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The map label for this gene is tlpB [H]

Identifier: 118581937

GI number: 118581937

Start: 3908801

End: 3910792

Strand: Reverse

Name: tlpB [H]

Synonym: Ppro_3537

Alternate gene names: 118581937

Gene position: 3910792-3908801 (Counterclockwise)

Preceding gene: 118581938

Following gene: 118581936

Centisome position: 97.57

GC content: 62.25

Gene sequence:

>1992_bases
ATGAGCACCAGTCCCATGACAAGGCACGCCACCCTCTTCTCCCTGATCGGTTTCATGCTGGGCATCGGCGCGCCCGTCGG
TTGGATCGTCCTGAGGCTGCTGCTGTTCCGCACAGGCGGTAAGCCGCTCGTGGAGCAGGCGCTGGGTGACATCCTGCTGA
GTGGCGAGCATCTCGCCCTCTACGCATACATGGGGATCGGCACGGCCCTGGTTCTTGCTCTGCTCGGCTTCCTGATCGGT
TCCTACGGCGACGAACGGCGCAGGCGCTCCGCCGAACTGGCCCAGCTCCACCGGGAAGTCGCCTCCCAGAAGGACCTCTT
CCAGAACCGCTACCAGGTGCTGGACAACAACATTAAGAACTTCCATCACATCAGCAGCAAAATCCAGACCTCGCTCAACC
TGGAGGAGATCCTGCTGCTCTGCGCCGAGGGGCTGCACGAAATCCTGGGGTACGAACGGGTCAACATCCTGATGACCCAG
CATGGCCAGCGGATCCGCTTCGTCACCGCCACCGGAAGCGACAGCTTCGACATAACCGGCGTCACCCTGCCGCTGGATCC
CTCCATCGGCGTCATCTACAAGTGCCTCAGCGAGAAGAAGGTCTTCCTGATCGACGACATCTCGCGCTATCCCCAGGATT
ACCAGATCCAGGAACCGCACCGTCGCCAGGCTCCCCTCCGCTCGCGCAGCTTCATCCTCTGCCCCATCGTGGTCAAGGGG
GAGGCCATCGGCGCCTTCGGCATCGACAACAAGACCAGCAAACGCGCCCTGAACGACTCGGACGTGGACACCATCATGCT
CTTCGCCGACCAGGTGGCATCGGCCATTACCCGCATCAACCTGCTCACCTCCATCGATGCCCTGACCAGCGAACTGGAGA
ATTCCTTCGCCTTCCTGCTGGGCAGTCGGCCGGAGTATTCGCGCAACGTCGTTGAGCTGAAGGAGGCGGTGGATTCGGTG
GCCGAGGGGTCTGGCGCCATAGCCTCCGCATCCGAGGGGGTCATGGCGGCGGTTGACGAGACCGGCATGGCCGTCAACGA
GATCTCCGTGGCCATCGAACAGGTGACCCGCAACCTGGACCACTTGGCCGGAATTGTGCGGCAGTCCGCGGCGGCCATGG
AGGGGATCACCAGAACCATCAACAACGTGGAACAGAGCGCCGCCATCTCCCATGAGGTCTCCAGCCAGGTCAAGTCCCGG
GCCGACGAGAGCTTCAGCGTGGTCACCGAAACGATCAATTCCCTGGCCGAGATCCAGTCCTCGGTCGAGCTCTCCTATAC
GGCAATCAGCCGTCTGGCGGAGAACAGCGCCCGCATCGAAAACGTCGTCAACGTTATCAACGACATCACCAAGCGCACCA
ATCTTTTGGCCTTCAATGCCGCCATCATCGCGGCCCAGGCCGGGGAGTACGGCAAGAGCTTCGGCGTCGTGGCCGACGAG
ATCCGCAACCTGTCGCTGCAGACCGGCCACTCCACCGGCGAGATCACCGGCATCATCAAAGAGATCCTGTCCGAGTCCCG
CACCGCCGCCGACAACATCACCGCCAGCAAAGAGCTTGTCCAGCGCGGCGTGGAGCTGGGCTCCTCCACGGGCGAGGCGC
TCAGGGCGATCCACGACAGTTCGGCCTGCTCCATGGACATGACCCAGCAGATCAAACAGGCCACCCGGGAACAGGTGGCC
AGTGTCCGTATGGTGGCCACCTCCATGGAAGAGATCAGCTCCATGACATCCCAGATACTGGCGGCTTCAGCGGATCAGGC
CAAGGCGACCCGCAGCATTGCCCGCTCCATCGAAACCATCACCGAGATGGCCCACGAAATGGTCGATTCAACCTCCCGCC
AGGTGCGGGATGGCCACCAGATCCGCCACTCCGTGGAGTCGGTCAGCGACATGGTCAGGGAGATGTTCGACAACATGGAA
CAGCGCCGCAACCAGAGCGCGGAGGTGGTCAAGGACCTGGAGTCCATGAAGAACCTCACCTGCCAACTCTGA

Upstream 100 bases:

>100_bases
CATCTCCTACAACATGAAGGACTCCGAAAAGGTGATGGAAGAGATCTACCACGCCATGGACGAGAAGCTGGCCCACCAGA
AGTAGGGGAGTCGCCGGTTG

Downstream 100 bases:

>100_bases
GGCCCGCTGGCGCTCTGCCCGCCCGGCCCCAGTGTATTTTTATCTGGAAACAGCTTTCGTTTTTTGCTATAAATTACACT
TTCAAACGACAACGGCTACC

Product: methyl-accepting chemotaxis sensory transducer with GAF sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MSTSPMTRHATLFSLIGFMLGIGAPVGWIVLRLLLFRTGGKPLVEQALGDILLSGEHLALYAYMGIGTALVLALLGFLIG
SYGDERRRRSAELAQLHREVASQKDLFQNRYQVLDNNIKNFHHISSKIQTSLNLEEILLLCAEGLHEILGYERVNILMTQ
HGQRIRFVTATGSDSFDITGVTLPLDPSIGVIYKCLSEKKVFLIDDISRYPQDYQIQEPHRRQAPLRSRSFILCPIVVKG
EAIGAFGIDNKTSKRALNDSDVDTIMLFADQVASAITRINLLTSIDALTSELENSFAFLLGSRPEYSRNVVELKEAVDSV
AEGSGAIASASEGVMAAVDETGMAVNEISVAIEQVTRNLDHLAGIVRQSAAAMEGITRTINNVEQSAAISHEVSSQVKSR
ADESFSVVTETINSLAEIQSSVELSYTAISRLAENSARIENVVNVINDITKRTNLLAFNAAIIAAQAGEYGKSFGVVADE
IRNLSLQTGHSTGEITGIIKEILSESRTAADNITASKELVQRGVELGSSTGEALRAIHDSSACSMDMTQQIKQATREQVA
SVRMVATSMEEISSMTSQILAASADQAKATRSIARSIETITEMAHEMVDSTSRQVRDGHQIRHSVESVSDMVREMFDNME
QRRNQSAEVVKDLESMKNLTCQL

Sequences:

>Translated_663_residues
MSTSPMTRHATLFSLIGFMLGIGAPVGWIVLRLLLFRTGGKPLVEQALGDILLSGEHLALYAYMGIGTALVLALLGFLIG
SYGDERRRRSAELAQLHREVASQKDLFQNRYQVLDNNIKNFHHISSKIQTSLNLEEILLLCAEGLHEILGYERVNILMTQ
HGQRIRFVTATGSDSFDITGVTLPLDPSIGVIYKCLSEKKVFLIDDISRYPQDYQIQEPHRRQAPLRSRSFILCPIVVKG
EAIGAFGIDNKTSKRALNDSDVDTIMLFADQVASAITRINLLTSIDALTSELENSFAFLLGSRPEYSRNVVELKEAVDSV
AEGSGAIASASEGVMAAVDETGMAVNEISVAIEQVTRNLDHLAGIVRQSAAAMEGITRTINNVEQSAAISHEVSSQVKSR
ADESFSVVTETINSLAEIQSSVELSYTAISRLAENSARIENVVNVINDITKRTNLLAFNAAIIAAQAGEYGKSFGVVADE
IRNLSLQTGHSTGEITGIIKEILSESRTAADNITASKELVQRGVELGSSTGEALRAIHDSSACSMDMTQQIKQATREQVA
SVRMVATSMEEISSMTSQILAASADQAKATRSIARSIETITEMAHEMVDSTSRQVRDGHQIRHSVESVSDMVREMFDNME
QRRNQSAEVVKDLESMKNLTCQL
>Mature_662_residues
STSPMTRHATLFSLIGFMLGIGAPVGWIVLRLLLFRTGGKPLVEQALGDILLSGEHLALYAYMGIGTALVLALLGFLIGS
YGDERRRRSAELAQLHREVASQKDLFQNRYQVLDNNIKNFHHISSKIQTSLNLEEILLLCAEGLHEILGYERVNILMTQH
GQRIRFVTATGSDSFDITGVTLPLDPSIGVIYKCLSEKKVFLIDDISRYPQDYQIQEPHRRQAPLRSRSFILCPIVVKGE
AIGAFGIDNKTSKRALNDSDVDTIMLFADQVASAITRINLLTSIDALTSELENSFAFLLGSRPEYSRNVVELKEAVDSVA
EGSGAIASASEGVMAAVDETGMAVNEISVAIEQVTRNLDHLAGIVRQSAAAMEGITRTINNVEQSAAISHEVSSQVKSRA
DESFSVVTETINSLAEIQSSVELSYTAISRLAENSARIENVVNVINDITKRTNLLAFNAAIIAAQAGEYGKSFGVVADEI
RNLSLQTGHSTGEITGIIKEILSESRTAADNITASKELVQRGVELGSSTGEALRAIHDSSACSMDMTQQIKQATREQVAS
VRMVATSMEEISSMTSQILAASADQAKATRSIARSIETITEMAHEMVDSTSRQVRDGHQIRHSVESVSDMVREMFDNMEQ
RRNQSAEVVKDLESMKNLTCQL

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=245, Percent_Identity=26.530612244898, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788195, Length=266, Percent_Identity=26.6917293233083, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788194, Length=255, Percent_Identity=27.0588235294118, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI2367378, Length=268, Percent_Identity=27.9850746268657, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1789453, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 72370; Mature: 72239

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSPMTRHATLFSLIGFMLGIGAPVGWIVLRLLLFRTGGKPLVEQALGDILLSGEHLAL
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEE
YAYMGIGTALVLALLGFLIGSYGDERRRRSAELAQLHREVASQKDLFQNRYQVLDNNIKN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHHISSKIQTSLNLEEILLLCAEGLHEILGYERVNILMTQHGQRIRFVTATGSDSFDITG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHEECCCCEEEEEEECCCCCCEEEE
VTLPLDPSIGVIYKCLSEKKVFLIDDISRYPQDYQIQEPHRRQAPLRSRSFILCPIVVKG
EEEECCCCHHHHHHHHCCCCEEEEECHHHCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEC
EAIGAFGIDNKTSKRALNDSDVDTIMLFADQVASAITRINLLTSIDALTSELENSFAFLL
CEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSRPEYSRNVVELKEAVDSVAEGSGAIASASEGVMAAVDETGMAVNEISVAIEQVTRNLD
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHH
HLAGIVRQSAAAMEGITRTINNVEQSAAISHEVSSQVKSRADESFSVVTETINSLAEIQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SVELSYTAISRLAENSARIENVVNVINDITKRTNLLAFNAAIIAAQAGEYGKSFGVVADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCCCCCCHHHHH
IRNLSLQTGHSTGEITGIIKEILSESRTAADNITASKELVQRGVELGSSTGEALRAIHDS
HHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
SACSMDMTQQIKQATREQVASVRMVATSMEEISSMTSQILAASADQAKATRSIARSIETI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TEMAHEMVDSTSRQVRDGHQIRHSVESVSDMVREMFDNMEQRRNQSAEVVKDLESMKNLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
CQL
CCC
>Mature Secondary Structure 
STSPMTRHATLFSLIGFMLGIGAPVGWIVLRLLLFRTGGKPLVEQALGDILLSGEHLAL
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEE
YAYMGIGTALVLALLGFLIGSYGDERRRRSAELAQLHREVASQKDLFQNRYQVLDNNIKN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHHISSKIQTSLNLEEILLLCAEGLHEILGYERVNILMTQHGQRIRFVTATGSDSFDITG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHEECCCCEEEEEEECCCCCCEEEE
VTLPLDPSIGVIYKCLSEKKVFLIDDISRYPQDYQIQEPHRRQAPLRSRSFILCPIVVKG
EEEECCCCHHHHHHHHCCCCEEEEECHHHCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEC
EAIGAFGIDNKTSKRALNDSDVDTIMLFADQVASAITRINLLTSIDALTSELENSFAFLL
CEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSRPEYSRNVVELKEAVDSVAEGSGAIASASEGVMAAVDETGMAVNEISVAIEQVTRNLD
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHH
HLAGIVRQSAAAMEGITRTINNVEQSAAISHEVSSQVKSRADESFSVVTETINSLAEIQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SVELSYTAISRLAENSARIENVVNVINDITKRTNLLAFNAAIIAAQAGEYGKSFGVVADE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCCCCCCHHHHH
IRNLSLQTGHSTGEITGIIKEILSESRTAADNITASKELVQRGVELGSSTGEALRAIHDS
HHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
SACSMDMTQQIKQATREQVASVRMVATSMEEISSMTSQILAASADQAKATRSIARSIETI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TEMAHEMVDSTSRQVRDGHQIRHSVESVSDMVREMFDNMEQRRNQSAEVVKDLESMKNLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
CQL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]