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The map label for this gene is clpB [H]

Identifier: 119356173

GI number: 119356173

Start: 362562

End: 365126

Strand: Direct

Name: clpB [H]

Synonym: Cpha266_0334

Alternate gene names: 119356173

Gene position: 362562-365126 (Clockwise)

Preceding gene: 119356171

Following gene: 119356176

Centisome position: 11.57

GC content: 48.69

Gene sequence:

>2565_bases
ATGGAAGGAAATTTTTCAAATAGAGTACAGGACGTGATCCGCCTGAGCAGGGAAGAGGCGCTGCGTTTGGGGCACGATTA
TATTGGCACCGAGCATCTGCTTCTTGGACTTATCAGGGAGGGGGAGGGAATTGCTGCCCGGATATTGAAAAACCTCAAAA
TTGATTTATACCGGCTGAAGCAGAAAATAGAGGACAGCACACATCCAAAAGTTCCTGCGACGCAGATGGGCAATGTGCCG
CTTACAAAACAGGCGGAAAAAGTGTTAAAGATAACCTATCTGGAAGCAAAAATCTGTAAATCGAATATCATAGGCACAGA
ACATCTTCTTCTCTCCATTCTCAAAGGAGAGGACAATATCGCGTCCCAGATTCTGGAGCAGTTTGGCGTGAGCTATGATA
TGGTGCGGGATGAACTGCTGAGCATTACCAGCGGGGGAACCGAATCGGATGAGCCTCCGGCAGAGGGGTATGCATCGTCA
GGAGGATCAGAAAGATCCGCGAAAAAGGCCGATCCAAAAAGAGGCGAAAGGACAAAGACGCCTGTGCTTGATAACTTCGG
AAGGGATATTACACGGCTTGCCCTTGATGACAAACTGGATCCCATCATCGGACGTGAAAAAGAGATTGAGCGGGTTGCCC
AGGTATTGAGCCGGCGCAAAAAGAATAATCCGGTGCTGATCGGTGAGCCTGGAGTTGGCAAAACGGCTATTGCCGAAGGT
CTTGCCCTCAAGATCGTACAGCGCAAGGTCTCCCGCGTTCTTTACGACAAGAGGGTTGTTGCCCTTGATCTTGCTGCTCT
TGTAGCCGGTACAAAATATCGCGGTCAGTTTGAGGAGCGCATGAAAGCGCTCATGAATGAGCTTGAGCGGTCTCGGGATG
TGATTCTTTTTATTGATGAACTGCACACGATTATCGGTGCTGGCGGCGCGTCAGGATCTCTTGACGCAAGCAACATTTTC
AAGCCTGCTCTGGCGCGAGGTGAACTGCAGTGTATCGGAGCAACCACGCTCGACGAGTACCGTCAGTATATTGAAAAAGA
CGGAGCGCTTGACCGCAGGTTTCAGAAGATCATGGTTGAACCGGCTACAGTTGACGAAACAATTCTGATTCTCAACAATA
TCAAGTCGAAGTATGAGGTTCATCACCATGTACGGTACTCTGAAGATGCCATTGAAAAAGCCGTCAAGCTTTCAGAGCGG
TATATTACCGACAGATTTTTGCCGGATAAGGCCATCGATGTTATGGATGAAGCCGGCGCCAGAGTGCATTTAAGCAATAT
TCATGTGCCCGATGAAATTCTTGAACTTGAGAAATCCATAGAAGCAATCAAGACCGAAAAGAATCAGGTCGTGAAGATGC
AGAACTTCGAAGAGGCGGCAAAGCTGCGCGACAAGGAGAAACATCTTCTTGAATCGCTTGATCACGCCAAGCAGGAGTGG
GAGGACAGGGCGGCTGAGAGCGTGTATGATGTAACCGAAACCGATATCACCTCTGTTATTGCCATGATGACCGGTATTCC
GGTTGCCAGGGTGGCGCAGTCCGAATCCAAAAAGCTGCTCTCGATGGAGGCTGATCTCATGAAAGAGGTTATTGGTCAGG
ATGAAGCCATCAAAAAGATCACCAAGGCAATACAGCGTACTCGTGCCGGTCTGAAAGATCCGTCAAGGCCTATCGGTTCG
TTTATTTTTCTCGGCCCGACGGGTGTCGGTAAAACCGAGCTTGCCAAGGCGCTGACCCGTTACATTTTTGATACCGAAGA
TGCCCTGATCAGGGCGGATATGAGCGAGTATATGGAAAAATTCTCGGTGAGCCGTCTTGTCGGAGCGCCTCCCGGCTATG
TGGGTTACGAAGAGGGCGGTCAGCTTACCGAAAAGGTTCGCCGCAAACCCTACTCTGTGGTGCTCATCGACGAAATCGAA
AAAGCGCACCCCGATGTGTTCAATATTCTGCTACAGGTGCTCGATGAAGGCGTGTTGACCGACGGGTTGGGCAGGAAGGT
GGATTTCCGCAACACCATTATTATCATGACCTCCAATATCGGAGCAAAAGATATCAAGAGTTTCGGGGCAGGATCAGGGA
TGGGCTTTACAGCTCCGGATGACGCTTCGGGAAGCTACAAGGCCATGAAATCAACCATTGAGGATGCGTTGAAACGGGTA
TTCAATCCCGAGTTTCTTAACCGTATCGATGATATTGTGGTCTTTCATCCTCTTGAAAAGCAGCATATTTTCAAAATCAT
CGATATTACTGCCGGCAAGCTGTTCAAAAGGCTGCGCGAAATGGGTATCGAAGTTGAGATTGATGAAAAAGCCAAGGAGT
TTCTTGTTGATAAAGGCTATGATCAGAAATACGGGGCGCGTCCACTCAAACGTGCGCTGCAGAAGTATGTTGAAGATCCT
CTTGCCGAAGAGATGCTCAAAGGGCGATTTATTGAAGGCAGCACCATCAGGATTCTTTTTGATGAAGATGAGGGCGAGCT
TCGATTTATCGATGGTGAGCCAGCAACGAAAAAACGAAAACGGGATGAAAAACTCGATAAAGAGGTTCCCGATCCTAACA
GTTAA

Upstream 100 bases:

>100_bases
GTATATTTATATAATTATTTTATAAGCGCGAAATGATGAAATAGATGGTCACGATGTTATGTGTACCTGGTGATTAAAAC
AATTTTACCTGGAATAAAGC

Downstream 100 bases:

>100_bases
GAAACAAAAACCCCCGGTTGATCCGGGGGTTTTTGTTTCTTATGCGCCTGGCGGTTTGGGATGATTCCTGACTGCGGCAA
GTGATTGTTGCAAAAGCTCA

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 854; Mature: 854

Protein sequence:

>854_residues
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIAARILKNLKIDLYRLKQKIEDSTHPKVPATQMGNVP
LTKQAEKVLKITYLEAKICKSNIIGTEHLLLSILKGEDNIASQILEQFGVSYDMVRDELLSITSGGTESDEPPAEGYASS
GGSERSAKKADPKRGERTKTPVLDNFGRDITRLALDDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
LALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDELHTIIGAGGASGSLDASNIF
KPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVEPATVDETILILNNIKSKYEVHHHVRYSEDAIEKAVKLSER
YITDRFLPDKAIDVMDEAGARVHLSNIHVPDEILELEKSIEAIKTEKNQVVKMQNFEEAAKLRDKEKHLLESLDHAKQEW
EDRAAESVYDVTETDITSVIAMMTGIPVARVAQSESKKLLSMEADLMKEVIGQDEAIKKITKAIQRTRAGLKDPSRPIGS
FIFLGPTGVGKTELAKALTRYIFDTEDALIRADMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDEIE
KAHPDVFNILLQVLDEGVLTDGLGRKVDFRNTIIIMTSNIGAKDIKSFGAGSGMGFTAPDDASGSYKAMKSTIEDALKRV
FNPEFLNRIDDIVVFHPLEKQHIFKIIDITAGKLFKRLREMGIEVEIDEKAKEFLVDKGYDQKYGARPLKRALQKYVEDP
LAEEMLKGRFIEGSTIRILFDEDEGELRFIDGEPATKKRKRDEKLDKEVPDPNS

Sequences:

>Translated_854_residues
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIAARILKNLKIDLYRLKQKIEDSTHPKVPATQMGNVP
LTKQAEKVLKITYLEAKICKSNIIGTEHLLLSILKGEDNIASQILEQFGVSYDMVRDELLSITSGGTESDEPPAEGYASS
GGSERSAKKADPKRGERTKTPVLDNFGRDITRLALDDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
LALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDELHTIIGAGGASGSLDASNIF
KPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVEPATVDETILILNNIKSKYEVHHHVRYSEDAIEKAVKLSER
YITDRFLPDKAIDVMDEAGARVHLSNIHVPDEILELEKSIEAIKTEKNQVVKMQNFEEAAKLRDKEKHLLESLDHAKQEW
EDRAAESVYDVTETDITSVIAMMTGIPVARVAQSESKKLLSMEADLMKEVIGQDEAIKKITKAIQRTRAGLKDPSRPIGS
FIFLGPTGVGKTELAKALTRYIFDTEDALIRADMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDEIE
KAHPDVFNILLQVLDEGVLTDGLGRKVDFRNTIIIMTSNIGAKDIKSFGAGSGMGFTAPDDASGSYKAMKSTIEDALKRV
FNPEFLNRIDDIVVFHPLEKQHIFKIIDITAGKLFKRLREMGIEVEIDEKAKEFLVDKGYDQKYGARPLKRALQKYVEDP
LAEEMLKGRFIEGSTIRILFDEDEGELRFIDGEPATKKRKRDEKLDKEVPDPNS
>Mature_854_residues
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIAARILKNLKIDLYRLKQKIEDSTHPKVPATQMGNVP
LTKQAEKVLKITYLEAKICKSNIIGTEHLLLSILKGEDNIASQILEQFGVSYDMVRDELLSITSGGTESDEPPAEGYASS
GGSERSAKKADPKRGERTKTPVLDNFGRDITRLALDDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
LALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDELHTIIGAGGASGSLDASNIF
KPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVEPATVDETILILNNIKSKYEVHHHVRYSEDAIEKAVKLSER
YITDRFLPDKAIDVMDEAGARVHLSNIHVPDEILELEKSIEAIKTEKNQVVKMQNFEEAAKLRDKEKHLLESLDHAKQEW
EDRAAESVYDVTETDITSVIAMMTGIPVARVAQSESKKLLSMEADLMKEVIGQDEAIKKITKAIQRTRAGLKDPSRPIGS
FIFLGPTGVGKTELAKALTRYIFDTEDALIRADMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDEIE
KAHPDVFNILLQVLDEGVLTDGLGRKVDFRNTIIIMTSNIGAKDIKSFGAGSGMGFTAPDDASGSYKAMKSTIEDALKRV
FNPEFLNRIDDIVVFHPLEKQHIFKIIDITAGKLFKRLREMGIEVEIDEKAKEFLVDKGYDQKYGARPLKRALQKYVEDP
LAEEMLKGRFIEGSTIRILFDEDEGELRFIDGEPATKKRKRDEKLDKEVPDPNS

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=353, Percent_Identity=36.2606232294618, Blast_Score=208, Evalue=2e-53,
Organism=Escherichia coli, GI1788943, Length=888, Percent_Identity=44.8198198198198, Blast_Score=703, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=810, Percent_Identity=39.1358024691358, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320464, Length=714, Percent_Identity=47.7591036414566, Blast_Score=608, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6323002, Length=899, Percent_Identity=35.817575083426, Blast_Score=513, Evalue=1e-146,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 95731; Mature: 95731

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIAARILKNLKIDLYRLK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QKIEDSTHPKVPATQMGNVPLTKQAEKVLKITYLEAKICKSNIIGTEHLLLSILKGEDNI
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHH
ASQILEQFGVSYDMVRDELLSITSGGTESDEPPAEGYASSGGSERSAKKADPKRGERTKT
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVLDNFGRDITRLALDDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
CCHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHH
LHTIIGAGGASGSLDASNIFKPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVE
HHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHCC
PATVDETILILNNIKSKYEVHHHVRYSEDAIEKAVKLSERYITDRFLPDKAIDVMDEAGA
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
RVHLSNIHVPDEILELEKSIEAIKTEKNQVVKMQNFEEAAKLRDKEKHLLESLDHAKQEW
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDRAAESVYDVTETDITSVIAMMTGIPVARVAQSESKKLLSMEADLMKEVIGQDEAIKKI
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TKAIQRTRAGLKDPSRPIGSFIFLGPTGVGKTELAKALTRYIFDTEDALIRADMSEYMEK
HHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDEIEKAHPDVFNILLQVLDEGVLT
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHHCCHHHHHHHHHHHCCHHC
DGLGRKVDFRNTIIIMTSNIGAKDIKSFGAGSGMGFTAPDDASGSYKAMKSTIEDALKRV
CCCCCCEECCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FNPEFLNRIDDIVVFHPLEKQHIFKIIDITAGKLFKRLREMGIEVEIDEKAKEFLVDKGY
CCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCC
DQKYGARPLKRALQKYVEDPLAEEMLKGRFIEGSTIRILFDEDEGELRFIDGEPATKKRK
CCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCHHHHH
RDEKLDKEVPDPNS
HHHHHHHCCCCCCC
>Mature Secondary Structure
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIAARILKNLKIDLYRLK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QKIEDSTHPKVPATQMGNVPLTKQAEKVLKITYLEAKICKSNIIGTEHLLLSILKGEDNI
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHH
ASQILEQFGVSYDMVRDELLSITSGGTESDEPPAEGYASSGGSERSAKKADPKRGERTKT
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVLDNFGRDITRLALDDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
CCHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHH
LHTIIGAGGASGSLDASNIFKPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVE
HHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHCC
PATVDETILILNNIKSKYEVHHHVRYSEDAIEKAVKLSERYITDRFLPDKAIDVMDEAGA
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
RVHLSNIHVPDEILELEKSIEAIKTEKNQVVKMQNFEEAAKLRDKEKHLLESLDHAKQEW
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDRAAESVYDVTETDITSVIAMMTGIPVARVAQSESKKLLSMEADLMKEVIGQDEAIKKI
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TKAIQRTRAGLKDPSRPIGSFIFLGPTGVGKTELAKALTRYIFDTEDALIRADMSEYMEK
HHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDEIEKAHPDVFNILLQVLDEGVLT
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHHCCHHHHHHHHHHHCCHHC
DGLGRKVDFRNTIIIMTSNIGAKDIKSFGAGSGMGFTAPDDASGSYKAMKSTIEDALKRV
CCCCCCEECCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FNPEFLNRIDDIVVFHPLEKQHIFKIIDITAGKLFKRLREMGIEVEIDEKAKEFLVDKGY
CCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCC
DQKYGARPLKRALQKYVEDPLAEEMLKGRFIEGSTIRILFDEDEGELRFIDGEPATKKRK
CCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCHHHHH
RDEKLDKEVPDPNS
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]