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The map label for this gene is hemH

Identifier: 118581125

GI number: 118581125

Start: 2961036

End: 2962004

Strand: Direct

Name: hemH

Synonym: Ppro_2715

Alternate gene names: 118581125

Gene position: 2961036-2962004 (Clockwise)

Preceding gene: 118581119

Following gene: 118581138

Centisome position: 73.88

GC content: 63.26

Gene sequence:

>969_bases
ATGGTCATAGACAGGACAGCCGTGCTGCTGCTTCAGATGGGGGGGCCGGACAGCATTGAGGCCGTGGAGCCGTTTCTGCG
CAACCTCTTTTCTGACCGGGATATCATCAGAATCGGCCCCGCCTTTCTCCAACCACTGATCGCCCGCCTGATAGCCCGCC
GCCGCTCGAAGCGGGTCGCGGAACAGTACCGCCAGATCGGTGGCGGTTCCCCGCTGCGAAAACTGACCGAGCAGCAGGCA
GCCGAACTGGAAAAGGTCCTGGGAGAGGGGTATCGCTGTTTCGTCGCCATGCGCTACTGGAAGCCCGACACGTCCCAAGC
ACTGGAAGCGGTCGTTCAAGCGGGCATCACCCGCATCGTCGCCCTGTCGCTCTACCCCCACTACTCCCGCGCCACATCCG
GTTCAAGCTTCAACGAACTGGAGCGGGTCAGGGCGCGCTCGGCCACACCGTTCCAGGTGACCTGCGTGCGCCAGTTCCAC
GACCACCCGCTCTACATCACCAGCCTGTGCGACAGGATCGGCCAGGCCCTGTCCGGGTACGCCGATCCCGGCGACGTACA
CCTGCTCTTCACCGCCCACGGCCTGCCCCAGTCGTTCATCGACTCGGGCGATCCCTACCTGGACCAGATCCGGGCAACGG
TTGCCCTGGTCATGGAGCGTTTCGGGGGCATCAACCATCACCTGGCCTTCCAGTCCCGGGCAGGTCCGGTGAAATGGCTG
GAGCCCTCCACGGAGAAGAAGATCAGGGAACTGGCCGGGCAAGGGGTGAAGAAGCTGCTGATGGTGCCGGTCTCGTTTGT
TTCCGATCACATCGAGACCCTGCACGAGATCGACATGCAGTACCGGCACGAGGCGTTGGAACTGGGGATTGAGGATTTCC
GGCGGGTGGAGTCGCTGAACAGTTCGCCCCTGTTCATCGACTGCCTGGCGGAACTGGTCAGGGGGGGCGACAGGACAGAG
GAGACATAG

Upstream 100 bases:

>100_bases
TTTGCTGGACTTCACAAATTTTTTCCCTATGTTGGCAGGGTGCGCCGTCGGAGAACGCACCAGCGAGGACGCTTCCGCGC
GAGAGGGAAAGGGGGAGGAG

Downstream 100 bases:

>100_bases
ATTCCAGGGATTCAGGTCAGGAGGGCGAGGCCACGTCCCCACGGGAGAGGGGGGAGTTTAGCGGGAAACGGACCGTAAAC
GTCGAACCGGTGCCCACCTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MVIDRTAVLLLQMGGPDSIEAVEPFLRNLFSDRDIIRIGPAFLQPLIARLIARRRSKRVAEQYRQIGGGSPLRKLTEQQA
AELEKVLGEGYRCFVAMRYWKPDTSQALEAVVQAGITRIVALSLYPHYSRATSGSSFNELERVRARSATPFQVTCVRQFH
DHPLYITSLCDRIGQALSGYADPGDVHLLFTAHGLPQSFIDSGDPYLDQIRATVALVMERFGGINHHLAFQSRAGPVKWL
EPSTEKKIRELAGQGVKKLLMVPVSFVSDHIETLHEIDMQYRHEALELGIEDFRRVESLNSSPLFIDCLAELVRGGDRTE
ET

Sequences:

>Translated_322_residues
MVIDRTAVLLLQMGGPDSIEAVEPFLRNLFSDRDIIRIGPAFLQPLIARLIARRRSKRVAEQYRQIGGGSPLRKLTEQQA
AELEKVLGEGYRCFVAMRYWKPDTSQALEAVVQAGITRIVALSLYPHYSRATSGSSFNELERVRARSATPFQVTCVRQFH
DHPLYITSLCDRIGQALSGYADPGDVHLLFTAHGLPQSFIDSGDPYLDQIRATVALVMERFGGINHHLAFQSRAGPVKWL
EPSTEKKIRELAGQGVKKLLMVPVSFVSDHIETLHEIDMQYRHEALELGIEDFRRVESLNSSPLFIDCLAELVRGGDRTE
ET
>Mature_322_residues
MVIDRTAVLLLQMGGPDSIEAVEPFLRNLFSDRDIIRIGPAFLQPLIARLIARRRSKRVAEQYRQIGGGSPLRKLTEQQA
AELEKVLGEGYRCFVAMRYWKPDTSQALEAVVQAGITRIVALSLYPHYSRATSGSSFNELERVRARSATPFQVTCVRQFH
DHPLYITSLCDRIGQALSGYADPGDVHLLFTAHGLPQSFIDSGDPYLDQIRATVALVMERFGGINHHLAFQSRAGPVKWL
EPSTEKKIRELAGQGVKKLLMVPVSFVSDHIETLHEIDMQYRHEALELGIEDFRRVESLNSSPLFIDCLAELVRGGDRTE
ET

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=38.7878787878788, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI60499025, Length=330, Percent_Identity=38.7878787878788, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=31.7460317460317, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324750, Length=321, Percent_Identity=37.6947040498442, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17864156, Length=321, Percent_Identity=38.3177570093458, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=35.9375, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=40, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_PELPD (A1ASJ7)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902375.1
- ProteinModelPortal:   A1ASJ7
- SMR:   A1ASJ7
- STRING:   A1ASJ7
- GeneID:   4573804
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2715
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- PhylomeDB:   A1ASJ7
- ProtClustDB:   CLSK790160
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36170; Mature: 36170

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIDRTAVLLLQMGGPDSIEAVEPFLRNLFSDRDIIRIGPAFLQPLIARLIARRRSKRVA
CCCCCEEHEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
EQYRQIGGGSPLRKLTEQQAAELEKVLGEGYRCFVAMRYWKPDTSQALEAVVQAGITRIV
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
ALSLYPHYSRATSGSSFNELERVRARSATPFQVTCVRQFHDHPLYITSLCDRIGQALSGY
HHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHCC
ADPGDVHLLFTAHGLPQSFIDSGDPYLDQIRATVALVMERFGGINHHLAFQSRAGPVKWL
CCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCC
EPSTEKKIRELAGQGVKKLLMVPVSFVSDHIETLHEIDMQYRHEALELGIEDFRRVESLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
SSPLFIDCLAELVRGGDRTEET
CCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVIDRTAVLLLQMGGPDSIEAVEPFLRNLFSDRDIIRIGPAFLQPLIARLIARRRSKRVA
CCCCCEEHEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
EQYRQIGGGSPLRKLTEQQAAELEKVLGEGYRCFVAMRYWKPDTSQALEAVVQAGITRIV
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
ALSLYPHYSRATSGSSFNELERVRARSATPFQVTCVRQFHDHPLYITSLCDRIGQALSGY
HHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHHCC
ADPGDVHLLFTAHGLPQSFIDSGDPYLDQIRATVALVMERFGGINHHLAFQSRAGPVKWL
CCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCC
EPSTEKKIRELAGQGVKKLLMVPVSFVSDHIETLHEIDMQYRHEALELGIEDFRRVESLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
SSPLFIDCLAELVRGGDRTEET
CCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA