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The map label for this gene is mutL

Identifier: 119356019

GI number: 119356019

Start: 194046

End: 195920

Strand: Reverse

Name: mutL

Synonym: Cpha266_0172

Alternate gene names: 119356019

Gene position: 195920-194046 (Counterclockwise)

Preceding gene: 119356021

Following gene: 119356017

Centisome position: 6.25

GC content: 49.97

Gene sequence:

>1875_bases
ATGGCAAAAATCGCGCGATTACCGGACAATGTCGCCAACAAAATTTCGGCTGGCGAGGTAGTGCAACGTCCGGCATCAGT
CATCAAGGAACTTCTCGAAAACGCCATTGATGCCTGCGCGTCAAAAATAACCGTGACCATCAAGGATGCCGGCAAAGAAC
TGGTGCAGATAGTTGACAACGGAATCGGTATGAGTCGCCAGGATGCGCTGCTCTCGGTTGAACGCTTTGCAACAAGCAAG
ATTTCAGGCGTTGAAGACCTCGACTCGCTCATGAGCCTTGGATTCAGAGGCGAAGCGCTGCCAAGCATCGCTTCGGTTTC
ACAGTTCGAACTGAAAACCAAGCCGGAAGGCGCCCTGCTCGGCTTCAGGTTTCGCTGCGACGGAGGAGAACCGGTTGAAG
AATCCGAAGTCAATGCCGAAAAGGGAACAACCATCACAGTAAGAAATCTCTTTTACAACGTTCCGGCACGCAGAAAATTC
CTCAAATCAAACGCAACAGAGTTCCGTCATATTTTCGAGTCAGTCAAGTCGCTGGCACTTGCCTATCCGGAAATCGAATG
GAAAATGGTCAGCGATGACGAAGAACTCTTCCACTTCAGAACTCCCGACATTTACGAACGCCTCGATGCTTTTTATGGTG
AAAATTTCTCCCTGAGCCTCATACCTGTTTCTGAAGAGAACGATTACCTGTCGATAAGCGGCTTTCTGGGAAAACCGGGC
ATGCAGAAACGGCAGAAACTCGATCAGTATATCTATGTTAACCGGAGAATTATTCAAAACAGGATGCTCTCACAAGCCTT
GCAGCAAGCCTATGGCGAACTGCTCGTCGAGCGTCAGGCTCCGTTTGCCCTGCTCTTTCTCGGCATTGACCCCTCACGTA
TTGATGTTAACGTACACCCGGCAAAACTTGAAGTCAAATTCGAAGATGAGCGAAGTGTACGGACCATGTTTTATCCTGTT
ATCAAGCGGACCATCCAGCTTCACGACTTTTCACCTGATGCCGCTGAAAAAGAACCCTGTTCGATCAAGGAAGGCACTCT
TGATTGTTCATCAAGAAAACTCGGGTTTCAGGACATCGCGGAACCTGCATCGACAACCAGCACACTCTATGCAAACTATC
GGCAGGGGGCTTTCGGCGATACACCCTTCGAACGACCTGCCTACGCGGAAAAAGAGCCCCGCCCGTCATCCATCAATACA
GGCTTTGAGCGTTTTGAACCAGATCTGCGCGAAGGAGGCGACCTGTTTTCGACAACACTCCAGGCAAGACCTTACGAGGA
CGACAACACTCCTGATCCGGGAGAAAACGACCCCAAAATCTGGCAACTGCACAACAAATACATTATCTGCCAGATCAAGA
CAGGAATGATGATTATCGACCAGCACGTAGCCCATGAGCGAGTGCTCTACGAACGAGCCGTTGATGTCATGAACCAGAAC
GTACCAAACTCTCAGCAACTGCTCTTCCCCCAGAAAATCGAACTCCGTGCCTGGGAATATGAAGTGTTCGAAGAAATTCG
GGACGACCTCTATCGGCTTGGATTCAACCTCCGCTCATTCGGCGCAAAAACAGTGATGATCGAAGGAATTCCTCAGGATG
TCAGACCCGGAACCGAAGTCACCATCCTGCAGGACATGATTACCGAGTTTCAGGAAAACAGCTCAAAGCTGAAACTCGAA
AGAAGAGAAAACCTTGCAAGATCCTACTCCTGCCGCAATGCCATTATGGCCGGTCAGAAACTATCGCTTGAAGAGATGCG
CTCGTTGATTGACAACCTCTTCGCCACACGGGTACCCTATACCTGTCCGCACGGCAGACCTGTTATCATAAAGCTCTCGC
TCGACCAGCTCGACAGGATGTTCGGGCGAAAATAA

Upstream 100 bases:

>100_bases
ATTTTATCGTAAAAGATCTCTATTTATCGATAACTTGTTTTTAGTTTGGCAGACGAGCAAAAACTTCCTATAACTGACCG
TATCGTTCCAACAGTTTTCT

Downstream 100 bases:

>100_bases
CTGCGGAGTTGTATCTTTTCAGAAAAGTACTAAATTTAGGCCATACCCTTGTAGCTCAGTGGATAGAGCAACAGTTTCCT
AAACTGTGGGTCGGCAGTTC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MAKIARLPDNVANKISAGEVVQRPASVIKELLENAIDACASKITVTIKDAGKELVQIVDNGIGMSRQDALLSVERFATSK
ISGVEDLDSLMSLGFRGEALPSIASVSQFELKTKPEGALLGFRFRCDGGEPVEESEVNAEKGTTITVRNLFYNVPARRKF
LKSNATEFRHIFESVKSLALAYPEIEWKMVSDDEELFHFRTPDIYERLDAFYGENFSLSLIPVSEENDYLSISGFLGKPG
MQKRQKLDQYIYVNRRIIQNRMLSQALQQAYGELLVERQAPFALLFLGIDPSRIDVNVHPAKLEVKFEDERSVRTMFYPV
IKRTIQLHDFSPDAAEKEPCSIKEGTLDCSSRKLGFQDIAEPASTTSTLYANYRQGAFGDTPFERPAYAEKEPRPSSINT
GFERFEPDLREGGDLFSTTLQARPYEDDNTPDPGENDPKIWQLHNKYIICQIKTGMMIIDQHVAHERVLYERAVDVMNQN
VPNSQQLLFPQKIELRAWEYEVFEEIRDDLYRLGFNLRSFGAKTVMIEGIPQDVRPGTEVTILQDMITEFQENSSKLKLE
RRENLARSYSCRNAIMAGQKLSLEEMRSLIDNLFATRVPYTCPHGRPVIIKLSLDQLDRMFGRK

Sequences:

>Translated_624_residues
MAKIARLPDNVANKISAGEVVQRPASVIKELLENAIDACASKITVTIKDAGKELVQIVDNGIGMSRQDALLSVERFATSK
ISGVEDLDSLMSLGFRGEALPSIASVSQFELKTKPEGALLGFRFRCDGGEPVEESEVNAEKGTTITVRNLFYNVPARRKF
LKSNATEFRHIFESVKSLALAYPEIEWKMVSDDEELFHFRTPDIYERLDAFYGENFSLSLIPVSEENDYLSISGFLGKPG
MQKRQKLDQYIYVNRRIIQNRMLSQALQQAYGELLVERQAPFALLFLGIDPSRIDVNVHPAKLEVKFEDERSVRTMFYPV
IKRTIQLHDFSPDAAEKEPCSIKEGTLDCSSRKLGFQDIAEPASTTSTLYANYRQGAFGDTPFERPAYAEKEPRPSSINT
GFERFEPDLREGGDLFSTTLQARPYEDDNTPDPGENDPKIWQLHNKYIICQIKTGMMIIDQHVAHERVLYERAVDVMNQN
VPNSQQLLFPQKIELRAWEYEVFEEIRDDLYRLGFNLRSFGAKTVMIEGIPQDVRPGTEVTILQDMITEFQENSSKLKLE
RRENLARSYSCRNAIMAGQKLSLEEMRSLIDNLFATRVPYTCPHGRPVIIKLSLDQLDRMFGRK
>Mature_623_residues
AKIARLPDNVANKISAGEVVQRPASVIKELLENAIDACASKITVTIKDAGKELVQIVDNGIGMSRQDALLSVERFATSKI
SGVEDLDSLMSLGFRGEALPSIASVSQFELKTKPEGALLGFRFRCDGGEPVEESEVNAEKGTTITVRNLFYNVPARRKFL
KSNATEFRHIFESVKSLALAYPEIEWKMVSDDEELFHFRTPDIYERLDAFYGENFSLSLIPVSEENDYLSISGFLGKPGM
QKRQKLDQYIYVNRRIIQNRMLSQALQQAYGELLVERQAPFALLFLGIDPSRIDVNVHPAKLEVKFEDERSVRTMFYPVI
KRTIQLHDFSPDAAEKEPCSIKEGTLDCSSRKLGFQDIAEPASTTSTLYANYRQGAFGDTPFERPAYAEKEPRPSSINTG
FERFEPDLREGGDLFSTTLQARPYEDDNTPDPGENDPKIWQLHNKYIICQIKTGMMIIDQHVAHERVLYERAVDVMNQNV
PNSQQLLFPQKIELRAWEYEVFEEIRDDLYRLGFNLRSFGAKTVMIEGIPQDVRPGTEVTILQDMITEFQENSSKLKLER
RENLARSYSCRNAIMAGQKLSLEEMRSLIDNLFATRVPYTCPHGRPVIIKLSLDQLDRMFGRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=316, Percent_Identity=35.4430379746835, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI4505913, Length=330, Percent_Identity=26.969696969697, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI310128478, Length=330, Percent_Identity=26.969696969697, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=26.7692307692308, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=26.2996941896024, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI189458896, Length=314, Percent_Identity=25.4777070063694, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI91992162, Length=262, Percent_Identity=30.5343511450382, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI91992160, Length=262, Percent_Identity=30.5343511450382, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=25.6756756756757, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI263191589, Length=222, Percent_Identity=29.2792792792793, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1790612, Length=611, Percent_Identity=30.7692307692308, Blast_Score=236, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=31.9875776397516, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=347, Percent_Identity=28.8184438040346, Blast_Score=135, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=31.9488817891374, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=352, Percent_Identity=26.4204545454545, Blast_Score=120, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323063, Length=153, Percent_Identity=28.1045751633987, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136968, Length=309, Percent_Identity=33.9805825242718, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17136970, Length=360, Percent_Identity=23.6111111111111, Blast_Score=102, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CHLPD (A1BCW2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_910663.1
- ProteinModelPortal:   A1BCW2
- SMR:   A1BCW2
- STRING:   A1BCW2
- GeneID:   4568469
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0172
- NMPDR:   fig|290317.7.peg.183
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   CLSK638049
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70994; Mature: 70862

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIARLPDNVANKISAGEVVQRPASVIKELLENAIDACASKITVTIKDAGKELVQIVDN
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHC
GIGMSRQDALLSVERFATSKISGVEDLDSLMSLGFRGEALPSIASVSQFELKTKPEGALL
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCCEE
GFRFRCDGGEPVEESEVNAEKGTTITVRNLFYNVPARRKFLKSNATEFRHIFESVKSLAL
EEEEECCCCCCCCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHH
AYPEIEWKMVSDDEELFHFRTPDIYERLDAFYGENFSLSLIPVSEENDYLSISGFLGKPG
HCCCCEEEEECCCHHHEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCC
MQKRQKLDQYIYVNRRIIQNRMLSQALQQAYGELLVERQAPFALLFLGIDPSRIDVNVHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECC
AKLEVKFEDERSVRTMFYPVIKRTIQLHDFSPDAAEKEPCSIKEGTLDCSSRKLGFQDIA
EEEEEEECCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
EPASTTSTLYANYRQGAFGDTPFERPAYAEKEPRPSSINTGFERFEPDLREGGDLFSTTL
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCHHHHHH
QARPYEDDNTPDPGENDPKIWQLHNKYIICQIKTGMMIIDQHVAHERVLYERAVDVMNQN
CCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHCC
VPNSQQLLFPQKIELRAWEYEVFEEIRDDLYRLGFNLRSFGAKTVMIEGIPQDVRPGTEV
CCCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCCCCCC
TILQDMITEFQENSSKLKLERRENLARSYSCRNAIMAGQKLSLEEMRSLIDNLFATRVPY
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
TCPHGRPVIIKLSLDQLDRMFGRK
CCCCCCEEEEEECHHHHHHHHCCC
>Mature Secondary Structure 
AKIARLPDNVANKISAGEVVQRPASVIKELLENAIDACASKITVTIKDAGKELVQIVDN
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHC
GIGMSRQDALLSVERFATSKISGVEDLDSLMSLGFRGEALPSIASVSQFELKTKPEGALL
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCCEE
GFRFRCDGGEPVEESEVNAEKGTTITVRNLFYNVPARRKFLKSNATEFRHIFESVKSLAL
EEEEECCCCCCCCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHH
AYPEIEWKMVSDDEELFHFRTPDIYERLDAFYGENFSLSLIPVSEENDYLSISGFLGKPG
HCCCCEEEEECCCHHHEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCC
MQKRQKLDQYIYVNRRIIQNRMLSQALQQAYGELLVERQAPFALLFLGIDPSRIDVNVHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECC
AKLEVKFEDERSVRTMFYPVIKRTIQLHDFSPDAAEKEPCSIKEGTLDCSSRKLGFQDIA
EEEEEEECCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHC
EPASTTSTLYANYRQGAFGDTPFERPAYAEKEPRPSSINTGFERFEPDLREGGDLFSTTL
CCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCHHHHHH
QARPYEDDNTPDPGENDPKIWQLHNKYIICQIKTGMMIIDQHVAHERVLYERAVDVMNQN
CCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHCC
VPNSQQLLFPQKIELRAWEYEVFEEIRDDLYRLGFNLRSFGAKTVMIEGIPQDVRPGTEV
CCCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCCCCCC
TILQDMITEFQENSSKLKLERRENLARSYSCRNAIMAGQKLSLEEMRSLIDNLFATRVPY
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
TCPHGRPVIIKLSLDQLDRMFGRK
CCCCCCEEEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA