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The map label for this gene is purD [H]

Identifier: 118581003

GI number: 118581003

Start: 2810772

End: 2812043

Strand: Reverse

Name: purD [H]

Synonym: Ppro_2591

Alternate gene names: 118581003

Gene position: 2812043-2810772 (Counterclockwise)

Preceding gene: 118581004

Following gene: 118581002

Centisome position: 70.16

GC content: 64.62

Gene sequence:

>1272_bases
ATGAAAATACTCGTTGTCGGCGGCGGCGGCCGCGAACATGCGCTGGTCTGGAAAATCGCCCAGTCCCCCCTGGTGAAGAA
GGTCTACTGCGCCCCGGGAAATCCGGGCACGGCCGGATTGGCCGAGAATCTCCCCATCCGGGCGGATGAGGTGGGCAAGT
TGCTGGAATTCGCCTGGAACGAAGGCATCGACCTGACCGTGGTCGGGCCGGAGCAACCGCTCTCCCTGGGGATCGTGGAT
ACGTTCGAGAATCACGACCTGAAAATTTTCGGACCGCATCAGCAGGCGGCGCTGATAGAGGGGAGCAAGGCCTTTTCCAA
GGACCTGATGCGGAAGTACAACGTACCCACCGCCGCCTACGGCGTGTTCAGCGACATCGGGGAGGCCGAGGCGTTCATCG
ACCGTACCGGCCTGCCCATCGTCATCAAGGCCGACGGCCTGGCTGCCGGCAAGGGGGTCATCATCGCCCAGACCCGCCAG
GAGGCGGTGGACACCGTCACAGACATGCTCAGCGGCAACGCCTTCGGCAGCGCCGGCTCCCGCGTGGTGATCGAGGAGTT
TCTCACCGGAGAGGAGGCCTCGTTCCTGGCCATTACCGATGGCAAAAACATCATCCCCCTGGCCAGCGCCCAGGATCACA
AGGCGATTTTCGACGGCGACCAGGGACCGAACACCGGCGGCATGGGCGCCTATTCCCCGGCACCGGTGGTGACGCGGGAA
ATCCACGAGATAGCCATGCGTGACGTGCTGCGCCCCACGGTGGACGGCATGGCGGCCGAAGGGCGTCCCTACCGCGGCGT
GCTCTACGCCGGCCTGATGGTCAAGGACGGCAAGGTCAAGACCCTGGAGTTCAACGCCCGTTTCGGCGACCCGGAGTGCC
AGCCGCTCTTGATGCGCATGAAGTCGGATATCGTGCCGCTGCTTTTGGCTGCCGCCTCGGGTGATATCTCCGGCATGGAC
ATTGAGTGGCATGACCGGGCAGCGGTCTGCGTCGTCATGGCGGCCGAAGGCTACCCGGGCGAGTATCGCAAGGGGGACGC
CATCAGCGGCCTGGCAGATGCCGCGAAACTGGACGACGTGTACGTCTTCCACGCCGGAACCGCCCAGGATGGGGGGCGCT
GCGTGACCAACGGCGGACGGGTACTGGGGGTCACCGCCATGGATGATACGGTTGAACAGGCCATTGCCCGAGCCTATCAG
GCGGCCAGCGTCATCTCCTGGCCCGGTGTGCAGTTCCGCACGGATATCGGCAGGAAGGCCATAGGACGCTGA

Upstream 100 bases:

>100_bases
TTCCCAGGCAGGCTCTGCTTTTTGCCGTTCTTCGTGAGTTGTGAGCCTTTGTGTGGGAACGGTCGTTTTTATACATGAAA
ATTTGATCGAGGTGTAAACC

Downstream 100 bases:

>100_bases
TTCGGGAAAGGTATTGCCTGTTCATTAAAAAATGATCCCTACTTGAAAAAAAGCTGCGCACGGTGGAAAAGTACGATACT
CTGATTGGGACATAACCGGG

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKILVVGGGGREHALVWKIAQSPLVKKVYCAPGNPGTAGLAENLPIRADEVGKLLEFAWNEGIDLTVVGPEQPLSLGIVD
TFENHDLKIFGPHQQAALIEGSKAFSKDLMRKYNVPTAAYGVFSDIGEAEAFIDRTGLPIVIKADGLAAGKGVIIAQTRQ
EAVDTVTDMLSGNAFGSAGSRVVIEEFLTGEEASFLAITDGKNIIPLASAQDHKAIFDGDQGPNTGGMGAYSPAPVVTRE
IHEIAMRDVLRPTVDGMAAEGRPYRGVLYAGLMVKDGKVKTLEFNARFGDPECQPLLMRMKSDIVPLLLAAASGDISGMD
IEWHDRAAVCVVMAAEGYPGEYRKGDAISGLADAAKLDDVYVFHAGTAQDGGRCVTNGGRVLGVTAMDDTVEQAIARAYQ
AASVISWPGVQFRTDIGRKAIGR

Sequences:

>Translated_423_residues
MKILVVGGGGREHALVWKIAQSPLVKKVYCAPGNPGTAGLAENLPIRADEVGKLLEFAWNEGIDLTVVGPEQPLSLGIVD
TFENHDLKIFGPHQQAALIEGSKAFSKDLMRKYNVPTAAYGVFSDIGEAEAFIDRTGLPIVIKADGLAAGKGVIIAQTRQ
EAVDTVTDMLSGNAFGSAGSRVVIEEFLTGEEASFLAITDGKNIIPLASAQDHKAIFDGDQGPNTGGMGAYSPAPVVTRE
IHEIAMRDVLRPTVDGMAAEGRPYRGVLYAGLMVKDGKVKTLEFNARFGDPECQPLLMRMKSDIVPLLLAAASGDISGMD
IEWHDRAAVCVVMAAEGYPGEYRKGDAISGLADAAKLDDVYVFHAGTAQDGGRCVTNGGRVLGVTAMDDTVEQAIARAYQ
AASVISWPGVQFRTDIGRKAIGR
>Mature_423_residues
MKILVVGGGGREHALVWKIAQSPLVKKVYCAPGNPGTAGLAENLPIRADEVGKLLEFAWNEGIDLTVVGPEQPLSLGIVD
TFENHDLKIFGPHQQAALIEGSKAFSKDLMRKYNVPTAAYGVFSDIGEAEAFIDRTGLPIVIKADGLAAGKGVIIAQTRQ
EAVDTVTDMLSGNAFGSAGSRVVIEEFLTGEEASFLAITDGKNIIPLASAQDHKAIFDGDQGPNTGGMGAYSPAPVVTRE
IHEIAMRDVLRPTVDGMAAEGRPYRGVLYAGLMVKDGKVKTLEFNARFGDPECQPLLMRMKSDIVPLLLAAASGDISGMD
IEWHDRAAVCVVMAAEGYPGEYRKGDAISGLADAAKLDDVYVFHAGTAQDGGRCVTNGGRVLGVTAMDDTVEQAIARAYQ
AASVISWPGVQFRTDIGRKAIGR

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=424, Percent_Identity=45.5188679245283, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI4503915, Length=424, Percent_Identity=45.5188679245283, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI209869995, Length=424, Percent_Identity=45.5188679245283, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI209869993, Length=424, Percent_Identity=45.5188679245283, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1790438, Length=430, Percent_Identity=56.7441860465116, Blast_Score=463, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17567511, Length=428, Percent_Identity=41.1214953271028, Blast_Score=295, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6321203, Length=441, Percent_Identity=44.4444444444444, Blast_Score=331, Evalue=1e-91,
Organism=Drosophila melanogaster, GI62471619, Length=430, Percent_Identity=42.5581395348837, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24582400, Length=430, Percent_Identity=42.5581395348837, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 44813; Mature: 44813

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVGGGGREHALVWKIAQSPLVKKVYCAPGNPGTAGLAENLPIRADEVGKLLEFAWN
CEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
EGIDLTVVGPEQPLSLGIVDTFENHDLKIFGPHQQAALIEGSKAFSKDLMRKYNVPTAAY
CCCEEEEECCCCCCEEEEEECCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHCCCHHHH
GVFSDIGEAEAFIDRTGLPIVIKADGLAAGKGVIIAQTRQEAVDTVTDMLSGNAFGSAGS
HHHHHCCHHHHHHHCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCC
RVVIEEFLTGEEASFLAITDGKNIIPLASAQDHKAIFDGDQGPNTGGMGAYSPAPVVTRE
EEEEHHHHCCCCCCEEEEECCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHH
IHEIAMRDVLRPTVDGMAAEGRPYRGVLYAGLMVKDGKVKTLEFNARFGDPECQPLLMRM
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCEEEEEEEECCCCCCCHHHHHHHH
KSDIVPLLLAAASGDISGMDIEWHDRAAVCVVMAAEGYPGEYRKGDAISGLADAAKLDDV
HHCHHHEEEEECCCCCCCCEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCE
YVFHAGTAQDGGRCVTNGGRVLGVTAMDDTVEQAIARAYQAASVISWPGVQFRTDIGRKA
EEEECCCCCCCCEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHEECCCCEEEHHHCHHH
IGR
CCC
>Mature Secondary Structure
MKILVVGGGGREHALVWKIAQSPLVKKVYCAPGNPGTAGLAENLPIRADEVGKLLEFAWN
CEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
EGIDLTVVGPEQPLSLGIVDTFENHDLKIFGPHQQAALIEGSKAFSKDLMRKYNVPTAAY
CCCEEEEECCCCCCEEEEEECCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHCCCHHHH
GVFSDIGEAEAFIDRTGLPIVIKADGLAAGKGVIIAQTRQEAVDTVTDMLSGNAFGSAGS
HHHHHCCHHHHHHHCCCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCC
RVVIEEFLTGEEASFLAITDGKNIIPLASAQDHKAIFDGDQGPNTGGMGAYSPAPVVTRE
EEEEHHHHCCCCCCEEEEECCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHH
IHEIAMRDVLRPTVDGMAAEGRPYRGVLYAGLMVKDGKVKTLEFNARFGDPECQPLLMRM
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCEEEEEEEECCCCCCCHHHHHHHH
KSDIVPLLLAAASGDISGMDIEWHDRAAVCVVMAAEGYPGEYRKGDAISGLADAAKLDDV
HHCHHHEEEEECCCCCCCCEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCE
YVFHAGTAQDGGRCVTNGGRVLGVTAMDDTVEQAIARAYQAASVISWPGVQFRTDIGRKA
EEEECCCCCCCCEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHEECCCCEEEHHHCHHH
IGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]