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The map label for this gene is gmd [H]

Identifier: 118581805

GI number: 118581805

Start: 3759155

End: 3760210

Strand: Reverse

Name: gmd [H]

Synonym: Ppro_3405

Alternate gene names: 118581805

Gene position: 3760210-3759155 (Counterclockwise)

Preceding gene: 118581806

Following gene: 118581804

Centisome position: 93.82

GC content: 62.59

Gene sequence:

>1056_bases
ATGAAAAAAGCACTCATCACCGGCATCACCGGCCAGGATGGTTCCTACCTGGCGGAACTTCTGCTGGAAAAGGGGTACCA
GGTACATGGCATGATCCGCCGCTCCTCCTCCTTCAACACCGGCCGTATCGACCACCTCTACCGCGACCCGCACGAGAAGG
ATGTGCGCCTGCTGCTGCACTACGGCGACCTGAACGATGCCAGCTCCATCAACACCCTGCTGCGCACCATCCGGCCGGAC
GAGATCTACAACCTGGGCGCCCAGAGCCACGTGCGGGTCTCCTTCGACGTGCCGGAGTACACCGCCGAAGTGGACGGCCT
GGGTGCGGTGCGTCTGCTGGAGGGGATTCGCGAGACCGGCCTGAATACCCGATTCTACCAGGCCTCGTCCTCCGAGCTGT
ACGGCAAGGTGGTGGAGACCCCCCAGAAAGAGACCACCCCCTTCTATCCCCGCTCCCCCTACGCCTGCGCTAAGGCCTAC
GCCTTCTACATCACCATGAACTACCGCGAGAGCTACGGCATCTACGCCTGCAACGGCATCCTCTTCAATCATGAATCCCC
CCGCCGTGGTGAGACCTTTGTCACCCGCAAGATCACCAGGGCAGCGGCCCGCATCAGCTTGGGGCTTCAGGACTGTCTCT
ACCTGGGCAACCTGGAGGCCAAACGCGACTGGGGCTTTGCCGGCGACTACGTGGAGGCCATGTGGCTGATGCTGCAGCAG
GAGCAACCGGAAGACTACGTCATTGCCACCGGCGAGACCTGGTCCGTGCGCAGCTTTGCCGAAATGGTCTTTCAGCGCCT
GGGCATGCCGCTGGAGTGGCGAGGGGGCGGCGTGGACGAGGTGGGGGTCGACACAAAGAGCGGCAACAGCGTCATTCGCA
TCGATCCCAAATATTTCCGCCCGGCCGAGGTGGACCTGCTGCTGGGCGACCCTTCCAAGGCCAGGCGCCAGCTGGGCTGG
AAGCAGAAGACCAGCTTCAGGGAACTTGTGGAGATGATGGCCGACGCGGACCTTGAACTGGCCCAGCGGGAACGCCGGGC
GGATGGAGTAAAATAA

Upstream 100 bases:

>100_bases
CTGTCTCGCGCAAGGACGCCAAGACGCGAAGAAACCGAAAAGATTTTCAGTCATCTTTCTGATTGGTAATTGAATTTAGG
CACATCCGGGAGCCAACAGC

Downstream 100 bases:

>100_bases
TGCGCATTCTGGTTACCGGCGGCGCCGGTTTCATTGGTTCGCACCTGTGCGAACGCCTGCTGAACGAGGGGCACGACGTC
ATCTGCCTGGACAACTTTTT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKKALITGITGQDGSYLAELLLEKGYQVHGMIRRSSSFNTGRIDHLYRDPHEKDVRLLLHYGDLNDASSINTLLRTIRPD
EIYNLGAQSHVRVSFDVPEYTAEVDGLGAVRLLEGIRETGLNTRFYQASSSELYGKVVETPQKETTPFYPRSPYACAKAY
AFYITMNYRESYGIYACNGILFNHESPRRGETFVTRKITRAAARISLGLQDCLYLGNLEAKRDWGFAGDYVEAMWLMLQQ
EQPEDYVIATGETWSVRSFAEMVFQRLGMPLEWRGGGVDEVGVDTKSGNSVIRIDPKYFRPAEVDLLLGDPSKARRQLGW
KQKTSFRELVEMMADADLELAQRERRADGVK

Sequences:

>Translated_351_residues
MKKALITGITGQDGSYLAELLLEKGYQVHGMIRRSSSFNTGRIDHLYRDPHEKDVRLLLHYGDLNDASSINTLLRTIRPD
EIYNLGAQSHVRVSFDVPEYTAEVDGLGAVRLLEGIRETGLNTRFYQASSSELYGKVVETPQKETTPFYPRSPYACAKAY
AFYITMNYRESYGIYACNGILFNHESPRRGETFVTRKITRAAARISLGLQDCLYLGNLEAKRDWGFAGDYVEAMWLMLQQ
EQPEDYVIATGETWSVRSFAEMVFQRLGMPLEWRGGGVDEVGVDTKSGNSVIRIDPKYFRPAEVDLLLGDPSKARRQLGW
KQKTSFRELVEMMADADLELAQRERRADGVK
>Mature_351_residues
MKKALITGITGQDGSYLAELLLEKGYQVHGMIRRSSSFNTGRIDHLYRDPHEKDVRLLLHYGDLNDASSINTLLRTIRPD
EIYNLGAQSHVRVSFDVPEYTAEVDGLGAVRLLEGIRETGLNTRFYQASSSELYGKVVETPQKETTPFYPRSPYACAKAY
AFYITMNYRESYGIYACNGILFNHESPRRGETFVTRKITRAAARISLGLQDCLYLGNLEAKRDWGFAGDYVEAMWLMLQQ
EQPEDYVIATGETWSVRSFAEMVFQRLGMPLEWRGGGVDEVGVDTKSGNSVIRIDPKYFRPAEVDLLLGDPSKARRQLGW
KQKTSFRELVEMMADADLELAQRERRADGVK

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=347, Percent_Identity=59.6541786743516, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI7657641, Length=332, Percent_Identity=23.4939759036145, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788366, Length=354, Percent_Identity=63.8418079096045, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI48994969, Length=348, Percent_Identity=26.1494252873563, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788353, Length=290, Percent_Identity=23.448275862069, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=345, Percent_Identity=60.5797101449275, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI133901790, Length=345, Percent_Identity=60.5797101449275, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17507723, Length=350, Percent_Identity=60.8571428571429, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI133901786, Length=345, Percent_Identity=60.5797101449275, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17539422, Length=345, Percent_Identity=60.5797101449275, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI133901788, Length=345, Percent_Identity=60.5797101449275, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24158427, Length=345, Percent_Identity=64.3478260869565, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 39872; Mature: 39872

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKALITGITGQDGSYLAELLLEKGYQVHGMIRRSSSFNTGRIDHLYRDPHEKDVRLLLH
CCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCCCCCEEEEEE
YGDLNDASSINTLLRTIRPDEIYNLGAQSHVRVSFDVPEYTAEVDGLGAVRLLEGIRETG
ECCCCCHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHCC
LNTRFYQASSSELYGKVVETPQKETTPFYPRSPYACAKAYAFYITMNYRESYGIYACNGI
CCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEEEEECCCCCCEEEEEEE
LFNHESPRRGETFVTRKITRAAARISLGLQDCLYLGNLEAKRDWGFAGDYVEAMWLMLQQ
EECCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
EQPEDYVIATGETWSVRSFAEMVFQRLGMPLEWRGGGVDEVGVDTKSGNSVIRIDPKYFR
CCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCC
PAEVDLLLGDPSKARRQLGWKQKTSFRELVEMMADADLELAQRERRADGVK
CCEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKALITGITGQDGSYLAELLLEKGYQVHGMIRRSSSFNTGRIDHLYRDPHEKDVRLLLH
CCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCCCCCEEEEEE
YGDLNDASSINTLLRTIRPDEIYNLGAQSHVRVSFDVPEYTAEVDGLGAVRLLEGIRETG
ECCCCCHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHCC
LNTRFYQASSSELYGKVVETPQKETTPFYPRSPYACAKAYAFYITMNYRESYGIYACNGI
CCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEEEEECCCCCCEEEEEEE
LFNHESPRRGETFVTRKITRAAARISLGLQDCLYLGNLEAKRDWGFAGDYVEAMWLMLQQ
EECCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
EQPEDYVIATGETWSVRSFAEMVFQRLGMPLEWRGGGVDEVGVDTKSGNSVIRIDPKYFR
CCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCC
PAEVDLLLGDPSKARRQLGWKQKTSFRELVEMMADADLELAQRERRADGVK
CCEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]