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The map label for this gene is hemE [H]

Identifier: 119356021

GI number: 119356021

Start: 198999

End: 200054

Strand: Reverse

Name: hemE [H]

Synonym: Cpha266_0174

Alternate gene names: 119356021

Gene position: 200054-198999 (Counterclockwise)

Preceding gene: 119356022

Following gene: 119356019

Centisome position: 6.38

GC content: 48.86

Gene sequence:

>1056_bases
ATGCTCAAAAATGATCTCTTCCTCCGGGCGTTAAAAAGACAGCCTTGCTCACGAACACCAATCTGGGTGATGCGGCAGGC
TGGCCGTTACTTGCCGGAATATCGTGCCGTAAGAGAAAAAACAGACTTTTTAACCTTGTGCAAAACCCCGGAACTGGCAG
CAGAAGTAACCATTCAGCCGGTTGACTTAATGGGTGTCGATGCAGCCATTATTTTCTCGGATATCCTTGTCGTCAACGAA
GCCATGGGAATGGACGTCGAAATCATCGAATCCAAAGGCATACGGCTCTCACCTGCTATCCGCTCGCAGGTCGACATTGA
TCGGCTTATCATCCCTGACATCAATGAAAAGCTCGGGTATGTGATGGATGCCATCCGCCTGACAAAAAAAGAGCTTGACA
ACAGAGTCCCGCTTATCGGATTTTCCGGTGCAGCATGGACGCTCTTCACCTATGCCGTCGAAGGTGGTGGGTCAAAGAAC
TACGCCTTTGCCAAAAAGATGATGTATCGTGAGCCGAAAATGGCCCATATGCTCCTCAGCAAAATTTCCAGCGTCATCAC
CGAATATGTCCTGATGCAGATCGAAGCCGGTGCAGATGCAATCCAGATATTCGATTCATGGGCAAGCGCACTTTCAGAAG
ACGACTATCGCGAATTTGCCCTTCCCTATATCAAGGAAAACGTTCAGGCAATCAAGACAAAATATCCCGACACTCCGGTA
ATTGTCTTCTCGAAAGACTGTAACACCATTCTCTCCGAAATTGCCGATACCGGCTGCGATGCCATGGGCCTTGGATGGAA
CATGGATATTGCCAAAGCGCGCAAAGAACTGAACGACAGAGTCTGCATTCAGGGCAATATGGATCCGACAGTACTGTACG
GCACTCCGGATAAAATCCGCTCGGAAGCAGCCAAAATACTCAAGCAGTTTGGCCAGCATACAGCGACATCAGGCCATGTG
TTCAACCTCGGACACGGCATTCTTCCGGATGTCGATCCTGCAAACCTGAAACTCCTTGTGGAATTTGTCAAGGAAGAAAG
TGTCAAGTACCACTAA

Upstream 100 bases:

>100_bases
AAAAACGTAGCTTTGCACGTTCACTTCGCTCTCAGTTCATACATTGACCGCTATGCTGAAGAGTATCTGTTTTTTTCAAC
CACTCAAATAACTGCGTTGC

Downstream 100 bases:

>100_bases
GTAACGCACCTTTTCTCTCTGATACCCTTTCTTCTGCGCCGCCTGATGCATCAACCATCAGGCGGCGTTTTTATGTACAA
CAGCCAGAATTAAAATCCGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MLKNDLFLRALKRQPCSRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELAAEVTIQPVDLMGVDAAIIFSDILVVNE
AMGMDVEIIESKGIRLSPAIRSQVDIDRLIIPDINEKLGYVMDAIRLTKKELDNRVPLIGFSGAAWTLFTYAVEGGGSKN
YAFAKKMMYREPKMAHMLLSKISSVITEYVLMQIEAGADAIQIFDSWASALSEDDYREFALPYIKENVQAIKTKYPDTPV
IVFSKDCNTILSEIADTGCDAMGLGWNMDIAKARKELNDRVCIQGNMDPTVLYGTPDKIRSEAAKILKQFGQHTATSGHV
FNLGHGILPDVDPANLKLLVEFVKEESVKYH

Sequences:

>Translated_351_residues
MLKNDLFLRALKRQPCSRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELAAEVTIQPVDLMGVDAAIIFSDILVVNE
AMGMDVEIIESKGIRLSPAIRSQVDIDRLIIPDINEKLGYVMDAIRLTKKELDNRVPLIGFSGAAWTLFTYAVEGGGSKN
YAFAKKMMYREPKMAHMLLSKISSVITEYVLMQIEAGADAIQIFDSWASALSEDDYREFALPYIKENVQAIKTKYPDTPV
IVFSKDCNTILSEIADTGCDAMGLGWNMDIAKARKELNDRVCIQGNMDPTVLYGTPDKIRSEAAKILKQFGQHTATSGHV
FNLGHGILPDVDPANLKLLVEFVKEESVKYH
>Mature_351_residues
MLKNDLFLRALKRQPCSRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELAAEVTIQPVDLMGVDAAIIFSDILVVNE
AMGMDVEIIESKGIRLSPAIRSQVDIDRLIIPDINEKLGYVMDAIRLTKKELDNRVPLIGFSGAAWTLFTYAVEGGGSKN
YAFAKKMMYREPKMAHMLLSKISSVITEYVLMQIEAGADAIQIFDSWASALSEDDYREFALPYIKENVQAIKTKYPDTPV
IVFSKDCNTILSEIADTGCDAMGLGWNMDIAKARKELNDRVCIQGNMDPTVLYGTPDKIRSEAAKILKQFGQHTATSGHV
FNLGHGILPDVDPANLKLLVEFVKEESVKYH

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=42.6136363636364, Blast_Score=305, Evalue=3e-83,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=49.0084985835694, Blast_Score=353, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6320252, Length=349, Percent_Identity=40.4011461318052, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI19921920, Length=350, Percent_Identity=40.5714285714286, Blast_Score=277, Evalue=7e-75,
Organism=Drosophila melanogaster, GI221330099, Length=350, Percent_Identity=40.5714285714286, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39333; Mature: 39333

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNDLFLRALKRQPCSRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELAAEVTIQP
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCCCEEEECE
VDLMGVDAAIIFSDILVVNEAMGMDVEIIESKGIRLSPAIRSQVDIDRLIIPDINEKLGY
EHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHCCCCEEECCCCHHHHHH
VMDAIRLTKKELDNRVPLIGFSGAAWTLFTYAVEGGGSKNYAFAKKMMYREPKMAHMLLS
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHH
KISSVITEYVLMQIEAGADAIQIFDSWASALSEDDYREFALPYIKENVQAIKTKYPDTPV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
IVFSKDCNTILSEIADTGCDAMGLGWNMDIAKARKELNDRVCIQGNMDPTVLYGTPDKIR
EEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEECCHHHHH
SEAAKILKQFGQHTATSGHVFNLGHGILPDVDPANLKLLVEFVKEESVKYH
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKNDLFLRALKRQPCSRTPIWVMRQAGRYLPEYRAVREKTDFLTLCKTPELAAEVTIQP
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCCCEEEECE
VDLMGVDAAIIFSDILVVNEAMGMDVEIIESKGIRLSPAIRSQVDIDRLIIPDINEKLGY
EHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHCCCCEEECCCCHHHHHH
VMDAIRLTKKELDNRVPLIGFSGAAWTLFTYAVEGGGSKNYAFAKKMMYREPKMAHMLLS
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHH
KISSVITEYVLMQIEAGADAIQIFDSWASALSEDDYREFALPYIKENVQAIKTKYPDTPV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
IVFSKDCNTILSEIADTGCDAMGLGWNMDIAKARKELNDRVCIQGNMDPTVLYGTPDKIR
EEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEECCHHHHH
SEAAKILKQFGQHTATSGHVFNLGHGILPDVDPANLKLLVEFVKEESVKYH
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA