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The map label for this gene is hppA [H]

Identifier: 118581442

GI number: 118581442

Start: 3318144

End: 3320198

Strand: Reverse

Name: hppA [H]

Synonym: Ppro_3037

Alternate gene names: 118581442

Gene position: 3320198-3318144 (Counterclockwise)

Preceding gene: 118581444

Following gene: 118581417

Centisome position: 82.84

GC content: 63.07

Gene sequence:

>2055_bases
ATGGAACAGTATGCTGTTATCTTTGCACTGGCTTGCGCCGTTGCAGCCGTTGCGTACGGTCTTGTGTCCGCACAGTGGAT
CCTGGGGCTTCCCCAGGGTAACGAGCGGATGCGCCAGATCGCTGCGGCCATCCAGGAGGGTGCCGGTGCTTACATGAAGC
GCCAGTACACGATTATCTCCGTGGTCGGCGTGGTCATGTTTATCGCCCTGTTCGCGTCTCTGGGGTGGAAGACCGCGGTC
GGCTTCGCTGTCGGTGCTCTCTTCTCCGGCCTGACCGGCTTCATCGGCATGTTCGTCTCCGTCCGCGCCAACGTGCGCAC
CACCGAGGCGGCCAAGTCCGGCATCGAGAAGGCGCTGAACGTGGCCTTCAAGGGCGGCGCCATCACCGGCATGCTGGTTG
TGGGCTTGGGCCTCTTGGGTGTTGCCGGCTACTATATGTTTCTGCAGCAGGTCATGCCGGACGCACCGGTCAAGGACGTT
GTCAGCCAGCTGGTCGGTCTGGGCTTCGGCGGCTCGCTGATCTCCATCTTCGCCCGTCTGGGCGGCGGTATCTTCACCAA
GGGCGCCGACGTGGGCGCCGACCTGGTGGGCAAGGTCGAGGCCGGTATTCCCGAGGACGACCCCCGCAACCCGGCGGTTA
TCGCCGACAACGTGGGTGACAACGTGGGCGACTGCGCCGGCATGGCTGCCGACCTGTTCGAGACCTATGCCGTCACCCTG
ATCGCCGCCATGCTGCTGGGCGCCATCGCCTTCAACAGCAATCCGGGCGCTGTCAGCTATCCGCTGATCCTGGGTGGCGT
TTCCATCATCGCCTCCATCATCGGCACCTTCTTCGTCAAGCTGGGCGCCAGCAAGAAGATCATGCCCGCCCTCTACAAGG
GGCTGATCGTTTCAGGTCTTCTGGCCTGTGTCGCCTTCTACTTCATCACCGTCCAGATGTTCCCCCAAGGGCTGACCAAT
GCCGAGGGAACGACCTTCACGGCGGTTAACCTCTTCATCACCTCGGTGGTGGGCCTGGTGGTGACCGGCGCCATCTTCTG
GATCACCGAATATTACACCGCCACCGAGTACGCTCCGGTGCGGCACATCGCCCAGGCCTCCACAACCGGCCACGGCACCA
ATGTTATTGCCGGTCTGGGTGTCTCCATGAAGGCCACCGCCCTGCCGGTGATCGTTATCGCCGCCGGCATCGTCATCTCC
TTCGAGTGTGCCGGTGTCTACGGCATCGCCATCGCCGCCGTCTCCATGCTGTCGCTCACCGGAATCGTGGTCGCCATGGA
CGCCTATGGCCCGATCACCGACAACGCCGGCGGGATCGCCGAGATGGCCGAACTGGACAAGTCGGTCCGCGACGTCACCG
ACCCGCTGGATGCGGTTGGCAACACCACCAAGGCAGTTACCAAGGGATACGCCATCGGCTCCGCCGGTCTGGCCGCCGTG
ATCCTGTTCACCTCCTATGTGGATGAGCTGAAACTGGCCGGCAAGAGCATCACCTTCGACCTGTCCGATCCCTACATCAT
CGTCGGCCTCTTCATCGGCGGCATGCTCCCCTACTACTTCGCCGCCCAGTGCATGGAAGCTGTCGGCAAGGCCGGCGGCG
CGGTTGTCATCGAAGTCCGTCGCCAGTTCCGCGAGATCAAGGGCATCATGCAGGGTACCGGCAAGCCGGACTACGCCTCC
TGCGTGGACATCGTCACCAAGACCGCCCTCAAGGAGATGGTCATTCCCGGCCTGATTCCGATCCTCGCTCCGGTCATCGT
CGGCTTCACCCTCGGTCCCAAGGCCTTGGGCGGCGTGATCGTCGGCACCATCGTCACCGGTATCTTCGTGGCTATCTCCA
TGACCACCGGCGGCGGTGCCTGGGATAACGCCAAGAAGTACATCGAAGACGGCCACCATGGCGGCAAGGGGGGCGAAGCC
CACAAGGCTGCCGTTACCGGCGACACCGTCGGCGACCCCTACAAGGACACCGCCGGTCCGGCGGTCAACCCGATGATCAA
GATCATCAACATCGTGTCGCTGCTGATCGTGCCGCTCCTGGCCAAGATGATGTAA

Upstream 100 bases:

>100_bases
TTGTTGACAAAACAGACATTTTTGTTTAACAATTTCCCGTTTTTACGCCGGGGCGTACTACAGCCATGAAGGCTGAATAT
ATTCAGGAGGGTTTGTAACA

Downstream 100 bases:

>100_bases
GCGAAACGCACATTCCGATAAACGAAAAGCGGCAGGGGATCAGATCTCCTGCCGCTTCTTGTTTGTGAGCGTAAAATAGA
AAACCGCTGACTCGCACGGA

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MEQYAVIFALACAVAAVAYGLVSAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIISVVGVVMFIALFASLGWKTAV
GFAVGALFSGLTGFIGMFVSVRANVRTTEAAKSGIEKALNVAFKGGAITGMLVVGLGLLGVAGYYMFLQQVMPDAPVKDV
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAIAFNSNPGAVSYPLILGGVSIIASIIGTFFVKLGASKKIMPALYKGLIVSGLLACVAFYFITVQMFPQGLTN
AEGTTFTAVNLFITSVVGLVVTGAIFWITEYYTATEYAPVRHIAQASTTGHGTNVIAGLGVSMKATALPVIVIAAGIVIS
FECAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDKSVRDVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
ILFTSYVDELKLAGKSITFDLSDPYIIVGLFIGGMLPYYFAAQCMEAVGKAGGAVVIEVRRQFREIKGIMQGTGKPDYAS
CVDIVTKTALKEMVIPGLIPILAPVIVGFTLGPKALGGVIVGTIVTGIFVAISMTTGGGAWDNAKKYIEDGHHGGKGGEA
HKAAVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLAKMM

Sequences:

>Translated_684_residues
MEQYAVIFALACAVAAVAYGLVSAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIISVVGVVMFIALFASLGWKTAV
GFAVGALFSGLTGFIGMFVSVRANVRTTEAAKSGIEKALNVAFKGGAITGMLVVGLGLLGVAGYYMFLQQVMPDAPVKDV
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAIAFNSNPGAVSYPLILGGVSIIASIIGTFFVKLGASKKIMPALYKGLIVSGLLACVAFYFITVQMFPQGLTN
AEGTTFTAVNLFITSVVGLVVTGAIFWITEYYTATEYAPVRHIAQASTTGHGTNVIAGLGVSMKATALPVIVIAAGIVIS
FECAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDKSVRDVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
ILFTSYVDELKLAGKSITFDLSDPYIIVGLFIGGMLPYYFAAQCMEAVGKAGGAVVIEVRRQFREIKGIMQGTGKPDYAS
CVDIVTKTALKEMVIPGLIPILAPVIVGFTLGPKALGGVIVGTIVTGIFVAISMTTGGGAWDNAKKYIEDGHHGGKGGEA
HKAAVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLAKMM
>Mature_684_residues
MEQYAVIFALACAVAAVAYGLVSAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIISVVGVVMFIALFASLGWKTAV
GFAVGALFSGLTGFIGMFVSVRANVRTTEAAKSGIEKALNVAFKGGAITGMLVVGLGLLGVAGYYMFLQQVMPDAPVKDV
VSQLVGLGFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
IAAMLLGAIAFNSNPGAVSYPLILGGVSIIASIIGTFFVKLGASKKIMPALYKGLIVSGLLACVAFYFITVQMFPQGLTN
AEGTTFTAVNLFITSVVGLVVTGAIFWITEYYTATEYAPVRHIAQASTTGHGTNVIAGLGVSMKATALPVIVIAAGIVIS
FECAGVYGIAIAAVSMLSLTGIVVAMDAYGPITDNAGGIAEMAELDKSVRDVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
ILFTSYVDELKLAGKSITFDLSDPYIIVGLFIGGMLPYYFAAQCMEAVGKAGGAVVIEVRRQFREIKGIMQGTGKPDYAS
CVDIVTKTALKEMVIPGLIPILAPVIVGFTLGPKALGGVIVGTIVTGIFVAISMTTGGGAWDNAKKYIEDGHHGGKGGEA
HKAAVTGDTVGDPYKDTAGPAVNPMIKIINIVSLLIVPLLAKMM

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 70390; Mature: 70390

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQYAVIFALACAVAAVAYGLVSAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGVVMFIALFASLGWKTAVGFAVGALFSGLTGFIGMFVSVRANVRTTEAAKSGIEKALN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAFKGGAITGMLVVGLGLLGVAGYYMFLQQVMPDAPVKDVVSQLVGLGFGGSLISIFARL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IAAMLLGAIAFNSNPGAVSYPLILGGVSIIASIIGTFFVKLGASKKIMPALYKGLIVSGL
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LACVAFYFITVQMFPQGLTNAEGTTFTAVNLFITSVVGLVVTGAIFWITEYYTATEYAPV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RHIAQASTTGHGTNVIAGLGVSMKATALPVIVIAAGIVISFECAGVYGIAIAAVSMLSLT
HHHHHHCCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHH
GIVVAMDAYGPITDNAGGIAEMAELDKSVRDVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
HHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHH
ILFTSYVDELKLAGKSITFDLSDPYIIVGLFIGGMLPYYFAAQCMEAVGKAGGAVVIEVR
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
RQFREIKGIMQGTGKPDYASCVDIVTKTALKEMVIPGLIPILAPVIVGFTLGPKALGGVI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGTIVTGIFVAISMTTGGGAWDNAKKYIEDGHHGGKGGEAHKAAVTGDTVGDPYKDTAGP
HHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
AVNPMIKIINIVSLLIVPLLAKMM
CHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEQYAVIFALACAVAAVAYGLVSAQWILGLPQGNERMRQIAAAIQEGAGAYMKRQYTIIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHH
VVGVVMFIALFASLGWKTAVGFAVGALFSGLTGFIGMFVSVRANVRTTEAAKSGIEKALN
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAFKGGAITGMLVVGLGLLGVAGYYMFLQQVMPDAPVKDVVSQLVGLGFGGSLISIFARL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTL
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IAAMLLGAIAFNSNPGAVSYPLILGGVSIIASIIGTFFVKLGASKKIMPALYKGLIVSGL
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LACVAFYFITVQMFPQGLTNAEGTTFTAVNLFITSVVGLVVTGAIFWITEYYTATEYAPV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RHIAQASTTGHGTNVIAGLGVSMKATALPVIVIAAGIVISFECAGVYGIAIAAVSMLSLT
HHHHHHCCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHH
GIVVAMDAYGPITDNAGGIAEMAELDKSVRDVTDPLDAVGNTTKAVTKGYAIGSAGLAAV
HHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHH
ILFTSYVDELKLAGKSITFDLSDPYIIVGLFIGGMLPYYFAAQCMEAVGKAGGAVVIEVR
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
RQFREIKGIMQGTGKPDYASCVDIVTKTALKEMVIPGLIPILAPVIVGFTLGPKALGGVI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGTIVTGIFVAISMTTGGGAWDNAKKYIEDGHHGGKGGEAHKAAVTGDTVGDPYKDTAGP
HHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
AVNPMIKIINIVSLLIVPLLAKMM
CHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]