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The map label for this gene is atoC [H]

Identifier: 118581509

GI number: 118581509

Start: 3409087

End: 3410472

Strand: Reverse

Name: atoC [H]

Synonym: Ppro_3108

Alternate gene names: 118581509

Gene position: 3410472-3409087 (Counterclockwise)

Preceding gene: 118581510

Following gene: 118581508

Centisome position: 85.09

GC content: 63.28

Gene sequence:

>1386_bases
ATGCCACAGAACCAGATTGGCCCGAATCCTGAAAGCCGCATCCTGATCGTTGATGACGAGGGGACGTCCCTGCTGATTCT
GGAGAACTACCTCCAGCACCATGGGCATGTGGCGATCTGCGCCGCCAACGGTCGTGAGGCACTCGCCCTGCTGAAAAAGC
AGCCGGTTGACCTGGTCATATCCGATCTGGTCATGCCGGGAATGGGCGGGATCGAGTTCATGGATCTGGCCAAGGAACGG
CACCCGGGACTCCCTTTTATCTTCTATACGGCACTGGGGAGCATCGAGAGCGCGGTCTCGGCCATCAAGCAGGGCGCCTT
CGACTATCTGGAAAAGCCGCTGGACCCCAAGACCTTCGACGTGGTCATCCAGCGCGCCCTGGAGTTTGCCCGCCTCTCCC
ACGAGAACGTTCAACTGCGCGAGCATTTCGCCGAGTTGTTCAGTTTCCAGAACATCGTGACCCAATCTCCTGCCATGCGC
ACGGTCCTGGAGTTGGCCTCCCGGGTGGCCGCGTCCCCCCGGACCACCGTCAGCCTGACCGGCGAGAGCGGCACCGGCAA
GGAGGTGCTGGCCCGGGCGATCCATTTTGCCTCCGGCTGCCTGCCGAGCAATTTCGTGGCGGTCAACTGCGCCGCCATCC
CCGAGGCGCTTCTGGAGAGCGAGTTGTTCGGCCATGTGCGCGGCGCGTTCACCGGGGCGGAACGTGACCGTGAGGGGAAG
TTCAGCCTGGCCCGGGGGGGAACCGTCCTTCTGGACGAGATCGGCGACATGCCGCTTCCGCTCCAGGCCAAGCTGCTGCG
GGTACTGGAGGAGCGGACCTTCGAGAAGGTGGGGGACAACCGCCCGCAGCCGGTAGATTTCCGGGTTATCGTTGCCACCT
ATCGCGACCTAGCCCAGCTGGTACGCAAGGGCAGATTCCGCGAAGACCTGTACCATCGCATCAACGTTGTTCCCATCGCG
ATCCCCCCCCTCAGGGAGCGGCTGGAGGACATCCCGCTTTTGGTGGACTTCTTCCTGAAGCTCTTCCGCCAGCACCAGGG
GAAGGCGCTTCCGGGGGTCTCGAAGAAAGCCATGGACCTGCTCATCGCCCACTCCTGGCCGGGCAATGTGCGCGAGCTGC
GCAACGTGCTGGAATATGCCGCCATCATGGTCAGCGACGAGCTGATCCGGCCCGAACACCTGCGCCTCTCCTCCTCTTCG
CCGTCAGCCTCTGCTCTCCCGTCCTCCAGCGGCACCGTTGAATTCCACATCAGTCTCCCCGCCGAAGATGTTTCCCTGGA
TGCCGTCGTCTCCCGGGTCCTGGAAAGCGCCCTCCAGCGTTGCCACGGCAACAAGTCCCGGGCCGCGGCCCTGCTCAAGG
TCAACCGCAAGATGTTCTATCGCTGA

Upstream 100 bases:

>100_bases
TGCCCCCGATCCGCCTTGGCTCTGTTCGGCCGCTGGAAGACGGAATCGCCGGCTGTTACGAAGGGGAAGGGGGATCTCCC
CATGAAAGCTGGACTCATCC

Downstream 100 bases:

>100_bases
TCCCCTGTCCGTCCTTTCTGGAAACACCCTTGTCCTTTGTAGGGACAGGAACGTCCGTTCTCCCTGTATAACTCATTGAA
AATAAAGAAAAGAATATTCT

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MPQNQIGPNPESRILIVDDEGTSLLILENYLQHHGHVAICAANGREALALLKKQPVDLVISDLVMPGMGGIEFMDLAKER
HPGLPFIFYTALGSIESAVSAIKQGAFDYLEKPLDPKTFDVVIQRALEFARLSHENVQLREHFAELFSFQNIVTQSPAMR
TVLELASRVAASPRTTVSLTGESGTGKEVLARAIHFASGCLPSNFVAVNCAAIPEALLESELFGHVRGAFTGAERDREGK
FSLARGGTVLLDEIGDMPLPLQAKLLRVLEERTFEKVGDNRPQPVDFRVIVATYRDLAQLVRKGRFREDLYHRINVVPIA
IPPLRERLEDIPLLVDFFLKLFRQHQGKALPGVSKKAMDLLIAHSWPGNVRELRNVLEYAAIMVSDELIRPEHLRLSSSS
PSASALPSSSGTVEFHISLPAEDVSLDAVVSRVLESALQRCHGNKSRAAALLKVNRKMFYR

Sequences:

>Translated_461_residues
MPQNQIGPNPESRILIVDDEGTSLLILENYLQHHGHVAICAANGREALALLKKQPVDLVISDLVMPGMGGIEFMDLAKER
HPGLPFIFYTALGSIESAVSAIKQGAFDYLEKPLDPKTFDVVIQRALEFARLSHENVQLREHFAELFSFQNIVTQSPAMR
TVLELASRVAASPRTTVSLTGESGTGKEVLARAIHFASGCLPSNFVAVNCAAIPEALLESELFGHVRGAFTGAERDREGK
FSLARGGTVLLDEIGDMPLPLQAKLLRVLEERTFEKVGDNRPQPVDFRVIVATYRDLAQLVRKGRFREDLYHRINVVPIA
IPPLRERLEDIPLLVDFFLKLFRQHQGKALPGVSKKAMDLLIAHSWPGNVRELRNVLEYAAIMVSDELIRPEHLRLSSSS
PSASALPSSSGTVEFHISLPAEDVSLDAVVSRVLESALQRCHGNKSRAAALLKVNRKMFYR
>Mature_460_residues
PQNQIGPNPESRILIVDDEGTSLLILENYLQHHGHVAICAANGREALALLKKQPVDLVISDLVMPGMGGIEFMDLAKERH
PGLPFIFYTALGSIESAVSAIKQGAFDYLEKPLDPKTFDVVIQRALEFARLSHENVQLREHFAELFSFQNIVTQSPAMRT
VLELASRVAASPRTTVSLTGESGTGKEVLARAIHFASGCLPSNFVAVNCAAIPEALLESELFGHVRGAFTGAERDREGKF
SLARGGTVLLDEIGDMPLPLQAKLLRVLEERTFEKVGDNRPQPVDFRVIVATYRDLAQLVRKGRFREDLYHRINVVPIAI
PPLRERLEDIPLLVDFFLKLFRQHQGKALPGVSKKAMDLLIAHSWPGNVRELRNVLEYAAIMVSDELIRPEHLRLSSSSP
SASALPSSSGTVEFHISLPAEDVSLDAVVSRVLESALQRCHGNKSRAAALLKVNRKMFYR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=42.350332594235, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=42.9530201342282, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1788905, Length=451, Percent_Identity=42.1286031042129, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=39.3548387096774, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=45.625, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082117, Length=253, Percent_Identity=50.5928853754941, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789087, Length=291, Percent_Identity=45.0171821305842, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=40, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786524, Length=366, Percent_Identity=37.431693989071, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1787583, Length=308, Percent_Identity=38.6363636363636, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=36.7601246105919, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789828, Length=331, Percent_Identity=36.2537764350453, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87081858, Length=318, Percent_Identity=32.0754716981132, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786784, Length=102, Percent_Identity=34.3137254901961, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50982; Mature: 50850

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQNQIGPNPESRILIVDDEGTSLLILENYLQHHGHVAICAANGREALALLKKQPVDLVI
CCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHH
SDLVMPGMGGIEFMDLAKERHPGLPFIFYTALGSIESAVSAIKQGAFDYLEKPLDPKTFD
HHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VVIQRALEFARLSHENVQLREHFAELFSFQNIVTQSPAMRTVLELASRVAASPRTTVSLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEE
GESGTGKEVLARAIHFASGCLPSNFVAVNCAAIPEALLESELFGHVRGAFTGAERDREGK
CCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FSLARGGTVLLDEIGDMPLPLQAKLLRVLEERTFEKVGDNRPQPVDFRVIVATYRDLAQL
EEEECCCEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHH
VRKGRFREDLYHRINVVPIAIPPLRERLEDIPLLVDFFLKLFRQHQGKALPGVSKKAMDL
HHCCCHHHHHHHHHCEEEEECCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
LIAHSWPGNVRELRNVLEYAAIMVSDELIRPEHLRLSSSSPSASALPSSSGTVEFHISLP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCEEEEEEECC
AEDVSLDAVVSRVLESALQRCHGNKSRAAALLKVNRKMFYR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQNQIGPNPESRILIVDDEGTSLLILENYLQHHGHVAICAANGREALALLKKQPVDLVI
CCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHH
SDLVMPGMGGIEFMDLAKERHPGLPFIFYTALGSIESAVSAIKQGAFDYLEKPLDPKTFD
HHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VVIQRALEFARLSHENVQLREHFAELFSFQNIVTQSPAMRTVLELASRVAASPRTTVSLT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEE
GESGTGKEVLARAIHFASGCLPSNFVAVNCAAIPEALLESELFGHVRGAFTGAERDREGK
CCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FSLARGGTVLLDEIGDMPLPLQAKLLRVLEERTFEKVGDNRPQPVDFRVIVATYRDLAQL
EEEECCCEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHH
VRKGRFREDLYHRINVVPIAIPPLRERLEDIPLLVDFFLKLFRQHQGKALPGVSKKAMDL
HHCCCHHHHHHHHHCEEEEECCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
LIAHSWPGNVRELRNVLEYAAIMVSDELIRPEHLRLSSSSPSASALPSSSGTVEFHISLP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCEEEEEEECC
AEDVSLDAVVSRVLESALQRCHGNKSRAAALLKVNRKMFYR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]