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The map label for this gene is murC

Identifier: 118581688

GI number: 118581688

Start: 3623321

End: 3624703

Strand: Reverse

Name: murC

Synonym: Ppro_3288

Alternate gene names: 118581688

Gene position: 3624703-3623321 (Counterclockwise)

Preceding gene: 118581689

Following gene: 118581687

Centisome position: 90.44

GC content: 64.35

Gene sequence:

>1383_bases
ATGTACGGAAAAATCGAGAAAATCCACTTCGTCGGCATCGGCGGCATCGGCATGAGCGGCATCGCCGAGGTGCTGCTGAA
TCTGGGCTACAAAGTGTCAGGCTCCGACCTGCGCGGCTCGGACATCACCGAGCGCTTGGCCCGTCTGGGGGCGGAGATCG
GCATTGGCCACAAGGCGGATAACCTTAAGGATGTGGACGTGGTGGTCATATCGTCGGCCGTGCATGACGACAACCCGGAG
GTGGTGGAGGCCAAGCGCCTGCACGTGCCGGTCATCCCCCGGGCCGAGATGCTGGCCGAGCTGATGCGCATGAAGTTCGG
CATCGCCATCGCCGGCACCCACGGCAAGACCACCACCACTTCCATGGCCGCTTCCATCCTGGGGCACGCCGGCATCGATC
CGACCATCGTCATCGGCGGCAAGCTGAACGCCATCGGCACCAACGCCCAGCTGGGACAGGGCAAGTTCCTGCTGGCCGAG
GCGGACGAGTCCGACGGCTCGTTCCTGGTGCTCTCCCCCACCATCGCCGTGGTCACCAACATCGACGCCGACCACCTGGA
CCACTACTCCGGCGGCATCGAGGAGATCAAGGATACCTTTGTCAAGTTCATCAACAAGGTGCCCTTCTACGGCATGGCGG
TGCTCTGCCTGGACGATCCCAACATCCGCGCCATCCTGCCGCGGGTCAAGAAACGCTACATGACCTATGGCCTCTCCTCC
CAGGCCGATATCCGCGCCACCCATGTCAGGCATGACGGGTTCACCACCAGCTTCACGGCCCACTTCAAGGGGTACCGCCT
GGGGGAGATCTCCTTCACCATGCCGGGGGCCCACAACGTGCTCAACGCCATGGCCTGCATCGCCGTTGCCCTGGAGCTGG
ACGTTCCCTTCTCCGCCATCCAGGAGGGATTCTCCCGCTTTGGCGGCGTGGGGCGGCGCTTCACCATCAAGGGGGAACCC
AGGGGGATCACGGTGGTGGACGACTACGGCCACCACCCGGCGGAGATCAAGGCGACCCTGGCCGCCGCGCGGCTGGGCTG
GCCGGAACGGCGTATCGTGGCCGTGTTTCAGCCGCATCGCTACACCCGCACCCACGAGCTGTTTGGCGAGTTCGTCACCG
CCTTCTACGATGCCGACGTGCTGATCCTGACCGATGTGTATGCCGCCGGGGAACAGCCTGTCGAGGGGGCCACGGCGGAA
CGCCTTTCCCAGGAGATCCTCAGGCACGGCCAGAAGGATGTCACCTGGATCCCTAACCGCGAGCTGATCCCCCAGCATCT
GCTGGGCATCGTCAAGGAGGGGGACATGGTCATCACCCTGGGGGCCGGCAGCATCTGGCAGCAGGGCGAGGCGCTGGTGA
CGCTTTTGGAGAAAACCTCGTGA

Upstream 100 bases:

>100_bases
GCGGCGCACCGGAGAGCTGGCCTTCTCCATGGCCCGCCTTGATGCGGCCAGGATCATCGTTGACGAGATACTCACACCAA
CCAACTGAAAAGGCATTCCC

Downstream 100 bases:

>100_bases
ATCTCTCCGGGCTGAACATGCGCGGCCTGCTTCTGGCTGACGAACCCATGAGCCGCCATACCTCCCTCAGGGTGGGCGGT
CCCGCGGACCTGTTCGCCAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSDITERLARLGAEIGIGHKADNLKDVDVVVISSAVHDDNPE
VVEAKRLHVPVIPRAEMLAELMRMKFGIAIAGTHGKTTTTSMAASILGHAGIDPTIVIGGKLNAIGTNAQLGQGKFLLAE
ADESDGSFLVLSPTIAVVTNIDADHLDHYSGGIEEIKDTFVKFINKVPFYGMAVLCLDDPNIRAILPRVKKRYMTYGLSS
QADIRATHVRHDGFTTSFTAHFKGYRLGEISFTMPGAHNVLNAMACIAVALELDVPFSAIQEGFSRFGGVGRRFTIKGEP
RGITVVDDYGHHPAEIKATLAAARLGWPERRIVAVFQPHRYTRTHELFGEFVTAFYDADVLILTDVYAAGEQPVEGATAE
RLSQEILRHGQKDVTWIPNRELIPQHLLGIVKEGDMVITLGAGSIWQQGEALVTLLEKTS

Sequences:

>Translated_460_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSDITERLARLGAEIGIGHKADNLKDVDVVVISSAVHDDNPE
VVEAKRLHVPVIPRAEMLAELMRMKFGIAIAGTHGKTTTTSMAASILGHAGIDPTIVIGGKLNAIGTNAQLGQGKFLLAE
ADESDGSFLVLSPTIAVVTNIDADHLDHYSGGIEEIKDTFVKFINKVPFYGMAVLCLDDPNIRAILPRVKKRYMTYGLSS
QADIRATHVRHDGFTTSFTAHFKGYRLGEISFTMPGAHNVLNAMACIAVALELDVPFSAIQEGFSRFGGVGRRFTIKGEP
RGITVVDDYGHHPAEIKATLAAARLGWPERRIVAVFQPHRYTRTHELFGEFVTAFYDADVLILTDVYAAGEQPVEGATAE
RLSQEILRHGQKDVTWIPNRELIPQHLLGIVKEGDMVITLGAGSIWQQGEALVTLLEKTS
>Mature_460_residues
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSDITERLARLGAEIGIGHKADNLKDVDVVVISSAVHDDNPE
VVEAKRLHVPVIPRAEMLAELMRMKFGIAIAGTHGKTTTTSMAASILGHAGIDPTIVIGGKLNAIGTNAQLGQGKFLLAE
ADESDGSFLVLSPTIAVVTNIDADHLDHYSGGIEEIKDTFVKFINKVPFYGMAVLCLDDPNIRAILPRVKKRYMTYGLSS
QADIRATHVRHDGFTTSFTAHFKGYRLGEISFTMPGAHNVLNAMACIAVALELDVPFSAIQEGFSRFGGVGRRFTIKGEP
RGITVVDDYGHHPAEIKATLAAARLGWPERRIVAVFQPHRYTRTHELFGEFVTAFYDADVLILTDVYAAGEQPVEGATAE
RLSQEILRHGQKDVTWIPNRELIPQHLLGIVKEGDMVITLGAGSIWQQGEALVTLLEKTS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=46.6377440347072, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1790680, Length=373, Percent_Identity=31.3672922252011, Blast_Score=162, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PELPD (A1AU60)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902938.1
- ProteinModelPortal:   A1AU60
- SMR:   A1AU60
- STRING:   A1AU60
- GeneID:   4572282
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3288
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A1AU60
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49884; Mature: 49884

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSDITERLARLGAEIGIGHKAD
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHCHHCCCCCCCC
NLKDVDVVVISSAVHDDNPEVVEAKRLHVPVIPRAEMLAELMRMKFGIAIAGTHGKTTTT
CCCCCEEEEEEEHHCCCCCCEEEHEECCCCCCCHHHHHHHHHHHHCCEEEECCCCCCHHH
SMAASILGHAGIDPTIVIGGKLNAIGTNAQLGQGKFLLAEADESDGSFLVLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECCEEEEEC
IDADHLDHYSGGIEEIKDTFVKFINKVPFYGMAVLCLDDPNIRAILPRVKKRYMTYGLSS
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADIRATHVRHDGFTTSFTAHFKGYRLGEISFTMPGAHNVLNAMACIAVALELDVPFSAI
CCCEEEEEEECCCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHEEECCCCHHHH
QEGFSRFGGVGRRFTIKGEPRGITVVDDYGHHPAEIKATLAAARLGWPERRIVAVFQPHR
HHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
YTRTHELFGEFVTAFYDADVLILTDVYAAGEQPVEGATAERLSQEILRHGQKDVTWIPNR
CCHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCC
ELIPQHLLGIVKEGDMVITLGAGSIWQQGEALVTLLEKTS
CCCHHHHHHHHCCCCEEEEECCCCHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSDITERLARLGAEIGIGHKAD
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHCHHCCCCCCCC
NLKDVDVVVISSAVHDDNPEVVEAKRLHVPVIPRAEMLAELMRMKFGIAIAGTHGKTTTT
CCCCCEEEEEEEHHCCCCCCEEEHEECCCCCCCHHHHHHHHHHHHCCEEEECCCCCCHHH
SMAASILGHAGIDPTIVIGGKLNAIGTNAQLGQGKFLLAEADESDGSFLVLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECCEEEEEC
IDADHLDHYSGGIEEIKDTFVKFINKVPFYGMAVLCLDDPNIRAILPRVKKRYMTYGLSS
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADIRATHVRHDGFTTSFTAHFKGYRLGEISFTMPGAHNVLNAMACIAVALELDVPFSAI
CCCEEEEEEECCCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHEEECCCCHHHH
QEGFSRFGGVGRRFTIKGEPRGITVVDDYGHHPAEIKATLAAARLGWPERRIVAVFQPHR
HHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
YTRTHELFGEFVTAFYDADVLILTDVYAAGEQPVEGATAERLSQEILRHGQKDVTWIPNR
CCHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCC
ELIPQHLLGIVKEGDMVITLGAGSIWQQGEALVTLLEKTS
CCCHHHHHHHHCCCCEEEEECCCCHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA