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The map label for this gene is cls [H]

Identifier: 118582006

GI number: 118582006

Start: 3988607

End: 3989812

Strand: Reverse

Name: cls [H]

Synonym: Ppro_3607

Alternate gene names: 118582006

Gene position: 3989812-3988607 (Counterclockwise)

Preceding gene: 118582007

Following gene: 118582005

Centisome position: 99.55

GC content: 63.43

Gene sequence:

>1206_bases
ATGGCCATGACGGAAGAGACCTACTTCAGACAGAACAAGCGGCTGGCGCGTCTCATGCGCCGCCTGGAGCGGGCGCGCAC
CCCTCCCCCGCCGGTCACCTACCGCCGCAACCGCGTCGCGCTACTGCCGGACGGGGAGAGCTTCTTCCGCGCCTTCCTGA
CCGCCATCCGCTCCGCTCGGTACGTCATCCTGCTGGAATACTACCTAATCCGCAACGATCGCACCGGTTCCGTCGTCGTG
GCCGAGTTGGCACGGGCCGTCGTGCGCGGTGTGCGGGTCATGCTGATCTACGATTACATCGGCTGCATGGATACCCCTTC
GTCCTTCTTCAGGTCCCTTGCCCAGCAGGGAATCGAATTGATCCCCTTCAACGTTCCCTCTTTCCGTCGTGGTATCCGCT
GGTTCGACCGCCGCGATCACCGCAAGATGATGGTGATCGATGGCTGCCGGGCTTTCCTGGGCGGCTTCAACATTGGTGAC
GAATACGCCGGCATTGCTTCACCGCCGCAACGCTTCCGCGACCTGGGTTTCAGCGTGGAGGGGAGCGCTGTCAGGGAGCT
GATCGGCATTTTCAATGAAACATGGCAGATGGAGGTGGGCCAGCTGCCGGAACTTCCGCGGGTCAGAGGGGTGAGCCCGG
GCAGCTCCAGTCATGGGGAGGCCAATGTGGCCTTTGTCAGCGGCGGCCCGCATCAGCGCAGCTCCTATATCCGCCATGCT
TTTCTGGTCAACATCGCCTCCGCCTCCGAGGATCTGTTGATCGTCAACCCCTATTTCGTGCCCGGCCCGCGCATTATCCG
CTCCCTGCTGCGGGCGGTGCGGCGCGGGGTGCGGGTGCGGCTGCTGCTGCCGGCACGCAGCGATGTGCCGCTGGTGCTGC
TGGTGGGGCGCAGCTCCTATGGCGCCCTGCTTAAGGGGGGGGTGGAGATTTACGAGCTGGAGGATGGCATTCTGCACGCC
AAGGTCATGCTGGTGGATGGAGAACGCACCATCCTGGGGTCGGCCAACCTGGATCAGCGCAGTTTCCACCGCAATTTCGA
GATCAACGGCATCATCGACAGCAGTTCCTTCGGCGCCCAGATTCGCCGGGTGGTGGAGCGGGAGGTGGTGGCCTCGCGGC
GCGTTACCCTGCATGGGCATGAGCGTCGGGGGCTCGTGACCCGTATGCTGGAAAAGCTGGTCAACCTGTTCGGCTGGTTT
CTGTAA

Upstream 100 bases:

>100_bases
AGGGTGAGTTTATCGGCTGTAGCGAAATGAGCCCTGGAATGACAGAAAGAGCCCGTCCGCACGAACGCAGGCAGCTCTCA
ACTGCCGAATACAGGTTGAT

Downstream 100 bases:

>100_bases
AACCATGACTGGTGATCCGTAATTTGTCGCCAATCACAAAGGTTCATGCCCATGAATCCACAGGAGTCGGAAGCGCAAAT
CGAGGACGGCATCAGGCTGC

Product: phospholipase D/transphosphatidylase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MAMTEETYFRQNKRLARLMRRLERARTPPPPVTYRRNRVALLPDGESFFRAFLTAIRSARYVILLEYYLIRNDRTGSVVV
AELARAVVRGVRVMLIYDYIGCMDTPSSFFRSLAQQGIELIPFNVPSFRRGIRWFDRRDHRKMMVIDGCRAFLGGFNIGD
EYAGIASPPQRFRDLGFSVEGSAVRELIGIFNETWQMEVGQLPELPRVRGVSPGSSSHGEANVAFVSGGPHQRSSYIRHA
FLVNIASASEDLLIVNPYFVPGPRIIRSLLRAVRRGVRVRLLLPARSDVPLVLLVGRSSYGALLKGGVEIYELEDGILHA
KVMLVDGERTILGSANLDQRSFHRNFEINGIIDSSSFGAQIRRVVEREVVASRRVTLHGHERRGLVTRMLEKLVNLFGWF
L

Sequences:

>Translated_401_residues
MAMTEETYFRQNKRLARLMRRLERARTPPPPVTYRRNRVALLPDGESFFRAFLTAIRSARYVILLEYYLIRNDRTGSVVV
AELARAVVRGVRVMLIYDYIGCMDTPSSFFRSLAQQGIELIPFNVPSFRRGIRWFDRRDHRKMMVIDGCRAFLGGFNIGD
EYAGIASPPQRFRDLGFSVEGSAVRELIGIFNETWQMEVGQLPELPRVRGVSPGSSSHGEANVAFVSGGPHQRSSYIRHA
FLVNIASASEDLLIVNPYFVPGPRIIRSLLRAVRRGVRVRLLLPARSDVPLVLLVGRSSYGALLKGGVEIYELEDGILHA
KVMLVDGERTILGSANLDQRSFHRNFEINGIIDSSSFGAQIRRVVEREVVASRRVTLHGHERRGLVTRMLEKLVNLFGWF
L
>Mature_400_residues
AMTEETYFRQNKRLARLMRRLERARTPPPPVTYRRNRVALLPDGESFFRAFLTAIRSARYVILLEYYLIRNDRTGSVVVA
ELARAVVRGVRVMLIYDYIGCMDTPSSFFRSLAQQGIELIPFNVPSFRRGIRWFDRRDHRKMMVIDGCRAFLGGFNIGDE
YAGIASPPQRFRDLGFSVEGSAVRELIGIFNETWQMEVGQLPELPRVRGVSPGSSSHGEANVAFVSGGPHQRSSYIRHAF
LVNIASASEDLLIVNPYFVPGPRIIRSLLRAVRRGVRVRLLLPARSDVPLVLLVGRSSYGALLKGGVEIYELEDGILHAK
VMLVDGERTILGSANLDQRSFHRNFEINGIIDSSSFGAQIRRVVEREVVASRRVTLHGHERRGLVTRMLEKLVNLFGWFL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=374, Percent_Identity=31.8181818181818, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1787007, Length=333, Percent_Identity=31.5315315315315, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081826, Length=411, Percent_Identity=27.4939172749392, Blast_Score=95, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR015679
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 45459; Mature: 45328

Theoretical pI: Translated: 11.07; Mature: 11.07

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMTEETYFRQNKRLARLMRRLERARTPPPPVTYRRNRVALLPDGESFFRAFLTAIRSAR
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCC
YVILLEYYLIRNDRTGSVVVAELARAVVRGVRVMLIYDYIGCMDTPSSFFRSLAQQGIEL
EEEEEEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEE
IPFNVPSFRRGIRWFDRRDHRKMMVIDGCRAFLGGFNIGDEYAGIASPPQRFRDLGFSVE
EECCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCC
GSAVRELIGIFNETWQMEVGQLPELPRVRGVSPGSSSHGEANVAFVSGGPHQRSSYIRHA
CHHHHHHHHHHHHCHHECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
FLVNIASASEDLLIVNPYFVPGPRIIRSLLRAVRRGVRVRLLLPARSDVPLVLLVGRSSY
HEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCC
GALLKGGVEIYELEDGILHAKVMLVDGERTILGSANLDQRSFHRNFEINGIIDSSSFGAQ
CHHHHCCEEEEEECCCEEEEEEEEEECCEEEEECCCCCHHHHHCCCEEEEEECCCHHHHH
IRRVVEREVVASRRVTLHGHERRGLVTRMLEKLVNLFGWFL
HHHHHHHHHHHHCCEEEECCHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AMTEETYFRQNKRLARLMRRLERARTPPPPVTYRRNRVALLPDGESFFRAFLTAIRSAR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCC
YVILLEYYLIRNDRTGSVVVAELARAVVRGVRVMLIYDYIGCMDTPSSFFRSLAQQGIEL
EEEEEEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEE
IPFNVPSFRRGIRWFDRRDHRKMMVIDGCRAFLGGFNIGDEYAGIASPPQRFRDLGFSVE
EECCCHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCC
GSAVRELIGIFNETWQMEVGQLPELPRVRGVSPGSSSHGEANVAFVSGGPHQRSSYIRHA
CHHHHHHHHHHHHCHHECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
FLVNIASASEDLLIVNPYFVPGPRIIRSLLRAVRRGVRVRLLLPARSDVPLVLLVGRSSY
HEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCC
GALLKGGVEIYELEDGILHAKVMLVDGERTILGSANLDQRSFHRNFEINGIIDSSSFGAQ
CHHHHCCEEEEEECCCEEEEEEEEEECCEEEEECCCCCHHHHHCCCEEEEEECCCHHHHH
IRRVVEREVVASRRVTLHGHERRGLVTRMLEKLVNLFGWFL
HHHHHHHHHHHHCCEEEECCHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA