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The map label for this gene is ubiE [H]

Identifier: 119356315

GI number: 119356315

Start: 527206

End: 527964

Strand: Reverse

Name: ubiE [H]

Synonym: Cpha266_0478

Alternate gene names: 119356315

Gene position: 527964-527206 (Counterclockwise)

Preceding gene: 119356316

Following gene: 119356309

Centisome position: 16.85

GC content: 49.54

Gene sequence:

>759_bases
ATGACGTTTACGGAAAAAAAAGCTGATATGCTGATGAGCCACCCAAAAGAGACCGCCAAATCCCTGAACCAGACAAAGTC
CCGTTCATCAATTCGGGAGATGTTTGACGAGGTTGCCCCAACCTACGACTTTCTCAACCACCTCCTGAGTCTCGGCATAG
ATAACTACTGGCGGGCAGCCGCAACGGGAAGGGCAAAAAAACTGCTCAAGAACGTCCCGCAGCCCCGGATTCTCGACGTC
GCAACCGGCACAGGAGATCTTGCCGCATCCATAGCAAAACTTCCTGGCGCAAAGGTAACCGGCCTCGATCTCTCTCCTGA
AATGCTTGAACTGGCCAGAAAAAAATATCCGGCAATCACCTTTCTTGAAGGATATGCGGAAAAGCTCCCTTTCGATACGG
CAAGTTTCGATGCCGTAAGCGCAGGATTCGGCGTAAGAAACTTTGAAAATCTGCAACAGGGGATGAGCGAATTCCACAGG
GTTCTCAAGCCGGGCGGCTATACGTTCATCATTGAGCCGATGATCCCGAGAAATCCTCTCATGAAAAAGCTCTATCTGAT
CTATTTTAAAAAAGTCCTGCCGAAAATCGCGGCACTGTTCAGCAAATCAACCTTTGCCTACGACTATCTCCCCCACTCCG
TCGAGCAGTTCCCGCAGGCAGAAGCATTCAGCGAAATCCTCAAAAAAGCCGGATTTCGAGCCGTCAGCTATTTCCCCATG
ACCTTTGAAACATCAATTCTCTACGTAGCCGGAAAATAA

Upstream 100 bases:

>100_bases
AAAGGCGGAGCGTGCCATGTCGGCTATCACTCCTGTTTCTATCGAAAAGTAAAAGAAACTCTTGATATGGAAATCTGTGA
CACCCTGATGTTCAATCCGG

Downstream 100 bases:

>100_bases
ACCGCGCTGCGCACGATGGAACAGCAATAACAGGGCAGGCACACAGAGGCCTGCCCATACAAACGGCAGCTCATCCCGAC
AGGCATAACAACGTTACCCG

Product: demethylmenaquinone methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTFTEKKADMLMSHPKETAKSLNQTKSRSSIREMFDEVAPTYDFLNHLLSLGIDNYWRAAATGRAKKLLKNVPQPRILDV
ATGTGDLAASIAKLPGAKVTGLDLSPEMLELARKKYPAITFLEGYAEKLPFDTASFDAVSAGFGVRNFENLQQGMSEFHR
VLKPGGYTFIIEPMIPRNPLMKKLYLIYFKKVLPKIAALFSKSTFAYDYLPHSVEQFPQAEAFSEILKKAGFRAVSYFPM
TFETSILYVAGK

Sequences:

>Translated_252_residues
MTFTEKKADMLMSHPKETAKSLNQTKSRSSIREMFDEVAPTYDFLNHLLSLGIDNYWRAAATGRAKKLLKNVPQPRILDV
ATGTGDLAASIAKLPGAKVTGLDLSPEMLELARKKYPAITFLEGYAEKLPFDTASFDAVSAGFGVRNFENLQQGMSEFHR
VLKPGGYTFIIEPMIPRNPLMKKLYLIYFKKVLPKIAALFSKSTFAYDYLPHSVEQFPQAEAFSEILKKAGFRAVSYFPM
TFETSILYVAGK
>Mature_251_residues
TFTEKKADMLMSHPKETAKSLNQTKSRSSIREMFDEVAPTYDFLNHLLSLGIDNYWRAAATGRAKKLLKNVPQPRILDVA
TGTGDLAASIAKLPGAKVTGLDLSPEMLELARKKYPAITFLEGYAEKLPFDTASFDAVSAGFGVRNFENLQQGMSEFHRV
LKPGGYTFIIEPMIPRNPLMKKLYLIYFKKVLPKIAALFSKSTFAYDYLPHSVEQFPQAEAFSEILKKAGFRAVSYFPMT
FETSILYVAGK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=278, Percent_Identity=30.2158273381295, Blast_Score=137, Evalue=9e-33,
Organism=Escherichia coli, GI48994983, Length=223, Percent_Identity=31.8385650224215, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557039, Length=238, Percent_Identity=29.4117647058824, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323526, Length=249, Percent_Identity=30.9236947791165, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24641702, Length=244, Percent_Identity=31.1475409836066, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28244; Mature: 28113

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFTEKKADMLMSHPKETAKSLNQTKSRSSIREMFDEVAPTYDFLNHLLSLGIDNYWRAA
CCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
ATGRAKKLLKNVPQPRILDVATGTGDLAASIAKLPGAKVTGLDLSPEMLELARKKYPAIT
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCHH
FLEGYAEKLPFDTASFDAVSAGFGVRNFENLQQGMSEFHRVLKPGGYTFIIEPMIPRNPL
HHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHH
MKKLYLIYFKKVLPKIAALFSKSTFAYDYLPHSVEQFPQAEAFSEILKKAGFRAVSYFPM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCCHHHHHHHHHHCCCCEEEECCE
TFETSILYVAGK
EEECEEEEEECC
>Mature Secondary Structure 
TFTEKKADMLMSHPKETAKSLNQTKSRSSIREMFDEVAPTYDFLNHLLSLGIDNYWRAA
CCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
ATGRAKKLLKNVPQPRILDVATGTGDLAASIAKLPGAKVTGLDLSPEMLELARKKYPAIT
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCHH
FLEGYAEKLPFDTASFDAVSAGFGVRNFENLQQGMSEFHRVLKPGGYTFIIEPMIPRNPL
HHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHH
MKKLYLIYFKKVLPKIAALFSKSTFAYDYLPHSVEQFPQAEAFSEILKKAGFRAVSYFPM
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCCHHHHHHHHHHCCCCEEEECCE
TFETSILYVAGK
EEECEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]