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The map label for this gene is gyrB [H]

Identifier: 119355886

GI number: 119355886

Start: 36774

End: 38705

Strand: Reverse

Name: gyrB [H]

Synonym: Cpha266_0036

Alternate gene names: 119355886

Gene position: 38705-36774 (Counterclockwise)

Preceding gene: 119355887

Following gene: 119355878

Centisome position: 1.24

GC content: 47.93

Gene sequence:

>1932_bases
ATGCAGGAAACCGTTCCGCAGGCCCCGTCCCCATATATTGCCTCAAATATTCAAATTCTCGACGGCATTGAACATGTTCG
TAAACGCCCTGCCATGTATATCGGCGATATACACACCAGAGGACTGCACCATCTCATTTACGAAATCGTCGACAACTCCA
TAGACGAAACCCTCGGAGGCTTCAACGAGTATATTTTTGTCTCCTTGAATCCTGACGGTTCGGTTACCGTTATCGACCAT
GGCCGCGGCATCCCTGTAGATATTCACCCTCAAAAGCAGAAATCCGCTCTTGAACTGGTCATGACCGTCATTGGGGCCGG
GGGTAAATTCGATAAAGGCTCCTATAAAGTTTCCGGAGGTCTTCATGGTGTAGGCGCATCCGTGGTGAACGCTCTTTCGG
AATGGTGCGAAGTCGAAGTATATCGCGACGGCAAAGCTTATTTTCAACGTTTCGAACGCGGTGTGCCTCAAGGCAATGTC
AGGGAGATCGGATTATCCGATCAAAAAGGAACAAAAACCACCTTCAAGCCTGACAATCTTATTTTCAAAACGACCGAGTT
CCGCAAAGACATCATTATCGATCGTATGCGGGAACTGGCATTCCTCAATAAAAATCTCAGCATTACCGTACAGGACGCTG
ATGGAGCCCAGGAGATCTTTCATTACGAAGGCGGTCTGAAAGAGTTCGTCCGCTTTACCGACATCAACAGACTGAGCCTC
ATCAAGGAACCAATCTACTTTATCGGAGAACGCGATACCACAATTGTTGAAATCGCCCTTCAATACAATGATTCGTATCA
GGAGAACGTCTTCAGCTACGTCAATAACATCAATACGCACGAAGGGGGAACGCACGTCACCGGGTTTCGCAAGGCATTGA
CAAGAACGCTTAACCTGTACGCGCAGAAAAACGATCTGCTGAAAAACCTGAAACTCTCATTGACCGGCGACGATTTCAAA
GAGGGTCTGACGGCGGTGATATCCGTCAAGGTTGAAGAACCTCAGTTTGAAGGTCAGACAAAAACGAAGCTTGGAAACTC
GGAAACGCAAAGCATTGTCGAAAGCATCGTCAATGAACTGCTTTCAGAATTTGCCGAAAGTAACCCGAATGTGATCAAAA
TGATCATTGAAAAGGTGAAAGGAGCGGCAATGTCGAGAGAAGCTGCAAGAAAAGCCAAAGAGCTGACCCGAAGAAAATCG
GTACTCGAAAGTTCAGGACTTCCCGGAAAACTCGCCGACTGCTCAATCAACGATCCGGAACACTGCGAGCTCTACATCGT
TGAGGGTGATTCGGCAGGAGGCAGCGCCAAACAGGGAAGAGACAGAAGCTTTCAGGCAATTCTGCCTCTTAAAGGCAAAA
TTCTGAACGTCGAAAAAGCCCGTCTTCACAAAATGCTTGAAAATGAGGAGATTAAAACCATCATTCTTGCCCTCGGCACA
AGCTTTGGCGAAGAAGAATTCTCGCCCGAAAAGCTTCGCTATGGAAAAATCATCATCATGACCGATGCCGACGTTGACGG
TGCGCATATCAGAACCCTGTTGCTGACGTTTTTCTTTCGCTATATGCGATCGTTGATCGAAGCAGGAAAGGTCTATATCG
CCCAACCCCCGCTTTACCTGGTCAAGTCGGGAAAAGATCAGCAGTACGCCTGGGATGACGAAGAGCGCAACAGTATTACC
GACACGCTCAAAAAGATGCAGAAAGGAAAAGCCAATATTCACATCCAGCGATACAAAGGCCTTGGAGAGATGAACCCCGA
ACAGCTCTGGAGCACGACCATGGATCCGGCTCATCGCTCGCTGTTACAGGTGAGCGTCGAAAATGCCCGTGAAGCAGATC
AGATATTTTCGACGCTGATGGGAGACAAGGTTGAACCGAGAAGAGAATTCATCGAGAAAAATGCTCGCTATGTCCGGCGA
TTAGATGTCTGA

Upstream 100 bases:

>100_bases
TGCTTTCCAGGCGGAATAGTCCTCCCGGAAGCAGCAGAATAGCGCTATTTTTGTTATCTTGAAGATTATCTTGTTCACCC
AGTTACCTTGTAAAAAGATT

Downstream 100 bases:

>100_bases
TATTCGGACAAGTACCTCTTTTTTGAGCTGGCTGAGCCATTCGTTATATCGCTCCTGCTTTTTGGCTTCAAGAGCCAGCT
CTTCAAGAGATGCGTAGTCC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MQETVPQAPSPYIASNIQILDGIEHVRKRPAMYIGDIHTRGLHHLIYEIVDNSIDETLGGFNEYIFVSLNPDGSVTVIDH
GRGIPVDIHPQKQKSALELVMTVIGAGGKFDKGSYKVSGGLHGVGASVVNALSEWCEVEVYRDGKAYFQRFERGVPQGNV
REIGLSDQKGTKTTFKPDNLIFKTTEFRKDIIIDRMRELAFLNKNLSITVQDADGAQEIFHYEGGLKEFVRFTDINRLSL
IKEPIYFIGERDTTIVEIALQYNDSYQENVFSYVNNINTHEGGTHVTGFRKALTRTLNLYAQKNDLLKNLKLSLTGDDFK
EGLTAVISVKVEEPQFEGQTKTKLGNSETQSIVESIVNELLSEFAESNPNVIKMIIEKVKGAAMSREAARKAKELTRRKS
VLESSGLPGKLADCSINDPEHCELYIVEGDSAGGSAKQGRDRSFQAILPLKGKILNVEKARLHKMLENEEIKTIILALGT
SFGEEEFSPEKLRYGKIIIMTDADVDGAHIRTLLLTFFFRYMRSLIEAGKVYIAQPPLYLVKSGKDQQYAWDDEERNSIT
DTLKKMQKGKANIHIQRYKGLGEMNPEQLWSTTMDPAHRSLLQVSVENAREADQIFSTLMGDKVEPRREFIEKNARYVRR
LDV

Sequences:

>Translated_643_residues
MQETVPQAPSPYIASNIQILDGIEHVRKRPAMYIGDIHTRGLHHLIYEIVDNSIDETLGGFNEYIFVSLNPDGSVTVIDH
GRGIPVDIHPQKQKSALELVMTVIGAGGKFDKGSYKVSGGLHGVGASVVNALSEWCEVEVYRDGKAYFQRFERGVPQGNV
REIGLSDQKGTKTTFKPDNLIFKTTEFRKDIIIDRMRELAFLNKNLSITVQDADGAQEIFHYEGGLKEFVRFTDINRLSL
IKEPIYFIGERDTTIVEIALQYNDSYQENVFSYVNNINTHEGGTHVTGFRKALTRTLNLYAQKNDLLKNLKLSLTGDDFK
EGLTAVISVKVEEPQFEGQTKTKLGNSETQSIVESIVNELLSEFAESNPNVIKMIIEKVKGAAMSREAARKAKELTRRKS
VLESSGLPGKLADCSINDPEHCELYIVEGDSAGGSAKQGRDRSFQAILPLKGKILNVEKARLHKMLENEEIKTIILALGT
SFGEEEFSPEKLRYGKIIIMTDADVDGAHIRTLLLTFFFRYMRSLIEAGKVYIAQPPLYLVKSGKDQQYAWDDEERNSIT
DTLKKMQKGKANIHIQRYKGLGEMNPEQLWSTTMDPAHRSLLQVSVENAREADQIFSTLMGDKVEPRREFIEKNARYVRR
LDV
>Mature_643_residues
MQETVPQAPSPYIASNIQILDGIEHVRKRPAMYIGDIHTRGLHHLIYEIVDNSIDETLGGFNEYIFVSLNPDGSVTVIDH
GRGIPVDIHPQKQKSALELVMTVIGAGGKFDKGSYKVSGGLHGVGASVVNALSEWCEVEVYRDGKAYFQRFERGVPQGNV
REIGLSDQKGTKTTFKPDNLIFKTTEFRKDIIIDRMRELAFLNKNLSITVQDADGAQEIFHYEGGLKEFVRFTDINRLSL
IKEPIYFIGERDTTIVEIALQYNDSYQENVFSYVNNINTHEGGTHVTGFRKALTRTLNLYAQKNDLLKNLKLSLTGDDFK
EGLTAVISVKVEEPQFEGQTKTKLGNSETQSIVESIVNELLSEFAESNPNVIKMIIEKVKGAAMSREAARKAKELTRRKS
VLESSGLPGKLADCSINDPEHCELYIVEGDSAGGSAKQGRDRSFQAILPLKGKILNVEKARLHKMLENEEIKTIILALGT
SFGEEEFSPEKLRYGKIIIMTDADVDGAHIRTLLLTFFFRYMRSLIEAGKVYIAQPPLYLVKSGKDQQYAWDDEERNSIT
DTLKKMQKGKANIHIQRYKGLGEMNPEQLWSTTMDPAHRSLLQVSVENAREADQIFSTLMGDKVEPRREFIEKNARYVRR
LDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=613, Percent_Identity=26.7536704730832, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI19913406, Length=613, Percent_Identity=26.5905383360522, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI48994957, Length=546, Percent_Identity=55.6776556776557, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1789408, Length=632, Percent_Identity=40.0316455696203, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17535065, Length=662, Percent_Identity=25.0755287009063, Blast_Score=139, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI212645845, Length=599, Percent_Identity=25.8764607679466, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI212645657, Length=284, Percent_Identity=26.4084507042254, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=568, Percent_Identity=26.5845070422535, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136538, Length=545, Percent_Identity=26.4220183486239, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 72419; Mature: 72419

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETVPQAPSPYIASNIQILDGIEHVRKRPAMYIGDIHTRGLHHLIYEIVDNSIDETLGG
CCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCC
FNEYIFVSLNPDGSVTVIDHGRGIPVDIHPQKQKSALELVMTVIGAGGKFDKGSYKVSGG
CCCEEEEEECCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCC
LHGVGASVVNALSEWCEVEVYRDGKAYFQRFERGVPQGNVREIGLSDQKGTKTTFKPDNL
CCCHHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCE
IFKTTEFRKDIIIDRMRELAFLNKNLSITVQDADGAQEIFHYEGGLKEFVRFTDINRLSL
EEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHCCHHHHH
IKEPIYFIGERDTTIVEIALQYNDSYQENVFSYVNNINTHEGGTHVTGFRKALTRTLNLY
HHCCHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AQKNDLLKNLKLSLTGDDFKEGLTAVISVKVEEPQFEGQTKTKLGNSETQSIVESIVNEL
HHHHHHHHHCEEEECCCHHHCCCEEEEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHH
LSEFAESNPNVIKMIIEKVKGAAMSREAARKAKELTRRKSVLESSGLPGKLADCSINDPE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
HCELYIVEGDSAGGSAKQGRDRSFQAILPLKGKILNVEKARLHKMLENEEIKTIILALGT
CEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEECHHHHHHHHHHCCCHHHEEEEECCC
SFGEEEFSPEKLRYGKIIIMTDADVDGAHIRTLLLTFFFRYMRSLIEAGKVYIAQPPLYL
CCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEE
VKSGKDQQYAWDDEERNSITDTLKKMQKGKANIHIQRYKGLGEMNPEQLWSTTMDPAHRS
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHH
LLQVSVENAREADQIFSTLMGDKVEPRREFIEKNARYVRRLDV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQETVPQAPSPYIASNIQILDGIEHVRKRPAMYIGDIHTRGLHHLIYEIVDNSIDETLGG
CCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCC
FNEYIFVSLNPDGSVTVIDHGRGIPVDIHPQKQKSALELVMTVIGAGGKFDKGSYKVSGG
CCCEEEEEECCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCC
LHGVGASVVNALSEWCEVEVYRDGKAYFQRFERGVPQGNVREIGLSDQKGTKTTFKPDNL
CCCHHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCE
IFKTTEFRKDIIIDRMRELAFLNKNLSITVQDADGAQEIFHYEGGLKEFVRFTDINRLSL
EEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHCCHHHHH
IKEPIYFIGERDTTIVEIALQYNDSYQENVFSYVNNINTHEGGTHVTGFRKALTRTLNLY
HHCCHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AQKNDLLKNLKLSLTGDDFKEGLTAVISVKVEEPQFEGQTKTKLGNSETQSIVESIVNEL
HHHHHHHHHCEEEECCCHHHCCCEEEEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHH
LSEFAESNPNVIKMIIEKVKGAAMSREAARKAKELTRRKSVLESSGLPGKLADCSINDPE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
HCELYIVEGDSAGGSAKQGRDRSFQAILPLKGKILNVEKARLHKMLENEEIKTIILALGT
CEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEECHHHHHHHHHHCCCHHHEEEEECCC
SFGEEEFSPEKLRYGKIIIMTDADVDGAHIRTLLLTFFFRYMRSLIEAGKVYIAQPPLYL
CCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEE
VKSGKDQQYAWDDEERNSITDTLKKMQKGKANIHIQRYKGLGEMNPEQLWSTTMDPAHRS
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHH
LLQVSVENAREADQIFSTLMGDKVEPRREFIEKNARYVRRLDV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]