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The map label for this gene is hisA

Identifier: 119356329

GI number: 119356329

Start: 539510

End: 540280

Strand: Direct

Name: hisA

Synonym: Cpha266_0492

Alternate gene names: 119356329

Gene position: 539510-540280 (Clockwise)

Preceding gene: 119356328

Following gene: 119356330

Centisome position: 17.22

GC content: 46.82

Gene sequence:

>771_bases
ATGCTGATAATTCCTGCTATAGACATTAAGGACGGAAGATGTGTGCGGTTGACTCGTGGTGATTTCAACCAGCAGAAAAT
CTACCTCGACAATCCCTGCGACATGGCCATCATCTGGAGAAAACAGAATGCCAAGATGCTTCATGTCGTTGATCTGGATG
CTGCATTGACCGGCGAAATGGTCAATTTTCTGAAAATAGAGCAAATCGTACGCGAACTGGATATTCCTTTGCAGGTTGGG
GGAGGAATCCGTTCTCTCGATGCGGTTAAGCGATATCTTGATATCGGTGTCGGCCGGGTGGTGATAGGGTCGGCAGCGGT
GACAAATCCCGGGTTGATTGAAGAAGTGCTGAAAATATATCGGCCCTCGAAAATTGTTGTCGGGATTGACGCGGAGAATG
GCATCCCTAAAATCAAGGGGTGGACAGAAAGCTGTGGTATGAAAGATTACGAGCTGGGGCTTGAGATGAAGCAAATGGGT
ATTGAACGCGTTGTCTATACCGATATTTCAAAAGACGGCATGATGCAGGGGTTTGGTTACGAAAGCACCAAGCGGTTTGC
CGAAATGACCGGCATGAAAGTAACTGCTTCCGGTGGCGTTACCAGTTCAGATGACCTCATGAAGCTTGTTGGCTTGCAGC
AGTACGGGGTTGATTCCGTTATTATCGGAAAAGCCCTGTACGAGTGTAATTTTCCGTGCCAGGAGCTTTGGTATAATTTT
GAAGAGGATATCTGTATTGATCATAACTTTTCCACAGCAAGGAAGAAGTGA

Upstream 100 bases:

>100_bases
ATTTTTGCAGTCCAGTTTCATCCTGAAAAAAGTTCCGAGGCCGGTTTACAGGTGCTGAAGAATTTTGCAGGGTGTTAAGA
ATCGTTTGTTTTGTTTTTTT

Downstream 100 bases:

>100_bases
TGCTGTGATCGGGGCAGAACGGGATCTCCCTCATTCAACCATCCTGACTAACTATGGCGCCCGAAGAGGATATCGTGCTG
AAACAGCAGGTTGAGGCTCT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLIIPAIDIKDGRCVRLTRGDFNQQKIYLDNPCDMAIIWRKQNAKMLHVVDLDAALTGEMVNFLKIEQIVRELDIPLQVG
GGIRSLDAVKRYLDIGVGRVVIGSAAVTNPGLIEEVLKIYRPSKIVVGIDAENGIPKIKGWTESCGMKDYELGLEMKQMG
IERVVYTDISKDGMMQGFGYESTKRFAEMTGMKVTASGGVTSSDDLMKLVGLQQYGVDSVIIGKALYECNFPCQELWYNF
EEDICIDHNFSTARKK

Sequences:

>Translated_256_residues
MLIIPAIDIKDGRCVRLTRGDFNQQKIYLDNPCDMAIIWRKQNAKMLHVVDLDAALTGEMVNFLKIEQIVRELDIPLQVG
GGIRSLDAVKRYLDIGVGRVVIGSAAVTNPGLIEEVLKIYRPSKIVVGIDAENGIPKIKGWTESCGMKDYELGLEMKQMG
IERVVYTDISKDGMMQGFGYESTKRFAEMTGMKVTASGGVTSSDDLMKLVGLQQYGVDSVIIGKALYECNFPCQELWYNF
EEDICIDHNFSTARKK
>Mature_256_residues
MLIIPAIDIKDGRCVRLTRGDFNQQKIYLDNPCDMAIIWRKQNAKMLHVVDLDAALTGEMVNFLKIEQIVRELDIPLQVG
GGIRSLDAVKRYLDIGVGRVVIGSAAVTNPGLIEEVLKIYRPSKIVVGIDAENGIPKIKGWTESCGMKDYELGLEMKQMG
IERVVYTDISKDGMMQGFGYESTKRFAEMTGMKVTASGGVTSSDDLMKLVGLQQYGVDSVIIGKALYECNFPCQELWYNF
EEDICIDHNFSTARKK

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=250, Percent_Identity=32.8, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1788336, Length=216, Percent_Identity=26.8518518518519, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CHLPD (A1BDS2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_910973.1
- ProteinModelPortal:   A1BDS2
- SMR:   A1BDS2
- STRING:   A1BDS2
- GeneID:   4569262
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0492
- NMPDR:   fig|290317.7.peg.510
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 28587; Mature: 28587

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIPAIDIKDGRCVRLTRGDFNQQKIYLDNPCDMAIIWRKQNAKMLHVVDLDAALTGEM
CEEEEEEECCCCCEEEEECCCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCHHHHHHH
VNFLKIEQIVRELDIPLQVGGGIRSLDAVKRYLDIGVGRVVIGSAAVTNPGLIEEVLKIY
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHH
RPSKIVVGIDAENGIPKIKGWTESCGMKDYELGLEMKQMGIERVVYTDISKDGMMQGFGY
CCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHCCHHHHCCCCEEEEECCCCCCCCCCCCC
ESTKRFAEMTGMKVTASGGVTSSDDLMKLVGLQQYGVDSVIIGKALYECNFPCQELWYNF
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHCCCC
EEDICIDHNFSTARKK
CCCEEEECCCHHCCCC
>Mature Secondary Structure
MLIIPAIDIKDGRCVRLTRGDFNQQKIYLDNPCDMAIIWRKQNAKMLHVVDLDAALTGEM
CEEEEEEECCCCCEEEEECCCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCHHHHHHH
VNFLKIEQIVRELDIPLQVGGGIRSLDAVKRYLDIGVGRVVIGSAAVTNPGLIEEVLKIY
HHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHH
RPSKIVVGIDAENGIPKIKGWTESCGMKDYELGLEMKQMGIERVVYTDISKDGMMQGFGY
CCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHCCHHHHCCCCEEEEECCCCCCCCCCCCC
ESTKRFAEMTGMKVTASGGVTSSDDLMKLVGLQQYGVDSVIIGKALYECNFPCQELWYNF
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHCCCC
EEDICIDHNFSTARKK
CCCEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA