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The map label for this gene is gdh [H]

Identifier: 118581897

GI number: 118581897

Start: 3865100

End: 3866455

Strand: Direct

Name: gdh [H]

Synonym: Ppro_3497

Alternate gene names: 118581897

Gene position: 3865100-3866455 (Clockwise)

Preceding gene: 118581896

Following gene: 118581898

Centisome position: 96.43

GC content: 60.62

Gene sequence:

>1356_bases
ATGGTAAGCATGGCTAAAGTTGACGAAAAACTGCATGGCATCTATCAGGACGTCGTGAAGCGCAACCCTGGCGAAGTCGA
GTACCACCAGGCAGTTGCCGAAGTTCTGGAGACTCTCGGACCTGTGGTTGCCAAAAACCCGGAATACCTGGAGCGCAAGA
TCATCGAGCGCATCTGTGAGCCAGAGCGTCAGATCATCTTCAGGGTGCCCTGGCAGGACGACAAGGGCGAAGTCCACATC
AACCGCGGCTTCCGCGTCCAGTTCAACTCGGCCATCGGCCCCTACAAGGGTGGCATCCGCTTCCATCCTTCCGTCTACCT
GGGCATCATCAAGTTCCTCGGCTTCGAGCAGATCTTCAAGAACTCCCTCACCGGCATGCCCATCGGCGGCGGCAAGGGCG
GTTCCGACTTCGATCCCAAGGGCAGATCTGATGACGAAATCATGCGCTTCTGCCAGAGCTTCATTACCGAACTGTTCCGC
CACCTGGGCGAGCACACCGATGTGCCGGCCGGCGACATCGGTGTTGGCGGCCGCGAGATCGGCTACATGTTCGGCCAGTA
CAAGCGCCTCACCAACCGCTGGGAAGCGGGCGTGCTGACCGGCAAGGGGCTCAAGTGGGGCGGTTCGCTGGTTCGCCCGG
AGGCCACCGGCTACGGGGCAACCTACTTCGTCAACGAAGCCCTCAAGGTGCGCAATGACTCCCTGGAAGGCAAGACCTGC
CTGGTTTCCGGTTCCGGCAACGTGGCCATCTACACCATCGAGAAGATCCAGCAGCTGGGCGGCAAATGCGTTGCCTGCTC
CGACAGCAACGGCGTGATCTACCATGAGAATGGTCTCGACCTGGCGCTGATCAAGCAACTCAAGGAAGTGGAGCGTCGCC
GCATCGCCGACTACGCCAGCTACCACAAGGATGCCAGGTACACCGCCAACGGCAATATCTGGGAGATCCCCTGCCAGGTG
GCCATGCCCTCCGCGACCCAGAACGAGATCAACGGCAAGGACGCCGCAATCCTGGTCAAGAACGGCTGCATCGCCGTAGG
CGAAGGCGCCAACATGCCGACCAATCCGGACGGCATCAAGGTGTTCCAGGACGCCAAGATCGCCTACTGCCCGGGCAAGG
CCTGCAACGCCGGCGGCGTCGCCACCTCTGCCCTGGAAATGCAGCAGAACGCCCAGCGCGACTCCTGGACCTTCGAAGAG
ACCGAGAAGAAGCTGGAGAAGATCATGGTCGGCATCCACAAGCTCTGCTACAAGACCGCCGAAGAGTATGGCCAGGCCGG
AAACTACGTGCTCGGCGCCAACATCGCCGGTTTCATCAAGGTTGCCGACGCAATGGTTGCCCACGGCCTTATCTAG

Upstream 100 bases:

>100_bases
GCCGATAAAATGTGCTCGACACCCCGGAACATGCCCACCCGGCAGGCACTCTTTGCTACCCAACGGGTAAAGCATCCATA
CACCAAAGGAGAAGAAAACG

Downstream 100 bases:

>100_bases
CCTTTGCGCAGCATTCAGTTCCTGCCACAAAAAAACCCCGCTCTCTGCGGGGTTTTTTTGTGGGCGCCGCGACCGCAGGC
CGGGATCAGGTCTACGGGTT

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MVSMAKVDEKLHGIYQDVVKRNPGEVEYHQAVAEVLETLGPVVAKNPEYLERKIIERICEPERQIIFRVPWQDDKGEVHI
NRGFRVQFNSAIGPYKGGIRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELFR
HLGEHTDVPAGDIGVGGREIGYMFGQYKRLTNRWEAGVLTGKGLKWGGSLVRPEATGYGATYFVNEALKVRNDSLEGKTC
LVSGSGNVAIYTIEKIQQLGGKCVACSDSNGVIYHENGLDLALIKQLKEVERRRIADYASYHKDARYTANGNIWEIPCQV
AMPSATQNEINGKDAAILVKNGCIAVGEGANMPTNPDGIKVFQDAKIAYCPGKACNAGGVATSALEMQQNAQRDSWTFEE
TEKKLEKIMVGIHKLCYKTAEEYGQAGNYVLGANIAGFIKVADAMVAHGLI

Sequences:

>Translated_451_residues
MVSMAKVDEKLHGIYQDVVKRNPGEVEYHQAVAEVLETLGPVVAKNPEYLERKIIERICEPERQIIFRVPWQDDKGEVHI
NRGFRVQFNSAIGPYKGGIRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELFR
HLGEHTDVPAGDIGVGGREIGYMFGQYKRLTNRWEAGVLTGKGLKWGGSLVRPEATGYGATYFVNEALKVRNDSLEGKTC
LVSGSGNVAIYTIEKIQQLGGKCVACSDSNGVIYHENGLDLALIKQLKEVERRRIADYASYHKDARYTANGNIWEIPCQV
AMPSATQNEINGKDAAILVKNGCIAVGEGANMPTNPDGIKVFQDAKIAYCPGKACNAGGVATSALEMQQNAQRDSWTFEE
TEKKLEKIMVGIHKLCYKTAEEYGQAGNYVLGANIAGFIKVADAMVAHGLI
>Mature_451_residues
MVSMAKVDEKLHGIYQDVVKRNPGEVEYHQAVAEVLETLGPVVAKNPEYLERKIIERICEPERQIIFRVPWQDDKGEVHI
NRGFRVQFNSAIGPYKGGIRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELFR
HLGEHTDVPAGDIGVGGREIGYMFGQYKRLTNRWEAGVLTGKGLKWGGSLVRPEATGYGATYFVNEALKVRNDSLEGKTC
LVSGSGNVAIYTIEKIQQLGGKCVACSDSNGVIYHENGLDLALIKQLKEVERRRIADYASYHKDARYTANGNIWEIPCQV
AMPSATQNEINGKDAAILVKNGCIAVGEGANMPTNPDGIKVFQDAKIAYCPGKACNAGGVATSALEMQQNAQRDSWTFEE
TEKKLEKIMVGIHKLCYKTAEEYGQAGNYVLGANIAGFIKVADAMVAHGLI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=356, Percent_Identity=30.3370786516854, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4885281, Length=356, Percent_Identity=30.3370786516854, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1788059, Length=443, Percent_Identity=53.4988713318284, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17544676, Length=392, Percent_Identity=25.5102040816327, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324951, Length=453, Percent_Identity=48.5651214128035, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319256, Length=455, Percent_Identity=47.9120879120879, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI45553475, Length=351, Percent_Identity=29.6296296296296, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI45549226, Length=351, Percent_Identity=29.6296296296296, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24649283, Length=334, Percent_Identity=29.6407185628743, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24649460, Length=291, Percent_Identity=29.2096219931272, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 49540; Mature: 49540

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSMAKVDEKLHGIYQDVVKRNPGEVEYHQAVAEVLETLGPVVAKNPEYLERKIIERICE
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHCC
PERQIIFRVPWQDDKGEVHINRGFRVQFNSAIGPYKGGIRFHPSVYLGIIKFLGFEQIFK
CCEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHH
NSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELFRHLGEHTDVPAGDIGVGGREI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
GYMFGQYKRLTNRWEAGVLTGKGLKWGGSLVRPEATGYGATYFVNEALKVRNDSLEGKTC
HHHHHHHHHHHHHHHCCEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCEE
LVSGSGNVAIYTIEKIQQLGGKCVACSDSNGVIYHENGLDLALIKQLKEVERRRIADYAS
EEECCCCEEEEEHHHHHHHCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
YHKDARYTANGNIWEIPCQVAMPSATQNEINGKDAAILVKNGCIAVGEGANMPTNPDGIK
HCCCCEEECCCCEEEECCEEECCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCEE
VFQDAKIAYCPGKACNAGGVATSALEMQQNAQRDSWTFEETEKKLEKIMVGIHKLCYKTA
EEECCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEYGQAGNYVLGANIAGFIKVADAMVAHGLI
HHHCCCCCEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSMAKVDEKLHGIYQDVVKRNPGEVEYHQAVAEVLETLGPVVAKNPEYLERKIIERICE
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHCC
PERQIIFRVPWQDDKGEVHINRGFRVQFNSAIGPYKGGIRFHPSVYLGIIKFLGFEQIFK
CCEEEEEECCCCCCCCCEEECCCEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHH
NSLTGMPIGGGKGGSDFDPKGRSDDEIMRFCQSFITELFRHLGEHTDVPAGDIGVGGREI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
GYMFGQYKRLTNRWEAGVLTGKGLKWGGSLVRPEATGYGATYFVNEALKVRNDSLEGKTC
HHHHHHHHHHHHHHHCCEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCEE
LVSGSGNVAIYTIEKIQQLGGKCVACSDSNGVIYHENGLDLALIKQLKEVERRRIADYAS
EEECCCCEEEEEHHHHHHHCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
YHKDARYTANGNIWEIPCQVAMPSATQNEINGKDAAILVKNGCIAVGEGANMPTNPDGIK
HCCCCEEECCCCEEEECCEEECCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCEE
VFQDAKIAYCPGKACNAGGVATSALEMQQNAQRDSWTFEETEKKLEKIMVGIHKLCYKTA
EEECCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEYGQAGNYVLGANIAGFIKVADAMVAHGLI
HHHCCCCCEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]