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The map label for this gene is hemA

Identifier: 118581777

GI number: 118581777

Start: 3728947

End: 3730257

Strand: Reverse

Name: hemA

Synonym: Ppro_3377

Alternate gene names: 118581777

Gene position: 3730257-3728947 (Counterclockwise)

Preceding gene: 118581778

Following gene: 118581776

Centisome position: 93.07

GC content: 62.7

Gene sequence:

>1311_bases
ATGAATATCATCGTTGTCGGCCTCTCCCACAAGACAGCGCCGGTGGAGGTACGGGAGAGGGTGGCATTCTCGCCCAACCT
GATTGAAAGGCCGCTGCGGGAACTGGTCAGCCTGGACGATATCAGCGAAGGGGTGATCGTCTCCACCTGCAACCGGGTGG
AGATCTATGCCACCACCCATGACATCGCCGGCGGCACGGCCCGCATCAAGCGTTTCCTGGCTGACCACCACCGCATACCG
CTGGAGAGCCTGGAGCAGTACCTGTACAGCTACCACTCCGAGGCAGCCATCCGCCACGTGTTCCGGGTGGCCTCCAGCCT
GGACTCCATGGTGGTGGGAGAACCCCAGATCCTGGGGCAGATCAAGACCGCCTACGGCTATGCGGCCGAATACCGGACAT
CGGGCACCATCCTGAACCGTTTCCTGCACAAAGCTTTCTCCGTTGCCAAGCGGGTGCGCACGGAAACCAGGATCGCCTCC
TCGGCGGTTTCGGTGGCCTTTGCCGCGGTGGAGCTTGCCCGCAAGATCCTGGGCGACCTGTCCGGCAAGACCGTCATGCT
GATCGGCGCCGGCGAGATGTGCGAGCTGGCAGCCAAGCATTTTCTCACCAGCGGCGCCCGTGGTCTGTTGGTGGCCAACC
GCACCTTTGCCAAGGGTGAGCGCCTGGCCGCCGAGTTCGGCGGTGAGGCGATACCCTTCGAGGAGCTGTTCCAGGAGCTC
CACCGGGCAGATATCGTGCTCTCCTCAACCGGCGCGCCGCACACCATCATCGCTCCCCGGGACGTGGAGGCGGTGGTGAA
ACGGCGCAAGTTCAAGCCGATGTTCTTCATCGACATCGCCGTGCCGCGCGACATCGATCCCCGGGTGAACGACCTGGAGA
GCGCCTACCTCTTCACGGTGGACGACCTGCAGGAGATCGTTGAGGCCAACATGGCCCAGCGCAACCAGGAGGCGAGCAAA
GGGGAAGAAATCGTCGAGCAGGAGATCGGACAGTTCCATTGCTGGCTCTCCTCCCTTGAATCGACCCCCACCATAGTTGC
CCTGCGCGCCAGGTTCGAGGAGATCAGGCGGGCGGAGTTGGAAAAGACTCTCTGCGGCTGGAAGGATCTCTCCCCCGAGG
CGGAAAAACGGCTGGAGATCATGACCCTCTCCATCATGAACAAACTGCTGCATACTCCCACGGCCGTGCTCAAGCGGGCC
GGCCAGGGGGGGCGCACCGACCTCTATACCGATGCCCTGCGGCAGCTTTTCGATCTTCAGACAAGCCGGCAGGACGACGA
CGAACTGGAGCTGGAACTGGAGGAGGAGTGA

Upstream 100 bases:

>100_bases
ATCGTCCTTTTGATCACCTTTTTCGGCATGAGGCACAGCGTCACATGGTAGCCCAGTCAGGACAGCGGTTGTCGCCAGGG
GCGGGGGAGACTGCGGCGCA

Downstream 100 bases:

>100_bases
GACTCCCTCCGCTGATAGCCGGAACACTGGTCAGGCGCTACAAGCGTTTCCTGGCCGATGTGATCCTGGAGGACGGCAGC
CCCGTCACGGTCCACTGCCC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNIIVVGLSHKTAPVEVRERVAFSPNLIERPLRELVSLDDISEGVIVSTCNRVEIYATTHDIAGGTARIKRFLADHHRIP
LESLEQYLYSYHSEAAIRHVFRVASSLDSMVVGEPQILGQIKTAYGYAAEYRTSGTILNRFLHKAFSVAKRVRTETRIAS
SAVSVAFAAVELARKILGDLSGKTVMLIGAGEMCELAAKHFLTSGARGLLVANRTFAKGERLAAEFGGEAIPFEELFQEL
HRADIVLSSTGAPHTIIAPRDVEAVVKRRKFKPMFFIDIAVPRDIDPRVNDLESAYLFTVDDLQEIVEANMAQRNQEASK
GEEIVEQEIGQFHCWLSSLESTPTIVALRARFEEIRRAELEKTLCGWKDLSPEAEKRLEIMTLSIMNKLLHTPTAVLKRA
GQGGRTDLYTDALRQLFDLQTSRQDDDELELELEEE

Sequences:

>Translated_436_residues
MNIIVVGLSHKTAPVEVRERVAFSPNLIERPLRELVSLDDISEGVIVSTCNRVEIYATTHDIAGGTARIKRFLADHHRIP
LESLEQYLYSYHSEAAIRHVFRVASSLDSMVVGEPQILGQIKTAYGYAAEYRTSGTILNRFLHKAFSVAKRVRTETRIAS
SAVSVAFAAVELARKILGDLSGKTVMLIGAGEMCELAAKHFLTSGARGLLVANRTFAKGERLAAEFGGEAIPFEELFQEL
HRADIVLSSTGAPHTIIAPRDVEAVVKRRKFKPMFFIDIAVPRDIDPRVNDLESAYLFTVDDLQEIVEANMAQRNQEASK
GEEIVEQEIGQFHCWLSSLESTPTIVALRARFEEIRRAELEKTLCGWKDLSPEAEKRLEIMTLSIMNKLLHTPTAVLKRA
GQGGRTDLYTDALRQLFDLQTSRQDDDELELELEEE
>Mature_436_residues
MNIIVVGLSHKTAPVEVRERVAFSPNLIERPLRELVSLDDISEGVIVSTCNRVEIYATTHDIAGGTARIKRFLADHHRIP
LESLEQYLYSYHSEAAIRHVFRVASSLDSMVVGEPQILGQIKTAYGYAAEYRTSGTILNRFLHKAFSVAKRVRTETRIAS
SAVSVAFAAVELARKILGDLSGKTVMLIGAGEMCELAAKHFLTSGARGLLVANRTFAKGERLAAEFGGEAIPFEELFQEL
HRADIVLSSTGAPHTIIAPRDVEAVVKRRKFKPMFFIDIAVPRDIDPRVNDLESAYLFTVDDLQEIVEANMAQRNQEASK
GEEIVEQEIGQFHCWLSSLESTPTIVALRARFEEIRRAELEKTLCGWKDLSPEAEKRLEIMTLSIMNKLLHTPTAVLKRA
GQGGRTDLYTDALRQLFDLQTSRQDDDELELELEEE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=416, Percent_Identity=41.3461538461538, Blast_Score=315, Evalue=5e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PELPD (A1AUE9)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903027.1
- ProteinModelPortal:   A1AUE9
- SMR:   A1AUE9
- STRING:   A1AUE9
- GeneID:   4572528
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3377
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   A1AUE9
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48747; Mature: 48747

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIVVGLSHKTAPVEVRERVAFSPNLIERPLRELVSLDDISEGVIVSTCNRVEIYATTH
CCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECC
DIAGGTARIKRFLADHHRIPLESLEQYLYSYHSEAAIRHVFRVASSLDSMVVGEPQILGQ
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IKTAYGYAAEYRTSGTILNRFLHKAFSVAKRVRTETRIASSAVSVAFAAVELARKILGDL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGKTVMLIGAGEMCELAAKHFLTSGARGLLVANRTFAKGERLAAEFGGEAIPFEELFQEL
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHH
HRADIVLSSTGAPHTIIAPRDVEAVVKRRKFKPMFFIDIAVPRDIDPRVNDLESAYLFTV
HHHCEEEECCCCCEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHEEEH
DDLQEIVEANMAQRNQEASKGEEIVEQEIGQFHCWLSSLESTPTIVALRARFEEIRRAEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EKTLCGWKDLSPEAEKRLEIMTLSIMNKLLHTPTAVLKRAGQGGRTDLYTDALRQLFDLQ
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TSRQDDDELELELEEE
CCCCCCCCCCEEECCC
>Mature Secondary Structure
MNIIVVGLSHKTAPVEVRERVAFSPNLIERPLRELVSLDDISEGVIVSTCNRVEIYATTH
CCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECC
DIAGGTARIKRFLADHHRIPLESLEQYLYSYHSEAAIRHVFRVASSLDSMVVGEPQILGQ
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IKTAYGYAAEYRTSGTILNRFLHKAFSVAKRVRTETRIASSAVSVAFAAVELARKILGDL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGKTVMLIGAGEMCELAAKHFLTSGARGLLVANRTFAKGERLAAEFGGEAIPFEELFQEL
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHH
HRADIVLSSTGAPHTIIAPRDVEAVVKRRKFKPMFFIDIAVPRDIDPRVNDLESAYLFTV
HHHCEEEECCCCCEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHEEEH
DDLQEIVEANMAQRNQEASKGEEIVEQEIGQFHCWLSSLESTPTIVALRARFEEIRRAEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EKTLCGWKDLSPEAEKRLEIMTLSIMNKLLHTPTAVLKRAGQGGRTDLYTDALRQLFDLQ
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
TSRQDDDELELELEEE
CCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA