTTTCAACCTTATTCGAGACAGACAAAC
CGCATTGCCGAGATGTATCT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKSVTDKPDQYLINCSGVTLDLRKAPVVMGIVNVTPDSFYDGGMFVQKKDKPDYDRALNHALQLIRSGATIIDIGGESSR
PGAEPIPTEEEIRRTVPLIGMLRKKTDALISIDTWKSEVAEAAIRAGAQLVNDISGFTFDADLPEICRKYQAAVILMHTP
TKPQSMQWSTGTSSTSNDIITTVTAYLQRSILTARHHGINDIIIDPGFGFGKTVEENYRLLGAMNKLQKLQRPLLAGVSR
KSFLGHVIAEPRQPTPPPSERLSATLAAETIALLNGASIIRAHDVKAAMQTIAVVMASRAASA

Sequences:

>Translated_303_residues
MKSVTDKPDQYLINCSGVTLDLRKAPVVMGIVNVTPDSFYDGGMFVQKKDKPDYDRALNHALQLIRSGATIIDIGGESSR
PGAEPIPTEEEIRRTVPLIGMLRKKTDALISIDTWKSEVAEAAIRAGAQLVNDISGFTFDADLPEICRKYQAAVILMHTP
TKPQSMQWSTGTSSTSNDIITTVTAYLQRSILTARHHGINDIIIDPGFGFGKTVEENYRLLGAMNKLQKLQRPLLAGVSR
KSFLGHVIAEPRQPTPPPSERLSATLAAETIALLNGASIIRAHDVKAAMQTIAVVMASRAASA
>Mature_303_residues
MKSVTDKPDQYLINCSGVTLDLRKAPVVMGIVNVTPDSFYDGGMFVQKKDKPDYDRALNHALQLIRSGATIIDIGGESSR
PGAEPIPTEEEIRRTVPLIGMLRKKTDALISIDTWKSEVAEAAIRAGAQLVNDISGFTFDADLPEICRKYQAAVILMHTP
TKPQSMQWSTGTSSTSNDIITTVTAYLQRSILTARHHGINDIIIDPGFGFGKTVEENYRLLGAMNKLQKLQRPLLAGVSR
KSFLGHVIAEPRQPTPPPSERLSATLAAETIALLNGASIIRAHDVKAAMQTIAVVMASRAASA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=287, Percent_Identity=39.7212543554007, Blast_Score=196, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324073, Length=326, Percent_Identity=30.3680981595092, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 32860; Mature: 32860

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVTDKPDQYLINCSGVTLDLRKAPVVMGIVNVTPDSFYDGGMFVQKKDKPDYDRALNH
CCCCCCCCCCEEEEECCCEEECCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHH
ALQLIRSGATIIDIGGESSRPGAEPIPTEEEIRRTVPLIGMLRKKTDALISIDTWKSEVA
HHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
EAAIRAGAQLVNDISGFTFDADLPEICRKYQAAVILMHTPTKPQSMQWSTGTSSTSNDII
HHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHEEEEEECCCCCCCEEECCCCCCCCCHHH
TTVTAYLQRSILTARHHGINDIIIDPGFGFGKTVEENYRLLGAMNKLQKLQRPLLAGVSR
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
KSFLGHVIAEPRQPTPPPSERLSATLAAETIALLNGASIIRAHDVKAAMQTIAVVMASRA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ASA
CCC
>Mature Secondary Structure
MKSVTDKPDQYLINCSGVTLDLRKAPVVMGIVNVTPDSFYDGGMFVQKKDKPDYDRALNH
CCCCCCCCCCEEEEECCCEEECCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHH
ALQLIRSGATIIDIGGESSRPGAEPIPTEEEIRRTVPLIGMLRKKTDALISIDTWKSEVA
HHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
EAAIRAGAQLVNDISGFTFDADLPEICRKYQAAVILMHTPTKPQSMQWSTGTSSTSNDII
HHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHEEEEEECCCCCCCEEECCCCCCCCCHHH
TTVTAYLQRSILTARHHGINDIIIDPGFGFGKTVEENYRLLGAMNKLQKLQRPLLAGVSR
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
KSFLGHVIAEPRQPTPPPSERLSATLAAETIALLNGASIIRAHDVKAAMQTIAVVMASRA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ASA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]