Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 119356237

GI number: 119356237

Start: 442245

End: 443093

Strand: Reverse

Name: uppS [H]

Synonym: Cpha266_0398

Alternate gene names: 119356237

Gene position: 443093-442245 (Counterclockwise)

Preceding gene: 119356240

Following gene: 119356236

Centisome position: 14.14

GC content: 47.11

Gene sequence:

>849_bases
ATGGCGCGCATAAGAACAATGGATCTTTCGCCAACCTTCAGATCGCCCTGGTTTACAACCGTGAGTGATACCGAAGACAA
GAAAATCCAGGCTGATTTGAAAGCATCGTGCGAGCTTCCTCTTCATATTGCCATTATTATGGATGGCAATGGCAGATGGG
CCAAACTGAAAGGAAAGACAAGGATTGAGGGACACATTGCCGGTGTTGATTCTGTCAGGGATATTGTCGAGGCAAGCAGG
CAGCTTGGCATTTCCTATCTCACGCTGTTCACCTTTTCAACTGAAAACTGGAACAGACCTGAAAAAGAGATCTCGGCACT
GATGCGACTGCTCATCAAGGTGCTGCGAAAAGAGGCGCGAGCACTGCACGACAATAACATCAGGCTTAACGTGATCGGCA
ACACCGCTCTTCTTCCGGAAAAAGTCCGGACCGTTCTTGATGAAACAGTAGTACTGACAGGACACAATAACGGACTGGTA
ATGAGCATTGCATTGAGCTACAGCGGCAAATGGGACATCGTCGAAGCATGCCGTTCCCTTGCTGTTGAGGTCAAGGCCGG
TCGCGTGAGTCCGGAGATGATCGATGAGCATCTGTTTCAGTCTTGCCTTTCGACGGCATCAATTCCTGATCCGGAACTGC
TCATTCGCACCAGCGGCGAATTCAGAATAAGCAACTTCATGCTCTGGCAAAGCGCCTATTCTGAAATTTATTTTACCAAA
ACCTACTGGCCTGATTTTCGAAGAGCGCAATTTTATGCTGCTCTTCGCGATTATCAAAACAGAGAAAGAAGGTTTGGCCA
GACAAGTGAACAAATTCAGAAAAAAAACACAGCAAACAGCAAGATTTAA

Upstream 100 bases:

>100_bases
ATCGAAAAAGCGCAGCACAATCCCGTCAACATCGGGACAAGAGGTTTTCGGGATGCTTTTTCCATAAAGCCCTCATGATG
ACAACAGGTAATAATTTCCT

Downstream 100 bases:

>100_bases
CTCTGACCGATCCGAAAGATTCTATGAAAAAAATGCAAAAACTGATAACCCTGGTACTGGTAGCCCTTGCCGTAAACGCT
ACAGGACAAACTGCCGAAGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MARIRTMDLSPTFRSPWFTTVSDTEDKKIQADLKASCELPLHIAIIMDGNGRWAKLKGKTRIEGHIAGVDSVRDIVEASR
QLGISYLTLFTFSTENWNRPEKEISALMRLLIKVLRKEARALHDNNIRLNVIGNTALLPEKVRTVLDETVVLTGHNNGLV
MSIALSYSGKWDIVEACRSLAVEVKAGRVSPEMIDEHLFQSCLSTASIPDPELLIRTSGEFRISNFMLWQSAYSEIYFTK
TYWPDFRRAQFYAALRDYQNRERRFGQTSEQIQKKNTANSKI

Sequences:

>Translated_282_residues
MARIRTMDLSPTFRSPWFTTVSDTEDKKIQADLKASCELPLHIAIIMDGNGRWAKLKGKTRIEGHIAGVDSVRDIVEASR
QLGISYLTLFTFSTENWNRPEKEISALMRLLIKVLRKEARALHDNNIRLNVIGNTALLPEKVRTVLDETVVLTGHNNGLV
MSIALSYSGKWDIVEACRSLAVEVKAGRVSPEMIDEHLFQSCLSTASIPDPELLIRTSGEFRISNFMLWQSAYSEIYFTK
TYWPDFRRAQFYAALRDYQNRERRFGQTSEQIQKKNTANSKI
>Mature_281_residues
ARIRTMDLSPTFRSPWFTTVSDTEDKKIQADLKASCELPLHIAIIMDGNGRWAKLKGKTRIEGHIAGVDSVRDIVEASRQ
LGISYLTLFTFSTENWNRPEKEISALMRLLIKVLRKEARALHDNNIRLNVIGNTALLPEKVRTVLDETVVLTGHNNGLVM
SIALSYSGKWDIVEACRSLAVEVKAGRVSPEMIDEHLFQSCLSTASIPDPELLIRTSGEFRISNFMLWQSAYSEIYFTKT
YWPDFRRAQFYAALRDYQNRERRFGQTSEQIQKKNTANSKI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=33.9285714285714, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=33.9285714285714, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=48.4581497797357, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=32.1739130434783, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=219, Percent_Identity=33.7899543378995, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=267, Percent_Identity=27.7153558052434, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18857969, Length=231, Percent_Identity=33.7662337662338, Blast_Score=148, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 32218; Mature: 32087

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIRTMDLSPTFRSPWFTTVSDTEDKKIQADLKASCELPLHIAIIMDGNGRWAKLKGKT
CCEEEEEECCCCCCCCCEEECCCCCCCCEECCHHCCCCCCEEEEEEECCCCCEEEECCCE
RIEGHIAGVDSVRDIVEASRQLGISYLTLFTFSTENWNRPEKEISALMRLLIKVLRKEAR
EECEEECCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ALHDNNIRLNVIGNTALLPEKVRTVLDETVVLTGHNNGLVMSIALSYSGKWDIVEACRSL
HHCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHH
AVEVKAGRVSPEMIDEHLFQSCLSTASIPDPELLIRTSGEFRISNFMLWQSAYSEIYFTK
EEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEHHHHHHHHHHHHEEEEE
TYWPDFRRAQFYAALRDYQNRERRFGQTSEQIQKKNTANSKI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
ARIRTMDLSPTFRSPWFTTVSDTEDKKIQADLKASCELPLHIAIIMDGNGRWAKLKGKT
CEEEEEECCCCCCCCCEEECCCCCCCCEECCHHCCCCCCEEEEEEECCCCCEEEECCCE
RIEGHIAGVDSVRDIVEASRQLGISYLTLFTFSTENWNRPEKEISALMRLLIKVLRKEAR
EECEEECCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ALHDNNIRLNVIGNTALLPEKVRTVLDETVVLTGHNNGLVMSIALSYSGKWDIVEACRSL
HHCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHH
AVEVKAGRVSPEMIDEHLFQSCLSTASIPDPELLIRTSGEFRISNFMLWQSAYSEIYFTK
EEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEHHHHHHHHHHHHEEEEE
TYWPDFRRAQFYAALRDYQNRERRFGQTSEQIQKKNTANSKI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]