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The map label for this gene is panB

Identifier: 118581936

GI number: 118581936

Start: 3907727

End: 3908536

Strand: Reverse

Name: panB

Synonym: Ppro_3536

Alternate gene names: 118581936

Gene position: 3908536-3907727 (Counterclockwise)

Preceding gene: 118581937

Following gene: 118581935

Centisome position: 97.52

GC content: 61.6

Gene sequence:

>810_bases
ATGAGCGATATGCGAAAAAAAGTGACCATACCGGACATACTCAAGATGAAGCAGGAGCGGCGGCGCATCACCATGATGAC
CGCCTACGACTACCCCTTTGCGCGGTTGGTGGACAGCGGCGGCGTTGATGCCATCCTGGTGGGGGACTCCCTGGGAGTTG
TCTTCTCCGGTCATGACAACACGTTGAGCGTCACCATGGATGAGATGATCTACCACACCAGGGCCGTCGCCCGCGCCAAG
CCGCAGGCAGTGCTGGTGACCGACATGCCTTTCATGTCCTACCAGGTGAGCGTCGAAGAGGCCTGTCGCAACTGCGGCAG
GATGATCCAGGAGGGGGGCGCCCAGGCGGTCAAGATCGAGGGGGGCATGAACATGTCCCACGTGATCCGGGCGGTGACCT
CCATCGACATCCCGGTCATGGGGCACATCGGCCTGACACCCCAGTCCATCCATCGCATGGGGGGCTACAGGGTACAGGGT
CGCAAGGAACAGGCGGAGCGGATCATGGAGGATGCCCTGGCGGTTCAGGCTGCCGGAGCGTTTTCCATCGTGCTGGAGGG
TATTCCCTCCTCCCTGGCGGCCAGCATCACCGCGGAGCTCTCCATCCCCACCATCGGCATCGGCGCCGGCCCCGACTGCG
ACGGCCAGGTGCTGGTGATCCACGACATTCTGGGGCTGTGTGAGAAGTATTCACCCAAGTTCGTCAAACGCTACGCTGAA
CTGGCTCCGGTCATCACCGATGCCGTCAACAGGTATGTGGAGGAGGTTCGCTCAGGCGCCTTCCCCACCGAGGAACACTC
CTTCAATTGA

Upstream 100 bases:

>100_bases
ACCGGGACGGAAGGGAATATCCCCTCAGGCATGCTGCCACCATGGCAAAGTCTGTCCGTCACGCGCCCCTGGAGCGTGTT
TTTTTTTGGGAAAAAACGGG

Downstream 100 bases:

>100_bases
TGCAACGACTCCGCCCAGGGCATGACCCGGGCGGAGTTTTTAGTATTCGGGGAAAACCATGAACATCATCGCCGGCATCA
ACGAAATGCAGACAACCGCC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSDMRKKVTIPDILKMKQERRRITMMTAYDYPFARLVDSGGVDAILVGDSLGVVFSGHDNTLSVTMDEMIYHTRAVARAK
PQAVLVTDMPFMSYQVSVEEACRNCGRMIQEGGAQAVKIEGGMNMSHVIRAVTSIDIPVMGHIGLTPQSIHRMGGYRVQG
RKEQAERIMEDALAVQAAGAFSIVLEGIPSSLAASITAELSIPTIGIGAGPDCDGQVLVIHDILGLCEKYSPKFVKRYAE
LAPVITDAVNRYVEEVRSGAFPTEEHSFN

Sequences:

>Translated_269_residues
MSDMRKKVTIPDILKMKQERRRITMMTAYDYPFARLVDSGGVDAILVGDSLGVVFSGHDNTLSVTMDEMIYHTRAVARAK
PQAVLVTDMPFMSYQVSVEEACRNCGRMIQEGGAQAVKIEGGMNMSHVIRAVTSIDIPVMGHIGLTPQSIHRMGGYRVQG
RKEQAERIMEDALAVQAAGAFSIVLEGIPSSLAASITAELSIPTIGIGAGPDCDGQVLVIHDILGLCEKYSPKFVKRYAE
LAPVITDAVNRYVEEVRSGAFPTEEHSFN
>Mature_268_residues
SDMRKKVTIPDILKMKQERRRITMMTAYDYPFARLVDSGGVDAILVGDSLGVVFSGHDNTLSVTMDEMIYHTRAVARAKP
QAVLVTDMPFMSYQVSVEEACRNCGRMIQEGGAQAVKIEGGMNMSHVIRAVTSIDIPVMGHIGLTPQSIHRMGGYRVQGR
KEQAERIMEDALAVQAAGAFSIVLEGIPSSLAASITAELSIPTIGIGAGPDCDGQVLVIHDILGLCEKYSPKFVKRYAEL
APVITDAVNRYVEEVRSGAFPTEEHSFN

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=265, Percent_Identity=47.1698113207547, Blast_Score=243, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6319653, Length=272, Percent_Identity=37.5, Blast_Score=189, Evalue=3e-49,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_PELPD (A1AUV8)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903186.1
- ProteinModelPortal:   A1AUV8
- SMR:   A1AUV8
- STRING:   A1AUV8
- GeneID:   4574618
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3536
- eggNOG:   COG0413
- HOGENOM:   HBG299908
- OMA:   YATPEQT
- PhylomeDB:   A1AUV8
- ProtClustDB:   PRK00311
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 29305; Mature: 29174

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: ACT_SITE 186-186 BINDING 88-88 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMRKKVTIPDILKMKQERRRITMMTAYDYPFARLVDSGGVDAILVGDSLGVVFSGHDN
CCCCHHCCCCHHHHHHHHHHHEEEEEEECCCCHHHHHCCCCCCEEEECCCCEEEEECCCC
TLSVTMDEMIYHTRAVARAKPQAVLVTDMPFMSYQVSVEEACRNCGRMIQEGGAQAVKIE
EEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHEEEEHHHHHHHHHHHHHHCCCEEEEEE
GGMNMSHVIRAVTSIDIPVMGHIGLTPQSIHRMGGYRVQGRKEQAERIMEDALAVQAAGA
CCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCH
FSIVLEGIPSSLAASITAELSIPTIGIGAGPDCDGQVLVIHDILGLCEKYSPKFVKRYAE
HHHHHHCCCHHHHHHHEEEEECCEEECCCCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHH
LAPVITDAVNRYVEEVRSGAFPTEEHSFN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SDMRKKVTIPDILKMKQERRRITMMTAYDYPFARLVDSGGVDAILVGDSLGVVFSGHDN
CCCHHCCCCHHHHHHHHHHHEEEEEEECCCCHHHHHCCCCCCEEEECCCCEEEEECCCC
TLSVTMDEMIYHTRAVARAKPQAVLVTDMPFMSYQVSVEEACRNCGRMIQEGGAQAVKIE
EEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHEEEEHHHHHHHHHHHHHHCCCEEEEEE
GGMNMSHVIRAVTSIDIPVMGHIGLTPQSIHRMGGYRVQGRKEQAERIMEDALAVQAAGA
CCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCH
FSIVLEGIPSSLAASITAELSIPTIGIGAGPDCDGQVLVIHDILGLCEKYSPKFVKRYAE
HHHHHHCCCHHHHHHHEEEEECCEEECCCCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHH
LAPVITDAVNRYVEEVRSGAFPTEEHSFN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA