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The map label for this gene is speA

Identifier: 118581018

GI number: 118581018

Start: 2831233

End: 2833140

Strand: Direct

Name: speA

Synonym: Ppro_2606

Alternate gene names: 118581018

Gene position: 2831233-2833140 (Clockwise)

Preceding gene: 118581010

Following gene: 118581019

Centisome position: 70.64

GC content: 56.6

Gene sequence:

>1908_bases
ATGGAGCGCTGGTCAATCAACGATTCCGCGAAAATTTACAATCTCAACAACTGGGGCGGTGATCTCTTCTCCATCAACAA
GAAGGGTAATATCTGCGTCCATCCTTCCCCCAATTCAAAGTATTCCATCGAACTGGCATCCCTGGTGGACGACCTGATCA
AGCGTAAGATAAAACCCCCCATCCTGCTCAGGTTCATGAACATCCTGGAGGGGCGCATCGCATCCATCAACCGGGTCTTC
AGGAATGCCATCCAGACCAACAACTACCCGGCCCAGTACCAGACCTTCTACCCCATCAAGGTCAACCAGCAGCGCCAGGT
CGTGGAGGCCATCGCCAACTTCGGCAAGAAGTACAACATCGGCCTGGAGGTGGGCTCCAAGCCTGAACTTGTGGCCGCCA
TTTCCATATCCACCAACAACAGCCTGCCGATCATCTGCAACGGCTACAAGGATACCGAGTTCATCGAGACCGTCCTGTAC
GCCACCAAGATCGGTTACAATATCACCATCGTGATCGAGAAGCTGTTCGAACTGGAGAAGGTCATCGAACTCTCCAGGAA
GACCGGCATCACCCCCAAACTGGGCATCAGGGTCAAGCTCTCCTCCAAGGGGACCGGCAAGTGGGCCACCTCCGGCGGCG
AGGACGCCAAGTTCGGCCTGCGCATCTCCGAGATAATCACCGCCATCGACCTGCTCAAGCAGTACAACCTGATCGACAGC
GTCAAGCTGCTGCACTCCCACATCGGCAGCCAGGTCACCAAGATCGACAAGATCAAAAACGCGCTGATCGAGGGGGCCCG
CATCTATGTGGAGATGAAGAAGCTGGGGGTCAACCTGGAGTACATCGACATCGGCGGCGGTCTGGGGGTGGACTACGACG
GATCCAAGTCCAGCTACTTCTCCAGCGTCAACTACTCGGTGGAAGAGTACGCCAACGACGTCATCTACCAGATCAAGAAC
ATCTGCGACGAGGCGGGGGTGGACTGCCCCAACATCATCTCCGAATCGGGCCGGGCCACCGTTGCCCACTACTCGGTGAT
GGTCACCAACATCCTCAACACCAACACCCAGAACCAGATGCCCGACTTCGAATCCATCCTGACCCAGGCGGAGCCCCTCT
CACCCACGGTCAGGAAGCTTGTGGACATCTACAAGAGCATCGACCGCCACTCCCTGCGCGAGGATTACCACGACACCCTC
CAGCTGATCCAGGAGGCGGTCAGCCTGTTCAACCTGGGCTACCTGAACCTGAACGACCGGGCCATGGCGGAATGGCTGTA
CACACGAATAATCAAGAAGATCAACAACCTGGTGGAAAAGATGAAGCCGGTCCCCGAGGAGTTGCAGAACTTCAAGCTGA
GCATGCGCCAGACCTATTTCGCCAACTTCTCCCTGTTCCAGTCCATACCGGATTCCTGGGCCATCGACCAGCTCTTCCCG
ATCATGCCGATCCAGCGGCTGGGGGAAAAGCCGGACGTGATCGCCTCCATCGCCGACATCACCTGCGATTCCGACGGCGA
GATCACCAGCTTCGTGGGCGAGAACGGACGGACCAAGTACCTGCCGCTGCACAAGATCAGAAAGAACGAGGAGTACTACA
TCGGCTTCTTCCTGATCGGCGCCTACCAGGAGATACTAGGGGACCTGCACAACCTGTTCGGTGACACCAATGCCGTGCAC
ATAACCTTCAACAAGAAGACCAACTACCGCATCGACACGGTCATCAGCGGCGACGCCATCCAGCAGTCCCTCAAATACGT
ACAGTACGACGGCAACGAGATACTGAAAAAAGTGCGCGACAGCCTGGAGAACGGGGTCGCCTCCAAGAAGATCTCCATCG
AGGAGAGCAGCCACTTCCTGGAACTGCTGGACAAGACCATCCAGGCCTACACCTACCTGGGTGAATAG

Upstream 100 bases:

>100_bases
GCTCCGACCCCGCTGATTGCCGTGCGAATCGCCATGGGCTGCGGTTTCTATTTTGGCATTCTATTGTATCATTACCACTA
TCCAGACGAGGAAACGGCCT

Downstream 100 bases:

>100_bases
GCGTTTCACCGCACCGCAACGACAGTATTGATGAGCACCATCGTCAGCCGCCAATTCCTCCCCCATCCCCTCTGAAGAGA
GAATGGGGAGGGGCTCGGCG

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MERWSINDSAKIYNLNNWGGDLFSINKKGNICVHPSPNSKYSIELASLVDDLIKRKIKPPILLRFMNILEGRIASINRVF
RNAIQTNNYPAQYQTFYPIKVNQQRQVVEAIANFGKKYNIGLEVGSKPELVAAISISTNNSLPIICNGYKDTEFIETVLY
ATKIGYNITIVIEKLFELEKVIELSRKTGITPKLGIRVKLSSKGTGKWATSGGEDAKFGLRISEIITAIDLLKQYNLIDS
VKLLHSHIGSQVTKIDKIKNALIEGARIYVEMKKLGVNLEYIDIGGGLGVDYDGSKSSYFSSVNYSVEEYANDVIYQIKN
ICDEAGVDCPNIISESGRATVAHYSVMVTNILNTNTQNQMPDFESILTQAEPLSPTVRKLVDIYKSIDRHSLREDYHDTL
QLIQEAVSLFNLGYLNLNDRAMAEWLYTRIIKKINNLVEKMKPVPEELQNFKLSMRQTYFANFSLFQSIPDSWAIDQLFP
IMPIQRLGEKPDVIASIADITCDSDGEITSFVGENGRTKYLPLHKIRKNEEYYIGFFLIGAYQEILGDLHNLFGDTNAVH
ITFNKKTNYRIDTVISGDAIQQSLKYVQYDGNEILKKVRDSLENGVASKKISIEESSHFLELLDKTIQAYTYLGE

Sequences:

>Translated_635_residues
MERWSINDSAKIYNLNNWGGDLFSINKKGNICVHPSPNSKYSIELASLVDDLIKRKIKPPILLRFMNILEGRIASINRVF
RNAIQTNNYPAQYQTFYPIKVNQQRQVVEAIANFGKKYNIGLEVGSKPELVAAISISTNNSLPIICNGYKDTEFIETVLY
ATKIGYNITIVIEKLFELEKVIELSRKTGITPKLGIRVKLSSKGTGKWATSGGEDAKFGLRISEIITAIDLLKQYNLIDS
VKLLHSHIGSQVTKIDKIKNALIEGARIYVEMKKLGVNLEYIDIGGGLGVDYDGSKSSYFSSVNYSVEEYANDVIYQIKN
ICDEAGVDCPNIISESGRATVAHYSVMVTNILNTNTQNQMPDFESILTQAEPLSPTVRKLVDIYKSIDRHSLREDYHDTL
QLIQEAVSLFNLGYLNLNDRAMAEWLYTRIIKKINNLVEKMKPVPEELQNFKLSMRQTYFANFSLFQSIPDSWAIDQLFP
IMPIQRLGEKPDVIASIADITCDSDGEITSFVGENGRTKYLPLHKIRKNEEYYIGFFLIGAYQEILGDLHNLFGDTNAVH
ITFNKKTNYRIDTVISGDAIQQSLKYVQYDGNEILKKVRDSLENGVASKKISIEESSHFLELLDKTIQAYTYLGE
>Mature_635_residues
MERWSINDSAKIYNLNNWGGDLFSINKKGNICVHPSPNSKYSIELASLVDDLIKRKIKPPILLRFMNILEGRIASINRVF
RNAIQTNNYPAQYQTFYPIKVNQQRQVVEAIANFGKKYNIGLEVGSKPELVAAISISTNNSLPIICNGYKDTEFIETVLY
ATKIGYNITIVIEKLFELEKVIELSRKTGITPKLGIRVKLSSKGTGKWATSGGEDAKFGLRISEIITAIDLLKQYNLIDS
VKLLHSHIGSQVTKIDKIKNALIEGARIYVEMKKLGVNLEYIDIGGGLGVDYDGSKSSYFSSVNYSVEEYANDVIYQIKN
ICDEAGVDCPNIISESGRATVAHYSVMVTNILNTNTQNQMPDFESILTQAEPLSPTVRKLVDIYKSIDRHSLREDYHDTL
QLIQEAVSLFNLGYLNLNDRAMAEWLYTRIIKKINNLVEKMKPVPEELQNFKLSMRQTYFANFSLFQSIPDSWAIDQLFP
IMPIQRLGEKPDVIASIADITCDSDGEITSFVGENGRTKYLPLHKIRKNEEYYIGFFLIGAYQEILGDLHNLFGDTNAVH
ITFNKKTNYRIDTVISGDAIQQSLKYVQYDGNEILKKVRDSLENGVASKKISIEESSHFLELLDKTIQAYTYLGE

Specific function: Catalyzes the biosynthesis of agmatine from arginine

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily

Homologues:

Organism=Escherichia coli, GI1789307, Length=632, Percent_Identity=37.1835443037975, Blast_Score=462, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEA_PELPD (A1AS90)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902268.1
- ProteinModelPortal:   A1AS90
- STRING:   A1AS90
- GeneID:   4572939
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2606
- eggNOG:   COG1166
- HOGENOM:   HBG321436
- OMA:   TCDSDGE
- PhylomeDB:   A1AS90
- ProtClustDB:   PRK05354
- HAMAP:   MF_01417
- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PANTHER:   PTHR11482:SF3
- PIRSF:   PIRSF001336
- PRINTS:   PR01180
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01273

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC

EC number: =4.1.1.19

Molecular weight: Translated: 71802; Mature: 71802

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERWSINDSAKIYNLNNWGGDLFSINKKGNICVHPSPNSKYSIELASLVDDLIKRKIKPP
CCCCCCCCCCEEEEECCCCCCEEEECCCCCEEECCCCCCCEEEEHHHHHHHHHHHHCCCH
ILLRFMNILEGRIASINRVFRNAIQTNNYPAQYQTFYPIKVNQQRQVVEAIANFGKKYNI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCEEEE
GLEVGSKPELVAAISISTNNSLPIICNGYKDTEFIETVLYATKIGYNITIVIEKLFELEK
EEEECCCCCEEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
VIELSRKTGITPKLGIRVKLSSKGTGKWATSGGEDAKFGLRISEIITAIDLLKQYNLIDS
HHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VKLLHSHIGSQVTKIDKIKNALIEGARIYVEMKKLGVNLEYIDIGGGLGVDYDGSKSSYF
HHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHHCCCEEEEEECCCCCCCCCCCCHHHH
SSVNYSVEEYANDVIYQIKNICDEAGVDCPNIISESGRATVAHYSVMVTNILNTNTQNQM
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEHHHHHHHHHHHHCCCCCCCC
PDFESILTQAEPLSPTVRKLVDIYKSIDRHSLREDYHDTLQLIQEAVSLFNLGYLNLNDR
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHH
AMAEWLYTRIIKKINNLVEKMKPVPEELQNFKLSMRQTYFANFSLFQSIPDSWAIDQLFP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
IMPIQRLGEKPDVIASIADITCDSDGEITSFVGENGRTKYLPLHKIRKNEEYYIGFFLIG
CCCHHHCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCEECCCHHHHCCCCCEEEEEEEHH
AYQEILGDLHNLFGDTNAVHITFNKKTNYRIDTVISGDAIQQSLKYVQYDGNEILKKVRD
HHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHH
SLENGVASKKISIEESSHFLELLDKTIQAYTYLGE
HHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERWSINDSAKIYNLNNWGGDLFSINKKGNICVHPSPNSKYSIELASLVDDLIKRKIKPP
CCCCCCCCCCEEEEECCCCCCEEEECCCCCEEECCCCCCCEEEEHHHHHHHHHHHHCCCH
ILLRFMNILEGRIASINRVFRNAIQTNNYPAQYQTFYPIKVNQQRQVVEAIANFGKKYNI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCEEEE
GLEVGSKPELVAAISISTNNSLPIICNGYKDTEFIETVLYATKIGYNITIVIEKLFELEK
EEEECCCCCEEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
VIELSRKTGITPKLGIRVKLSSKGTGKWATSGGEDAKFGLRISEIITAIDLLKQYNLIDS
HHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VKLLHSHIGSQVTKIDKIKNALIEGARIYVEMKKLGVNLEYIDIGGGLGVDYDGSKSSYF
HHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHHCCCEEEEEECCCCCCCCCCCCHHHH
SSVNYSVEEYANDVIYQIKNICDEAGVDCPNIISESGRATVAHYSVMVTNILNTNTQNQM
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEHHHHHHHHHHHHCCCCCCCC
PDFESILTQAEPLSPTVRKLVDIYKSIDRHSLREDYHDTLQLIQEAVSLFNLGYLNLNDR
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHH
AMAEWLYTRIIKKINNLVEKMKPVPEELQNFKLSMRQTYFANFSLFQSIPDSWAIDQLFP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
IMPIQRLGEKPDVIASIADITCDSDGEITSFVGENGRTKYLPLHKIRKNEEYYIGFFLIG
CCCHHHCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCEECCCHHHHCCCCCEEEEEEEHH
AYQEILGDLHNLFGDTNAVHITFNKKTNYRIDTVISGDAIQQSLKYVQYDGNEILKKVRD
HHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHH
SLENGVASKKISIEESSHFLELLDKTIQAYTYLGE
HHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA