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The map label for this gene is uvrB [H]

Identifier: 118581885

GI number: 118581885

Start: 3849128

End: 3851233

Strand: Direct

Name: uvrB [H]

Synonym: Ppro_3485

Alternate gene names: 118581885

Gene position: 3849128-3851233 (Clockwise)

Preceding gene: 118581884

Following gene: 118581886

Centisome position: 96.04

GC content: 64.62

Gene sequence:

>2106_bases
ATGTCCATCTTCACCCTGAAAACCGACTACACCCCCCGTGGCGACCAGCCGGCGGCCATCGCCGAACTGGTGGAAGGGAT
CGAGCGGGGCGACCAGCACCAGGTCCTCCTGGGCGTCACCGGCTCGGGCAAGACCTTCACCGTGGCCAACGTCATCGCCC
GGACCGGCAGGCCGGCCCTGCTGCTGGCCCCCAACAAGACCCTGGCGGCCCAACTCTACGCTGAGATGAAGGAACTCTTC
CCGGACAACGCCGTGGAGTTCTTCGTCTCCTACTACGACTACTACCAGCCGGAAGCCTACCTCCCCTCCAGCGACACCTT
CATCGAGAAGGACTCGGCCATCAACGACGAGATCGACAAGATGCGCCACTCGGCCACCCGGAGCCTCTTAACCCGGCGGG
ACGTGATCATCGTGGCCTCGGTCTCCTGCATCTACGGCATCGGCTCGCCCGAGGCCTACGCCAGCCTGCACATCTTCTTC
CGCCAGGGAGAGGAGTATGGCCGCGACACCCTGCTGCAGAAACTGGTGGCCATCCAGTACGAGCGCAACGACACCGACTT
CCACCGCGGCACCTTCCGGGTGCGGGGGGACGTGGTGGAGGTCTTCCCGGCCTACGACAGCGACAAGGCGCTACGCATCG
AGTTCTTCGGCGACGAGGTGGAGAGCATCTCCGAAATCGACCCCCTGCGGGGGGCGGTGTTGCAGCGTTTGACCAAGTGC
ACCATCTACCCCGCCTCCCACTACGTCGCCACCCGCGAGACCCTGGAGCGGGCCGTGGAGCAGATCCGGGTGGACCTGGG
AGAGCGCATCCGTTACTTCAGGGAGAACAACATGCTGCTGGAGGCCCAGCGCATCGAGCAGCGCACCTTCTTCGACATCG
AGATGATGGAGGAAATGGGCTTCTGCCAGGGGATCGAGAACTATTCGCGCTACTTCGACGGCCGCGAGACGGGTGAACCT
CCCTACACCCTGATCGACTACTTCCCGGACGACTTCGTGCTCTACGTGGACGAGTCCCACATCAGCATCCCCCAGGTGGG
GGGGATGTACCGCGGCGACCGCAGCCGCAAGGAGACCCTGGTCAACTACGGCTTCCGCCTCCCGGCGGCCCTGGACAACC
GGCCGCTCAACTTCAGGGAGTTCGAGGCCCGCGTGCACCAGGCGGTGTACGTCTCGGCCACCCCGGCCGACTACGAGCTG
GAGAAGAGCAACGGCGTGTTTGTGGAGCAGGTCATCCGCCCCACCGGGCTTCTGGACCCGGTGATCCAGGTGCGGCCGGT
GACAGCGGGCCGGCAAATCCCCCCAAGTCCCCCTTTGAAAAAGGGGGACTTACCGTCTGGTGACGATGAGTATCCCCCCT
TTGAAAAAGGGGGGGCGGGGGGGATGTACGGCCAGGTGGACGACCTGCTGCACGAGGTGCGTCAGACCGTGGCCAAGGGG
GAGCGGGTGCTGGTGACCACCCTGACCAAGCGCATGGCCGAGGAGCTGACCAGCTATTACGGGGAGTTGGGGGTGCGGAT
CAGGTACCTGCACTCTGATATCGTGACCATCGAGCGGATGCAGATCCTGCGCGATCTGAGGATGGGGGAGTTCGACGTGC
TGGTGGGGATCAACCTGCTGCGGGAGGGGCTGGATCTGCCGGAAGTGTCGCTCGTGGCCATCCTGGACGCGGACAAGGAG
GGGTTCCTCAGGTCGGAGCGTTCCCTGATCCAGACCTGCGGCCGGGCTGCCCGCAACGCTAATGGCCGGGTGCTGATGTA
CGCCGACTCAATTACCCGCTCCATGCAGGCCTGCATCGACGAGACCCAGCGCCGGCGGGAGAAGCAGTTGGCCTGGAACC
AGGAGCACGGTATCACCCCGGAGACGGTCAGGAAGAGCATGCAGACCATCCTGGGCTCCATCGAGGAAAAGGACTATTAC
ACGCCGAAGGTCAGCGCCGCCGAGACGCCCGAGGAGTACGGGGTGGCGCCCAAGGATATTCCCAAGCTGGTCAAGAAGCT
GCGCAAGGAGATGCTCGGGGCGGCCAAGCAGCTGGACTTCGAGAAGGCGGCCGAGCTGCGCGACCGGGTCAGGACGCTGG
AGGAGATGGAGTTGGCCCTGCGCTGA

Upstream 100 bases:

>100_bases
GGAGTTCGTGGAGAAGCAGTAGCAACGCCGCTCTTGTTCGTTCGCGTACACACGTGGTGCGCCGTTGACGGGCACGCCGA
CGAAAGGGGTAGACAGTGCC

Downstream 100 bases:

>100_bases
TGCTTTCACCCCAACGATTGACAGAACAGTACCATGCCGCGGGAGAGCTGGACGCGGCCACCGTGACAGCCTTCCGCCGG
GCGATCTATCGCCACTTCCA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 701; Mature: 700

Protein sequence:

>701_residues
MSIFTLKTDYTPRGDQPAAIAELVEGIERGDQHQVLLGVTGSGKTFTVANVIARTGRPALLLAPNKTLAAQLYAEMKELF
PDNAVEFFVSYYDYYQPEAYLPSSDTFIEKDSAINDEIDKMRHSATRSLLTRRDVIIVASVSCIYGIGSPEAYASLHIFF
RQGEEYGRDTLLQKLVAIQYERNDTDFHRGTFRVRGDVVEVFPAYDSDKALRIEFFGDEVESISEIDPLRGAVLQRLTKC
TIYPASHYVATRETLERAVEQIRVDLGERIRYFRENNMLLEAQRIEQRTFFDIEMMEEMGFCQGIENYSRYFDGRETGEP
PYTLIDYFPDDFVLYVDESHISIPQVGGMYRGDRSRKETLVNYGFRLPAALDNRPLNFREFEARVHQAVYVSATPADYEL
EKSNGVFVEQVIRPTGLLDPVIQVRPVTAGRQIPPSPPLKKGDLPSGDDEYPPFEKGGAGGMYGQVDDLLHEVRQTVAKG
ERVLVTTLTKRMAEELTSYYGELGVRIRYLHSDIVTIERMQILRDLRMGEFDVLVGINLLREGLDLPEVSLVAILDADKE
GFLRSERSLIQTCGRAARNANGRVLMYADSITRSMQACIDETQRRREKQLAWNQEHGITPETVRKSMQTILGSIEEKDYY
TPKVSAAETPEEYGVAPKDIPKLVKKLRKEMLGAAKQLDFEKAAELRDRVRTLEEMELALR

Sequences:

>Translated_701_residues
MSIFTLKTDYTPRGDQPAAIAELVEGIERGDQHQVLLGVTGSGKTFTVANVIARTGRPALLLAPNKTLAAQLYAEMKELF
PDNAVEFFVSYYDYYQPEAYLPSSDTFIEKDSAINDEIDKMRHSATRSLLTRRDVIIVASVSCIYGIGSPEAYASLHIFF
RQGEEYGRDTLLQKLVAIQYERNDTDFHRGTFRVRGDVVEVFPAYDSDKALRIEFFGDEVESISEIDPLRGAVLQRLTKC
TIYPASHYVATRETLERAVEQIRVDLGERIRYFRENNMLLEAQRIEQRTFFDIEMMEEMGFCQGIENYSRYFDGRETGEP
PYTLIDYFPDDFVLYVDESHISIPQVGGMYRGDRSRKETLVNYGFRLPAALDNRPLNFREFEARVHQAVYVSATPADYEL
EKSNGVFVEQVIRPTGLLDPVIQVRPVTAGRQIPPSPPLKKGDLPSGDDEYPPFEKGGAGGMYGQVDDLLHEVRQTVAKG
ERVLVTTLTKRMAEELTSYYGELGVRIRYLHSDIVTIERMQILRDLRMGEFDVLVGINLLREGLDLPEVSLVAILDADKE
GFLRSERSLIQTCGRAARNANGRVLMYADSITRSMQACIDETQRRREKQLAWNQEHGITPETVRKSMQTILGSIEEKDYY
TPKVSAAETPEEYGVAPKDIPKLVKKLRKEMLGAAKQLDFEKAAELRDRVRTLEEMELALR
>Mature_700_residues
SIFTLKTDYTPRGDQPAAIAELVEGIERGDQHQVLLGVTGSGKTFTVANVIARTGRPALLLAPNKTLAAQLYAEMKELFP
DNAVEFFVSYYDYYQPEAYLPSSDTFIEKDSAINDEIDKMRHSATRSLLTRRDVIIVASVSCIYGIGSPEAYASLHIFFR
QGEEYGRDTLLQKLVAIQYERNDTDFHRGTFRVRGDVVEVFPAYDSDKALRIEFFGDEVESISEIDPLRGAVLQRLTKCT
IYPASHYVATRETLERAVEQIRVDLGERIRYFRENNMLLEAQRIEQRTFFDIEMMEEMGFCQGIENYSRYFDGRETGEPP
YTLIDYFPDDFVLYVDESHISIPQVGGMYRGDRSRKETLVNYGFRLPAALDNRPLNFREFEARVHQAVYVSATPADYELE
KSNGVFVEQVIRPTGLLDPVIQVRPVTAGRQIPPSPPLKKGDLPSGDDEYPPFEKGGAGGMYGQVDDLLHEVRQTVAKGE
RVLVTTLTKRMAEELTSYYGELGVRIRYLHSDIVTIERMQILRDLRMGEFDVLVGINLLREGLDLPEVSLVAILDADKEG
FLRSERSLIQTCGRAARNANGRVLMYADSITRSMQACIDETQRRREKQLAWNQEHGITPETVRKSMQTILGSIEEKDYYT
PKVSAAETPEEYGVAPKDIPKLVKKLRKEMLGAAKQLDFEKAAELRDRVRTLEEMELALR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=704, Percent_Identity=56.9602272727273, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=236, Percent_Identity=24.1525423728814, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79739; Mature: 79607

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFTLKTDYTPRGDQPAAIAELVEGIERGDQHQVLLGVTGSGKTFTVANVIARTGRPAL
CEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHCCCCEE
LLAPNKTLAAQLYAEMKELFPDNAVEFFVSYYDYYQPEAYLPSSDTFIEKDSAINDEIDK
EECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHH
MRHSATRSLLTRRDVIIVASVSCIYGIGSPEAYASLHIFFRQGEEYGRDTLLQKLVAIQY
HHHHHHHHHHHHCCEEEEEEHHHHEECCCCHHHHEEEEEECCCHHCCHHHHHHHHHHHHC
ERNDTDFHRGTFRVRGDVVEVFPAYDSDKALRIEFFGDEVESISEIDPLRGAVLQRLTKC
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHC
TIYPASHYVATRETLERAVEQIRVDLGERIRYFRENNMLLEAQRIEQRTFFDIEMMEEMG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHH
FCQGIENYSRYFDGRETGEPPYTLIDYFPDDFVLYVDESHISIPQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
VNYGFRLPAALDNRPLNFREFEARVHQAVYVSATPADYELEKSNGVFVEQVIRPTGLLDP
HHCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEECCCCCCHHHHHCCCCCCCC
VIQVRPVTAGRQIPPSPPLKKGDLPSGDDEYPPFEKGGAGGMYGQVDDLLHEVRQTVAKG
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
ERVLVTTLTKRMAEELTSYYGELGVRIRYLHSDIVTIERMQILRDLRMGEFDVLVGINLL
CEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
REGLDLPEVSLVAILDADKEGFLRSERSLIQTCGRAARNANGRVLMYADSITRSMQACID
HCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHH
ETQRRREKQLAWNQEHGITPETVRKSMQTILGSIEEKDYYTPKVSAAETPEEYGVAPKDI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHH
PKLVKKLRKEMLGAAKQLDFEKAAELRDRVRTLEEMELALR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIFTLKTDYTPRGDQPAAIAELVEGIERGDQHQVLLGVTGSGKTFTVANVIARTGRPAL
EEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHCCCCEE
LLAPNKTLAAQLYAEMKELFPDNAVEFFVSYYDYYQPEAYLPSSDTFIEKDSAINDEIDK
EECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHH
MRHSATRSLLTRRDVIIVASVSCIYGIGSPEAYASLHIFFRQGEEYGRDTLLQKLVAIQY
HHHHHHHHHHHHCCEEEEEEHHHHEECCCCHHHHEEEEEECCCHHCCHHHHHHHHHHHHC
ERNDTDFHRGTFRVRGDVVEVFPAYDSDKALRIEFFGDEVESISEIDPLRGAVLQRLTKC
CCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHHC
TIYPASHYVATRETLERAVEQIRVDLGERIRYFRENNMLLEAQRIEQRTFFDIEMMEEMG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHH
FCQGIENYSRYFDGRETGEPPYTLIDYFPDDFVLYVDESHISIPQVGGMYRGDRSRKETL
HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
VNYGFRLPAALDNRPLNFREFEARVHQAVYVSATPADYELEKSNGVFVEQVIRPTGLLDP
HHCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCEEECCCCCCHHHHHCCCCCCCC
VIQVRPVTAGRQIPPSPPLKKGDLPSGDDEYPPFEKGGAGGMYGQVDDLLHEVRQTVAKG
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
ERVLVTTLTKRMAEELTSYYGELGVRIRYLHSDIVTIERMQILRDLRMGEFDVLVGINLL
CEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
REGLDLPEVSLVAILDADKEGFLRSERSLIQTCGRAARNANGRVLMYADSITRSMQACID
HCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHH
ETQRRREKQLAWNQEHGITPETVRKSMQTILGSIEEKDYYTPKVSAAETPEEYGVAPKDI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHH
PKLVKKLRKEMLGAAKQLDFEKAAELRDRVRTLEEMELALR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA