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The map label for this gene is mutM

Identifier: 118582007

GI number: 118582007

Start: 3990116

End: 3990919

Strand: Reverse

Name: mutM

Synonym: Ppro_3608

Alternate gene names: 118582007

Gene position: 3990919-3990116 (Counterclockwise)

Preceding gene: 118582008

Following gene: 118582006

Centisome position: 99.57

GC content: 64.43

Gene sequence:

>804_bases
GTGCCGGAACTTCCCGAGGTGGAACTGACCAGACGCAGGCTGGAGCGGGACATAACAGGAAAACAGGTCCAGCAGGTGCT
GGTCCGGGCTCCCAAGCTCCGCTTACCGGTCCCGCCGGAGCTGGAGGAAGCCCTGAAGGGGCGAACGGTCCGGGCCGTGG
AGCGGCGGGGAAAGTATCTGCTGTTGGAATGTGAAGCCGGATGGCTCATCGTCCACCTGGGGATGACCGGATTTCTCCGG
CTGCTCCATACCCCTCAGCTTCCCGGAAAGCACGATCATGTGGACATCGTCTTTACCGATGGTTCGGTGCTGCGGTTCCA
CGACCCGCGCAAGTTCGGCACCATTGCCTGGACAACGGATAGCCTCGACAAACACCCGCTCCTGGCCGGAATCGGCCCCG
AGCCGCTGACCGCGGCATTCAGTGGCGCCTACCTCTTCAGGGTGAGCCGGACCCGCCGGGTGGTGGTCAAGCTGTTGATC
ATGAACATGGCAATAGTCGCCGGGGTCGGCAACATCTACGCCAACGAGGCGCTGTTTCGCGCCGGAATCCGCCCCGACCG
GGCCGCGTCCTCCCTCAGCCGTACCGAATGCGAGCGGCTGGCCGTCACCATTCGGGAGGTGTTGCAGGAGTCCATCGATC
TGGGAAGCACCTATCGGGTGGAGGAGGGCACCGTCACCTATCACCCCCTTGCGTTCGACGTGTACGGGAGGGGACATGGC
ACCTGCACCAGCTGCGGCGGTGCGCTGGAAGCCGTCCGGCTCGGCAACCGGAGCACGGTGTTCTGTCCCCGCTGTCAGCA
GTGA

Upstream 100 bases:

>100_bases
AGGCCGTGCCTCGCTTCCACTGAGGGGAATCTGCAATGGCAAATCAAACGATGGGAACAAGAGGACAAAGACATTACATA
GGCCGAGATCGGAGGAACGG

Downstream 100 bases:

>100_bases
AAGTGCCGCTGCTCGGGCAGACAGAGCGGATAGGGGTACGGCTCATGACTCACCACAAATCAGCGCTGATGTCGAACCGC
CCATTTTCAATGACGTGATT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MPELPEVELTRRRLERDITGKQVQQVLVRAPKLRLPVPPELEEALKGRTVRAVERRGKYLLLECEAGWLIVHLGMTGFLR
LLHTPQLPGKHDHVDIVFTDGSVLRFHDPRKFGTIAWTTDSLDKHPLLAGIGPEPLTAAFSGAYLFRVSRTRRVVVKLLI
MNMAIVAGVGNIYANEALFRAGIRPDRAASSLSRTECERLAVTIREVLQESIDLGSTYRVEEGTVTYHPLAFDVYGRGHG
TCTSCGGALEAVRLGNRSTVFCPRCQQ

Sequences:

>Translated_267_residues
MPELPEVELTRRRLERDITGKQVQQVLVRAPKLRLPVPPELEEALKGRTVRAVERRGKYLLLECEAGWLIVHLGMTGFLR
LLHTPQLPGKHDHVDIVFTDGSVLRFHDPRKFGTIAWTTDSLDKHPLLAGIGPEPLTAAFSGAYLFRVSRTRRVVVKLLI
MNMAIVAGVGNIYANEALFRAGIRPDRAASSLSRTECERLAVTIREVLQESIDLGSTYRVEEGTVTYHPLAFDVYGRGHG
TCTSCGGALEAVRLGNRSTVFCPRCQQ
>Mature_266_residues
PELPEVELTRRRLERDITGKQVQQVLVRAPKLRLPVPPELEEALKGRTVRAVERRGKYLLLECEAGWLIVHLGMTGFLRL
LHTPQLPGKHDHVDIVFTDGSVLRFHDPRKFGTIAWTTDSLDKHPLLAGIGPEPLTAAFSGAYLFRVSRTRRVVVKLLIM
NMAIVAGVGNIYANEALFRAGIRPDRAASSLSRTECERLAVTIREVLQESIDLGSTYRVEEGTVTYHPLAFDVYGRGHGT
CTSCGGALEAVRLGNRSTVFCPRCQQ

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=271, Percent_Identity=45.3874538745387, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1786932, Length=273, Percent_Identity=26.3736263736264, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PELPD (A1AV29)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903257.1
- ProteinModelPortal:   A1AV29
- SMR:   A1AV29
- STRING:   A1AV29
- GeneID:   4574536
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3608
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   A1AV29
- ProtClustDB:   CLSK770481
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29719; Mature: 29588

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 257-257 BINDING 91-91 BINDING 110-110 BINDING 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVELTRRRLERDITGKQVQQVLVRAPKLRLPVPPELEEALKGRTVRAVERRGKYL
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHCCCEE
LLECEAGWLIVHLGMTGFLRLLHTPQLPGKHDHVDIVFTDGSVLRFHDPRKFGTIAWTTD
EEEECCCEEEEEECHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEECC
SLDKHPLLAGIGPEPLTAAFSGAYLFRVSRTRRVVVKLLIMNMAIVAGVGNIYANEALFR
CCCCCCEEECCCCCCHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AGIRPDRAASSLSRTECERLAVTIREVLQESIDLGSTYRVEEGTVTYHPLAFDVYGRGHG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCCCCC
TCTSCGGALEAVRLGNRSTVFCPRCQQ
CHHCCCCHHHHHEECCCCEEECCCCCC
>Mature Secondary Structure 
PELPEVELTRRRLERDITGKQVQQVLVRAPKLRLPVPPELEEALKGRTVRAVERRGKYL
CCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHCCCEE
LLECEAGWLIVHLGMTGFLRLLHTPQLPGKHDHVDIVFTDGSVLRFHDPRKFGTIAWTTD
EEEECCCEEEEEECHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEECC
SLDKHPLLAGIGPEPLTAAFSGAYLFRVSRTRRVVVKLLIMNMAIVAGVGNIYANEALFR
CCCCCCEEECCCCCCHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AGIRPDRAASSLSRTECERLAVTIREVLQESIDLGSTYRVEEGTVTYHPLAFDVYGRGHG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEECCCCCC
TCTSCGGALEAVRLGNRSTVFCPRCQQ
CHHCCCCHHHHHEECCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA