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The map label for this gene is pleC [H]

Identifier: 118581133

GI number: 118581133

Start: 2976332

End: 2978038

Strand: Reverse

Name: pleC [H]

Synonym: Ppro_2725

Alternate gene names: 118581133

Gene position: 2978038-2976332 (Counterclockwise)

Preceding gene: 118581134

Following gene: 118581132

Centisome position: 74.3

GC content: 59.81

Gene sequence:

>1707_bases
GTGGCATCCATATCCACCCTGCTTCTGTCGACGCTTGTCAATGCCCGCAATCTGGTGGAGGAGGCGCTGCGCGCCTCGGA
GGAAAAATTCAGGAACATCTTCGAGAAAGCGCCCATCGGCATATTCCAGTCCAGCATTGAGGGCAGATTCACCAGTGTCA
ACGGGACCCTTGCCACCATGTTCCGCTACTCGTCTCCCCGGGAGATGATCATGGACGCGCGGGATATTTCACGCCAGCTC
TTCATCTGTCCCGACCAGAGGAACGCCATCATAGCCCGTGCGCGCGACTCACTGACCTATGTCAGGGAGGAGATCGCCTA
CCGCCGCAGGGATGGTTCGGAATTCATCGCCAACCTGTATATGCGGCTGTTGCGCGGCGCCACGGAGAACGAGGCGGATC
TGGAAGGTTTCGTGGAGGACATCACCGAACGCAAGCGTGCCGAAGACAGCCTGCGGGTCTATCAGGAAAACCTGGAAAAC
CTGGTCAGGGCGAGGACGTCGGAGCTTCAGGATGCCAATGAACGGCTGACGAGGGAGATCGAAGAGCGTAACAGGGCCGA
GCGGATCCTCATCGAACGCGAGGCGCAGTATCGGGATCTCGTGGAGAGCGCCAACTGCGTCATCCTGCGTTGGCTGCCGG
ATGGGAGGATCATCTTCTTCAACCGCTTCGCCCAGTCCTTTTTCGGGTATCGTGAAGAGGAGGTCCTGGGGCGCAGCATC
ATCGGCACGCTGATTCCTCCCGCGGATTCCACCGGCCACGAGCTCACATCCCTGGCAACGGATATCGTTTCCCATCCGGA
AGCGTACGCCCACAATATTAACGAGAATCTGCGCAAGAACGGGGAACTGGTCTGGGTTGCCTGGACCAACAAGCCAATCC
TCGCACCTGACGGCTCTGTCGCGGAAATCCTCTCCATCGGTATCGACATCACCCAGTTGGTGCATACGGAGCAAGCGTTG
CGGCGGACGCTGGACGAACTGGCATGGGCCAAGGAGAGGGCCGAATCCGCCGACCATTTGAAATCGGCCTTTCTTGCCAC
CATGTCCCATGAGCTGCGCACCCCGCTCAACTCGATCATCGGTTTCACCGGCATACTGCTGCAGGGATTGAGCGGCCCGA
TCAACGACGAACAGGCCAAGCAGCTCGGCATGGTAAAAAACAGCGCCAATCACCTGCTCTCCCTGATCAGCGACGTGCTG
GACATCTCCAAGATCGAGGCGGGACAGCTGAAGGTGGAGCATGAGCCGTTCGACCTCCGCGAGTCGATTCTCAAGGTTGT
CCAGAGCGTGCGCCCCCTGGCGGAGAAGAAGGGACTCGATCTCTCCTGCGACCTGGCGGAACAGGTGGGGAACATCAGCG
GAGATGCGCGCCGGGTGGAGCAGGTTCTGCTCAACCTGCTCAGCAACGCGCTCAAGTTCACGGAGCAGGGAGGCGTCCGC
GTCAGCTGCGGCCGTGAAGGAGACGCCTTCCTGACCAGCGTACGCGACAGCGGCATCGGCATCAAGGACGAGGAGCTGGA
GCGTCTGTTCAAACCATTCCATCAGGTCGACACCGGCCTGAGCCGCAAATACGAAGGGACCGGCCTGGGGCTCTCCATCA
GCAAGAAACTGGTGGAGTTGATGGGGGGCGAGATCCGGGTCGAAAGCAGTCCGGGGAAGGGGAGCACTTTTGCCTTCACG
CTTCCCCTTGAAAGGAATCCCGTATGA

Upstream 100 bases:

>100_bases
GGTTATGCTGAGTTTCCTGGCATGGACCGTTACGGGGCTCGGTCCCTTCAGCGTTACTAACCTGAATTATTCACTTCTTT
TTCTTCAATCCTATCTGGGT

Downstream 100 bases:

>100_bases
AAAAAAAGATTCTCTATATCGAAGACAACGAGCAGAACCTGTATCTGGTAAAGTTTCTCATGGAAAAGCATGGCTATGAG
GTGAGCGCGGCCATGGATGG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MASISTLLLSTLVNARNLVEEALRASEEKFRNIFEKAPIGIFQSSIEGRFTSVNGTLATMFRYSSPREMIMDARDISRQL
FICPDQRNAIIARARDSLTYVREEIAYRRRDGSEFIANLYMRLLRGATENEADLEGFVEDITERKRAEDSLRVYQENLEN
LVRARTSELQDANERLTREIEERNRAERILIEREAQYRDLVESANCVILRWLPDGRIIFFNRFAQSFFGYREEEVLGRSI
IGTLIPPADSTGHELTSLATDIVSHPEAYAHNINENLRKNGELVWVAWTNKPILAPDGSVAEILSIGIDITQLVHTEQAL
RRTLDELAWAKERAESADHLKSAFLATMSHELRTPLNSIIGFTGILLQGLSGPINDEQAKQLGMVKNSANHLLSLISDVL
DISKIEAGQLKVEHEPFDLRESILKVVQSVRPLAEKKGLDLSCDLAEQVGNISGDARRVEQVLLNLLSNALKFTEQGGVR
VSCGREGDAFLTSVRDSGIGIKDEELERLFKPFHQVDTGLSRKYEGTGLGLSISKKLVELMGGEIRVESSPGKGSTFAFT
LPLERNPV

Sequences:

>Translated_568_residues
MASISTLLLSTLVNARNLVEEALRASEEKFRNIFEKAPIGIFQSSIEGRFTSVNGTLATMFRYSSPREMIMDARDISRQL
FICPDQRNAIIARARDSLTYVREEIAYRRRDGSEFIANLYMRLLRGATENEADLEGFVEDITERKRAEDSLRVYQENLEN
LVRARTSELQDANERLTREIEERNRAERILIEREAQYRDLVESANCVILRWLPDGRIIFFNRFAQSFFGYREEEVLGRSI
IGTLIPPADSTGHELTSLATDIVSHPEAYAHNINENLRKNGELVWVAWTNKPILAPDGSVAEILSIGIDITQLVHTEQAL
RRTLDELAWAKERAESADHLKSAFLATMSHELRTPLNSIIGFTGILLQGLSGPINDEQAKQLGMVKNSANHLLSLISDVL
DISKIEAGQLKVEHEPFDLRESILKVVQSVRPLAEKKGLDLSCDLAEQVGNISGDARRVEQVLLNLLSNALKFTEQGGVR
VSCGREGDAFLTSVRDSGIGIKDEELERLFKPFHQVDTGLSRKYEGTGLGLSISKKLVELMGGEIRVESSPGKGSTFAFT
LPLERNPV
>Mature_567_residues
ASISTLLLSTLVNARNLVEEALRASEEKFRNIFEKAPIGIFQSSIEGRFTSVNGTLATMFRYSSPREMIMDARDISRQLF
ICPDQRNAIIARARDSLTYVREEIAYRRRDGSEFIANLYMRLLRGATENEADLEGFVEDITERKRAEDSLRVYQENLENL
VRARTSELQDANERLTREIEERNRAERILIEREAQYRDLVESANCVILRWLPDGRIIFFNRFAQSFFGYREEEVLGRSII
GTLIPPADSTGHELTSLATDIVSHPEAYAHNINENLRKNGELVWVAWTNKPILAPDGSVAEILSIGIDITQLVHTEQALR
RTLDELAWAKERAESADHLKSAFLATMSHELRTPLNSIIGFTGILLQGLSGPINDEQAKQLGMVKNSANHLLSLISDVLD
ISKIEAGQLKVEHEPFDLRESILKVVQSVRPLAEKKGLDLSCDLAEQVGNISGDARRVEQVLLNLLSNALKFTEQGGVRV
SCGREGDAFLTSVRDSGIGIKDEELERLFKPFHQVDTGLSRKYEGTGLGLSISKKLVELMGGEIRVESSPGKGSTFAFTL
PLERNPV

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=261, Percent_Identity=43.6781609195402, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=43.2950191570881, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=42.2131147540984, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI48994928, Length=423, Percent_Identity=32.387706855792, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=38.2470119521912, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1786600, Length=392, Percent_Identity=28.0612244897959, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=29.1845493562232, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=32.9059829059829, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=30.4347826086957, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=32.6359832635983, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=28.6919831223629, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082128, Length=248, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=29.5454545454545, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=26.5486725663717, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=26.1061946902655, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=261, Percent_Identity=26.0536398467433, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=72, Percent_Identity=51.3888888888889, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63710; Mature: 63579

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASISTLLLSTLVNARNLVEEALRASEEKFRNIFEKAPIGIFQSSIEGRFTSVNGTLATM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEECCCHHHHH
FRYSSPREMIMDARDISRQLFICPDQRNAIIARARDSLTYVREEIAYRRRDGSEFIANLY
HHCCCCHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MRLLRGATENEADLEGFVEDITERKRAEDSLRVYQENLENLVRARTSELQDANERLTREI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERNRAERILIEREAQYRDLVESANCVILRWLPDGRIIFFNRFAQSFFGYREEEVLGRSI
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCCHHHHHHHHH
IGTLIPPADSTGHELTSLATDIVSHPEAYAHNINENLRKNGELVWVAWTNKPILAPDGSV
HHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCH
AEILSIGIDITQLVHTEQALRRTLDELAWAKERAESADHLKSAFLATMSHELRTPLNSII
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFTGILLQGLSGPINDEQAKQLGMVKNSANHLLSLISDVLDISKIEAGQLKVEHEPFDLR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
ESILKVVQSVRPLAEKKGLDLSCDLAEQVGNISGDARRVEQVLLNLLSNALKFTEQGGVR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
VSCGREGDAFLTSVRDSGIGIKDEELERLFKPFHQVDTGLSRKYEGTGLGLSISKKLVEL
EECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
MGGEIRVESSPGKGSTFAFTLPLERNPV
CCCEEEEECCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
ASISTLLLSTLVNARNLVEEALRASEEKFRNIFEKAPIGIFQSSIEGRFTSVNGTLATM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEECCCHHHHH
FRYSSPREMIMDARDISRQLFICPDQRNAIIARARDSLTYVREEIAYRRRDGSEFIANLY
HHCCCCHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MRLLRGATENEADLEGFVEDITERKRAEDSLRVYQENLENLVRARTSELQDANERLTREI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERNRAERILIEREAQYRDLVESANCVILRWLPDGRIIFFNRFAQSFFGYREEEVLGRSI
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHCCCHHHHHHHHH
IGTLIPPADSTGHELTSLATDIVSHPEAYAHNINENLRKNGELVWVAWTNKPILAPDGSV
HHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCH
AEILSIGIDITQLVHTEQALRRTLDELAWAKERAESADHLKSAFLATMSHELRTPLNSII
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFTGILLQGLSGPINDEQAKQLGMVKNSANHLLSLISDVLDISKIEAGQLKVEHEPFDLR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHH
ESILKVVQSVRPLAEKKGLDLSCDLAEQVGNISGDARRVEQVLLNLLSNALKFTEQGGVR
HHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
VSCGREGDAFLTSVRDSGIGIKDEELERLFKPFHQVDTGLSRKYEGTGLGLSISKKLVEL
EECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
MGGEIRVESSPGKGSTFAFTLPLERNPV
CCCEEEEECCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]