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The map label for this gene is hisS

Identifier: 119356203

GI number: 119356203

Start: 407766

End: 409055

Strand: Direct

Name: hisS

Synonym: Cpha266_0364

Alternate gene names: 119356203

Gene position: 407766-409055 (Clockwise)

Preceding gene: 119356202

Following gene: 119356204

Centisome position: 13.01

GC content: 49.61

Gene sequence:

>1290_bases
ATGTCGCAGTATCAGGTTGTCAAGGGTGCCAGGGATATTTTTCCGGATGAAATAGTCCGCTGGCACTATGTCGAGGACGT
TGTTCATCGTCTTGCGTCTCTTTATGGATATAGTGAAATTCGTACTCCTGTTTTTGAATATACGGAGCTTTTTCAACGTA
GTATCGGGACTACAACGGATATTGTGGGCAAGGAGATGTTTTCCTTTCTTCCGGATCCTCAGGGTCGATCCATTACCTTG
CGTCCAGAGATGACTGCGGGAGTTATGCGGGCGGTTTTGCAGAAAAATCTGCTTTCGACGGCACCGATACACAAGCTTTT
TTATCTTTCAGAGCTTTTTCGAAAAGAGCGTCCGCAGGCCGGACGCCAGCGACAGTTTTCACAGTTTGGCGCCGAATTGC
TCGGGGTTTCCTCGCCTGCTGCCGTTGCCGAGGTCATAACCTTTATGATGCAGGTGTTCGAAACTCTCGGAATACGAGGT
TTGAAGCTTCGGATCAATACCCTTGGCGACAGCAGCGATCGAGCAAGGTATCGCGAAATACTCAGAGCGTATCTCGCGCC
TTTTTATGACAGGCTTGATCTGGCATCCCGGGAGCGGTTTGAAAAAAATCCTCTGAGAATTCTCGATTCGAAAAATCCTG
ATATGCAGGAGATCATTGAAGGAGCTCCAACGCTGCATGATTCTCTTTCTCATGAAGCTTTGGAAGATTTTGAGAAAGTG
CGTTTCTATCTTGACAGTCGGAGTATAGCTTACGATATTGACTATCGTCTTGTTCGCGGCCTCGATTACTACTGCCATAC
CGCATTTGAGGTGACCAGTCCGGAACTTGGTGCACAGGATGCTATTGGCGGGGGAGGCAGATATGACGGTCTTGCGAAAG
AGTTGGGAAGTTCCGGAGATGTTCCTGCATCAGGTTTTGCCGCAGGGATGGAAAGAGTGCTGATCACGATGGAAAAGCAG
GGTTTATTCGCCGCCCTGCGTCCTTCTGGTCCGAAGGTCTATGTTGTTGCCCAGCAGCACGCCCTGCTTGACCATGCCTT
GCAGGTGGCTTATCGTTTGAGGCGCGAGGGGATCAGCACTGAAGTTGATCTTGCCGGAAGAAGCATGAAAGCCCAGATGA
GAGATGCCAACAGGATGCGCGCCTGCTTTGCGCTTTTTATCGGCGAAGATGAGGTGGTTTCCGGCTCGTATGCGCTGAAA
AATCTTGTTACTGCCGACCAGACGGCACAATCGATTGAAACCATTATTGAAATGCTCAATCAATATTCGGGAGCGGAGCA
GGGATCATGA

Upstream 100 bases:

>100_bases
TGCAGCGCTTATTGCGCGGCATTAAAAAACTTCTGATCCGGAACTTATTCGGATTGGAAGTCTTGTAATTATTTTATCAG
CAGGGGATTAATCAATAGTT

Downstream 100 bases:

>100_bases
CAGAGTCTCTTCATACTGTTACAATCTATGGAGCAAAAGGGTGTTGTCTTTGTGACGATGCTCTGGAAAGAGTGCTCGAT
GTCCAGGGTTCAGTACCGTT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSQYQVVKGARDIFPDEIVRWHYVEDVVHRLASLYGYSEIRTPVFEYTELFQRSIGTTTDIVGKEMFSFLPDPQGRSITL
RPEMTAGVMRAVLQKNLLSTAPIHKLFYLSELFRKERPQAGRQRQFSQFGAELLGVSSPAAVAEVITFMMQVFETLGIRG
LKLRINTLGDSSDRARYREILRAYLAPFYDRLDLASRERFEKNPLRILDSKNPDMQEIIEGAPTLHDSLSHEALEDFEKV
RFYLDSRSIAYDIDYRLVRGLDYYCHTAFEVTSPELGAQDAIGGGGRYDGLAKELGSSGDVPASGFAAGMERVLITMEKQ
GLFAALRPSGPKVYVVAQQHALLDHALQVAYRLRREGISTEVDLAGRSMKAQMRDANRMRACFALFIGEDEVVSGSYALK
NLVTADQTAQSIETIIEMLNQYSGAEQGS

Sequences:

>Translated_429_residues
MSQYQVVKGARDIFPDEIVRWHYVEDVVHRLASLYGYSEIRTPVFEYTELFQRSIGTTTDIVGKEMFSFLPDPQGRSITL
RPEMTAGVMRAVLQKNLLSTAPIHKLFYLSELFRKERPQAGRQRQFSQFGAELLGVSSPAAVAEVITFMMQVFETLGIRG
LKLRINTLGDSSDRARYREILRAYLAPFYDRLDLASRERFEKNPLRILDSKNPDMQEIIEGAPTLHDSLSHEALEDFEKV
RFYLDSRSIAYDIDYRLVRGLDYYCHTAFEVTSPELGAQDAIGGGGRYDGLAKELGSSGDVPASGFAAGMERVLITMEKQ
GLFAALRPSGPKVYVVAQQHALLDHALQVAYRLRREGISTEVDLAGRSMKAQMRDANRMRACFALFIGEDEVVSGSYALK
NLVTADQTAQSIETIIEMLNQYSGAEQGS
>Mature_428_residues
SQYQVVKGARDIFPDEIVRWHYVEDVVHRLASLYGYSEIRTPVFEYTELFQRSIGTTTDIVGKEMFSFLPDPQGRSITLR
PEMTAGVMRAVLQKNLLSTAPIHKLFYLSELFRKERPQAGRQRQFSQFGAELLGVSSPAAVAEVITFMMQVFETLGIRGL
KLRINTLGDSSDRARYREILRAYLAPFYDRLDLASRERFEKNPLRILDSKNPDMQEIIEGAPTLHDSLSHEALEDFEKVR
FYLDSRSIAYDIDYRLVRGLDYYCHTAFEVTSPELGAQDAIGGGGRYDGLAKELGSSGDVPASGFAAGMERVLITMEKQG
LFAALRPSGPKVYVVAQQHALLDHALQVAYRLRREGISTEVDLAGRSMKAQMRDANRMRACFALFIGEDEVVSGSYALKN
LVTADQTAQSIETIIEMLNQYSGAEQGS

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=467, Percent_Identity=24.4111349036403, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788861, Length=428, Percent_Identity=39.4859813084112, Blast_Score=294, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI71993686, Length=465, Percent_Identity=24.9462365591398, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71993693, Length=465, Percent_Identity=24.9462365591398, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325290, Length=465, Percent_Identity=23.6559139784946, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_CHLPD (A1BDE6)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_910847.1
- ProteinModelPortal:   A1BDE6
- SMR:   A1BDE6
- STRING:   A1BDE6
- GeneID:   4569342
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0364
- NMPDR:   fig|290317.7.peg.371
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48204; Mature: 48072

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQYQVVKGARDIFPDEIVRWHYVEDVVHRLASLYGYSEIRTPVFEYTELFQRSIGTTTD
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHCCCHHH
IVGKEMFSFLPDPQGRSITLRPEMTAGVMRAVLQKNLLSTAPIHKLFYLSELFRKERPQA
HHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRQRQFSQFGAELLGVSSPAAVAEVITFMMQVFETLGIRGLKLRINTLGDSSDRARYREI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHH
LRAYLAPFYDRLDLASRERFEKNPLRILDSKNPDMQEIIEGAPTLHDSLSHEALEDFEKV
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFYLDSRSIAYDIDYRLVRGLDYYCHTAFEVTSPELGAQDAIGGGGRYDGLAKELGSSGD
HHHHCCCCEEEECHHHHHHCCHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCC
VPASGFAAGMERVLITMEKQGLFAALRPSGPKVYVVAQQHALLDHALQVAYRLRREGIST
CCCHHHHHHHHHHHHHEECCCCEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCC
EVDLAGRSMKAQMRDANRMRACFALFIGEDEVVSGSYALKNLVTADQTAQSIETIIEMLN
CHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QYSGAEQGS
HHCCCCCCC
>Mature Secondary Structure 
SQYQVVKGARDIFPDEIVRWHYVEDVVHRLASLYGYSEIRTPVFEYTELFQRSIGTTTD
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHCCCHHH
IVGKEMFSFLPDPQGRSITLRPEMTAGVMRAVLQKNLLSTAPIHKLFYLSELFRKERPQA
HHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRQRQFSQFGAELLGVSSPAAVAEVITFMMQVFETLGIRGLKLRINTLGDSSDRARYREI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHH
LRAYLAPFYDRLDLASRERFEKNPLRILDSKNPDMQEIIEGAPTLHDSLSHEALEDFEKV
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFYLDSRSIAYDIDYRLVRGLDYYCHTAFEVTSPELGAQDAIGGGGRYDGLAKELGSSGD
HHHHCCCCEEEECHHHHHHCCHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCC
VPASGFAAGMERVLITMEKQGLFAALRPSGPKVYVVAQQHALLDHALQVAYRLRREGIST
CCCHHHHHHHHHHHHHEECCCCEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCC
EVDLAGRSMKAQMRDANRMRACFALFIGEDEVVSGSYALKNLVTADQTAQSIETIIEMLN
CHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QYSGAEQGS
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA