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The map label for this gene is pyrD

Identifier: 118581041

GI number: 118581041

Start: 2856975

End: 2857889

Strand: Reverse

Name: pyrD

Synonym: Ppro_2629

Alternate gene names: 118581041

Gene position: 2857889-2856975 (Counterclockwise)

Preceding gene: 118581042

Following gene: 118581040

Centisome position: 71.3

GC content: 66.45

Gene sequence:

>915_bases
ATGAAGCCAGATATGACCGTCAACCTGGCCGGGCTTGAATTGCGCAATCCGGTGATGACCGCCTCCGGCACCTTCGGCTA
TGGCCGGGAATTCGCCGATTATGTGGATCTGGAGAAGATCGGCGCCTTCGTCACCAAGGGGCTTTCGCTGAAGCCGCGCC
CGGGCAATCCCACCCCGCGCATCGTGGAGACGCCGGGCGGCATGCTCAACGCCATCGGCCTGCAGAACGTGGGCATCGAG
GCCTTCATAGCCGAAAAGGTCCCCTTCCTGGCCAGGGTGAACACGCCCGCCATCGTCAACTTCTTCGGCAGCACGCCCGA
GGAGTACGCCGAACTGGCCGGCCGGCTGGACGAAATCCCCCAGGTGGCCGGACTGGAGGTCAACATCTCCTGCCCCAACG
TGAAGCAGGGGGGGATCGTCTTCGGCACCGACCCGGCCTGTGCCGGCCAGGTGGTCGCGGCCTGCCGCAGGGCCACCAAA
AAACCGCTGATCGTCAAGCTCTCCCCCAATGTGACCGATGTGGTGGTCATGGCCCAGGCCTGCGCCGATGCAGGCGCCGA
TGCCCTGTCGCTGATCAATACCCTGACCGGCATGGCCATCGACCTGAAGAGCCGCAAGCCGGTGCTGGCCAACATCACCG
GCGGCCTGTCCGGGCCGGCCATCAAGCCGGTGGCGCTGCGCATGGTCTGGCAGGTGAGCCGGGCGGTTCAGGTGCCGCTC
ATCGGCATCGGCGGGATCACGAGCGCCACGGACGCCCTGGAGTTCATTCTGGCCGGGGCCAGCGCCGTGCAGGTGGGCAC
GGCCAGCTTCATCACCCCCTCAGCTAGCCAGGAGATCGCTCAAGGGATGGAACGCTGGCTGGAGGAGCACGGTGTGGCCC
GGGTCAGCGACCTGGTCGGCGCGCTGGAGTGTTGA

Upstream 100 bases:

>100_bases
CCCGGCCACGGGCATACGGCCGAGACCCCCGATTACCGCTGCGTCTGCAAGGAGGGACCGGTCTTTCCGGCCCATGAGCT
GGGATGGGAGGAGTGAGACC

Downstream 100 bases:

>100_bases
TCCGATGATTCTCCCTCCGGATAAATCTAGCTGCCGGATACATGTTCATTCAAAACAGGAGCTATGACCATGACACCACG
AACTCTGCGAATCATGCCGC

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKPDMTVNLAGLELRNPVMTASGTFGYGREFADYVDLEKIGAFVTKGLSLKPRPGNPTPRIVETPGGMLNAIGLQNVGIE
AFIAEKVPFLARVNTPAIVNFFGSTPEEYAELAGRLDEIPQVAGLEVNISCPNVKQGGIVFGTDPACAGQVVAACRRATK
KPLIVKLSPNVTDVVVMAQACADAGADALSLINTLTGMAIDLKSRKPVLANITGGLSGPAIKPVALRMVWQVSRAVQVPL
IGIGGITSATDALEFILAGASAVQVGTASFITPSASQEIAQGMERWLEEHGVARVSDLVGALEC

Sequences:

>Translated_304_residues
MKPDMTVNLAGLELRNPVMTASGTFGYGREFADYVDLEKIGAFVTKGLSLKPRPGNPTPRIVETPGGMLNAIGLQNVGIE
AFIAEKVPFLARVNTPAIVNFFGSTPEEYAELAGRLDEIPQVAGLEVNISCPNVKQGGIVFGTDPACAGQVVAACRRATK
KPLIVKLSPNVTDVVVMAQACADAGADALSLINTLTGMAIDLKSRKPVLANITGGLSGPAIKPVALRMVWQVSRAVQVPL
IGIGGITSATDALEFILAGASAVQVGTASFITPSASQEIAQGMERWLEEHGVARVSDLVGALEC
>Mature_304_residues
MKPDMTVNLAGLELRNPVMTASGTFGYGREFADYVDLEKIGAFVTKGLSLKPRPGNPTPRIVETPGGMLNAIGLQNVGIE
AFIAEKVPFLARVNTPAIVNFFGSTPEEYAELAGRLDEIPQVAGLEVNISCPNVKQGGIVFGTDPACAGQVVAACRRATK
KPLIVKLSPNVTDVVVMAQACADAGADALSLINTLTGMAIDLKSRKPVLANITGGLSGPAIKPVALRMVWQVSRAVQVPL
IGIGGITSATDALEFILAGASAVQVGTASFITPSASQEIAQGMERWLEEHGVARVSDLVGALEC

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=289, Percent_Identity=31.4878892733564, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI45006951, Length=323, Percent_Identity=30.9597523219814, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87082059, Length=324, Percent_Identity=26.5432098765432, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71984108, Length=294, Percent_Identity=27.2108843537415, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17509475, Length=324, Percent_Identity=25, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322633, Length=279, Percent_Identity=31.5412186379928, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640763, Length=291, Percent_Identity=30.9278350515464, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI18858217, Length=291, Percent_Identity=30.9278350515464, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281361352, Length=320, Percent_Identity=26.25, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137316, Length=320, Percent_Identity=26.25, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PELPD (A1ASB3)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902291.1
- ProteinModelPortal:   A1ASB3
- SMR:   A1ASB3
- STRING:   A1ASB3
- GeneID:   4574701
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2629
- eggNOG:   COG0167
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- PhylomeDB:   A1ASB3
- ProtClustDB:   PRK07259
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 31664; Mature: 31664

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDMTVNLAGLELRNPVMTASGTFGYGREFADYVDLEKIGAFVTKGLSLKPRPGNPTPR
CCCCCEEEEECEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
IVETPGGMLNAIGLQNVGIEAFIAEKVPFLARVNTPAIVNFFGSTPEEYAELAGRLDEIP
EEECCCCCEECCCCCCCCHHHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHCC
QVAGLEVNISCPNVKQGGIVFGTDPACAGQVVAACRRATKKPLIVKLSPNVTDVVVMAQA
CCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
CADAGADALSLINTLTGMAIDLKSRKPVLANITGGLSGPAIKPVALRMVWQVSRAVQVPL
HHHCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCE
IGIGGITSATDALEFILAGASAVQVGTASFITPSASQEIAQGMERWLEEHGVARVSDLVG
EEECCCCHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHH
ALEC
HHCC
>Mature Secondary Structure
MKPDMTVNLAGLELRNPVMTASGTFGYGREFADYVDLEKIGAFVTKGLSLKPRPGNPTPR
CCCCCEEEEECEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
IVETPGGMLNAIGLQNVGIEAFIAEKVPFLARVNTPAIVNFFGSTPEEYAELAGRLDEIP
EEECCCCCEECCCCCCCCHHHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHCC
QVAGLEVNISCPNVKQGGIVFGTDPACAGQVVAACRRATKKPLIVKLSPNVTDVVVMAQA
CCCCEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
CADAGADALSLINTLTGMAIDLKSRKPVLANITGGLSGPAIKPVALRMVWQVSRAVQVPL
HHHCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCE
IGIGGITSATDALEFILAGASAVQVGTASFITPSASQEIAQGMERWLEEHGVARVSDLVG
EEECCCCHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHH
ALEC
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA